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Wednesday, April 23, 2025

Rep. Mills ‘cautiously optimistic’ after meeting Syria’s new leader

 Rep. Cory Mills (R-Fla.) said he is “cautiously optimistic” after he met with new Syrian President Ahmed al-Sharaa.

Mills traveled to Damascus last week on an unofficial fact-finding mission, where he held talks with al-Sharaa about economic sanctions and peace between Syria and Israel, Bloomberg reported.

“I am cautiously optimistic and look to maintain open dialogue,” Mills, an army veteran, told the outlet of his visit.

Mills, a close ally of President Trump’s, told the outlet he plans to brief the president and national security adviser Mike Waltz when he returns to the U.S., as well as deliver a letter from al-Sharaa to Trump.

The Florida lawmaker took the trip with a group of influential Syrian Americans who are lobbying the U.S. government to lift the sanctions imposed on the former Syrian administration.

Mills told the outlet that he spoke with al-Sharaa to outline the Trump administration’s expectations for the strict sanctions to be lifted, which the Syrian leader is hoping to facilitate to help his devastated economy and war-torn country via foreign investors. Qatar and Saudi Arabia have shown willingness to help Syria financially but are being blocked from doing so by the U.S. sanctions, Bloomberg noted.

Mills said part of the U.S. conditions would be that any chemical weapons left over from the administration of former President Bashar Assad must be destroyed, and the country would have to coordinate on counterterrorism initiatives with other U.S. allies.

Assad’s regime fell in December to Syrian rebels, ending his nearly 30 years in power.

The country would also have to provide assurances to Israel, which does not trust al-Sharaa and is opposed to the U.S. lifting its sanctions, Bloomberg reported.

Mills’s visit comes just days after the U.S. announced it would be withdrawing hundreds of troops from Syria. The Pentagon argued the shift is a “consolidation” to reflect a changing security environment in the country and highlighted the success of the 2019 Trump-era ISIS defeat.

The Trump administration said the withdrawing of troops would bring U.S. forces down to less than 1,000 over the next few months, though it faces risks, as there’s been an uptick of attacks on American bases in Syria over the last year.

Mills noted to Bloomberg that once Germany and Japan were enemies of the U.S., but “we have to move beyond this if we are to have stabilization” with Syria.

https://thehill.com/policy/international/5264384-rep-mills-cautiously-optimistic-after-meeting-syrias-new-leader/

Iraqis Outraged By Visit Of Syrian Leader Jolani Over al-Qaeda Past

 Via Middle East Eye

Safaa Rashid was barely an adult in 2005 when an explosion ripped through the Iraqi capital Baghdad, killing his 21-year-old cousin, a university student who was working part-time at an electrical goods shop in the city's center. "A suicide bomber stormed the market and detonated his explosive belt, killing my cousin and dozens of innocent people in an instant," said Rashid, now 38 and still living in Baghdad. "He was just at the beginning of his life."

Safaa lost two other cousins that same year in blasts that were attributed to al-Qaeda in Iraq (AQI), the armed group that would evolve into ISI, the Islamic State in Iraq (later just Islamic State), and is responsible for tens of thousands of deaths in Iraq and abroad.

One of those who joined AQI's campaign at the time was a young Syrian named Ahmed al-Sharaa, who later would reappear in his homeland under the name Abu Mohammed al-Jolani and last year successfully overthrew President Bashar al-Assad to become Syria's new ruler.

Although Sharaa has since disavowed his time in al-Qaeda [in terms of public rhetoric at least], his possible presence at an Arab League summit in Baghdad next month has provoked outrage from victims of AQI and its successors, as well as dozens of MPs who are trying to prevent his attendance. "Jolani is the face of terrorism," said Rashid.

"He must be held accountable - I lost three cousins to his group’s violence...how can someone like this be welcomed as if he were an honoured guest?"

'Premature' meeting?

Iraqi Prime Minister Mohammed Shia al-Sudani said last week that he had formally invited Sharaa to attend the upcoming summit, which is scheduled to be held in Baghdad on May 17. The two also met in Qatar last week for the first time since the overthrow of Assad.

Although the Iraqi government had been one of the few in the region to continuously maintain relations with Sharaa's predecessor, Iraq like many other Arab states appears to be trying to integrate post-Assad Syria diplomatically, possibly hoping to end the instability unleashed by the country's 13-year war.

But the extension of the invitation has outraged many. Iraqi media reported that at least 50 MPs from Asaib Ahl al-Haq and Kataib Hezbollah - two Iran-backed armed political factions that provided military support to Assad against Sharaa and other Syrian opposition groups - have filed criminal complaints in Iraqi courts against the Syrian president.

Iraq’s Supreme Judicial Council has yet to take any official action and previously issued a statement saying that several complaint documents circulating on social media were fake and invalid.

Nevertheless, it has led Asaib Ahl al-Haq's leader, Qais al-Khazali, to brand Sharaa's invite "premature", warning there could be a diplomatic incident between the "brotherly nations" should he be arrested. "In light of this, and in accordance with the principle of separation of powers, the decisions of the Iraqi judiciary must be adhered to and respected by all," he wrote on X.

Abu Ali al-Askari, a senior Kataib Hezbollah figure, meanwhile described Sharaa as a "convict".

Change of attitude

Sharaa travelled from Damascus to Baghdad in 2003 to join al-Qaeda shortly before the US-led invasion that toppled President Saddam Hussein. Though he has denied being close to the group's leader Abu Musab al-Zarqawi, other outlets have claimed he quickly rose through the ranks to a senior position.

During the insurgency against US-led forces in Iraq, AQI was responsible for numerous sectarian atrocities across the country, triggered by the group bombing al-Askari Shrine in Samarra on 22 February 2006.

Zarqawi had earlier declared all-out war on Iraqi Shias, "wherever they are in Iraq". Sharaa has argued his time in AQI was more about gaining fighting experience and defending Iraqis than building a caliphate or imposing al-Qaeda's harsh variant of Islamic law.

"There was a massive Arab and Islamic response to the American intervention," he told The Rest Is Politics podcast. He added that during his time in a range of US-run facilities, including the notorious Abu Ghraib prison, his attitude towards the conflict changed and he began to fall out with other al-Qaeda members over their support for overt sectarianism.

Iraqi Telegram accounts linked to pro-Iran groups have posted documents they say further implicate Sharaa in AQI's actions, though they also suggested Sharaa was released from an Iraqi prison for lack of evidence.

The Islamic Dawa Party, which held the prime ministership during the bulk of the AQI and ISI insurgency, also warned against inviting Sharaa to Iraq. Though they did not mention the prime minister by name, they said that anyone invited to the Arab League conference should have a "spotless" legal record both at home and abroad.

In a statement on Sunday, they also drew comparisons with Israeli Prime Minister Benjamin Netanyahu and the outstanding arrest warrant issued against him by the International Criminal Court over the war in Gaza.

"The same should be done in Iraq towards those who have committed heinous crimes against its people, whatever the excuses, out of respect for Iraqi blood and in loyalty to the martyrs who gave their lives for the nation’s dignity and honour," said the party.

'A significant step'

Although many of Syria's neighbours have tried to rebuild links with the country following Assad's defeat, much of the international community has continued to be wary, not least after the recent outbreak of sectarian violence on the country's west coast.

The violence in Latakia, which erupted after attacks by Assad loyalists on pro-government forces, has seen widespread killings of hundreds of members of the Alawi religious minority by armed groups. Sharaa condemned the killings and has sought to calm tensions through dialogue, but the attacks have again raised the spectre of sectarian violence and drawn parallels with the Sunni-Shia bloodshed that devastated Iraq in the mid-2000s.

Not everyone has opposed diplomatic meetings with Sharaa. A number of MPs have emphasised the need for dialogue between the two countries after decades of violence.

Khamis al-Khanjar, an MP and head of the Azem Alliance, welcomed the meeting in Qatar between Sudani and Sharaa. "This meeting represents a significant step toward enhancing Arab cooperation and promoting the principles of dialogue and joint action to address current challenges, rebuild bridges of trust and integration among our peoples, and serve the security and stability of our region," he wrote on social media.

But with the pain of decades of bloodshed still fresh in the mind of many in Iraq, and with AQI's descendents still wreaking havoc in parts of the country, the visit is likely to trigger further outcry.

"Inviting Sharaa to visit Baghdad just returned painful memories for victims’ families," said Rashid. "Many of whom are still waiting for justice nearly two decades after the worst years and al-Qaeda attacks post-2003."

https://www.zerohedge.com/geopolitical/iraqis-outraged-planned-visit-syrian-leader-jolani-over-al-qaeda-past

Legal Aid’s relentless pro-crime push puts all New Yorkers in danger

 You’ve heard the old saying, “don’t shoot yourself in the foot“ — but that’s exactly what New Yorkers are doing by pouring state and local tax dollars into the Legal Aid Society. 

Most people think Legal Aid, which is publicly funded, exists to defend the poor in court.

But it spends millions of dollars — your hard-earned dollars — on class-action litigation and lobbying to force changes in the law that benefit criminals and handcuff cops.

Illegal Aid Society is more like it.

“The Legal Aid Society seems hell-bent on ignoring the plight of the victim while hampering the police at every turn,” Ray Kelly, Gotham’s longest-serving police commissioner, told me this week.

Andrew Cuomo, the Democratic Party’s front-runner in its mayoral  primary, is promising to add 5,000 cops to the NYPD’s ranks.

Kelly laughs off the pledge.

“With the rules in place, people don’t want the job,” he said. “Experienced cops are telling their sons and daughters not to enter the force.”

The Legal Aid Society’s relentless anti-policing campaign is a big reason why.

In its latest bout of loony leftism, Legal Aid this month demanded that cops stop arresting people for what it calls ”low-level” crimes like shoplifting and drug possession.

Instead, the group said in a letter to the city’s Department of Investigation, offenders should merely receive summonses instructing them to appear in court at a later date, not be hauled into a police station.

In 2021, the letter noted, more than half of those accused of petit larceny got off with a mere summons — but now, Legal Aid lawyers complained, 75% of them are being taken into custody.

That’s a good trend, said Kelly, not something to sue about.

“Every arrest should have an investigatory aspect to it,” he explained. “Is the suspect wanted for more serious crimes, or violating parole?  There is no way to find that out except bringing the suspect into the police station.”

Why should someone accused of stealing $200 worth of goods at CVS be set free without an arrest? The city is in the middle of a theft epidemic.  

And state data show that suspects handed a summons fail to show up for their court appearances more than half the time.

Here’s another doozy of a Legal Aid goal: outlawing the handcuffing of accused criminals in court. 

Legal Aid, which calls handcuffing “dehumanizing,” recently filed a class-action lawsuit against the NYPD to block anyone from being handcuffed “absent an individualized judicial determination” that it’s necessary.

Ridiculous, said Kelly.  Handcuffing “safeguards everybody including judges, court personnel and the police. It’s just common sense.”

Legal Aid opposes using weapons scanners to detect guns being carried into the subway, deeming them “invasive.” Have its lawyers never passed through an airport, a courthouse or a federal building?

Legal Aid is pushing the City Council to abolish the NYPD’s Gang Database, calling it a “racist tool”  because nearly all the gang members it lists are black or Hispanic.

But Mayor Eric Adams, who opposes the council’s bill, says the database helps cops solve and actually prevent gang shootings: “96% of the victims of shootings in the city are people of color. Let’s keep them in mind.”

Legal Aid even had the gall to demand that the NYPD turn over photographs and tax identification numbers for all active-duty officers so that the group could produce a mug book — one of cops, not perps.

The goal: making it easier for its clients to identify and file complaints against the NYPD.

Even leftist Judge Arthur Engoron, famous for presiding over Donald Trump’s 2024 trial, saw the danger, denying the request last month in a ruling that said it would be akin “to having a billboard in Times Square” targeting every police officer.

Ensuring that the poor have adequate legal representation is a noble goal, worthy of taxpayer support.

But Legal Aid goes way beyond that to, in its own words, “shape the legal landscape.”  

Its lobbying is largely responsible for the state’s no-cash-bail laws, Raise the Age laws and the 2019 discovery “reforms” that require prosecutors to meet rigid deadlines and share reams of largely irrelevant paperwork with the defense.

The discovery rules have enabled thousands of defendants to walk free.

“Cops risk their lives making arrests only to have cases dismissed on hyper-technicalities brought by these ridiculous discovery rules,” said Kelly. 

The damage has to stop.

Forget defunding the police — that not-so-brilliant leftist notion.

Instead, Albany should be defunding Legal Aid’s lobbying and class-action operations, along with any other nonprofit that protects criminals and makes crime pay.  

Your money is being spent to make you less safe. That’s crazy — a self-inflicted wound if ever there was one.

Betsy McCaughey is a former lieutenant governor of New York and co-founder of the Committee to Save Our City.

https://nypost.com/2025/04/23/opinion/how-legal-aids-pro-crime-push-puts-all-of-us-in-danger/

Palestinian Authority's Abbas Calls Hamas 'Sons Of Dogs' & Demands Release Of Hostages

 Political fractures on the Palestinian side have become more and more public as the Gaza war persists. On Wednesday Palestinian Authority (PA) President Mahmoud Abbas issued a strong declaration demanding that Hamas release all remaining Israeli captives in order to prevent Israel from using "an excuse" to continue destroying Palestinian homes and waging war in the Gaza Strip.

In the unexpected statement, Abbas went so far as to call Hamas militants "sons of dogs". He said while chairing a Palestinian Liberation Organization (PLO) Central Council meeting in the West Bank city of Ramallah, "You sons of dogs, hand over what you have and get us out of this. Don't give Israel an excuse. Don't give them an excuse."

AFP/Getty

"Every day there are hundreds of deaths. Why? They don't want to hand over the US hostage," Abbas said, as cited in regional media. This was in reference to US-Israeli captive Adi Alexander. His family has been imploring President Trump to help gain his release. Alexander was born and raised in New Jersey.

Abbas highlighted that Israel sees itself as justified in erasing Palestinian identity so long as the hostage crisis continues. Fifty-nine hostages, living and dead, remain in the Gaza Strip. Abbas urged Hamas to hand over the hostages in order to "be done with it."

However, Prime Minister Netanyahu and his military leaders have vowed to purse the complete destruction of Hamas. So likely the US-designated terror group believes that if it frees all remaining hostages, the Israeli military will then even more relentlessly seek its total defeat. Israel has vowed to never let Hamas return to governance or power over the Strip.

The BBC commented on 89-year old Abbas' statement:

The remarks were the strongest against the group that the president has delivered since the war began 18 months ago.

A Hamas official condemned what he called Abbas's "derogatory language" towards "a significant proportion... of his own people".

The aforementioned Hamas representative added, "Abbas repeatedly and suspiciously lays the blame for the crimes of the occupation and its ongoing aggression on our people."

The West Bank leader's provocative words received some pushback from within Abbas' own political camp, and among other West Bank officials. "The victim cannot be held responsible for the crimes of the occupation. Today, we face the threat of a new catastrophe that may be more horrific than the 1948 Nakba," Secretary-General of the Palestinian National Initiative, Mustafa Barghouti, told Al Araby TV.

This PA vs. Hamas back-and-forth highlights that the two groups have long been rivals and political enemies. While there are occasional statements of 'solidarity' issued between both, much of the history of their interaction has been marred by political fighting, which has at times in past years spilled over into gunfights in the streets.

The PA, which has always been more secular-leaning and filled with Left-wing officials, is seen as weak and ineffectual by the Sunni hardliners in Hamas. It was Fatah, which makes up the core of the PA, which led resistance to Israeli policy for decades prior to Hamas gaining full power over the Gaza Strip.

While anti-Israeli terrorism of the latter half of the 20th century was dominated by Marxist guerrillas, such as the Popular Front for the Liberation of Palestine (PFLP), recent decades have seen the rise of the Islamists.

The founder of the PFLP, which became infamous for hijacking airplanes throughout the 60s, 70s, and 80s, was George Habash - born to a Christian Palestinian family. He was even given an Orthodox Christian funeral in Amman, Jordan upon his death from natural causes in January 2008.

The founder of the PFLP George Habash was given a Christian funeral at an Orthodox Christian cathedral in Amman. This highlights that prior to the rise of Hamas, Palestinian militants tended to be secular, Left-leaning, and from diverse religious backgrounds. 

The PA (PLO/Fatah) continues to even have Christian officials in its ranks, while Hamas is purely Sunni and often threatens the remaining Palestinian Christians in Gaza.

The whole rivalry is a further reminder that Western officials and populations often approach the Palestine-Israel conflict in an overly simplistic manner. They tend to assume the Palestinians have a singular worldview and politics. Similarly, Israeli politics are also often deeply divided, revealing deeper complexities.

https://www.zerohedge.com/geopolitical/pas-abbas-calls-hamas-sons-dogs-demands-release-hostages-fiery-speech

Inhibition of enzyme that promotes inflammation may reduce cardiovascular risk in obese

 A research team led by Dr. Martin Mollenhauer from the Heart Center at University Hospital Cologne has investigated the link between obesity and the risk of cardiovascular disease in greater detail. The researchers have discovered that in obese patients and in mouse models, increased levels of the oxidative enzyme myeloperoxidase (MPO) are associated with poorer vascular function.

The results of the research have been published under the title "Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in " in Cell Reports Medicine.

In people suffering from obesity, MPO is active in a particular form of fatty tissue surrounding the aorta. This fatty tissue is called perivascular adipose tissue (PVAT). MPO promotes inflammatory processes in PVAT and at the same time inhibits protective mechanisms that normally keep the  elastic and healthy.

In order to obtain a more precise understanding of the underlying mechanism, the effects of the absence of MPO were investigated in small animal models. "Interestingly,  without MPO exhibited better vascular function, fewer signs of inflammation within the PVAT and a conversion of fatty tissue into a more active, energy-consuming form. In addition, there was an increase in the release of the hormone adiponectin, which protects the blood vessels," explains Dr. Mollenhauer.

The results suggest that targeted inhibition of MPO may be a promising new therapeutic approach for people with obesity and increased cardiovascular risk. However, further studies must be carried out before this type of obesity therapy can be applied.

More information: Alexander Hof et al, Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in obesity, Cell Reports Medicine (2025). DOI: 10.1016/j.xcrm.2025.102087


https://medicalxpress.com/news/2025-04-inhibition-enzyme-inflammation-cardiovascular-obese.html

Clinical trials next step for testing vaccine against Alzheimer's-promoting tau protein

 University of New Mexico Health Sciences researchers hope to launch human clinical trials in their quest for a vaccine to prevent the buildup of pathological tau—a protein in the brain associated with Alzheimer's dementia.

In a new paper published in Alzheimer's & Dementia, a team led by Kiran Bhaskar, Ph.D., professor in the Department of Molecular Genetics & Microbiology in the UNM School of Medicine, found that an  generated a robust immune response in both mice and non-human primates, building on earlier research.

"Because we've shown efficacy in the non-human primate, I think that is suggesting to us it's much closer to a clinical trial," Bhaskar said, adding that he and his colleagues are seeking funding from venture capitalists and the Alzheimer's Association to launch a Phase 1 trial in humans.

Tau is a naturally occurring protein that helps stabilize neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the , creating the tangles that are characteristic of Alzheimer's and other .

There are several new FDA-approved treatments for drugs that reduce levels of amyloid beta, another protein implicated in Alzheimer's pathology, but they have only a modest effect on the progression of the disease, leading many to wonder whether targeting tau might be a better bet.

The active immunotherapy developed at UNM generates antibodies that bind to pT181, a region of the altered tau protein that has been identified as an Alzheimer's biomarker. In a 2019 paper published in npj Vaccines, Bhaskar and his colleagues reported that when the vaccine was given to mice bred to express pathological tau, they generated antibodies, reduced the extent of the tangles in key brain structures and improved their performance on tests to gauge their cognitive disability.

The new paper expands on those findings. The vaccine elicited a strong immune response in two other strains of mice bred to develop tau-related disease—one of which had a human tau gene inserted in its genome. In a collaboration with the University of California, Davis, and the California National Primate Research Center, the vaccine was also administered to macaques, primates whose immune systems and brains are closer to humans. They also showed a strong and durable immune response.

The researchers also tested antibodies in the serum from the immunized monkeys on samples of blood plasma drawn from people with , often a precursor to full-blown Alzheimer's dementia, as well as the sera in brain tissue from people who had died from Alzheimer's, and found that they bound to the human version of the tau protein.

The vaccine was developed using a virus-like particle (VLP) platform developed by Bryce Chackerian and David Peabody, Bhaskar's colleagues in Molecular Genetics & Microbiology. VLPs are essentially viruses whose DNA has been removed, rendering them harmless. Snippets of proteins—in this case pT181—can be attached to their surface, rendering them visible to immune cells on the lookout for invaders.

VLP-based vaccines have been shown to create durable immunity, with one primary inoculation and two booster shots, Bhaskar said. They don't require adjuvants—substances (such as aluminum) administered with a vaccine to enhance the immune response. They have also been shown to be safe in humans.

Nicole Maphis, Ph.D., a postdoctoral researcher in the UNM Department of Neurosciences, was the first author on both of the vaccine papers. She said the collaboration with UC Davis was critical for validating the vaccine's efficacy.

"This was important because it extends our work in an  that is more similar to humans," she said. "Mice don't have a human immune response, but these , their immune response is much more similar to humans."

More information: Nicole M. Maphis et al, Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques, Alzheimer's & Dementia (2025). DOI: 10.1002/alz.70101


https://medicalxpress.com/news/2025-04-clinical-trials-vaccine-alzheimer-tau.html

'Davos Alzheimer’s Collaborative Selects PacBio Tech Partner for Alzheimer’s Research in North Africa'



PacBio (NASDAQ: PACB) has been selected as a technology partner by the Davos Alzheimer's Collaborative (DAC) for the North African Dementia Registry (NADR) project. The initiative brings together The American University in Cairo and UCL Queen Square Institute of Neurology to create a comprehensive multi-omics dataset focused on Alzheimer's disease and dementia research in North African populations.

The NADR, the first dementia-focused registry of its kind in North Africa, will utilize PacBio's long-read sequencing technology to collect biosamples, conduct cognitive assessments, and perform digital phenotyping. The project aims to address the underrepresentation of North African populations in dementia research, with a particular focus on Egypt's population of over 110 million.