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Tuesday, March 16, 2021

Israel's Covid-19 Vaccinations Hold Lessons for U.S.

 Israel has rolled out the fastest Covid-19 vaccination campaign in the world, inoculating more than 55% of its population with at least one shot since late December. The small country -- with roughly nine million people, about the same as New York City -- is pushing to fully vaccinate most of its population by the end of March, but faces fresh challenges as it enters a new phase to convince vaccine holdouts.

While Israel's vaccination campaign is relatively simple compared with the mass mobilizations needed by countries such as the U.S. that have many more people spread over a greater sweep of geography, the effort offers some clear lessons.

Bring the Vaccines to the People

Israel has begun to transition away from its early efforts to deliver vaccines at large venues and clinics to mobile vaccination sites, aiming to make it easier for those sitting on the fence to get vaccinated. Health officials say they are hoping to reach those who aren't making the decision to seek the vaccine out but who aren't opposed to getting jabs if they are easily accessible.

Refine Administrative Acts

Israel's healthcare providers are reaching out early and often to those eligible to receive vaccines, via applications, text messages and websites. Some cities are also offering free food and even vouchers for alcoholic beverages in bars to entice people to vaccinate.

Israel, which is providing the vaccine free of charge to everyone, has also rolled out a green passport system that allows those who have been vaccinated to show a QR code on their cellphone to access gyms, hotels, bars, restaurants and other venues closed off to people who aren't vaccinated.

Reach Out to Minority Groups

Ahead of the vaccine rollout, public-health officials lobbied the country's minority groups that would be less disposed to take the vaccine: the ultraorthodox and Israel's Arab population, which together make up about 33% of the population.

Public-health officials met with ultraorthodox rabbis and leaders in Arab communities to get them to back the vaccination campaign. Prime Minister Benjamin Netanyahu made a special effort to visit Arab towns as part of his public-relations campaign.

Public-health officials traveled to ultraorthodox towns to meet with rabbis and dispatched Arabic speakers to Arab towns to meet with health professionals. They outlined all of the available information to indicate that the vaccine is safe and effective. They secured the signoff of the ultraorthodox leadership, which issued a statement urging anyone who could to get the vaccine.

Research Suggests One Shot Can Provide Robust Protection

The Pfizer vaccine is 85% effective in preventing symptomatic disease 15 to 28 days after being administered, according to a peer-reviewed study conducted by the Israeli government-owned Sheba Medical Center and published in the Lancet medical journal.

The study, which involved about 9,000 people, also found a 75% reduction in both symptomatic and asymptomatic infections after the first shot. The study was published as a correspondence, meaning it represents the views of the authors and not the Lancet.

Pfizer says its vaccine only reaches full effectiveness after two doses. It recommends that a second dose is administered 21 days after the first.

Early Data Suggests Significant Drop in Infections After Second Dose

Analysis from Israel released in early March by Israel's health ministry found that maximum protection from Pfizer Inc. and BioNTech SE's Covid-19 vaccine kicked in at least two weeks after people received the second dose, and it held up even against a more transmissible variant.

The Israeli analysis of real-world use of the vaccine also showed that the shot was highly effective at preventing infections that don't cause symptoms, a sign that it could be helping to limit the spread of the virus. And the data indicated two doses were more protective than one.

An earlier study by Clalit, Israel's largest healthcare provider, showed a 94% drop in symptomatic Covid-19 infections among 600,000 people who received two doses of Pfizer's vaccine.

The vaccinated group was also 92% less likely to develop severe illness from the disease, according to the study. It compared 600,000 people who got the vaccine with a group of the same size and similar medical histories that didn't.

Clalit said the study, which was carried out with a team from Harvard University, included 430,000 people who were between 16 and 59 years of age, and 170,000 who were over 60. It was the first of its kind to show such a high level of efficacy for Pfizer's vaccine for those aged 70 and higher due to the limited scope of the clinical trials.

Separately, researchers at the central-Israel based Weizmann Institute found that in relation to previous lockdowns, hospitalizations and serious illness among those first vaccinated -- meaning those 60 and older -- dropped 48%, while deaths decreased 50% among that group. For those aged 55-60, the next most-vaccinated group, researchers found a 36% decrease in hospitalizations and 30% decrease in serious illness.

https://www.marketscreener.com/quote/stock/PFIZER-INC-23365019/news/Pfizer-nbsp-Israel-s-Covid-19-Vaccinations-Hold-Lessons-for-U-S-Update-32695631/

India's Gland Pharma to make up to 252 million Sputnik V vaccine doses

 

Gland Pharma Ltd said on Tuesday it had struck a deal with the Russian Direct Investment Fund (RDIF) to make up to 252 million doses of the Sputnik V COVID-19 vaccine, bringing India's total production of the shot to at least 352 million.

Shares of Gland Pharma, which is backed by China-based Shanghai Fosun Pharmaceutical Group Co Ltd, surged as much as 9.5% to hit a record high of 2,783.85 rupees.

India's Hetero already has a deal in place to produce over 100 million doses of the vaccine, which has proven to be 91.6% effective against COVID-19.

Sputnik V, developed by Moscow's Gamaleya Institute, has been approved in 22 countries, with the RDIF signing supply deals with over 13 countries.

Indian drugmaker Dr.Reddy's Laboratories Ltd has also been holding small clinical studies of Sputnik V domestically. It had sought emergency use approval for the vaccine last month, but India's drug regulator had asked for more data.

Production is expected to begin in the third quarter at its facilities in Hyderabad, with deliveries estimated in the final quarter of the year, Gland Pharma said in a statement. It did not specify which countries it would supply the doses to.

Gland Pharma also said it would explore more deals for the vaccine.

India, the world's biggest vaccine maker, has so far given emergency use approval to AstraZeneca Plc's shot and a homegrown vaccine made by Bharat Biotech. It has donated or sold vaccines to more than three dozen countries, while significantly ramping up its own inoculation program this month.

European Union (EU) governments are considering launching talks with Sputnik V developers as the EU tries to get its vaccination program back on track, EU diplomatic and official sources have told Reuters.

https://www.marketscreener.com/quote/stock/ASTRAZENECA-PLC-4000930/news/India-s-Gland-Pharma-to-make-up-to-252-million-Sputnik-V-vaccine-doses-32695864/

ASTRAZENECA: Jefferies raises its recommendation to Buy

 Jefferies's analyst Peter Welford has upgraded his rating from Neutral to Buy. The target price is reviewed upwards from GBX 8250 to GBX 8850.

https://www.marketscreener.com/quote/stock/ASTRAZENECA-PLC-4000930/news/ASTRAZENECA-nbsp-Jefferies-raises-its-recommendation-to-Buy-32693269/

Sweden Suspends Use of AstraZeneca Vaccine

 Sweden has joined a growing list of European countries to suspend the use of AstraZeneca's Covid-19 vaccine, reversing its earlier decision to continue administering the drug.

In a statement Tuesday, the Swedish Public Health Agency said it has decided to suspend use of the vaccine until the European Medicines Agency's investigation into suspected side effects is complete.

The European Medicines Agency and Sweden's Medical Products Agency are investigating reports of suspected side effects, including blood clots and bleeding in individuals vaccinated.

The suspected side effects have included blood clots, in combination with low levels of platelets in a few people.

In Sweden, no such case has been reported so far, the agency said.

Last week, Sweden said there was insufficient to support the halting of the use of the vaccine as there was no evidence it had caused blood clots and the benefit of the vaccine outweighed the risks.

"There is good knowledge about the vaccine, but it is still important that we now pause the vaccination until the EMA has investigated whether these events may be related to vaccination," said state epidemiologist Anders Tegnell.

"The decision is a precautionary measure."

https://www.marketscreener.com/quote/stock/ASTRAZENECA-PLC-4000930/news/AstraZeneca-nbsp-Sweden-Suspends-Use-of-AstraZeneca-Vaccine-32694454/

India widens coronavirus curbs as infections top 20,000 for sixth day

 India reported 24,492 new coronavirus cases on Tuesday, the sixth straight day of more than 20,000 infections, as curbs to try to stop the spread of COVID-19 were expanded in parts of the country that have recorded a surge.

Total cases have now risen to 11.41 million, the highest in the world after the United States and Brazil. Deaths increased by 131 to 158,856 in the past 24 hours, data from the health ministry showed.

The government has blamed crowding and a general reluctance to wear masks for the spike, ruling out mutations of the virus as a factor, unlike in the West.

India’s worst affected state, Maharashtra, on Monday ordered cinemas, hotels and restaurants to limit guests to half of capacity until the end of the month. Weddings and other social events will also have limited attendance.

Maharashtra has also locked down some districts.

Another western state, Gujarat, has also decided to not allow fans into the world's biggest cricket stadium hosting international matches here between India and England, after seeing a spurt in cases.

The initial matches were attended by tens of thousands of people sitting or standing shoulder to shoulder, with few wearing masks, leading to widespread criticism on social media.

India has vaccinated nearly 26 million people since beginning its inoculation campaign in mid-January. The country aims to vaccinate 300 million of its 1.35 billion people by August.

https://www.reuters.com/article/us-health-coronavirus-india-cases/india-widens-coronavirus-curbs-as-infections-top-20000-for-sixth-day-idUSKBN2B80D4

AstraZeneca, U.S. agree 500,000 more supplies of COVID-19 antibody cocktail

 AstraZeneca will supply up to half a million extra doses of its experimental antibody-based COVID-19 combination therapy to the United States, in a bright spot for the company after more governments suspended use of its vaccine over safety fears.

The antibody therapy, which has yet to be approved by U.S. regulators, is designed to treat the disease rather than prevent it like the vaccine, which several countries have stopped using while reports of blood clots in some people are investigated.

The Anglo-Swedish drugmaker said on Tuesday the $205 million U.S. extension for 500,000 antibody doses builds on a contract agreed with government agencies in October for initial supplies of 200,000 doses of the antibody cocktail, AZD7442.

The treatment is a combination of two monoclonal antibodies, London-listed AstraZeneca said, adding that the new agreement is contingent on an emergency use approval by the U.S. Food and Drug Administration.

“The US Government’s support is critical in helping accelerate the development of AZD7442,” AstraZeneca Chief Executive Pascal Soriot said.

The total value of the deal now stands at $726 million for up to 700,000 doses. AZD7442 is being evaluated in late-stage trials, the company said, adding that it currently does not expect any changes to its 2021 forecasts due to the deal.

While AstraZeneca has undergone a rollercoaster ride with its COVID-19 vaccine, it has been working on developing new treatments and repurposing its existing drugs to prevent and treat coronavirus infections.

Monoclonal antibodies, such as the ones being used in AZD7442, are synthetically manufactured copies of the human body’s natural infection-fighting proteins, and are already being used to treat some types of cancers.

A series of issues have bogged down the drugmaker’s vaccine rollout: including pauses in trials, questions over the most effective dosing, and supply problems. Share gains from optimism around the cheap and easy-to-ship shot have also been decimated.

On Tuesday, the stock was up 1.5% at 7,090 pence in early trading. At its peak in July last year, the company hit 10,120 pence.

https://www.reuters.com/article/us-health-coronavirus-astrazeneca-usa/astrazeneca-u-s-agree-500000-more-supplies-of-covid-19-antibody-cocktail-idUSKBN2B80PP

AstraZeneca boss in 'hot seat' over vaccine delays: French minister

 AstraZeneca’s chief executive is in the “hot seat” over delays to deliveries of its COVID-19 vaccine shot to European countries and must provide more details of his production plans, France’s Industry Minister Agnes Pannier-Runacher said.

AstraZeneca said last week it would try to deliver 30 million doses to the European Union by the end of March, down from a contractual obligation of 90 million and a previous pledge made last month to deliver 40 million doses.

The new target is not guaranteed as it hinges on regulatory approval of a vaccine factory in the Netherlands.

Asked if chief executive Pacal Soriot was under sufficient pressure from the EU, Pannier-Runacher told France Info radio: “I think he is in the hot seat and that he absolutely aware of it.”

“In any business, there is a fiduciary responsibility, you have to be accountable. When you do not honour a contract, this can cause problems, individual problems.”

Pannier-Runacher said France would receive just 25% of some 15 million doses it was expecting in March and April and that AstraZeneca was not giving enough details on production plans.

“We have identified contradictions in indications given by AstraZeneca,” she said.

Pannier-Runacher’s comments come as a number of EU countries, including France and Germany, have suspended the use of the AstraZeneca vaccine after reports a small number of recipients have suffered blood clots, in some cases fatal.

“There must not be public mistrust. If you see decisions taken in other countries, the risk is that a mistrust of the vaccine develops,” the minister said.

The World Health Organization (WHO) said there was no proven link and called on people not to panic. The European Medical Agency, which is investigating the incidents, is expected to address the issue publicly on Thursday.

https://www.reuters.com/article/us-health-coronavirus-france-vaccine/astrazeneca-boss-is-in-the-hot-seat-over-vaccine-delays-france-says-idUSKBN2B812K