Search This Blog

Saturday, August 1, 2020

Kodak top executive got Trump deal windfall on an ‘understanding’

Eastman Kodak Co on Monday granted its executive chairman options for 1.75 million shares as the result of what a person familiar with the arrangement described as an “understanding” with its board that had previously neither been listed in his employment contract nor made public.

One day later, the administration of President Donald Trump announced a $765 million financing deal with Eastman Kodak, and in the days that followed the stock soared, making those additional options now held by executive chairman Jim Continenza worth tens of millions.
The decision to grant Continenza options was never formalized or made into a binding agreement, which is why it was not disclosed previously, according to the person familiar with the arrangement. The options were granted to shield Continenza’s overall stake in the company from being diluted by a $100 million convertible bond deal clinched in May 2019 to help Eastman Kodak stay afloat, according to the person’s account.
While Kodak’s approach is permissible, it is unusual because executives are paid to grow a company’s long-term value and are not usually given extra compensation personally to cover events that may hurt share prices, several experts said.
Kodak disclosed the stock options award to Continenza in a filing to the U.S. Securities and Exchange Commission, which was previously reported. But the person familiar with the arrangement told Reuters that the transaction occurred because of the understanding with the board.
That arrangement reported by Reuters for the first time sheds new light on Eastman Kodak’s handling of the unexpected windfall for its top executives.
An Eastman Kodak spokeswoman said that Continenza had no comment. The spokeswoman said the gains reflected by the rise in the share price are only on paper: Continenza, she said, “is a strong believer in the future of the company, and has never sold a single share of stock.”
Prior to this week’s financing deal, the company warned investors it was at risk of not continuing as a going concern, but it was boosted by the agreement with the Trump administration on Tuesday to supply drug ingredients.
As a result, Continenza’s gains at the end of this week amounted to about $83 million following a roughly 10-fold increase in Eastman Kodak’s stock, compared to the approximately $53 million in gains he would have seen were it not for the additional options, according to a Reuters analysis of company filings.
Roughly 29% of the options Continenza received on Monday vested immediately, giving him the right to cash them out as soon as possible.
WIDE LATITUDE
While most corporate boards and their committees have wide latitude in awarding options, three corporate governance experts interviewed by Reuters said the move to mitigate the impact of dilution on Continenza’s stake in the company without a prior contractual obligation was unusual.
“The compensation committee’s job is not to protect the CEO from every adverse effect on the stock price,” said Sanjai Bhagat, a finance professor at the University of Colorado. “It’s to get the CEO to think about long-term value.”
A fourth expert, Robin Ferracone, chief executive of compensation consultant Farient Advisors, said the company may have offered the prospect of additional options to executives as they worked toward the convertible bond offering — to avoid them being “disincentivized” to seal a deal that would help the firm but potentially water down their holdings.
The additional options awarded to Continenza, a former telecommunications executive, were approved by the board’s compensation committee on Monday, the spokeswoman said. Shareholders had voted in May of this year to increase the shares available for executive compensation.
“The issue is the board wanted to make sure the CEO had the same economic alignment as was contemplated when he took the job,” said a person close to the company.
The company’s market capitalization jumped from a little over $100 million at the start of the week to almost $1 billion by Friday following the deal.
Eastman Kodak also granted options on Monday to three other executives, worth $712,000 each, according to regulatory filings. Kodak declined to comment on the reason for these awards.
The company has struggled to reinvent itself from a flagging camera company after emerging from bankruptcy in 2013. Its selection by the U.S. government for the production of key pharmaceutical ingredients surprised many industry analysts who expected such a deal to go to a major generic drug maker.
The government’s U.S. International Development Finance Corporation released a July 28 statement quoting Continenza as saying: “Kodak will play a critical role in the return of a reliable American pharmaceutical supply chain.”
President Trump, too, hailed the development. “I want to congratulate the people in Kodak,” he said at a press briefing. “They’ve been working very hard.”

Resveratrol and Copper for treatment of severe COVID-19: an observational study

Indraneel Mittra, Rosemarie de Souza, Rakesh Bhadade, Tushar Madke, P.D. Shankpal, Mohan Joshi, Burhanuddin Qayyumi, Atanu Bhattacharya, Vikram Gota, Sudeep Gupta, Pankaj Chaturvedi, Rajendra Badwe

Abstract

Background To be universally applicable in treatment of severe COVID-19, novel therapies, especially those with little toxicity and low cost, are urgently needed. We report here the use of one such therapeutic combination involving two commonly used nutraceuticals, namely resveratrol and copper in patients with this disease. This study was prompted by pre-clinical reports that sepsis-related cytokine storm and fatality in mice can be prevented by oral administration of small quantities of resveratrol and copper. Since cytokine storm and sepsis are major causes of death in severe COVID-19, we retrospectively analyzed outcomes of patients with this condition who had received resveratrol and copper. Methods & Findings Our analysis comprised of 230 patients with severe COVID-19 requiring inhaled oxygen who were admitted in a single tertiary care hospital in Mumbai between April 1 and May 13 2020. Thirty of these patients received, in addition to standard care, resveratrol and copper at doses of 5.6 mg and 560 ng, respectively, orally, once every 6 hours, until discharge or death. These doses were based on our pre-clinical studies, and were nearly 50 times and 2000 times less, respectively, than those recommended as health supplements. A multivariable-adjusted analysis was used to model the outcome of death in these patients and evaluate factors associated with this event. A binary logistic regression analysis was used, with age, sex, presence of comorbidities and receipt of resveratrol-copper as covariates. Data were updated as of May 30 2020. The number of deaths in resveratrol-copper and standard care only groups were 7/30 (23.3%, 95% CI 8.1%-38.4%) and 89/200 (44.5%, 95% CI 37.6%-51.3%), respectively. In multivariable analysis, age >50 years [odds ratio (OR) 2.558, 95% CI 1.454-4.302, P=0.0011] and female sex (OR 1.939, 95% CI 1.079-3.482, P=0.0267) were significantly associated, while presence of co-morbidities was not significantly associated (OR 0.713, 95% CI 0.405-1.256, P=0.2421) with death. There was a trend towards reduction in death in patients receiving resveratrol-copper (OR 0.413, 95% CI 0.164-1.039, P= 0.0604). Conclusions We provide preliminary results of a novel approach to the treatment of severe COVID-19 using a combination of small amounts of commonly used nutraceuticals, which is non-toxic and inexpensive, and therefore could be widely accessible globally. The nearly two-fold reduction in mortality with resveratrol-copper observed in our study needs to be confirmed in a randomized controlled trial.

Competing Interest Statement

The authors have declared no competing interest.

Clinical Trial

Clinical Trials Registry of India; Registration Number CTRI/2020/06/026256

Clinical Protocols

Funding Statement

This study was supported by the Department of Atomic Energy, Government of India through its grant CTC to Tata Memorial Centre.

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms determining such variable outcomes remain unresolved. Here, we investigated SARS-CoV-2 spike glycoprotein (S)-reactive CD4+ T cells in peripheral blood of patients with COVID-19 and SARS-CoV-2-unexposed healthy donors (HD). We detected SARS-CoV-2 S-reactive CD4+ T cells in 83% of patients with COVID-19 but also in 35% of HD. S-reactive CD4+ T cells in HD reacted primarily to C-terminal S epitopes, which show a higher homology to spike glycoproteins of human endemic coronaviruses, compared to N-terminal epitopes. S-reactive T cell lines generated from SARS-CoV-2-naive HD responded similarly to C-terminal S of human endemic coronaviruses 229E and OC43 and SARS-CoV-2, demonstrating the presence of S-cross-reactive T cells, probably generated during past encounters with endemic coronaviruses. The role of pre-existing SARS-CoV-2 cross-reactive T cells for clinical outcomes remains to be determined in larger cohorts. However, the presence of S-cross-reactive T cells in a sizable fraction of the general population may affect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming COVID-19 vaccine trials.

COVID-19 and cannabis use under study

Researchers are analyzing the effects of the coronavirus on medicinal cannabis users, one of the vulnerable populations that may be disproportionately affected by the disease. Their study includes an electronic survey to obtain epidemiologic data.
A large portion of medicinal cannabis users are people with compromised immune systems or chronic medical conditions. These are also many of the same traits that people most vulnerable to COVID-19 share. That is why a University of Miami research team is hoping to document how cannabis users are faring during the height of the coronavirus pandemic in the United States.
“The global qualifying conditions for medical cannabis, though not uniform, all include individuals with compromised immune systems and other chronic health conditions. Therefore, this is a population that we cannot forget about in our joint effort to ‘flatten the curve,'” said Denise C. Vidot, an assistant professor in the School of Nursing and Health Studies and a trained epidemiologist.
Vidot is leading the preliminary study, which involves a collaborative group of experts from the School of Nursing and Health Studies, Office of Hemispheric and Global Affairs, and Miller School of Medicine’s Department of Public Health Sciences.
Medicinal cannabis users have been advised to prepare for possible delays in health care delivery while the coronavirus continues to plague the U.S. The study seeks to collect data on the patterns and trends of this population during these unprecedented times.
Through an anonymous electronic survey, experts will obtain epidemiologic data on the mental and physical health among those who use cannabis for medicinal purposes. The survey will also help examine potential changes in frequency, dose, and route of cannabis use patterns based on COVID-19-related closures and updates. Another topic that researchers will be investigating is the sharing of inhaled cannabis products, such as joints and vapes among users, which could be a contributing factor to the spread of the novel coronavirus.
“If COVID-19 has taught us anything, it is that population-based data is vital to make informed decisions,” Vidot said. “So, we are combining our skills to do our part to provide that data. Our goal is to have cannabis users from every country complete this survey, so the data is more generalizable.”
Participate in the anonymous electronic survey here.

Reduced susceptibility to SARS-CoV-2 in metropolitan regions

Thomas J. Barrett, Karen C. Patterson, Timothy M. James, Peter Kruger

Abstract

The coronavirus pandemic is wreaking public health, social, and economic havoc across the globe, and to date a variety of strategies have been implemented to attempt to control the spread of disease [1, 2]. A critical unknown for policy planning is the number of people who have been infected and are no longer susceptible [3]. Tests for active SARS-CoV-2 infection or antibody presence can provide an indication, but both are prone to selection bias, under-representative population sampling and insufficient reliability [4, 5]. Here, we present an alternative to determine residual susceptibilities based on the analysis of observed population-wide disease dynamics data. For four highly-affected countries, we directly compared the dynamics in the largest metropolitan regions with the rest of the countries. We show that substantial susceptibility reductions are measurable in the metropolitan regions, which all continued in a phase of exponential growth of case numbers for a relatively longer time before public health interventions were introduced. Compared to these interventions, the reduction in metropolitan region susceptibility had a substantial role in the post-growth decline in infection rates. Reduced population susceptibility has far reaching consequences on future policy responses and disease forecasts including vaccine trial planning and, in the case of a second epidemic wave, higher population-normalised mortality rates for non-metropolitan regions.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This work was supported by the University of Sussex Strategic Development Fund. No authors received payment from a third party for any aspect of the submitted work.


Colchicine Cuts Lung Injury in Induced Acute Respiratory Distress Syndrome

Jocelyn Dupuis, Martin G. Sirois, Eric Rhéaume, Quang T. Nguyen, Marie-Élaine Clavet-Lanthier, Geneviève Brand, Téodora Mihalache-Avram, Gabriel Théberge-Julien, Daniel Charpentier, David Rhainds, Paul-Éduard Neagoe, Jean-Claude Tardif
License:
This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License
Declarations:

Declarations

  • This study involved the use of non-human vertebrates.
  • The author has confirmed that all appropriate ethical guidelines for the handling and use of animals in research have been followed and details of the oversight board have been included in the text.
  • The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.

Abstract

The acute respiratory distress syndrome (ARDS) is characterized by intense dysregulated inflammation leading to lung injury and respiratory failure. We studied the effects of colchicine pre-treatment on oleic acid-induced ARDS in rats. Colchicine reduced histological lung injury by 61%, reduced lung edema, and markedly improved blood oxygenation by increasing PaO2/FiO2 from 66 ± 13 mmHg (mean ± SEM) to 246 ± 45 mmHg. Lung neutrophil recruitment was reduced by colchicine with evidence for reduced neutrophils activation, as assessed by flow cytometry. This study strongly supports the clinical development of colchicine, a widely available low-cost drug, for the prevention of ARDS in conditions causing acute lung injury.

100 COVID-19 Positive Patients Treated with Ivermectin and Doxycycline Combo

  • Mohammed Tarek Alam
    Mohammed Tarek Alam
  • + 2
  • Sadia Saber
    Sadia Saber
    Abstract
    Background: A definitive treatment of SARS CoV-2 is yet to arrive and the human death toll rises exponentially globally. In this health emergency, it might be useful to look into the old therapies which could be effective against the virus. In vitro research showed Ivermectin could decrease the concentration of coronavirus 4000 to 5000 folds in living lung tissue. Aim: In this prospective study a combination of Ivermectin and Doxycycline will be evaluated therapeutically to treat COVID-19 patients. Methods: 100 COVID-19 patients were enrolled in this study with a predefined inclusion and exclusion criteria. RT- PCR of the SERS-CoV-2 will be done at designated government hospitals. The clinical features and response to treatment were noted according to a dedicated protocol. Results: In this study male and female were 64 and 36 respectively, the age ranged between 8 to 84 years. Retesting was done between 4 and 18 days of starting medication. All patients tested negative and their symptoms improved within 72 hours. There were no noticeable side effects. Conclusion: Combination of Ivermectin and doxycycline was found to be very effective in viral clearance in mild and moderately sick COVID-19 patients. Medical societies and institutions should undertake larger multi center studies to validate and recommend this combination therapy to include in national guidelines.