Oncology Institute Expands Partnership with Helios Clinical Research to Up Trial Access

 The Oncology Institute expands its partnership with Helios Clinical Research to enhance patient access to clinical trials and improve oncology care.

The Oncology Institute, Inc. (TOI) announced an expansion of its partnership with Helios Clinical Research to enhance clinical research capabilities in community oncology. This collaboration follows a successful initiative in Florida and aims to integrate clinical trials into routine patient care. TOI's CEO, Dr. Daniel Virnich, emphasized the benefits of the partnership, which include improved access to clinical trials for patients, streamlined processes for research sponsors, and a scalable infrastructure to support oncology clinicians. Both organizations are dedicated to promoting equity in oncology research by enrolling diverse patient populations. TOI, founded in 2007, serves over 1.8 million patients and is focused on providing high-quality, value-based cancer care across its extensive network of clinics.

Potential Positives

• Expansion of strategic partnership with Helios Clinical Research enhances TOI’s research capabilities and infrastructure.
• Increased access to clinical trials for patients leads to better treatment options and improved patient outcomes.
• Commitment to advancing health equity by enrolling diverse and underrepresented patient populations in clinical research.

Potential Negatives

• Expansion of partnership may indicate challenges in managing existing operations or a need to enhance research capabilities beyond current resources.
• Dependence on a third-party partner like Helios Clinical Research could pose risks to TOI's autonomy and control over its clinical trials.
• Potential scrutiny on the effectiveness and quality of care due to the integration of clinical research in community settings, which may raise questions about prioritization of patient care.

The Oncology Institute is expanding its strategic partnership with Helios Clinical Research to enhance clinical trial access and execution in community oncology.

This initiative will provide patients greater access to advanced therapies through clinical trials and improve overall care delivery.

The goals include integrating clinical research into patient care, improving trial performance, and ensuring health equity in oncology research.

The Oncology Institute was founded in 2007 and has since been dedicated to advancing value-based cancer care in community settings.

For more details, visit The Oncology Institute's official website at www.theoncologyinstitute.com.

TOI Insider Trading Activity

$TOI insiders have traded $TOI stock on the open market 10 times in the past 6 months. Of those trades, 10 have been purchases and 0 have been sales.

Here’s a breakdown of recent trading of $TOI stock by insiders over the last 6 months:

• RICHARD A BARASCH purchased 1,358,448 shares for an estimated $1,415,095
• MARK L PACALA purchased 90,562 shares for an estimated $94,338
• BRAD HIVELY has made 3 purchases buying 309,056 shares for an estimated $59,433 and 0 sales.
• KAREN MARIE JOHNSON purchased 36,224 shares for an estimated $37,734
• DANIEL VIRNICH (Chief Executive Officer) purchased 22,640 shares for an estimated $23,584
• YALE PODNOS (Chief Medical Officer) purchased 9,056 shares for an estimated $9,433
• JEREMY CASTLE (Chief Operating Officer) purchased 9,056 shares for an estimated $9,433
• ROBERT ROSS CARTER (Chief Financial Officer) purchased 9,056 shares for an estimated $9,433

TOI Hedge Fund Activity

We have seen 13 institutional investors add shares of $TOI stock to their portfolio, and 11 decrease their positions in their most recent quarter

Here are some of the largest recent moves:

• FMR LLC removed 4,749,900 shares (-100.0%) from their portfolio in Q4 2024, for an estimated $1,467,719
• KENT LAKE PR LLC removed 2,000,000 shares (-100.0%) from their portfolio in Q4 2024, for an estimated $618,000
• FREEGULLIVER LLC added 412,578 shares (+219.3%) to their portfolio in Q4 2024, for an estimated $127,486
• TIFF ADVISORY SERVICES, LLC added 346,256 shares (+13.2%) to their portfolio in Q4 2024, for an estimated $106,993
• VIRTU FINANCIAL LLC added 131,759 shares (+inf%) to their portfolio in Q4 2024, for an estimated $40,713
• JANE STREET GROUP, LLC added 109,769 shares (+613.6%) to their portfolio in Q4 2024, for an estimated $33,918
• CITADEL ADVISORS LLC removed 91,337 shares (-100.0%) from their portfolio in Q4 2024, for an estimated $28,223

https://www.nasdaq.com/articles/oncology-institute-expands-partnership-helios-clinical-research-enhance-access-clinical

BriaCell Confirms 100% Resolution of Lung Metastasis with Bria-OTS™

BriaCell Therapeutics (Nasdaq: BCTX) has confirmed complete resolution of lung metastasis in their Phase 1/2a Bria-OTS study. The breakthrough was observed in a 78-year-old woman with hormone receptor positive (HR+) metastatic breast cancer who had previously failed multiple therapies.

The patient, enrolled on November 21, 2024, received Bria-OTS intradermal injections every 2 weeks for six weeks (4 doses), followed by dosing every 3 weeks. The treatment resulted in complete resolution of lung metastasis at 2 months, confirmed at 4 months follow-up, with stable disease maintained elsewhere.

The patient entered the study with extensive metastases in bone, lymph node, and lung. This response was achieved with the lowest dose level in the trial, demonstrating promising activity of the Bria-OTS platform as monotherapy. The Phase 1/2a dose escalation study (NCT06471673) will evaluate Bria-OTS both as monotherapy and in combination with an immune checkpoint inhibitor.

https://www.stocktitan.net/news/BCTX/bria-cell-confirms-100-resolution-of-lung-metastasis-with-bria-j68myb6l87om.html

"Vladimir, STOP!" Trump Responds To 'Massive' Russian Missile Strike On Kiev, Leaving 9 Dead

 Amid stalled US-led peace talks, Russia launched a massive overnight attack on Ukraine, including raining down ballistic missiles on the center of Kiev, unleashing large-scale death and destruction.

At least nine people have been reported killed and over 70 injured in the capital city, in what was one of the largest and deadliest missile strikes on Ukraine in months. Some other cities, including Kharkiv, were also hit.

Stillframe from video of the attack, via The Guardian

Anti-aircraft systems began engaging inbound missiles and drones at about 1am local time. But after drones and missiles were able to make it through, several buildings - including a factory - and a house, as well as cars, were set on fire.

BBC writes, "An apartment block was completely flattened during the attack and the windows of surrounding buildings were blown out and balconies ripped down."

"Russia has launched a massive combined strike on Kyiv," Ukraine’s state emergency service announced on Telegram. "According to preliminary data, nine people were killed, 63 injured."

President Trump early Thursday condemned the attack, saying he's "not happy" with the Russian move. "Vladimir, STOP!" he wrote on Truth Social. "5000 soldiers a week are dying. Let's get the Peace Deal DONE!"

A large rescue effort has been underway given a missile head a densely populated area, with Ukraine’s interior minister, Ihor Klymenko, saying of Svyatoshinsky district of Kiev, "Mobile phones can be heard ringing under the ruins. The search will continue until everybody is got out. We have information about two children who cannot be found at the scene of the incident."

Ukrainian officials have cited that some 70 missiles and up to 150 drones were used against several cities in the devastating overnight attack.

BBC footage from the Russian attack in Kyiv last night.

According to available information, at least 8 people were killed during the strikes in the Ukrainian capital.

Ukrainian Air Force informed that Russia launched 11 Iskander-M/KN-23 ballistic missiles, 37 Kh-101… pic.twitter.com/zucVYlpWi9

— Status-6 (Military & Conflict News) (BlueSky too) (@Archer83Able) April 24, 2025

This new Thursday attack on the capital was the deadliest since last year's July 8 attack on Kiev, which left 34 people dead and 121 injured.

It comes after the Zelensky government has expressed frustration that the White House should be more concerned and standing by Ukraine's side, instead of holding bilateral talks toward diplomatic normalization with Russia.

The latest Trump and Zelensky back-and-forth has focused on Crimea. Trump on Wednesday slammed the Ukrainian leader for rejecting a US proposal that would see Kiev give up all claims on Crimea. Trump pointed out that Crimea "was lost years ago" and that Zelensky has "no cards to play".

Zelensky then cited the 2018 "Crimea declaration" by Trump's then secretary of state Mike Pompeo, which laid out that the United States "rejects Russia's attempted annexation".

Emotions have run high today. But it is good that 5 countries met to bring peace closer. Ukraine, the USA, the UK, France and Germany. The sides expressed their views and respectfully received each other’s positions. It’s important that each side was not just a participant but… pic.twitter.com/lDFV5WK8tw

— Volodymyr Zelenskyy / Володимир Зеленський (@ZelenskyyUa) April 23, 2025

"There is nothing to talk about. This violates our Constitution. This is our territory, the territory of the people of Ukraine," Zelensky had initially told reporters of the question of giving up Crimea permanently.

But Vice President JD Vance had also articulated while traveling in India, "We’ve issued a very explicit proposal to both the Russians and the Ukrainians, and it’s time for them to either say yes or for the United States to walk away from this process."

Kyiv is under Russian attack. 21 people are hospitalized, including a pregnant woman and three children. pic.twitter.com/IQZw9TkV8I

— Marta Havryshko (@HavryshkoMarta) April 24, 2025

He emphasized "The only way to really stop the killing is for the armies to both put down their weapons, to freeze this thing and to get on with the business of actually building a better Russia and a better Ukraine."

Freezing the war now would certainly give Russian forces a huge advantage, given the immense territory in the East they now hold, and this is in large part why Zelensky is refusing such a deal.

https://www.zerohedge.com/geopolitical/russia-launches-massive-missile-strike-kiev-leaving-9-dead

Massive Buying Of Boeing Aircraft Sends US Durable Goods Orders Soaring In March

 US Durable Goods Orders printed a massive 9.2% MoM surge in preliminary March data, massively beating the +2.0% MoM expectation) and pulling orders up 10.9% YoY - the highest since Jan 2022. This is the third straight month of strong orders...

Source: Bloomberg

That is a four sigma beat of expectations...

Source: Bloomberg

But... and its a big but!

Ex-Transportation, durable goods orders were unchanged MoM (rising 2.2% YoY)...

Source: Bloomberg

And so - all of the gains in the headline orders print were due to a 139% surge in orders for commercial aircraft and parts...

Source: Bloomberg

Boeing Co. said it received 192 orders in March, the most since the end of 2023 and up from 13 in the previous month. At the same time, China recently ordered its airlines not to take further deliveries of Boeing jets as the trade war escalates.

However, non-defense capital goods shipments including aircraft, which feed directly into the equipment investment portion of the gross domestic product report, dropped 1.9%, the most since October.

What will The Atlanta Fed GDPNOW forecast do with this massively mixed big picture data?

https://www.zerohedge.com/markets/massive-buying-boeing-aircraft-sends-us-durable-goods-orders-soaring-march

NPR: Abrego Garcia Was "Living Quietly" In Maryland Before He Was Deported

 by Jonathan Turley,

Yesterday, I tweeted out after hearing a segment on National Public Radio on the case of Kilmar Abrego Garcia. NPR reported that there was no evidence presented that Abrego Garcia was an MS-13 member and that “he had been living quietly in Maryland” before he was suddenly arrested and deported. 

While many disagree on the handling of the case, few would agree that Abrego Garcia who was reported for spousal abuse and suspected of human trafficking was “living quietly in Maryland.”

Anyone listening to the radio program would have been left with an incomplete and distorted account of the case.

The print story used the same language as the radio segment. NPR claimed that Abrego Garcia

“was granted protection by an immigration judge in 2019 that should have prevented his deportation. He had been living quietly in Maryland with his wife and three children and working in construction until Immigration and Customs Enforcement officers arrested and deported him last month.”

I have previously said that I believe the Administration should have returned Abrego Garcia to the United States for a correct and prompt deportation. If he were to be brought back, I cannot see any barrier to Abrego Garcia not only being deported but deported back to El Salvador.

NPR leaves out a couple of facts in its passing reference to his being “granted protection by an immigration judge.” 

Abrego Garcia already had a hearing at which the judge found evidence that he was an MS-13 member. It was not only based on his being arrested with MS-13 gang members and wearing clothing associated with the gang. It was also based on a confidential source connected to the gang. After losing at his hearing, Abrego Garcia then lost on appeal.

The only reason that Abrego Garcia was not removed is that he said that he was being threatened by a gang that could harm him in El Salvador. That gang, however, reportedly no longer exists.

More importantly, President Trump has declared MS-13 a Foreign Terrorist Organization, which bars the use of the justification for his not being removed. In other words, he has little factual or legal foundation under his original claims to remain in the country.

However, putting the merits aside, NPR’s portrayal of Abrego Garcia was bizarre. He was repeatedly accused of beating his wife. The court record states:

“Per the Prince Georges County Police Gang Unit, ABREGO-Garcia was validated as a member of the Mara Salvatrucha (MS13) Gang. Subject was identified as a member of the Mara Salvatrucha MS-13, “Chequeo” from the Western Clique a transnational criminal street gang. This information was provided by tested source who has provided truthful accurate information in the past. See Prince Georges County Police Department (Gang Sheet).”

Abrego Garcia was also suspected of human trafficking. Indeed, the description of the stop leaves one astonished that he was allowed to simply drive away. According to DHS:

“On Dec. 1, 2022, Abrego Garcia was stopped by the Tennessee Highway Patrol for speeding. Upon approach to the vehicle, the encountering officer noted eight other individuals in the vehicle. There was no luggage in the vehicle, leading the encountering officer to suspect this was a human trafficking incident. Additionally, all the passengers gave the same home address as the subject’s home address. During the interview, Abrego Garcia pretended to speak less English than he was capable of and attempted to put the encountering officer off-track by responding to questions with questions. When asked what relationship he had with the registered owner of the vehicle, Abrego Garcia replied that the owner of the vehicle is his boss, and that he worked in construction…

The encountering officer decided not to cite the subject for driving infractions but gave him a warning citation for driving with an expired driver’s license. Abrego Garcia’s driver’s license was a MD “Limited Term Temporary” license. The encountering officer gathered names of other occupants in the vehicle but could not read their handwriting. The officer did not pursue further information due to no citation being issued.”

So Abrego Garcia, an undocumented immigrant, was stopped with an expired license in a car with  eight others and no luggage on a trip from Texas to Maryland. He gave a false statement and the officer suspected human trafficking but let him go.

It is now being reported that the person whom Abrego Garcia described as his “boss” at a construction job was Jose Ramon Hernandez Reyes, an illegal migrant previously convicted of human smuggling. The black 2001 Chevrolet Suburban belonged to Hernandez Reyez.

One can reasonably object that there was no final adjudication of these claims from spousal abuse to human trafficking to gang membership. However, it strains credulity to claim that Abrego Garcia was living a “quiet” life in Maryland. The complaint of his wife that he was a wife-beater alone would seem to contradict NPR’s claim.

The claim has that certain “fiery but mostly peaceful” quality to it . . . except NPR just decided to leave out the “fiery” and the “mostly” parts.

This month I wrote about NPR repeating a false claim that the Supreme Court rejected the claim the government was involved in censorship — despite the express statement of the Court to the contrary.

NPR has long been accused of showing bias in its coverage. It is now facing calls to end the public subsidy for the news outlet.

https://www.zerohedge.com/political/npr-abrego-garcia-was-living-quietly-maryland-he-was-deported

China to Kick Off Special Bond Sale as Tariffs Threaten Economy

 

China is set to issue the first batch of special sovereign bonds for the year on Thursday as part of the stimulus announced by authorities to soften the blow from simmering trade tensions with the US.

The Ministry of Finance plans to raise 286 billion yuan ($39 billion) via a three-part issuance later in the day, according to Bloomberg calculations. The bond sale is to fund the fiscal package approved in March, but unlike sovereign debt, special bonds are issued for specific purposes and aren’t accounted for in China’s record high fiscal deficit target of 4% for the year.

https://www.bloomberg.com/news/articles/2025-04-24/china-to-kick-off-special-bond-sale-as-tariffs-threaten-economy

Fetterman calls on Trump to ‘strike and destroy Iran’s nuclear facilities’

 Sen. John Fetterman (D-Pa.) is calling on President Trump to “strike and destroy” the nuclear facilities in Iran ahead of a third round of talks later this week. 

“You’re never going to be able to negotiate with that kind of regime that has been destabilizing the region for decades already, and now we have an incredible window, I believe, to do that, to strike and destroy Iran’s nuclear facilities,” Fetterman said Wednesday in an interview with the Washington Free Beacon.

Fetterman’s comments come as the Trump administration’s two-month timeline to reach a deal with Iran over its nuclear program nears an end.

Trump has expressed confidence ahead of a third round of talks to be held later this week, but it’s unclear if the two countries can find common ground about eliminating Iran’s nuclear program, among other priorities.

Fetterman dismissed foreign policy experts who say the U.S. striking Iran would lead to a regional war.

He sharply criticized Hezbollah, the Iranian proxy group, as a group that “couldn’t fight” and slammed the Palestinian militant group Hamas as a “bunch of tunnel rats with junkie rockets in the back of a Toyota truck.”

It’s unclear if the Trump administration will look to strike a deal with Iran that resembles the Obama-era nuclear agreement that restricted the country’s ability to create a nuclear weapon but kept the infrastructure intact.

Fetterman said that years ago he understood why Trump withdrew from the Obama-era deal, but today, “I can’t understand why Trump would negotiate with this diseased regime.”

“The negotiations should be comprised of 30,000-pound bombs and the IDF [Israel Defense Forces,]” Fetterman said.

The Pennsylvania senator has been one of the most vocal Democratic voices in support of Israel in its war with Hamas and regional enemies.

https://thehill.com/homenews/senate/5264452-fetterman-calls-on-trump-to-strike-and-destroy-irans-nuclear-facilities/