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Wednesday, January 30, 2019

Avalon GloboCare wraps up 64% after finding oral cancer biomarker

In its latest volatile swing, Avalon GloboCare (OTCQB:AVCO) wrapped the regular session up 63.8% after a morning announcement that it’s discovered a biomarker that can help prevent development of oral cancer.
Via subsidiary Genexosome, it says it’s found the world’s first saliva-based exosomal microRNA biomarker, miR-185, as a dual diagnostic and therapeutic target.
It’s also announced publication of a PCT patent application covering a method for preventing and treating oral cancer with extracellular vesicles carrying miR-185, allowing the company to seek protection in most major national and regional world markets.

Eyenovia gains on positive results in trial of device used to cause eye dilation

Shares of biotech Eyenovia Inc. EYEN, +15.54% rose 78% in premarket trade Wednesday, after the company reported positive results in a late-stage trial of a device that causes dilation of the eye. The New York-based company said results from the MicroStat Phase 3 MIST-1 study showed a statistically and clinically superior effect using a fixed-combination formulation than either component formulation. “We believe this is the first time in a Phase III FDA registration program that drugs have been delivered to the ocular surface using a smart microdose eyedropper-free delivery system — a meaningful step forward as we try to modernize the legacy eyedropper paradigm,” Eyenovia CEO and chief medical officer Sean Ianchulev said in a statement. The treatment is expected to make in-office eye exams easier and more efficient.

Novartis expects FY19 revenue to grow mid-single digit under new structure

Excluding Alcon and the Sandoz US oral solids and dermatology business from both 2018 and 2019, group core operating income in 2019 is expected to grow mid-to-high single-digit. Assuming Alcon and the Sandoz US oral solids and dermatology business remain part of Novartis for the full year 2019, group net sales in 2019 are expected to grow low to mid single digit and group core operating income in 2019 is expected to grow mid single digit.

Novartis provides strategy update

Novartis provided the following update: “Our long-term strategy is to focus Novartis (NVS) as a leading medicines company with five priorities: embrace operational excellence, deliver transformative innovation, go big on data and digital, build trust with society, and build a new culture by unleashing the power of our people. During 2018, we took actions that reflect this strategy and our capital allocation priorities. We concluded the strategic review of Alcon and expect to spin-off the division in H1 2019. Alcon is positioned for sustainable long term top line growth and margin expansion as demonstrated by the strong 2018 results. We agreed to sell the Sandoz US oral solids and dermatology portfolio. Our planned Sandoz transformation is expected to enable us to compete in a more challenging environment by increasing our share of higher-margin differentiated products while driving efficiency with a geographic focus and a lean cost structure. Additionally we sold our stake in the GSK (GSK) consumer healthcare joint venture for $13B. This capital was re-deployed to drive long term growth through cutting edge advanced therapy platforms, including acquiring AveXis gene therapy, AAA and Endocyte radioligand therapies and expanding global manufacturing capacity for cell therapy Kymriah. Operationally, four additional drugs reached $1B and three more potential blockbusters were launched, Lutathera, Aimovig and Kymriah in DLBCL. Innovative Medicines margin increased by 1.0 percentage point to 32.0% of sales, and we expect this margin to expand further. Our culture is transforming to become more open, empowered and collaborative. We advanced an enterprise-wide digital transformation including the launch of the first digital cognitive therapy, reSET, and an artificial intelligence program to drive salesforce effectiveness by optimizing visits to healthcare professionals. We continue our journey to rebuild trust with society. For all our new medicines, we will systematically integrate access strategies in our research and development efforts and we are working to develop innovative treatments for under treated diseases. Additionally, Novartis improved to the number 2 ranking in the Access to Medicines Index for 2018.”

Anthem sees FY19 adjusted EPS greater than $19.00, consensus $17.61

https://thefly.com/landingPageNews.php?id=2855646

Allergan price target lowered to $200 from $213 at Mizuho

Mizuho analyst Irina Koffler lowered her price target for Allergan to $200 citing the company’s “disappointing” 2019 guidance. The analyst, however, says her thesis remains unchanged and she keeps a Buy rating the stock. Koffler still sees Allergan shares as attractively valued and she believes company has a number of catalysts to help it recover throughout the year.

Can-Fite BioPharma publishes on drugs’ potential to treat CRS

 Can-Fite announced that Drug Design, Development and Therapy has published an article titled, “Targeting the A3 Adenosine Receptor to Treat Cytokine Release Syndrome in Cancer Immunotherapy.” The article presents data from numerous studies that show adenosine’s role in inhibiting inflammatory cytokine production. Can-Fite’s Piclidenoson, a Phase III drug candidate, and Namodenson, a Phase II drug candidate, both target the A3 adenosine receptor, which the Company believes may treat cytokine release syndrome while also promoting an anti-cancer effect. CRS is a potentially life threatening side effect of cancer immunotherapies including CAR-T. The market for CAR-T drugs is estimated to reach approximately $5.4B in 2024 according to Evaluate Pharma. Can Fite’s platform technology selectively targets A3AR, which plays a central role in mediating the mechanism of inflammation by reducing elevated levels of pro-inflammatory cytokines such as IL-6, IL-1beta, NF-Kbeta, TNF-alpha, and more.