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Sunday, January 6, 2019

bluebird bio to Present at J.P. Morgan


-bluebird bio, Inc. (Nasdaq: BLUE) today announced that members of the management team will present at the 37th Annual J.P. Morgan Healthcare Conference, Tuesday, January 8, at 2:30 p.m. PT at the Westin St. Francis Hotel, San Francisco, followed by a question and answer breakout session at 3:00 p.m.
To access the live webcast of bluebird bio’s presentation and breakout session, please visit the “Events & Presentations” page within the Investors & Media section of the bluebird bio website at http://investor.bluebirdbio.com. A replay of the webcast will be available on the bluebird bio website for 90 days following the conference.

With its lentiviral-based gene therapies, T cell immunotherapy expertise and gene editing capabilities, bluebird bio has built a pipeline with broad potential application in severe genetic diseases and cancer.
bluebird bio’s gene therapy clinical programs include investigational treatments for cerebral adrenoleukodystrophy, transfusion-dependent β-thalassemia and sickle cell disease.
bluebird bio’s oncology pipeline is built upon the company’s lentiviral gene delivery and T cell engineering, with a focus on developing novel T cell-based immunotherapies, including chimeric antigen receptor (CAR T) and T cell receptor (TCR) therapies. The company’s lead oncology programs are anti-BCMA CAR T programs partnered with Celgene.
bluebird bio’s discovery research programs include utilizing megaTAL/homing endonuclease gene editing technologies with the potential for use across the company’s pipeline.
bluebird bio has operations in Cambridge, Massachusetts; Seattle, Washington; Durham, North Carolina and Zug, Switzerland. For more information, visit bluebirdbio.com.

Saturday, January 5, 2019

South Korea’s Celltrion aims to set up China JV in first half of 2019: chairman


South Korean drugmaker Celltrion Inc aims to set up a joint venture in China within the first half of this year, and begin selling products in the country next year, its chairman said on Sunday.

“Since last year, we’ve been pushing on with a plan to set up a joint venture in China,” Chairman Seo Jung Jin told reporters. The firm has been in talks with several Chinese companies, he said, declining to elaborate.
Celltrion sells drugs known as biosimilars, mainly to Europe and the United States.
It is South Korea’s third-largest company by market value, after Samsung Electronics Co Ltd and chipmaker SK Hynix Inc, according to the Korea Stock Exchange.
On Friday, it said it would build a third domestic plant and is continuing to review potential manufacturing sites overseas.

US loses, EU wins as Chinese biotech investment shifts focus


Chinese biotech investors are taking an interest in the European market as diplomatic relations with the US become strained. Richard Staines spoke to Nooman Haque, managing director of life sciences and healthcare at Silicon Valley Bank to find out more.
Sino-US relations are going through a fraught period, with the detention of Meng Wanzhou, chief financial officer of the Chinese tech firm Huawei in Canada just the latest in a series of diplomatic rows.
Meng has been charged with violating sanctions with Iran at the request of US authorities, and as the political relationship has soured, so has the trade relationship.
Although the US is now talking about cutting tariffs with China, the behaviour of president Trump is anything but predictable and the situation can change overnight.
The uncertainty is driving Chinese investors’ interest towards Europe as a place to invest in biotech, according to Nooman Haque, managing director of life sciences and healthcare at Silicon Valley Bank.
Figures released that emerged in the summer backed up Haque’s argument: they showed China is investing nine times more into Europe than it is into North America.
According to the report from multinational law firm Baker Mackenzie, newly-announced Chinese M&A activity into Europe in all sectors was $20 billion compared to $2.5 billion in North America in the first half of 2018.
The report showed foreign direct investment from China swung dramatically toward Europe – while US revenues fell 92% from $24 billion in the same period last year.
Biotech and health were among the main areas interesting Chinese investors in Europe, as well as the automotive industry.
Amid the growing trade tensions between the US and China, Chinese firms are also divesting in North America, according to the report, with $9.6 billion being divested in the first half of the year.
Haque told pharmaphorum in an interview: “The US’s loss is going to be Europe’s gain. It’s more because of the political climate.”
According to Haque there is a “growing recognition” amongst Chinese investors of the value in the European pharma and biotech market, in early and late stage development.
And the UK in particular is of interest because of the government’s decision to back the life sciences as part of its industrial strategy.
It’s not necessarily a conversation starter but could help to set the right tone during negotiations.
Haque said: “They certainly noticed that the strategy is being developed. I would not say that the specifics of the strategy are in the minds of the Chinese investors.”
However, getting a return in the short or medium term will be the main goal of Chinese investors, who will be looking for something that will pay off at the latest at some point in 2019.
Several European biotechs have already benefited from support from Chinese investors – such as UK-based Kymab.
Doing business with Chinese investors is also a different proposition from European and US counterparts, Haque said.
One of the main barriers to overcome is a lack of knowledge about markets and products, which will mean taking time to ensure deals reach a conclusion.
It’s important to think about the details of any deal, such as whether it will be a joint venture, and how it will be structured, according to Haque.
“Thinking creatively about how to get a deal done is going to be key,” said Haque.
Haque said: “Chinese venture capitalists won’t have the same knowledge of the market. It takes longer to acquire that knowledge.”
On the positive side, Chinese investors are starting to set up offices and ramp up their scouting operations in Europe to improve their knowledge, instead of basing deals on flying visits every few months or so.
He said: “We have seen a couple of firms putting a few people on the ground as scouting and contact points for the opportunities that are here. They are starting to show that initial commitment.”
The European biotech investment market lacks the scale of the US, but Haque predicts that Chinese investment will help it to grow in the near future.
Despite the big numbers in the Baker Mackenzie report, the Chinese investment will still not be enough to see the European market grow to the same size as the US market, said Haque.
But the Chinese investment will allow companies to grow and realise their ambitions – in particular allowing biotechs to grow, let their products gain traction and head through the development process, and go public at the right time.
A common issue in Europe is that biotechs often go public before they are ready to be publicly traded because the private venture capital is not available to drive the development process.
Chinese investment could go some way to solve this problem, according to Haque, and give European biotechs the breathing space to develop.
Haque said: “Overall it’s very positive. There has been a lot of capital in biotech, but what has been lacking is the capital to scale companies.”

Ligand: Interesting Pharma Play On Sale


Ligand Pharmaceuticals is an interesting and diverse play on growth of the pharmaceutical industry.
I like the interesting business model, as Ligand appears to have a very rich pipeline.
A very strong momentum run has seen a big reversal, yet current valuations require further pipeline conversion to offer appeal.
Ligand Pharmaceuticals (LGND) is an interesting business with a distinctive business model, which actually looks quite compelling. Investors feel the same as shares have seen a huge run higher over the past few years, which has violently reversed course in recent months actually creating a more compelling situation currently.
Nonetheless, I am not actively buying a big stake just yet. For now I just hold a symbolic stake, as I require continued growth or a further pullback before buying a larger stake.

Ligand – The Alternative Business Model

Ligand itself explains quite well why it is pursuing an alternative strategy in the complicated pharmaceutical industry. It rightfully observes that most research programs fail and that not all programs are created equal in terms of risks and reward. Ligand aims to create the best of both worlds by connecting its patent, know how and data together with the research programs of partners, thereby creating the best of both worlds.
Specific tasks provided by Ligand include early research, drug discovery, tools, data and patents, new technologies and assets. The combination of current revenues, pipeline and strong technology drive the value created by Ligand and has been the major force behind the huge run higher in the shares.
Over time, the portfolio of underlying approved drugs has grown dramatically, with underlying product revenues increasing from less than $400 million in 2012 to more than $2.3 billion in 2018. On these sales, the company has on average obtained royalty rates between 3.5% and 5.5% on aggregate, with current rates trending towards the higher of the range.
The company currently has a program with 178 (potential) drugs with over a 100 partners of which half is still pre-clinical phase. 18 products are being marketed and about 35% is in either phase 1, 2 or 3. Note that the partners of the company include all the major players within the industry. The underlying technology which makes Ligand a desired collaboration partner for these companies include the OmniAb and Captisol technologies. …

Solid Biosciences to Present at J.P. Morgan


Solid Biosciences Inc. (NASDAQ: SLDB) today announced that Ilan Ganot, Co-Founder, Chief Executive Officer and President of Solid Biosciences will present at the 37th Annual J.P. Morgan Healthcare Conference on Wednesday, January 9th at 7:30 am PT. Members of the management team will participate in a question and answer session following the presentation at 8:00 am PT.
A live webcast of the presentation and question and answer session can be found under the investor relations section of Solid Biosciences’ website at www.solidbio.com and will be archived there following the presentation for 30 days.
Solid Biosciences is a life science company focused solely on finding meaningful therapies for Duchenne muscular dystrophy (DMD). Founded by those touched by the disease, Solid is a center of excellence for DMD, bringing together experts in science, technology and care to drive forward a portfolio of candidates that have life-changing potential. Solid is progressing programs across four scientific platforms: Corrective Therapies, Disease-Modifying Therapies, Disease Understanding and Assistive Devices. For more information, please visit www.solidbio.com.

FDA clears Bruin Biometrics’ wireless device to detect bedsore risk


(Bruin Biometrics)

Swiss biotech Oculis raises cash, nabs Novartis eye drug in extended series B


Hoping to push on with its work on next-gen eye treatments, Oculis has raised an extra CHF 15 million ($15.2 million) as it looks to fellow native Swiss biopharma Novartis for its next project.
First up, its cash haul: Its extended series B bumps its total to around $35 million for the round, a healthy start for a European biotech, with funds coming from the likes of Tekla Capital Management and included Nan Fung Life Sciences as new investors.
And it’s putting this cash boost to work straight away, wrapping up a deal with Novartis that sees it nab a license to the Big Pharma’s unwanted topical anti-TNF alpha antibody.

As is often the case in these types of deals, no financials were disclosed but the compound, named LME636, is based on a “single-chain antibody fragment technology specifically designed for topical delivery,” according to the company.
The drug has undergone early testing in three clinical trials, which the biotech says shows a “promising profile for treating inflammatory conditions of the anterior segment of the eye, including dry eye disease,” which has few treatments.
This comes as Novartis is looking to draw back from work on ophthalmology, with a planned spinoff for its Alcon eye unit slated in the coming months. This itself comes on the heels of Novartis CEO Vas Narasimhan’s strategy to focus the company on innovative meds, such as its work in CAR-T cancer therapies.

Oculis hopes that LME636, now to be renamed OCS-02, will get through the testing phase and be the “first topical anti-TNF alpha therapy for ophthalmic indications.”
Dr. Riad Sherif, CEO of Oculis, said: “This agreement [with Novartis] is part of our ongoing strategy to access multiple sources of technologies and compounds that bolster our portfolio of innovative products to treat eye diseases. We are looking forward to working with the ophthalmology community on the rapid development of this promising therapy.”