Hunter's search history reveals his obsession with porn and sex fantasies

 

• Hunter Biden's internet search history from March 2019 reveals his obsession with porn and penchant for filming himself having sex with prostitutes
• The president's son, who dated his late brother's wife Hallie, repeatedly searched Pornhub for titles involving 'lonely widows' as well as videos with 18- and 19-year-old girls 
• Of the 281 websites found in his search history over six days, 98 were pornographic, DailyMail.com can reveal
• Hunter, 52, who had a paid Pornhub Premium account under 'RHEast', also uploaded his own amateur videos but was careful not to show his face
• He was also a regular user of sex cam sites, particularly Glasscams.com, where he made screen recordings of himself interacting live with the women on the site
• Text messages also show Hunter apparently sent a link to a Pornhub page to a phone number he had saved in his contacts book as 'Dad' on October 22, 2018
• Among his search history is a visit to an article about his sister Ashley Biden's partying and arrest history, as well as repeated Google searches of himself 

Hunter Biden's search history reveals an obsession with porn including incest fantasies, '18yrs old', 'lonely widow' porn, 'MILF crack cocaine porn', as well as instructions on how to hack a lover's cell phone and repeated google searches of himself.

The list of searches covers just six days in March 2019 before he broke his laptop, took it to be repaired a Delaware shop, and then abandoned it. But it is packed full of revealing and disturbing websites.

Dozens of videos on the laptop also reveal Hunter's penchant for filming himself having sex with prostitutes and posting the home movies on his own Pornhub account under the username 'RHEast'.

The president's son took care not to show his face in his uploaded videos.

Hunter Biden's abandoned laptop has laid bare his secret porn addiction as well as his penchant for making his own amateur sex videos. The internet search list shows Hunter was frequently visiting porn sites and making other Google searches shortly before he broke his laptop and took it to be repaired a Delaware shop where he abandoned it 

The president's son was a frequent visitor of porn sites including adult cam site Glasscams.com, where he often made screen recordings of himself (bottom right corner) interacting live with women

The list of searches covers just six days in March 2019 during which he visited 281 websites, 98 of them pornographic 

His browsing history from March 12, 2019 shows he spent time on Pornhub and also searched  for 'girl nude' on Google 

Of the 281 websites captured in his browsing history over six days, 98 were pornographic.

Shockingly, Hunter texted a link to a Pornhub page to a phone number he had saved in his contacts book as 'Dad' on October 22, 2018.

However, other texts show he and Joe Biden used each other's phone numbers at various times, so it is unclear whether the president was using that number at the time.

Hunter, who had a controversial relationship with his brother's widow, also repeatedly searched Pornhub for videos involving widows, including 'Homemade widow porn', 'Homemade lonely widow porn' and 'Lonely widow porn'.

The Biden son, who was 49 at the time, searched for porn videos involving teenagers according to his browsing history.

Videos he visited included '18 Yrs old and really Good at Riding D***', 'TEENFIDELITY Country Girl Raylin Ann C****pie' and 'Lucky Foreign Student Stripped & F***ed by Horny Teen Pals'.

Texts, photos and video footage on the laptop show the president's son ordering prostitutes and filming porn videos with them which he then posted online on his Pornhub account

Hunter - who had a controversial relationship with his late brother's wife after his death - appeared to have a taste for incest fantasies as well as '18yrs old', 'lonely widow' porn, 'MILF crack cocaine porn'

Above is a grab from a screen recording he took of his live web cam interactions with cam girls

He also searched for 'Washington DC Milf Crack Cocaine' seven times throughout the week. 

Among his porn searches is a record of Hunter visiting a 2009 New York Post article about his sister Ashley Biden and her history of partying, arrests, and alleged cannabis use while she was a college student in New Orleans.

He also used search engine DuckDuckGo, a more discreet alternative to Google, to search for himself several times between March 12 and March 17, 2019.

Texts and videos on the laptop show the president's son ordering prostitutes to his hotel rooms in California and Connecticut, discussing buying and using crack with them, and filming porn videos with them which he then posted online on his Pornhub account. 

The profile picture for his account is a photo of two women sitting on him on a bed in a messy room, with a small white dog also perched on the bed in the background.

The videos Hunter filmed on his laptop include one where a woman uses her feet during sex. 

In another video, Hunter puts his hand around a woman's throat while having sex. 

Photos found on the device included selfies and candid shots with his father, President Joe Biden 

iMessage records appear to show Hunter sent a link to a Pornhub page to a phone number he had saved in his contacts book as 'Dad' on October 22, 2018. However, other texts show he and Joe Biden used each other's phone numbers at various times, so it is unclear whether the president was using that number at the time

The profile picture for his account is a photo of two women (pictured) sitting on him on a bed in a messy room, with a small white dog also perched on the bed in the background

In one embarrassing video, a post-coital Hunter is seen nude and grimacing before farting audibly. In several of the raw videos on his computer, Hunter finished with the woman and then left the camera running as he hunched in front of the screen, poring over the footageScreenshots from another explicit video show Hunter left a woman tied up on his bed with a red stocking over her head while he went out to get pastries. 

He returned, and took a screenshot as he munched on a sandwich and laid a chocolate croissant out in front of the hooded and trussed woman.

The videos are mainly filmed using his laptop's webcam, though he also filmed himself using a phone on a selfie stick, and in a threesome with two women, one of them uses an iPad to film a hard-to-reach angle.

In several of the raw videos on his computer, he finishes with the woman and then leaves the camera running as he hunches in front the screen, poring over the footage. 

In one embarrassing post-coital moment the disheveled Hunter grimaces, leans to the left and farts audibly.

Hunter had a paid-for, premium account on the website Pornhub where he earned several badges for his prolific use of the site and even uploaded his own explicit video.

'Natasha Nice? Abella Danger?' user GoonMcCumd commented, referring to the porn stars in the playlist's videos. 'Pretty good taste, Hunter. Now if only you didn't have that taste for crack and meth…'

Another user named 'ChinaJoeBiden' wrote 'good morning. It's a beautiful day to make money in China!' in an apparent reference to Hunters controversial Chinese business dealings reportedly under investigation by the FBI.

On top of his pornography and prostitute interests, the president's son was a regular user of sex cam sites. 

His search history includes five visits to adult cam site Glasscams.com, and screen recordings he made on his computer show him naked, interacting live with the women on the site.

Hunter's internet browsing also focused on hacking and spying on phones to catch infidelity. 

He looked up a private investigator's website and searched for questions on crowdsourcing Q&A site Quora including 'who may hack a cell phone?', 'Hire A Professional Hacker', 'Catch a Cheater', 'How do I track a cheating husband?', 'Have you ever hired someone to hack a cheating spouses cell phone?', and 'Can my cheating girlfriend cell phone be hacked?' 

Hunter searched for questions and answers on the site about 'spoofing' cell phone numbers, which involves creating a fake copy of a number to intercept calls and texts, and looked up articles on an Indian hacker called Kashmiri Cheetah.

https://www.dailymail.co.uk/news/article-10846603/Hunter-Bidens-search-history-reveals-obsession-porn.html

Shooter warning signs get lost in sea of social media posts

 The warning signs were there for anyone to stumble upon, days before the 18-year-old gunman entered a Texas elementary school and slaughtered 19 children and two teachers.

There was the Instagram photo of a hand holding a gun magazine, a TikTok profile that warned, “Kids be scared,” and the image of two AR-style semi-automatic rifles displayed on a rug, pinned to the top of the killer’s Instagram profile.

Shooters are leaving digital trails that hint at what’s to come long before they actually pull the trigger.

“When somebody starts posting pictures of guns they started purchasing, they’re announcing to the world that they’re changing who they are,” said Katherine Schweit, a retired FBI agent who spearheaded the agency’s active shooter program. “It absolutely is a cry for help. It’s a tease: can you catch me?”

The foreboding posts, however, are often lost in an endless grid of Instagram photos that feature semi-automatic rifles, handguns and ammunition. There’s even a popular hashtag devoted to encouraging Instagram users to upload daily photos of guns with more than 2 million posts attached to it.

For law enforcement and social media companies, spotting a gun post from a potential mass shooter is like sifting through quicksand, Schweit said. That’s why she tells people not to ignore those type of posts, especially from children or young adults. Report it, she advises, to a school counselor, the police or even the FBI tip line.

Increasingly, young men have taken to Instagram, which boasts a thriving gun community, to drop small hints of what’s to come with photos of their own weapons just days or weeks before executing a mass killing.

Before shooting 17 students and staff members dead at Marjory Stoneman Douglas High School in 2018, Nikolas Cruz posted on YouTube that he wanted to be a “professional school shooter” and shared photos of his face covered, posing with guns. The FBI took in a tip about Cruz’s YouTube comment but never followed up with Cruz.

In November, 15-year-old Ethan Crumbley shared a photo of a semi-automatic handgun his dad had purchased with the caption, “Just got my new beauty today,” days before he went on to kill four students and injure seven others at his high school in Oxford Township, Michigan.

And days before entering a school classroom on Tuesday and killing 19 small children and two teachers, 18-year-old Salvador Ramos left similar clues across Instagram.

On May 20, the day that law enforcement officials say Ramos purchased a second rifle, a picture of two AR-style semi-automatic rifles appeared on his Instagram. He tagged another Instagram user with more than 10,000 followers in the photo. In an exchange, later shared by that user, she asks why he tagged her in the photo.

“I barely know you and u tag me in a picture with some guns,” the Instagram user wrote, adding, “It’s just scary.”

The school district in Uvalde had even spent money on software that, using geofencing technology, monitors for potential threats in the area.

Ramos, however, didn’t make a direct threat in posts. Having recently turned 18, he was legally allowed to own the weapons in Texas.

His photos of semi-automatic rifles are one of many on platforms like Instagram, Facebook and YouTube where it’s commonplace to post pictures or videos of guns and shooter training videos are prevalent. YouTube prohibits users from posting instructions on how to convert firearms to automatic. But Meta, the parent company of Instagram and Facebook, does not limit photos or hashtags around firearms.

That makes it difficult for platforms to separate people posting gun photos as part of a hobby from those with violent intent, said Sara Aniano, a social media and disinformation researcher, most recently at Monmouth University.

“In a perfect world, there would be some magical algorithm that could detect a worrisome photo of a gun on Instagram,” Aniano said. “For a lot of reasons, that’s a slippery slope and impossible to do when there are people like gun collectors and gunsmiths who have no plan to use their weapon with ill intent.”

Meta said it was working with law enforcement officials Wednesday to investigate Ramos’ accounts. The company declined to answer questions about reports it might have received on Ramos’ accounts.

https://apnews.com/article/uvalde-school-shooting-technology-shootings-social-media-texas-b8dc7a615765e17d46313bc83e2fe452

Welcome to the Next COVID Wave

 Another big COVID-19 wave, fueled by more-transmissible BA.2.12.1 and BA.2 subvariants of the Omicron strain, is definitely under way in the United States. CDC data indicates that at least 86 percent of Americans now live in communities where there is high COVID transmission, up from 72 percent the previous week and 57 percent the week before that. At least 95 percent of Americans now live in areas where there is substantial transmission; only one percent live in communities where the transmission is estimated to be low. It’s the fifth time one COVID strain — or in this case two subvariants — has generated a large wave of cases in the U.S. as well the country’s sixth or even seventh overall wave of infections since the pandemic began.

Illustration: Our World In Data

But this wave of new infections is significantly larger than official case counts suggest, since many if not most cases are either being detected using at-home tests that are never reported or are asymptomatic and not being detected at all. As the Washington Post pointed out last week, nobody actually knows how big this new COVID wave is right now; COVID experts suspect the number of new cases in communities across the U.S. is actually five to ten times higher than official counts indicate. “Any sort of look at the metrics on either a local, state, or national level is a severe undercount,” Pandemic Prevention Institute epidemiologist Jessica Malaty Rivera told the Post. Scripps’ Dr. Eric Topol wrote a week ago that there are likely at least half a million new infections happening every day, making this new wave the second largest to strike the country. And it’s been under way for a while.

To be clear, while COVID hospitalizations are again rising in parts of the country — to the extent that the CDC is escalating its warnings to the public and expanding both eligibility and the strength of its recommendations for booster shots — there is not yet any indication that this new wave, by any metric, will reach anywhere near the overwhelming proportions of the Omicron-fueled fourth wave over the winter or that the Omicron subvariants infecting Americans have evolved to cause more severe illness than previous strains. (Whether or not the world is as lucky with the future variants and subvariants that evolve is anyone’s guess.)

Most important, while the COVID death rate always lags behind new cases and hospitalizations, fewer people are now dying from COVID-19 in the U.S. — an average of 350 each day as of this weekend — than at any point since last summer’s pre-Delta-variant lull. Though they arguably remain underused, we now have powerful weapons, like the COVID antiviral Paxlovid, to combat severe illness that we didn’t have then. And there are other COVID treatments, at-home tests, and high-filtration face masks like N95s, which provide meaningful one-way protection against COVID transmission, that are far more widely available now as well.

Illustration: Our World In Data

But nothing good has ever come ​​from another big wave of COVID infections. And this wave is rising at a time when countless Americans have concluded (and are behaving as if) the pandemic is over. The new wave is also rising as many politicians and public officials at every level of government have largely abandoned interventions aimed at curbing the spread of COVID. Dr. Topol has aptly described this ongoing failure, which includes Congress refusing to adequately fund the U.S. pandemic response moving forward, as “the COVID capitulation” — and there is no end to it in sight. It has been clear for months that Americans are more and more on their own when it comes to avoiding COVID. Don’t count on the return of mask mandates or “stop the spread” initiatives or more yard signs professing the need to protect essential workers. The pandemic isn’t over, but the U.S. pandemic response continues to steadily wind down.

In addition, despite some meaningful improvements over the past two-plus years, public-health authorities continue to struggle to clearly and effectively communicate COVID warnings and public-health messages. The CDC’s current face-mask recommendations, for instance, are linked to health-care system capacity, not to the level of community transmission (and even so, the CDC currently says that nearly 50 percent of Americans now live in places with high enough risk that they “should consider” wearing a mask in public indoor places).

The U.S. wave is also being fueled by at least one subvariant, BA.2.12.1, that seems to be able to reinfect people who were previously infected with the original Omicron strains (BA.1 and BA.1.1) just months ago. As of the week ending May 14, the CDC estimated that 47.5 percent of new U.S. COVID infections were from the BA.2.12.1 variant, which means the next round of data will likely indicate the subvariant has become the dominant COVID strain in the country, beating out BA.2, which had itself become dominant by the end of March. And the Omicron subvariants, each with their own unique advantageous mutations, are still coming: BA.4 and BA.5 are circulating in the U.S.; it remains to be seen if they will be more dangerous than BA.2.12.1.

Furthermore, thanks to waning immunity and low booster uptake, 60 percent of American seniors may now lack adequate protection against severe illness from COVID-19, according to CDC director Rochelle Walensky. Last week, she highlighted in a public meeting that there has been “a steep and substantial increase in hospitalizations for older Americans” — including a 25 percent rise among people 70 and older from the previous week. She also noted that just 43 percent of Americans 65 and older have received a dose of COVID vaccine in the past six months. Among seniors (and all U.S. demographics), the uptake of booster shots — which provide meaningful additional protection from severe illness and death — trails other comparable nations by a significant margin. Half of the unboosted Americans surveyed earlier this year by the Kaiser Family Foundation said they would either never get boosted, or only would if it was required.

There is currently no timetable for when new vaccines tailored to better target the Omicron lineage may become available in the U.S., though there is at least some ongoing debate about how necessary they are in the near term. There is also no timetable for the arrival of intranasal COVID vaccines, which scientists say could offer potentially superior protection in the mucus membranes where the virus enters the body and the infection actually starts. Meanwhile, further spread of COVID, in the U.S. and globally, means more opportunities for SARS-CoV-2 to evolve, and it’s always a roll of the dice whether that leads to mutated strains that are better or worse at infecting us and making us really ill. The fact that we have already seen so many waves from COVID strains which have quickly dominated the globe, each more transmissible than the last, in less than two and a half years does not bode well for what’s to come, particularly when the newest Omicron subvariants are already reinfecting people who had Omicron. And there are other built-in risks to further waves, like the still-murky threat of developing long COVID, the possibility of recombinant strains, additional economic disruption, domestic political consequences, and further hardships and more dangerous health outcomes determined by comorbidity, age, race, ethnicity, and/or class.

The U.S. recently surpassed 1 million confirmed deaths from COVID, and the full total is undoubtedly much higher when including other preventable deaths that happened as a direct result of the pandemic. Though other countries, like India, have lost more people to COVID-19, the U.S. leads the world in confirmed (recorded) COVID deaths. Those million deaths in part prompted this sobering thought in a recent Associated Press article: “The sheer numbers of deaths from preventable causes, and the apparent acceptance that no policy change is on the horizon, raises the question: Has mass death become accepted in America?” It’s a good question and one a lot of Americans probably already know how to answer.

https://nymag.com/intelligencer/2022/05/welcome-to-the-fifth-covid-wave.html

BlackRock, Vanguard, State Street Forced Into the Abortion Debate

 Shareholders have placed abortion-rights proposals on the proxies at three big retailers this spring: Walmart Inc. WMT 1.64%▲ ; Lowe’s LOW 2.30%▲ Cos.; and TJX TJX 2.03%▲ Cos., the owner of off-price chains including TJ Maxx. Many more could follow next year.

That development is pressuring asset managers such as BlackRock Inc., BLK 3.96%▲ Vanguard Group and State Street STT 4.55%▲ Global Advisors to confront the issue because they hold significant stakes in those and other companies on behalf of millions of other investors.

Activist investors submitted the shareholder proposals in December. Broadly, they ask each company to compile a report evaluating the risks and costs of restricted reproductive rights, including on employee hiring and retention. In early May, a leaked Supreme Court draft opinion suggested that the court could overturn Roe v. Wade, the 1973 decision that established a constitutional right to an abortion.

Trillium Asset Management submitted the shareholder proposal for TJX, while Clean Yield Asset Management did so for Walmart. Both financial firms are focused on environmental, social and corporate-governance concerns. Educational Foundation of America, a private foundation that makes grants to nonprofits and invests with social and environmental impacts in mind, submitted the proposal for Lowe’s.

Asset managers such as BlackRock, Vanguard and State Street have grown rapidly in recent years. Investors have flocked to them hoping that passive, index-tracking funds can get them steady gains at low cost.

One consequence is that the firms have accumulated voting power in thousands of public companies. They can influence corporate decision-making on a host of issues, including some they might prefer to avoid.

Abortion rights is a polarizing issue nationally. In a new Wall Street Journal poll, conducted with the nonpartisan research organization NORC at the University of Chicago, 68% of respondents said they wouldn’t like to see the court completely overturn Roe, while 30% supported such a move.

Urska Velikonja, a law professor at Georgetown University who focuses on securities regulation and enforcement, predicts that if Roe v. Wade is struck down, there could be hundreds of abortion-related shareholder proposals on company proxies next year.

“We expect for these large asset managers to consider abortion in the same way they consider other social-policy issues like climate change and diversity audits,” she said. “This one seems more head-on a business issue given that it affects a substantial portion of the employees.”

The financial firms have at times initiated their own campaigns to pressure companies to pursue social changes. In 2017, State Street publicly identified more than 1,500 companies with all-male boards as part of its Fearless Girl campaign. Since then, 60% of those companies have added at least one female director. In 2018, following the deadly school shooting in Parkland, Fla., BlackRock stripped retailers that sell guns from some of its environmental, social and corporate governance-focused exchange-traded funds. BlackRock has said its positions are about long-term returns, not politics.

Shareholder proposals often don’t pass, and activists said their intent was to get companies’ attention. As proposals get more support, companies often work out compromises with the sponsors and implement the changes outside the proxy process.

Lowe’s and Walmart, which held their annual meetings in the past week,said the abortion-rights proposals didn’t pass. Walmart said that 13% of participating shareholders voted in support. Lowe’s said it would release more details in the coming days.

TJX’s annual meeting is scheduled for next week.

BlackRock, Vanguard and State Street are required by the Securities and Exchange Commission to eventually detail how they voted, though they have until the end of August to release that information. The firms declined this week to say how they voted.

Ben Colton, global head of asset stewardship at State Street, said the company approached the abortion proposals “with our general framework on social and environmental shareholder proposals.” The firm evaluates social proposals “with a focus on creating value and fulfilling our fiduciary duty,” he said.

Vanguard and BlackRock declined to comment. Together, the three firms own 20% of Lowe’s, 18% of TJX and 10% of Walmart.

The shareholder groups asked the companies to address whether they plan to close or expand operations in states that enact antiabortion laws.

Trillium Asset Management, which led the shareholder proposal at TJX, has reached out to all three asset-management firms, said Trillium’s chief advocacy officer, Jonas Kron.

“Universally, the asset managers tend to keep their cards pretty close to their chest,” Mr. Kron said. “We’ve seen a fair amount of nodding heads in these meetings, but they’re not going to give a weather report on how they will vote.”

David Stocks, executive director of Educational Foundation of America, which filed the proposal at Lowe’s, said the retailer was “chosen strategically” because it operates across the country with a large female employee base. “These big companies are the deciders of healthcare benefits for all these people because that is how America works,” he said. “These companies are now thrust into this issue whether they want to be or not.”

Management at the three retailers recommended investors vote “no” on the proposals, and they highlighted company benefits and programs for female employees. Lowe’s and Walmart said the proposal was too broad. “It would be extremely difficult for any company operating in all 50 states to create a document that would be of utility for our shareholders, associates and other stakeholders,” Lowe’s said in its response to the shareholder proposal.

TJX, whose workforce is 77% women, said there was no need to compile a report when its current healthcare coverage offers many reproductive benefits, including abortion.

https://archive.ph/d97XQ#selection-4203.0-4771.169

Insulet Delivery System Significantly Improves Glycemic Outcomes in Children Aged 2-6

 nsulet Corporation presented new Omnipod(R) 5 Automated Insulin Delivery System (Omnipod 5) study results for very young children with type 1 diabetes. Omnipod 5, the first tubeless, wearable automated insulin delivery (AID) system in the U.S., significantly improved time in range and reduced HbA1c in children aged 2 through 5.9 years with type 1 diabetes over 12 months of use. This pivotal trial extension data was presented at the American Diabetes Association (ADA) 82(nd) Scientific Sessions in New Orleans, Louisiana. In the original three-month pivotal trial, Omnipod 5 was shown to be safe and effective, significantly improving time in range and reducing HbA1c in 80 very young children (ages 2 to 5.9 years) with type 1 diabetes. Insulet previously presented these results at the ADA Virtual 81(st) Scientific Sessions in 2021. The pivotal trial participants were invited to continue using the Omnipod 5 System in an ongoing 12+ month extension phase, with 100% electing to participate. Results were analyzed after all participants had completed a total of 12 months of Omnipod 5 use (three months in the pivotal trial and nine months in the extension phase). The extension phase results demonstrated that participants continued to experience significantly improved outcomes compared with baseline throughout 12 months of system use, including lower HbA1c and greater time in range, and there were no episodes of DKA or severe hypoglycemia. After 12 months of Omnipod 5 use, average HbA1c was 6.9%, compared with 7.4% at baseline and 6.9% at the end of the three-month pivotal trial. Similarly, % time in range during months 10 -- 12 of use was 67.6%, compared with 57.2% during standard therapy and 68.1% during the three-month pivotal trial. % time in hypoglycemia (<70 mg/dL) was reduced compared with standard therapy: the median was 1.9% during months 10 -- 12 of use compared with 2.2% during standard therapy and 1.9% during the three-month pivotal trial. "I'm delighted to report that the safety and improved glycemic outcomes from the initial three-month pivotal study in pre-school aged children continued for an additional nine months, indicating the potential long-term benefit of the Omnipod 5 System in very young people with type 1 diabetes," said Dr. Daniel DeSalvo, MD of Baylor College of Medicine.

https://www.marketscreener.com/quote/stock/INSULET-CORPORATION-50468/news/Omnipod-R-5-Automated-Insulin-Delivery-System-Significantly-Improves-Glycemic-Outcomes-Over-12-Mont-40638426/

CStone Pharmaceuticals Presents Clinical Results of Sugemalimab in Lymphoma

 CStone Pharmaceuticals announced that the company has reported primary results from the registrational GEMSTONE-201 study of anti-PD-L1 antibody sugemalimab treating patients with relapsed or refractory extranodal natural killer cell/T-cell lymphoma (R/R ENKTL) as an oral presentation at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. The GEMSTONE-201 study was designed to evaluate the efficacy and safety of sugemalimab as monotherapy for the treatment of adult patients with R/R ENKTL. As of November 10, 2021, 80 patients were enrolled in the GEMSTONE-201 study and received sugemalimab monotherapy. As of the data cutoff date, median follow-up duration was 13.4 months, and 23 patients remained on treatment with sugemalimab in this study. Key results of this study are the following: Results on the primary endpoint showed that sugemalimab significantly improved objective response rate (ORR) compared to historical controls. In 78 evaluable patients, ORR assessed by Independent Radiology Review Committee (IRRC) was 46.2% and the complete response (CR) rate reached 37.2%.; Based on the evaluation by IRRC, durable objective response was observed in patients who responded to sugemalimab. Median duration of response (DoR) was not reached at the time of the analysis. The 6-month and 12-month DoR rates were 90.8% and 86.0%, respectively.; Investigator-assessed efficacy was found highly consistent with IRRC evaluations. The concordance rate between investigator- and IRRC-assessed ORR reached 97.1%.; The analysis of overall survival (OS) showed a signal of OS benefit with sugemalimab as monotherapy in patients with R/R ENKTL; the OS rates at 6 months, 12 months and 24 months were 79.2%, 68.6% and 54.6%, respectively.; Sugemalimab also demonstrated a well-tolerated safety profile in patients with R/R ENKTL, and no new safety signals were observed.

https://www.marketscreener.com/quote/stock/CSTONE-PHARMACEUTICALS-57946082/news/CStone-Pharmaceuticals-Presents-Clinical-Results-of-Sugemalimab-in-Patients-with-Relapsed-or-Refract-40638403/