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Thursday, May 28, 2026

FAA institutes "drone no-fly zones" for FIFA World Cup

 The Federal Aviation Administration (FAA) announced on Thursday that, in coordination with the Department of Homeland Security and the Department of Justice, it has designated all stadiums hosting FIFA World Cup 2026 matches, official fan events, and base camps as strict "No Drone Zones".

The FAA further added that Temporary Flight Restrictions (TFRs) will be implemented on match days, generally prohibiting all drones within a 3-nautical-mile radius and up to 3,000 feet above ground level around the venues, "unless otherwise authorized by air traffic control."

Drone operators who enter restricted airspace without permission risk federal criminal prosecution, drone confiscation, and fines of up to $100,000.

https://breakingthenews.net/Article/FAA-institutes-%22drone-no-fly-zones%22-for-FIFA-World-Cup/66392085

Too Many E-Scooter Injuries in the Trauma Bay, Regs Needed

 With their sleek black bodies and shock absorbers, powered scooters are an attractive toy. For many, they seem like a convenient solution to urban traffic, but based on what I've seen in the trauma department, they may be causing more harm than good.

As a rotating medical student on the trauma service, I expected to see many motor vehicle collisions involving cars and motorcycles. Instead, I was shocked by the number of electric scooter (e-scooter) accidents that wheeled into the resuscitation bay. I witnessed a 26-year-old male who presented after simply hitting a pothole during his morning commute, sustaining a deep abrasion to the left half of his face along with an open left clavicle fracture and dislocated left shoulder.

His face will likely have a permanent scar mirroring the likes of a certain Batman villain. His shoulder will be prone to future dislocations and may limit his ability to play golf, which brings him great joy. Open fractures and severe head injuries are just a few of the injuries I routinely saw in patients presenting from a powered scooter accident.

As powered scooters continue to gain popularity and become more accessible via scooter share apps, we need to prevent the uptick in traumatic injury that's bound to follow. A study that analyzed the National Electronic Injury Surveillance System database shows a steady increase in electric scooter injuries, from 29,344 in 2020 to 115,713 in 2024 -- a nearly four-fold rise.

This begs the question: how have powered scooters vaulted into routine public use given their clear injury risk?

The issue lies, at least in part, within the regulatory process. While cars have federal oversight, powered scooters have been left to be handled by state and local legislation, leading to significant inconsistencies across the country. Some states have age restrictions while others do not; some have traffic laws dictating where the scooters can operate (high speed roadways versus smaller streets versus sidewalks).

Only three states -- Illinois, New York, and Utah -- explicitly outlaw operating an e-scooter while carrying alcoholic beverages or while under the influence of drugs and alcohol; and five states specify helmet requirements for teenage operators, yet no states mandate helmet use for adult e-scooter riders. Concerningly, among patients who present to trauma centers, the large majority were not wearing a helmet while riding.

Limiting access to scooter-share apps with a poor safety record is one potential intervention. One study found that limiting e-scooter use in Miami (by revoking the permits to five major mobile applications for violation of safety protocols) led to a significant drop in orthopedic trauma cases at a Level 1 trauma center, with injuries caused by e-scooters falling from 2.8% to 1.8% of patients.

However, the number of injuries are only part of the problem; it's also about the types of injuries and who is being harmed. E-scooter users have an average age much lower than the general population (median age 30), meaning their consequences go beyond the cost and recovery from a hospital stay. Traumatic brain injuries and complex fractures are only a few of the sustained injuries that can leave lifelong changes in functioning. Whether it be mental limitations, decreased mobility, or difficulty performing activities of daily life, the loss of quality-adjusted life years is concerning. For example, the patient on my rotation may never play golf to the same capacity ever again, and his scar may change how he is perceived by others. These consequences last a lifetime.

We need to normalize helmet use, regulate traffic patterns, and ensure accountability on the part of the companies that produce these products. Anyone who visits the trauma bay will understand that powered scooters are not just toys. Until we stop treating them as such, we will continue to see the consequences of our own negligence -- fractures, brain injury, and lives permanently affected for the worse.

https://www.medpagetoday.com/opinion/second-opinions/121384

Novel Hep B Drug Delivers Functional Cures in Late-Stage Trials

 Treatment with the investigational antisense oligonucleotide bepirovirsen led to functional cure in one in five patients with chronic hepatitis B virus (HBV) infection, the phase III B-Well 1 and B-Well 2 trials showed.

Among patients taking stable nucleoside or nucleotide analogue (NA) therapy, 20% and 19% of those taking bepirovirsen in the two trials, respectively, had a functional cure at week 72 compared with no patients taking placebo, reported Seng-Gee Lim, MD, of the National University Health System in Singapore, at the European Association for the Study of the Liver annual meeting in Barcelona.

The common risk difference between bepirovirsen and placebo was 17.5 percentage points in B-Well 1 (95% CI 14.6-20.3) and 13.3 percentage points in B-Well 2 (95% CI 10.4-16.1; P<0.001 for both comparisons).

The twin trials' findings, which were published simultaneously in the New England Journal of Medicine, "will change the landscape of hepatitis B treatment," Lim said during his presentation.

In an accompanying editorial, Anna Lok, MD, of the University of Michigan in Ann Arbor, noted that the B-Well studies' results were "remarkable" and "represent a major step toward a functional cure for HBV infection."

While the studies show that bepirovirsen is an attractive option for selected patients, Lok added, their results can't be generalized to the patients who weren't included in the trials: those with cirrhosis, HIV coinfection, or hepatitis B surface antigen (HBsAg) levels greater than 3,000 IU/mL.

"The durability of HBsAg loss has to be confirmed with longer follow-up, and alternative therapies are needed for other patients," Lok cautioned.

A functional cure for chronic HBV infection is defined as an HBV DNA level below the lower limit of quantification (less than 20 IU/mL or not detected) and the loss of HBsAg (level less than 0.05 IU/mL) for at least 24 weeks after fixed-duration therapy ends. Reaching a functional cure makes further NA therapy unnecessary.

HBsAg loss is linked with better clinical outcomes compared with HBV DNA suppression alone, but treatment with NA therapies or pegylated interferon rarely achieves HBsAg loss. After 8 to 10 years of NA therapy, only about 3% of patients reach HBsAg loss. An estimated 8% to 11% of those treated with pegylated interferon achieve HBsAg loss 3 years after treatment.

The identically designed B-Well 1 and B-Well 2 double-blind trials included patients from 29 countries, enrolling adults with chronic HBV infection who were on stable NA therapy for at least 6 months. Trial participants had HBsAg levels between 100 and 3,000 IU/mL, an HBV DNA level below 90 IU/mL, and alanine aminotransferase (ALT) levels no more than twice the upper limit of the normal range. Exclusion criteria included cirrhosis and coinfection with hepatitis C, hepatitis D, or HIV.

Across the two trials, mean age was 49-50, 69-73% were men, 67-70% were Asian, 24-27% were white, 4-5% were Black, and 5-12% were Hispanic or Latino.

Patients were randomized 2:1 to either weekly subcutaneous injections of 300-mg bepirovirsen or placebo from week 1 to week 24. All patients received NA therapy from week 1 to week 48. Those who reached an HBV DNA level below the lower limit of quantification, HBsAg loss, and ALT values no more than twice the normal range's upper limit from week 24 to week 48 stopped NA therapy. In both trials, 24% of those in the bepirovirsen groups discontinued NA therapy at week 48, while no placebo patients did.

The study's primary outcome was functional cure at week 72, 24 weeks after eligible patients stopped all HBV treatment.

Among patients with lower HBsAg levels (100-1,000 IU/mL), 25% and 28% of bepirovirsen patients in B-Well 1 and B-Well 2, respectively, reached functional cure, compared with no placebo patients (P<0.001 in both trials).

Functional cure rates fell as HBsAg levels rose. In those with higher HBsAg levels (>1,000 to ≤3,000 IU/mL), functional cure was reached by 10% and 5% of B-Well 1 and B-Well 2 bepirovirsen patients, respectively, while no placebo patients with higher HBsAg levels in either trial achieved functional cure.

In a pooled analysis of both trials, 91% of bepirovirsen patients and 73% of placebo patients reported adverse events by week 72, with 7% and 4%, respectively, reporting severe adverse events. Grade 3 or higher adverse events occurred in 16% of those in the bepirovirsen groups and 3% of those in the placebo groups during the trials' treatment periods, with increases in ALT level being the most common grade 3 adverse events with bepirovirsen (6%). Three percent of bepirovirsen patients stopped treatment because of adverse events.

Lim noted that 24% of patients in the bepirovirsen groups had ALT levels rise more than three times above the normal range's upper limit. Those who had these increases had an 85% chance of HBsAg loss. Those with ALT levels below that threshold had only a 35% chance of HBsAg loss.

"Clearly, those flares are important from an efficacy viewpoint," Lim said. "It was probably an effect of efficacy of the drug."

Study limitations included the relatively small number of patients in some racial and ethnic groups such as Black and Hispanic or Latino patients, which could limit the findings' generalizability. In addition, the studies' central stratification may have led to different average HBsAg baseline levels in different countries.

Disclosures

The studies were funded by GSK.

Lim disclosed relationships with Abbott Diagnostics, Aligos Therapeutics, Arbutus, Assembly Biosciences, AusperBio, Eisai, F. Hoffmann-La Roche, Gilead Sciences, GSK, Grifols, IRnovate, Janssen Biotech, and Sysmex Inostics. Colleagues disclosed relationships with multiple organizations.

Lok disclosed relationships with Chroma Medicine, Flagship Pioneering, GSK, Grifols, Moderna, Novo Nordisk, Pfizer, Precision BioSciences, Virion, and Zenas BioPharma.

Illumina expands in oncology with fireflyGO library prep platform, WGS-based MRD research solution

 

Illumina expands oncology portfolio with fireflyGO library prep platform and WGS-based MRD research solution entering early access

  • fireflyGO platform automates library preparation and integrates with MiSeq i100 for streamlined sequencing workflows
  • Illumina and Pillar Biosciences expand oncoReveal targeted oncology research panel portfolio to broaden tumor profiling applications
  • New WGS-based molecular residual disease research solution, first in Illumina's new oncology portfolio, enters early access ahead of global launch

SpaceX’s IPO Could Pressure Legacy Aerospace Stocks, Says BNP Paribas

 SpaceX’s planned IPO could pressure legacy aerospace and defense stocks, but BNP Paribas says that the biggest disruption may not come from rocket launches alone. Five-star analyst Matt Akers noted that SpaceX is already the clear leader in launch, with more than 160 launches in 2025, nearly 10 times Rocket Lab’s RKLB -0.81% ▼ total. That lead could widen as Starship production ramps up. As a result, Boeing BA +2.02% ▲ and Lockheed Martin LMT +0.95% ▲ face the most obvious launch risk through their United Launch Alliance joint venture, which competes for U.S. national security missions at higher prices than SpaceX’s Falcon 9.

However, BNP said that the direct earnings hit from the launch competition looks limited. Indeed, ULA contributed less than 1% of Lockheed’s operating profit in 2024, while the impact on Boeing was described as “non-meaningful.” The bigger long-term story may be Starship’s ability to change the economics of space. BNP estimates that Starship could lower launch costs to under $1,000 per kilogram to low Earth orbit, which could open new markets such as orbital AI computing, larger satellite networks, and eventually Mars-related infrastructure

Still, cheaper launches may not drastically change near-term Pentagon spending, since launch costs made up only about 7% of Space Force modernization spending in fiscal 2026. The more important risk may be military communications. BNP pointed to SpaceX’s $2.3 billion Space Data Network Backbone contract, which replaced a planned satellite constellation involving Northrop Grumman NOC +1.24% ▲ , Lockheed, Rocket Lab, and York Space Systems. SpaceX’s Starshield system could also compete with tactical communications products from L3Harris LHX +1.82% ▲ and General Dynamics GD +2.31% ▲

Turning to Wall Street, out of the aerospace stocks mentioned above, analysts think that NOC stock has the most room to run. In fact, NOC’s price target of $713.15 per share implies 28.2% upside potential.

https://www.tipranks.com/news/spacexs-ipo-could-pressure-legacy-aerospace-stocks-says-bnp-paribas

SciSparc unit gets conditional TSX Venture Exchange OK for ~ $9.5 m share deal for 54% of CliniQuantum

 

SciSparc unit NeuroThera receives conditional TSX Venture Exchange approval for approximately $9.5 million share deal for 54% of CliniQuantum

  • NeuroThera Labs, a majority-owned subsidiary of SciSparc, is leading the CliniQuantum acquisition.
  • Deal terms were amended and the closing deadline extended to June 1, 2026.
  • CliniQuantum is described as a quantum clinical-trial analytics firm by SciSparc.

Less Is More in Medicine



In modern medicine, the zeitgeist today seems to be captured in one word: “more.” We need more MRI machines, more screenings, more surgical interventions, more drugs, more doctors. More. More. More. Like the internal logic of capitalism that is built on eternal growth, so too is our health care system.

Given this ever-expanding demand, we need to be asking some hard questions about whether sending even more of our collective wealth towards our healthcare system is producing good returns. We might expect that anything spent on healthcare provides good returns, but what if, frequently, those investments end in losses?

There have been some significant strides against diseases over the last 30 years, but for many of the common sicknesses we all face, we’re seeing very little progress. This, despite the climbing price tag. Americans spent about $3.2 trillion in 2015 on healthcare, and that ballooned to about $4.8 trillion in 2023, representing a roughly 50% growth. By contrast GDP grew by only 25% over that period of time.

 

What’s all the additional money buying us? 

In the things that matter, such as life expectancies, we are going backwards. The average life expectancy of Americans has dropped 2-3 years since the pandemic and we currently have among the lowest life expectancy among the world’s developed countries. The mental health of children and many adults is cratering, despite the mountains of expensive drugs we throw at these problems. Any advances on reducing mortality due to cardiovascular disease or cancer–the two biggest killers of Americans– are mostly disappointing, small, and incremental. And above all, in some key areas of healthcare, the more money we spend the worse outcomes we seem to get, a practice that culturally and financially threatens to bankrupt us. 

Despite the juggernaut of more, more, more, there has been a small but growing voice of those who say it’s time to apply the brakes, and fast. Regardless of what area you look at: hospitals, medical screening, drug treatments, orthopaedic surgeries, cancer treatments, you name it, a case can be made almost everywhere that we need to slow healthcare activity, especially in areas where it’s clear that it’s delivering us negative returns. 

I would argue that we are increasingly allowing the normal ups and downs of aging to be medicalized, where typical signs of lives well-lived are redefined as sickness and in need of medical intervention. An aging population, therefore, becomes an increasingly lucrative market to go after. 

Medicalizing Normal: The “Grey Hair” of Joints

Let’s take one example, orthopaedic surgery—to examine what I mean by the medicalization of normality. Orthopaedic surgeons typically operate on hips, knees, elbows, shoulders, spines, and hands, often providing an important and essential service. 

No one would argue against the value of hip replacement surgery in those suffering intolerable pain from worn out hip joints. But not all surgery or medical imaging relating to our joints is necessary. And some of it is harmful. Looking closely at the evidence behind MRI or CT scans, X-rays, and knee, shoulder, or elbow surgeries, you will find that many of the scans or surgeries we submit to do almost nothing to improve the length and quality of our lives. 

The use of MRI machines provides a stellar example. Everyone seems to believe that there are not enough MRI machines to go around even though the overall volume of MRI machines has grown immensely. Over the last decade, the number of MRI machines has grown by 35% in some states, and total MRI-related revenue has increased by up to 40%. 

MRIs are clearly a big moneymaker for hospitals but what do those machines really do? Spoiler alert: they often do little more than detect the natural physiological signs of aging. 

Earlier this year the Finnish Centre for Evidence-Based Orthopaedics (FICEBO), did something so amazing, it’s hard to believe that no one else had thought of this. They took about 600 healthy middle-aged Finns and conducted MRIs of their shoulders. These were people who had no pain or no symptoms. They were just like you and I, everyday people. 

The result? Ninety-nine percent of these healthy adults aged 41 to 76 had at least one rotator cuff abnormality on an MRI. No symptoms. No pain. No disfigurement. But a high-tech machine telling them they were diseased. This eye-opening study was published in February in JAMA Internal Medicine. It should have shaken the medical world but it barely made a ripple.

Let’s think through the implications of this. What should we make of the fact that “abnormalities” in our shoulders are found by MRIs in almost all of us who have no symptoms at all? There was no difference in the prevalence of full-thickness tears between symptomatic and asymptomatic patients. Despite the zillions of expensive MRI scans Americans have every year, this study’s findings suggest that in the case of rotator cuff changes after midlife, they are as normal as grey hair and wrinkles in older people. When we use these incidental findings to justify surgery, we aren’t curing a disease; we are performing expensive, invasive procedures on the natural process of growing older. 

Now extrapolate that to knees. Same thing: many people with “normal” knees will have a “meniscal tear” found on an MRI machine. 

Making the case for “De-implementation:” Why Some Surgeries Must Stop

In the world of prescribing, there is a lot of interest lately in “deprescribing,” which is about actively cutting, reducing, and sometimes eliminating prescriptions in order to improve the care of patients. In the world of medical procedures that is a strong case to be made for “de-implementation,” which is about rethinking the value of the procedures and rewriting the rules on when those procedures should be done. This is not just about avoiding unnecessary scans; it is about avoiding common surgeries that high-quality science has proven to be ineffective. Two major trials, again produced by Finnish researchers, have shattered deeply held medical beliefs regarding shoulder and knee pain.

Arthroscopic subacromial decompression (ASD)— the act of removing a section of bone in one’s shoulder is done to theoretically “increase space” for tendons for those who are suffering what is colloquially known as “shoulder impingement.” 

It is one of the most commonly-performed orthopaedic procedures globally. However, high-quality research like this trial found that the ASD procedure offered no relevant benefit compared to a placebo surgery (where they go in to inspect the joint but no bone was removed). Even after a 10-year followup, the results remained unchanged. The British Medical Journal made a “strong recommendation” against performing this surgery, seeing as it is no more effective than doing nothing. Despite this evidence, worldwide ASD surgeries are widely done, and done frequently.

But that’s not the worst example. 

The Poster Child for unnecessary surgeries is APM or arthroscopic partial meniscectomy (APM) for degenerative knee tears. This long-used “meniscal resection” surgery for torn menisci in the knee has been studied for many years. The best and longest trial was likely the Fidelity Trial (published last month in the New England Journal of Medicine) which involved following patients for ten years, a span of time almost unheard of in the world of orthopaedic surgery. The results are definitive: APM provides minimal to no improvement in symptoms compared to placebo surgery. Beyond its clinical futility, economic evaluations conclude that APM for degenerative tears is not cost-effective. Why? Long term, patients are generally worse off, because those surgeries are more likely to actually accelerate the development of knee osteoarthritis.

The Economic Toll: The North American “Cash Cow”

While countries like Finland are world leaders in “de-implementing” low value orthopaedic procedures, North American hospitals are heavily invested in these “cash cow” procedures. In the United States, approximately 750,000 knee meniscectomy or repair surgeries are performed annually. The financial burden is immense, amounting to several billions per year in the US alone. The average cost of an APM ranges from $3,800 to $4,300, but without insurance, costs can reach $10,000 to $15,000. 

In the US alone, unneeded pre-surgical testing and imaging for these knees accounted for an estimated $9.5 billion in avoidable spending in a single year. 

A key marker of low value care is the variation between jurisdictions. Compare two similar places and ask: why is there such a massive difference in the frequency with which some procedures are performed? For example, what should we make of the fact that surgeons in Florida or Texas perform twice as many meniscectomy procedures, per capita, as those in Washington or Oregon? Are Texans and Floridians receiving better care? Big no. Now compare Finland which does virtually no meniscectomies versus the US which does half a million per year. Can we say the American knees are better off? Not at all. The key here is when you’ve got a procedure that is low value, you see wide ranges of variation and this unwarranted variation—differences in treatment rates based on geography rather than clinical need—is a hallmark of a system that rewards volume over value.

A Systemic and Ethical Imperative: We Need to Wage War on Healthcare Waste

There are a number of noteworthy groups in the US trying to buck the incessant demand for more and more medicine, groups like Choosing Wisely, the Institute for Healthcare Improvement or the Lown Institute. They are good at studying the futility and waste that characterizes a lot of modern American medicine. They are however, like heroic Davids fighting against the Goliaths of the Medical Industrial Complex. 

However, what they are fighting for is a noble public-spirited exercise, where medical practices or interventions that have been found to be ineffective or harmful are abandoned. Reports from the Institute of Medicine suggest that as much as 30% of all healthcare is considered low-value, providing no patient benefit or, worse, causing evidence-based harm. Unless health systems are reigned in against the tide of “more,” we will be denying needed resources to provide high-value care to those who truly need it.

De-implementation is not merely a cost-saving exercise; it is central to health equity and sustainability. Low-value care has physical, psychological, and financial consequences that impact the healthcare workforce and the environment. Low-value care, where the public payers decide that certain procedures aren’t worthy of public funding, often drives people to the private market, where they pay for the low-value care out of their own pockets. It’s crazy. Especially when you consider that we’ve also got the problem of underserved populations at the highest risk of receiving low-value care, further widening disparities in health outcomes.

The US has to catch up to the rest of the world and systematically identify areas of overuse, barriers to change, and then produce and disseminate effective reduction and “de-implementation” programs. 

The path to a sustainable healthcare system requires us to stop treating the “grey hair” of our joints as a surgical emergency. As long as we continue to pour billions into surgeries for sore shoulders or knees which have been proven no better than a placebo, we drain the resources necessary for life-saving care.

  • Alan Cassels is a Brownstone Fellow and a drug policy researcher and author who has written extensively about disease mongering. He is the author of four books, including The ABCs of Disease Mongering: An Epidemic in 26 Letters.

  • https://brownstone.org/articles/less-is-more-in-medicine/