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Thursday, March 25, 2021

Human rhinovirus infection blocks SARS-CoV-2 replication within respiratory epithelium

 Kieran Dee, Daniel M Goldfarb, Joanne Haney, Julien A R Amat, Vanessa Herder, Meredith Stewart, Agnieszka M Szemiel, Marc Baguelin, Pablo R Murcia 

PDF: https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab147/36659461/jiab147.pdf

Abstract

Virus-virus interactions influence the epidemiology of respiratory infections. However, the impact of viruses causing upper respiratory infections on SARS-CoV-2 replication and transmission is currently unknown. Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans. Interactions between rhinoviruses and co-circulating respiratory viruses have been shown to shape virus epidemiology at the individual host and population level. Here, we examined the replication kinetics of SARS-CoV-2 in the human respiratory epithelium in the presence or absence of rhinovirus. We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. Mathematical simulations show that this virus-virus interaction is likely to have a population-wide effect as an increasing prevalence of rhinovirus will reduce the number of new COVID-19 cases.

https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab147/6179975

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants

 Aaron J. Schmitz, Jackson S. Turner, Zhuoming Liu, Ishmael D. Aziati, Rita E. Chen, Astha Joshi, Traci L. Bricker, Tamarand L. Darling, Daniel C. Adelsberg, Wafaa B. Al Soussi, James Brett Case, Tingting Lei, Mahima Thapa, Fatima Amanat, Jane A. O'Halloran, Pei-Yong Shi, Rachel M. Presti, Florian Krammer, Goran Bajic, 

Sean P.J. WhelanMichael S. DiamondAdrianus C.M. BoonAli H. Ellebedy

B.1.526 SARS-CoV-2 variants IDed in NYC neutralized by vaccine-elicited and therapeutic monoclonal antibodies

 Hao Zhou, 

Belinda M. DcostaMarie I. SamanovicMark J. MulliganNathaniel R. LandauTakuya Tada

Variant of interest of SARS-CoV-2 with multiple spike mutations seen in travel surveillance in Africa

 Authors: de Oliveira T, Lutucuta S, Nkengasong J, Morais J, Paixão JP, Neto Z, Afonso P, Miranda J, David K, Inglês L, Amilton P A P R R C, Freitas H R, Mufinda F, Tessema K S , Tegally H, San E J, Wilkinson EGiandhari JPillay S, Giovanetti M, Naidoo YSingh L, Tshiabuila D, Martin D, Lessells R.

PDF: https://www.krisp.org.za/manuscripts/MEDRXIV-2021-254323v1-deOliveira.pdf

Abstract

At the end of 2020, the Network for Genomic Surveillance in South Africa (NGS-SA) detected a SARS-CoV-2 variant of concern (VOC) in South Africa (501Y.V2 or PANGO lineage B.1.351)1. 501Y.V2 is associated with increased transmissibility and resistance to neutralizing antibodies elicited by natural infection and vaccination2,3. 501Y.V2 has since spread to over 50 countries around the world and has contributed to a significant resurgence of the epidemic in southern Africa. In order to rapidly characterize the spread of this and other emerging VOCs and variants of interest (VOIs), NGS-SA partnered with the Africa Centres for Disease Control and Prevention and the African Society of Laboratory Medicine through the Africa Pathogen Genomics Initiative to strengthen SARS-CoV-2 genomic surveillance across the region.

https://www.krisp.org.za/publications.php?pubid=330

Walgreens to open first corporate COVID-19 vaccine clinics at Amtrak

 Walgreens Boot Alliance is opening its first corporate COVID-19 vaccine clinics at several Amtrak offices in early April to vaccinate “large numbers” of the U.S. passenger railroad’s employees, the companies told Reuters exclusively.

Deerfield, Illinois-based Walgreens said the clinics will be similar to those set up for flu vaccinations and will be run by a combination of pharmacists and technicians from Walgreens stores.

American corporations are counting down the days to when their employees will be eligible for vaccine shots.

A Willis Towers Watson survey published on Thursday showed that one in four employers is trying to help employees get vaccinated by obtaining vaccines or facilitating access to vaccines through a third party.

With nearly 70% of Americans over 65 now vaccinated, as well as willing healthcare workers and teachers around the country, most states have begun inoculating essential workers, people with health conditions and/or people in older age groups.

It is up to state governments to decide which industries and workers in their jurisdictions are considered essential.

“We run a 24/7/365 operation providing intercity rail service across 46 states so all of our employees are considered essential workers under most eligibility guidelines,” Amtrak said in a statement.

Vaccines will not be mandatory, but Amtrak is “encouraging all employees across the country” to get them.

Walgreens said it has been approached for months by companies looking for guidance on when their workers will be eligible.

“As long as they fall within the eligibility criteria and they have a vaccine allocated from the state, then we’re able to support them,” said Rick Gates, Walgreens’ head of pharmacy and healthcare.

The company also told Reuters it has tested over 400,000 U.S. corporate employees at about 14 companies since the pandemic began.

Walmart, CVS Health and Kroger and others have yet to set up corporate clinics with companies. CVS, Walgreens’ biggest rival, said it does not have information to share on its plans.

https://www.reuters.com/article/us-health-coronavirus-walgreens-boots-am/walgreens-to-open-first-corporate-covid-19-vaccine-clinics-at-amtrak-idUSKBN2BH3J3

California, Florida, North Carolina expand COVID-19 vaccine eligibility

 Several U.S. states on Thursday announced broad expansions of their COVID-19 vaccine rollouts, with California opening immunizations to all adults aged 50 and older starting April 1 and Florida making anyone 40 and up eligible from Monday.

California, the most populous state, said it would further widen vaccine eligibility to all individuals at least 16 years of age beginning April 15, while Florida, ranking third in U.S. population, said it would lower its age threshold to 18 and up on April 5.

North Carolina said it was accelerating its timeline for vaccination eligibility to begin making shots available to all adults on April 7.

The three states join a growing list moving well ahead of the Biden administration’s goal of expanding coronavirus immunizations to U.S. adults of all ages by May 1.

Georgia officially opened inoculations to all adults on Thursday, with Texas set to do the same on Monday, followed by Indiana two days later. Those three states announced their universal expansions on Tuesday, the same day New York state dropped its eligibility age from 60 to 50.

In announcing its widening campaign, California, a major flashpoint of the U.S. pandemic during the COVID-19 surge at the end of last year, cited nationwide progress in vaccine distributions as supplies continue to grow.

“With vaccine supply increasing and by expanding eligibility to more Californians, the light at the end of the tunnel continues to get brighter,” said California Governor Gavin Newsom, who began relaxing tough restrictions on social and economic life as coronavirus caseloads waned in recent weeks.

Vaccine eligibility in California is currently restricted to adults 65 and older and individuals of all ages in various high-priority classifications, including medical personnel, first-responders, nursing home residents, food and grocery workers, teachers and people with underlying chronic health conditions.

Florida, home to large concentrations of elderly residents especially vulnerable to the virus, has already vaccinated more than 70% of its roughly 4.4 million seniors, aged 65 and up, Governor Ron DeSantis said.

He said that tally appeared to account for a sharp drop in case rates and hospitalizations among elderly residents in the state, which lowered its vaccine age threshold to 50 on Monday.

Alaska was the first state to lower statewide eligibility to age 16, the youngest age allowed to be immunized with any of the three vaccines that have so far received emergency use authorization from the U.S. Food and Drug Administration.

It also has the highest rate of vaccination in the United States, with 31.5% of its residents having received at least one dose, according to the Centers for Disease Control and Prevention (CDC).

In the United States as a whole, 26% of the population has received at least one vaccine dose, with about 2.4 million shots being given each day during the past week, according to tracking data compiled by Reuters.

https://www.reuters.com/article/us-health-coronavirus-usa/california-florida-north-carolina-announce-expanded-covid-19-vaccine-eligibility-idUSKBN2BH3DH

Robinhood aims to allow users to buy into IPOs

 Robinhood Markets Inc is building a platform to “democratize” initial public offerings (IPOs), including its own, that would allow users of its trading app to snap up shares alongside Wall Street funds, according to people familiar with the matter.

The move could further erode Wall Street’s grip on stock market flotations. It would be easier to implement for Robinhood’s own IPO, given how companies and their investment bankers tightly control allocations to investors in new listings.

Currently, Robinhood users and other amateur traders cannot buy into stock of a newly listed company until its shares start trading. Since shares often trade higher when they debut, big funds that get allocations in the IPO have an advantage. The average first-day trading pop on U.S. listings of businesses in 2020 was 36%, according to data provider Dealogic.

Robinhood plans to carve out a chunk of its shares on offer in its IPO for its 13 million users, and to use technology it is building to administer this part of the offering, the sources said.

While Robinhood’s technology would be new, the concept of reserving shares for users is not. Deliveroo Holdings Plc, the Amazon.com Inc-backed food delivery firm that announced plans this month to list in London, is doing this, although a third-party provider is administering the process.

More novel are Robinhood’s ambitions to let users directly buy into IPOs of other companies. It would need to negotiate agreements with companies and their brokerages and get the blessing of U.S. regulators, the sources said. Robinhood could have leverage in these negotiations by arguing it would be acting as a bridge between the IPO and a major pool of investor demand, the sources added.

It was not clear what kind of arrangements Robinhood would seek to put in place, and no certainty its ambition will come to fruition, said the sources, who requested anonymity because the matter is confidential. Robinhood declined comment.

Providing access to IPOs could boost Robinhood’s appeal with users, some of whom criticized it over restrictions it placed on trading of heavily shorted “meme stocks” such as GameStop Corp following a Reddit-driven buying frenzy earlier this year. Robinhood said its clearinghouse forced it to place the curbs because it lacked sufficient capital to settle the trades.

The move could also boost Robinhood’s valuation in its own IPO, as the offering would price in additional demand for the shares that would normally have come through only after the stock market debut.

On Tuesday, Robinhood announced it had confidentially filed paperwork with the U.S. Securities and Exchange Commission for its IPO. While the company has yet to disclose details, the offering could happen in coming weeks and value Robinhood at up to $50 billion, the sources said.

Robinhood’s plans to let amateur traders buy into IPOs represent the latest attempt by Silicon Valley firms to disrupt the traditional IPO. A number of companies, including Slack Technologies and Palantir Technologies Inc, have listed directly without using investment bankers.

The move would antagonize Wall Street, which is accustomed to getting big allocations in IPOs. Fund giants such as BlackRock Inc and State Street Corp have argued they are better owners of companies than day-traders, because they stick with companies for the long run.

The Menlo Park, California-based company was founded in 2013 by Baiju Bhatt and Vladimir Tenev with the aim of “democratizing finance”, by giving people access to markets normally dominated by professional investors.

Backed by investors including Andreessen Horowitz, Ribbit Capital and 9Yards Capital, its platform allows users to make unlimited commission-free trades in stocks, exchange-traded funds, options and cryptocurrencies.

https://www.reuters.com/article/robinhood-ipo-distribution/rpt-exclusive-robinhood-aims-to-allow-users-to-buy-into-ipos-sources-idUSL1N2LN3DT