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Saturday, November 1, 2025

Bicycle Therapeutics (BCYC) Downgraded by RBC Capital on Delays

 RBC Capital Markets has downgraded Bicycle Therapeutics (BCYC) from "outperform" to "sector perform," citing delays in its pipeline programs. The bank reduced its price target for the stock to $11 from $27, reflecting a potential 36% upside from the October 31 closing price. Analyst Leonid Timashev highlighted setbacks in the development of zelenectide pevedotin, which is in phase 2/3 trials for metastatic urothelial cancer, with dose selection now deferred to Q1 2026. Peak sales projections for the drug have been lowered to $800 million from $1.1 billion.

https://www.gurufocus.com/news/3176301/bicycle-therapeutics-bcyc-downgraded-by-rbc-capital-on-delays

Obamacare’s Chronic Conditions

 We have been witnessing lunacy. Senate Democrats repeatedly voted against a short-term, “clean” resolution to reopen the federal government because they insist, amidst massive deficits and dangerous debt, on adding another $1.5 trillion in total federal spending.

Among other items on their wish list, such as Medicaid eligibility for illegal aliens - House and Senate Democrats want to make the expansion of  temporary Covid-era emergency taxpayer subsidies for Obamacare insurance premiums permanent. The Covid pandemic is over, folks.

Recall that  President Obama and Congress established an income cap for the taxpayer insurance subsidies at 400% of the federal poverty level, or $128,600 for a family of four.

Today, congressional Democrats want to abolish that six-figure cap and subsidize the rich. Beyond fiscal insanity, this is a surreal rewrite of the social contract: compel today’s lower income taxpayers to subsidize tomorrow’s higher income Obamacare beneficiaries - indefinitely.

While Congress should reform the Obamacare subsidies to ensure that poor and lower middle-income people can afford coverage, they should refrain from expanding dependency on government up the income scale.

When this madness ends, Congress must address the routinely neglected and supremely unpleasant underlying problem: the indisputable and costly failures of the Affordable Care Act of 2010, or Obamacare, itself. Rarely has there been such a massive disparity between the official promises and the real-world performance of any major government program.

Let us pass over, for the moment, President Obama’s solemn 2009 promise that if you liked your health plan you could keep it. If fact, millions of Americans lost the coverage they knew and liked. Even Politifact, the lefty “fact-checker”, called Obama’s promise the “lie of the year”.  

But Obamacare’s chronic conditions are still with us. The rapidly rising health care costs, the collapse of personal choice and competition in the individual markets, and the widespread reduction of patient access to preferred doctors and hospitals in the Obamacare plans.

The law was supposed to solve, prevent, or at least ameliorate these problems. It did not.

Lest we forget. During the health care debate, President Obama boldly promised that his signature legislation would “bend the cost curve” downward, and furthermore,  the “typical” American family would see a yearly reduction in their health insurance premium costs of $2500.  Even without the benefit of hindsight, President Obama’s claim seemed extravagant.  

So, what happened? A comprehensive Heritage Foundation analysis of the insurance data describes the trends in quantitative detail. For example: 

Premium costs exploded. Between 2013 and 2022, average monthly health insurance premiums in the individual markets rose from $244 to $568, a 133% increase. In 2014, the sticker shock hit the nation’s individual markets immediately, with radical hikes in premiums even among young people in their 20s. Obamacare’s top heavy regulatory system contributed to these dramatic increases, evidenced by the fact that 15 states over this period managed to reduce their premiums by securing waivers from Obamacare rules. Meanwhile, premium increases in the employer-based markets, which are less regulated by Obamacare, saw an increase of only 44% over the same nine-year period. Of course, for lower income people, these premium increases are papered over by very generous taxpayer subsidies, funding the coverage through ever larger payments to health insurance corporations. In the current government shutdown debate, Democratic congressional leaders want to expand these taxpayer subsidies to upper income families as well. 

Deductibles Soared. There is a routine trade-off between rising premiums and deductibles, or front-end payments, for medical services. In 2024, workers in relatively small firms (less than 200 employees) offering “high deductible” employer-sponsored    health insurance, faced a deductible averaging $2,317 for “self-only” coverage. Among Obamacare’s “bronze” plans, the lowest premium cost offerings, average deductibles for “self-only” coverage increased from $5,094 in 2014 to $7,144 in 2024. And for family coverage, the average annual deductible jumped from $10,278 in 2014 to $14,310 in 2024. Some enrollees, presumably, can afford “Affordable Care Act” coverage.

Choice and Competition Declined. Between 2013 and 2024, the number of plans available in the individual markets declined from 395 to 304, a 23% decline. The disruption, however, was periodically very severe. In 2018, for example, there were just 181 plans in these damaged and increasingly expensive markets; and in eight states patients had no plan choice at all. Government-sponsored monopolies.

Reduced Access to Providers. In a 2022 survey of large employer plans, the Kaiser Family Foundation found that 63% had “very broad” provider networks. Health plans could and did reduce their premium costs by narrowing their networks of doctors, hospitals, and medical specialists. In 2014, the first year that Obamacare’s rules on the insurance markets were implemented, it became clear that insurance companies were responding by restricting their contracts with medical professionals and institutions. By 2018, Avalere, a research firm specializing in health policy, reported that 73% of Obamacare plans had narrow networks. By 2024, according to the Heritage Foundation analysis, 80% of Obamacare plans had “more restrictive” access to medical professionals and specialists. Please note: Congressional liberals and their allies in academia used to call this “junk insurance.”  

During the debate on the 2025 government shutdown, congressional liberals have tried to reframe it as a debate about health policy.

OK! Let’s engage. The “Affordable Care Act” coverage is unaffordable. So, Congress must fix the badly broken status quo that Obama locked in statutory concrete 15 years ago and follow some basic principles. 

First, personal freedom is the best tool in the box. If any American citizen wants to purchase their health insurance on today’s Obamacare health insurance exchanges, they should be free to do so. But Congress and the Trump administration should also provide an “off-ramp” for Americans who want better and more affordable options.

Second, Americans should be able to control their health care dollars and decisions. They should be free to secure affordable, portable, quality coverage of their personal choice, with guaranteed consumer protections, especially for those with pre-existing medical conditions. On this, there is and should be a bipartisan consensus: big insurance cannot be trusted.

Third, any such reform should also provide for enforceable and fully transparent health care pricing, as well as intense market competition among health plans and providers to control cost and stimulate innovations in health care financing, benefit design, and care delivery.

Health policy is complicated and hard. Sound reform does not require the enactment of one giant, unreadable Obamacare-like 2700-page bill, riddled with mysteries and mistakes. Reform can be accomplished in stages, step by step, bill by bill. Small changes in law can have large impacts.

House and Senate members, working closely with the administration, should take their time, conduct the necessary hearings, and deliberate and debate and resolve their differences over specific policy changes. That is the best way to ensure their well-intentioned efforts do not result in the unintended consequences. The iron law of unintended consequences routinely goes berserk in health policy. 

Americans are again ready for a change. It’s time for the Trump administration and its allies in Congress to go on offense.

Robert Moffit, Ph.D., is a senior research fellow in the Center for Health and Welfare Policy at The Heritage Foundation.

https://www.realclearhealth.com/articles/2025/10/27/obamacares_chronic_conditions_1143531.html

Watch: "Petrified" Woman Details Brutal Reality Of Lawless, Borderless Britain

 by Steve Watson via Modernity.news,

A clip of a TalkTV caller from London has gone viral after she expressed her extreme distress over rising violence in her area, particularly stabbings, in the wake of yet another horrific incident Tuesday.

As we earlier highlighted, an innocent man walking his dog in West London was brutally stabbed to death for no reason whatsoever by an illegal Afghan migrant, with two others being seriously injured by the knife wielding maniac.

It was quickly ascertained that the suspect arrived into the country completely illegally on the back of a lorry, yet was granted leave to remain in 2022.

The caller, a woman named Sarah, was explained that she lives near Hillingdon, the area where the attack yesterday was carried out. 

She noted that since moving into her house in 2019, her local shop has experienced three stabbings and one murder.

“My friend was murdered last year up on The High Street. A girl that I know was murdered in South Ball Park. Government are failing us. We’re scared for our children,” the caller urged.

“I have a 22-year old son and I’m begging him to move out of this country,” she continued, adding “What are these politicians doing to us? They’re putting our children in so much danger. They put everyone in danger and they’re doing nothing to help us.”

She then expressed deep frustration that despite being peaceful people, the community feels pushed to take action because their concerns are not being addressed.

“They’re pushing us to do something that we don’t want. We are peaceful people. British people never revolt against their government. They’re going to push us to it because they are not listening to us. Please, our friends, our family are dying,” the woman pleaded.

“I don’t leave the house without a man,” she further revealed, urging “everyone I know is getting stabbed. They’re getting raped in parks. This is where I live, not where the politicians live.”

She then directly addressed British Prime Minister Keir Starmer, stating “if you’re listening to this, please do something. I’m petrified. I’ve never broken the law in my life. I have been a law abiding citizen, a civil servant. Please do something. It’s us that are dying on the streets.”

At time of writing, Starmer has not said anything about yesterday’s stabbing spree.

“You talk about being racist,” the tearful caller further stated, referring to Starmer’s repeated characterisation of those concerned about rampant illegal immigration as “far right.”

“We’re not racists,” the woman stressed, adding “My sister’s mixed race. I was a white child brought up in a mixed-race family, it’s nothing to do with race.”

Other callers were furious with rage.

GB News is exposing the kind of individuals who are arriving and being housed in hotels and former military bases.

All of this comes after another migrant who was imprisoned for sexually abusing a teenage girl in Epping, sparking mass protests at the hotel housing illegals there, was accidentally released from prison and left to wander around London.

The man has since been arrested and quietly deported to Ethiopia, having reportedly been paid a paltry sum of money to not make a fuss about it.

https://nypost.com/2025/11/01/us-news/nypd-floods-washington-square-park-with-dozens-of-cops-24-7-to-wipe-out-junkies-dealers-for-good/

https://www.zerohedge.com/geopolitical/will-afd-party-be-banned-germany

https://breakingthenews.net/Article/Berkshire-Hathaway-Q3-revenue-rises-2-to-dollar94.9B/65099363

https://breakingthenews.net/Article/S.-Korea-China-sign-seven-cooperation-deals-at-APEC/65099298