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Sunday, August 29, 2021

Japan detects more Moderna vaccine contamination

 Japan's Okinawa region suspended the use of Moderna's Covid-19 vaccine on Sunday after another contamination was spotted, the local government said.

It comes a day after the Japanese health ministry said it was investigating the death of two men who received shots from tainted Moderna batches -- though the cause of their death is unknown.

The Okinawa prefecture, in southern Japan, said Sunday's vaccination programme was partially postponed.

"We are suspending the use of Moderna's Covid-19 vaccines as foreign substances were spotted in some of them," it said in a statement.

The lots affected by the contamination spotted in Okinawa on Saturday are different from the 1.63 doses suspended after the two deaths, according to local media reports.

That suspension came after the health ministry said two men, aged 30 and 38, died in early August after getting their second Moderna doses.

Those doses were drawn from one of three batches suspended by the government on Thursday after several vials were found to be contaminated.

The ministry said however that it was investigating the cause of death and it is unknown currently if there is a causal link with the vaccine.

"At this time, we do not have any evidence that these deaths are caused by the Moderna COVID-19 vaccine, and it is important to conduct a formal investigation to determine whether there is any connection," Moderna and its Japanese distributor Takeda said in a joint statement on Saturday.

The nature of the particles found in the vials, which were manufactured by a Moderna contractor in Europe, is also not known yet.

"The vials have been sent to a qualified lab for analysis and initial findings will be available early next week," Moderna and Takeda said.

The contractor, Spanish pharmaceutical firm ROVI, said in a statement Thursday that it was investigating the cause of the contamination in the batch, which was only distributed in Japan.

It added that the issue may have originated on one of its manufacturing lines.

Around 44 percent of Japan's population has been fully vaccinated, as the country battles a record surge of coronavirus cases driven by the more contagious Delta variant.

More than 15,800 people have died from Covid-19 in Japan, and large parts of the country are under strict virus restrictions.

https://www.france24.com/en/live-news/20210829-japan-detects-more-moderna-vaccine-contamination

Saturday, August 28, 2021

Singapore: 80% of population now fully vaccinated

 Singapore has fully inoculated 80 percent of its 5.7 million people against Covid-19, the health minister said, becoming the world's most vaccinated country and setting the stage for further easing of curbs.

"We have crossed another milestone, where 80 percent of our population has received their full regimen of two doses," Ong Ye Kung said in a Facebook post.

That gives the tiny city-state the world's highest rate of complete vaccinations, according to a Reuters tracker.

Authorities have said they will further ease Covid-19 restrictions after hitting the 80 percent milestone.

https://www.trtworld.com/life/singapore-s-80-population-now-fully-vaccinated-latest-updates-49537

Health Care Costs For America's Veterans Are Skyrocketing

 by Ken Silva via The Epoch Times (emphasis ours),

A new study projects that cumulative health care costs for U.S. military veterans will reach as much as $2.5 trillion by 2050—a figure that nearly doubles previous forecasts—raising concern about whether the government will take care of its war vets in the coming decades.

According to research from Brown University’s Costs of War Project, the total costs of caring for post-9/11 war veterans will reach $2.2 trillion to $2.5 trillion from 2001 to 2050. This includes the amount already paid in medical care and benefits, as well as the projected future costs already “baked” into the system, the Aug. 18 report shows.

The study notes that federal expenditures for veteran care have doubled over the past two decades, to 4.9 percent of the U.S. budget in 2020 from 2.4 percent in 2001—even as the total number of living war vets declined to 18.5 million from 25.3 million during that time.

Harvard University professor Linda Bilmes, who authored the study, pointed to several factors that led to the skyrocketing costs.

“Compared to those who served in earlier wars, the post-9/11 troops experienced more frequent and longer deployments, higher levels of exposure to combat, higher rates of survival from injuries, higher incidence of serious disability, and more complex medical treatments,” said Bilmes, the Daniel Patrick Moynihan senior lecturer in public policy at the Harvard Kennedy School.

Veterans of these conflicts have had access to a broader range of government benefits, improved systems for submitting and appealing disability and healthcare claims, and expanded post-military transition services such as re-entry and employment training.

“Long after the post-9/11 wars end, the largest single long-term cost of these wars will be benefits and medical care for the men and women who served in Afghanistan, Iraq, and related theatres since 2001, and their dependents.”

The Costs of War Project released similar cost projections in 2011 and 2013. Bilmes said her forecast nearly doubles the estimates of the earlier research, attributing this increase to higher-than-expected disabilities and expenditures.

Citing Bureau of Labor Statistics (BLS) data, Bilmes said that more than 40 percent of those who have served in the post-9/11 era have already been certified as having a “service-connected disability,” compared to fewer than 25 percent of veterans from World War II, Korea, Vietnam, and the first Gulf War.

Bilmes also said that more than 20 percent of all post-9/11 era veterans have serious disabilities, compared with fewer than 10 percent of veterans from previous U.S. wars.

The Harvard researcher noted that the post-9/11 veterans have an outsized impact on the health care system, while making up less than a quarter of total living U.S. vets.

“Although this cohort makes up only 24 percent of all living veterans, it accounts for more than half of the severely disabled veteran population in America,” she said. “Over 1 million post-9/11 veterans have significant disabilities.”

Annual health care costs will continue to skyrocket in the coming decades, as the cohort of post-9/11 war vets ages and increases in size, the paper said, pointing to the more than 40 percent of veterans that have already been approved for lifetime disability benefits.

Bilmes raised concerns that the U.S. government could default on its obligations to its veterans. Even though the Department of Veterans Affairs (VA) budgets for disability benefits to increase as claims rise over time, “there are always political pressures to cut unfunded entitlements,” she said.

And while cutting veterans’ benefits may seem unconscionable to voters today, the political landscape could look much different in 2050, Bilmes warned. The number of American men who are veterans has halved to one in eight in 2021 from one in four in 2001, and will further decline to one in 14 men by 2040, according to her research.

By 2050, when the costs of providing medical care and benefits for veterans of the post-9/11 wars reach their peak, few Americans alive will have direct relatives who were involved in these conflicts,” Bilmes said.

Bilmes suggested that veterans should work to guarantee their benefits now, while they still have relatively more political power.

“Postponing this discussion may eventually put veterans’ funding in competition with all the other future claims on federal tax dollars—including paying back the trillions of dollars of debt we incurred to finance the wars in the first place,” Blimes said.

The research paper concluded by recommending a Veterans Trust Fund, which would earmark funds for disability benefits and create awareness of the magnitude of the problem.

“A Veterans Trust Fund would only begin the process of setting aside money for the long-term costs of war, but it would establish the right framework,” Bilmes said. “It would also begin to introduce better financial management into the system.”

The research from the Costs of War Project follows a June 21 report finding that U.S. veterans are committing suicide at record rates. The combined analysis suggests that even though health care costs are skyrocketing, war vets still aren’t having their needs met.

According to the June report, the VA has failed to spend “millions” of dollars set aside for suicide prevention outreach.

“Worse, 31 percent of ‘denied or rejected non-VA emergency care claims were inappropriately processed’ in 2017, meaning veterans had to take on the financial burden of health care for an incredible sum of $716 million,” the June report reads, citing internal VA audits.

“Unless the U.S. government and U.S. society make significant changes in the ways we manage the mental health crisis among our service members and veterans, suicide rates will continue to climb.

https://www.zerohedge.com/economics/health-care-costs-americas-veterans-are-skyrocketing-report

CDC’s new ‘inclusive’ health equity guide tackles anti-vaxxers, smokers

 The CDC is going woke with an exhaustive new guide of “inclusive” terms meant to tackle “health equity.”

The Health Equity Guiding Principles for Inclusive Communication suggest new descriptive terms for everyone from smokers, to anti-vaxxers, to criminals, according to a report.

Those who puff on cancer-sticks should no longer be called “smokers,” according to the CDC, but “people who smoke.”

The disabled shouldn’t be referred to as “differently abled,” but simply as “people with disabilities.”

And using the word “homosexual” is out in favor of a variety of alphabet soup terms, including “LGBTQ (or LGBTQIA or LGBTQ+ or LGBTQIA2),” according to the guide.

“The way people’s social identities overlap should be considered to better understand, interpret, and communicate health outcomes,” the agency said.

Poor people should be referred to as “with self-reported income in the lowest income bracket (if income brackets are defined).”

And don’t say “the black community.”

“If you are creating an image, do not illustrate the patient as a minority and the doctor as white; likewise do not illustrate a homeless person as a minority,” the CDC now says.

Even criminals are no longer criminals, but should be called “persons in pre-trial or with charge,” “persons on parole or probation,” or “people in immigration detention facilities.”

The CDC will eschew the word "smoker" in favor of the term "people who smoke."
The CDC will eschew the word “smoker” in favor of the term “people who smoke.”
Getty Images/iStockphoto

The guide even includes favored terms for skeptics of COVID-19 countermeasures.

Instead of saying someone “refuse[s]” the vaccine, medical professionals should simply say a person has “yet to receive” their inoculation. And instead of stating whether some people “do not use PPE,” or personal protective equipment like masks, the preferred term is that someone may have limited access to PPE.

The new guide recalls the controversy sparked when Missouri Congresswoman Cori Bush was slammed for using the term “birthing people” in a speech at the Capitol, in a bid to recognize surrogates or transgender men who can give birth.

https://nypost.com/2021/08/28/cdcs-inclusive-health-equity-guide-tackles-anti-vaxxers-smokers/

Phase I Trial of Multi-Peptide COVID-19 Vaccine for Induction of SARS-CoV-2 T-Cell Immunity

 

Juliane Walz, Jonas Heitmann, Tatjana Bilich, Claudia Tandler, Annika Nelde, Yacine Maringer, Maddalena Marconato, Julia Reusch, Simon Jäger, Monika Denk, Marion Richter, Leonard Anton, Lisa Weber, Malte Roerden, Jens Bauer, Jonas Rieth, Marcel Wacker, Sebastian Hörber, Andreas Peter, Christoph Meisner, Imma Fischer, Markus Löffler, Reinhild Klein, Hans-Georg Rammensee, Helmut Salih


PDF: https://www.researchsquare.com/article/rs-820910/v1.pdf?c=1629489587000


T-cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based vaccine candidate, composed of SARS-CoV-2 T-cell epitopes derived from various viral proteins, combined with the toll-like receptor 1/2 agonist XS15 emulsified in MontanideTM ISA51 VG, aiming to induce superior SARS-CoV-2 T-cell immunity to combat COVID-19. We conducted a Phase I open-label trial, including 36 participants aged 18 to 80 years, who received one single subcutaneous CoVAC-1 vaccination. The primary endpoint was safety analyzed until day 56. Immunogenicity in terms of CoVac-1-induced T-cell response was analyzed as main secondary endpoint until day 28. No serious adverse events and no grade 4 adverse events were observed. Expected local granuloma formation was observed in all study subjects, while systemic reactogenicity was absent or mild. SARS-CoV-2-specific T-cell responses targeting multiple vaccine peptides were induced in all study participants, mediated by multifunctional T-helper 1 CD4+ and CD8+ T cells. CoVac-1-induced interferon-γ T-cell responses by far surpassed those detected in COVID-19 convalescents and were unaffected by current SARS-CoV-2 variants of concern (VOC). Together, CoVac-1 showed a favorable safety profile and induced broad, potent, and VOC-independent T-cell responses, supporting the presently ongoing evaluation in a Phase II trial for patients with B-cell/antibody deficiency.

Funded by the Ministry of Science, Research and the Arts Baden-Württemberg, Germany; ClinicalTrials.gov number, NCT04546841.


Yes there is potential Competing Interest. T.B., A.N.,H.-G.R., and J.S.W. are listed as inventors on a patent related to the SARS-CoV-2 T cell epitopes included in CoVac-1. H.-G.R. is listed as inventor on a patent related to the adjuvant XS15 included in CoVac-1.

https://www.researchsquare.com/article/rs-820910/v1

Rapid initiation of nasal saline irrigation cuts hospitalizations in COVID-19

 

Amy Lynn BaxterKyle R. SchwartzRyan W. JohnsonArni S. R. Srinivasa RaoRobert W. GibsonErica CherianAnn-Marie KuchinskiMatthew LyonRichard Schwartz

Metabolic Regulation of SARS-CoV-2 Infection

 

Yaakov Nahmias, Avner Ehrlich, Konstantinos Ioannidis, Makram Nasar, Ismaeel Abu Alkian, Matan Hofree, Sigal Shafran Tikva, Nir Rainy, Inbal Houri, Arrigo Cicero, Chiara Pavanello, Cesare Sirtori, Jordana Cohen, Julio Chirinos, Lisa Deutsch, Amichai Gottlieb, Oren Shibolet, Shlomo Maayan


PDF: https://www.researchsquare.com/article/rs-770724/v1.pdf?c=1628812034000


Viruses are efficient metabolic engineers that actively rewire host metabolic pathways to support their lifecycle, presenting attractive metabolic targets for intervention. Here we chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples. Bulk and single-cell analyses show that viral replication induces endoplasmic stress and lipid accumulation. Protein expression screen suggests a role for viral proteins in mediating this metabolic response even in the absence of replication. Metabolism-focused drug screen showed that fenofibrate reversed lipid accumulation and blocked SARS-CoV-2 replication. Analysis of 3,233 Israeli patients hospitalized due to COVID-19 supported in vitro findings. Patients taking fibrates showed significantly lower markers of immunoinflammation and faster recovery. Additional corroboration was received by comparative epidemiological analysis from cohorts in Europe and the United States. A subsequent prospective interventional open-label study was carried out in 15 patients hospitalized with severe COVID-19. The patients were treated with 145 mg/day of nanocrystallized fenofibrate (TriCor®) in addition to standard-of-care. Patients receiving fenofibrate demonstrated a rapid reduction in inflammation and a significantly faster recovery compared to control patients admitted during the same period and treated with the standard-of-care. Taken together, our data show that elevated lipid metabolism underlies critical aspects of COVID-19 pathogenesis, suggesting that pharmacological modulation of lipid metabolism should be strongly considered for the treatment of coronavirus infection.

https://www.researchsquare.com/article/rs-770724/v1