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Sunday, October 30, 2022

Montana may be moving away from iinnovative plan to set hospital prices for public workers

 Montana is signaling it might step away from an innovative way of setting the prices its public employee health plan pays hospitals for services, an approach that has saved the state millions of dollars and become a model for health plans nationwide.

The plan gained national renown among employers and health care price reform advocates when, in 2016, it established maximum amounts the health plan would pay for all inpatient and outpatient services. Those amounts were pegged to Medicare reimbursement rates. The adoption of that model, known as reference-based pricing, has saved the state tens of millions of dollars. Taxpayers help fund the medical plan, which insures public employees and their families, for a total of about 28,800 people.

Montana didn’t invent reference-based pricing, but the state made waves by having a health care plan of that size set prices for all services, not just certain procedures, such as knee replacements.

Now, Montana is positioning itself to tweak its model, just as more states and employers, seeking to cut costs, consider adopting it. That has health economists and those working to lower hospital prices elsewhere wondering whether the state is once again moving ahead of the curve — or setting itself up for a setback.

“We look to Montana for the success story,” said Gloria Sachdev, president of the Employers’ Forum of Indiana, a nonprofit that tries to improve health care pricing. “Now that it’s doing something new, I think a lot of eyes will be on Montana.”

In September, the state awarded Blue Cross and Blue Shield of Montana a contract to take over administration of the public employee health plan starting next year. The contract calls for using Medicare’s rates as a baseline to set overall targets for the amounts the plan will reimburse hospitals. It gives Blue Cross the ability to meet those goals with reference-based pricing — but also by negotiating deals with individual health care providers using a mix of reimbursement models.

The state said in a news release announcing the contract that its new reimbursement targets will save $28 million over the next three years. But the details in the contract on how that will be achieved are vague.

Blue Cross, one of Montana’s largest insurers, won’t elaborate on its plans while Allegiance Benefit Plan Management, the public employee health plan’s current administrator, challenges the state’s contracting decision. Allegiance had held the contract since the state adopted the reference-based pricing model.

John Doran, a Blue Cross spokesperson, said state officials instructed company officials to direct all questions to the Montana Department of Administration.

Asked how upcoming changes will affect the health plan’s existing model, Montana officials pointed to the state’s contract with Blue Cross. According to that document, Blue Cross can create “custom alternative payment arrangements with providers” with state approval.

In the state’s news release, officials said the goal is to “modernize” its six-year-old reimbursement strategy. Department of Administration Director Misty Ann Giles said in the release that the state picked a vendor to help it “become more flexible to reach its goals efficiently.”

The U.S. has struggled to respond to the rising cost of health care. The Centers for Medicare & Medicaid Services estimated that in 2020, health spending grew nearly 10%, reaching $4.1 trillion, or $12,530 per person. More than 160 million people in the U.S. have employer-sponsored health insurance. Historically, the prices that employee health plans pay have been privately negotiated between health care providers and third-party administrators like Blue Cross, with negotiations often starting at the prices that hospitals propose.

That process has exacerbated the lack of transparency in the cost of care and has contributed to wide variation in the prices that private insurance plans pay. In a study of medical claims data from 2018 to 2020, think tank Rand Corp. found that private insurers in some states, such as Washington, paid hospital prices that were less than 175% of what Medicare would have paid for the same services at the same facilities, while in other states, they paid prices that were 310% of the Medicare rate or higher.

In 2016, Montana took a bold leap. Instead of negotiating down from hospitals’ listed prices, the state set a range for what hospitals can charge for services, establishing maximum costs as a set percentage above Medicare rates. If hospitals refused to negotiate through that model, they risked losing access to the patients insured through the state’s largest employer.

Marilyn Bartlett, who led the change to reference-based pricing when she worked for Montana, said that at that time, the plan had been losing money for years and risked its reserves dropping into the negatives. By 2017, Bartlett said, the plan’s reserves had accumulated more money than the state’s general fund, and the premiums state employees paid stayed level.

“We had flattened the price curve, and in fact we had a negative,” said Bartlett, now a senior policy fellow with the National Academy for State Health Policy advising other states on how to lower health care costs. “That was unheard of.”

Stephen Tahta, president of Allegiance Benefit Plan Management, said that while Allegiance was administrator of the health plan, it saved more than $48 million.

Hospital representatives have said a growing number of employer-based plans are considering increasing their reliance on reference-based pricing.

In recent years, California’s retirement plan that offers insurance benefits to public employees has worked to expand reference pricing for certain medications.

And the state of Colorado joined a purchasing alliance to negotiate with hospitals over pricing for its public employee medical plan this year, seeking to use Medicare rates as a baseline. Bob Smith, executive director of that alliance, the Colorado Business Group on Health, said that while major health systems have bucked that process so far, patients also have a health care price comparison tool to pick providers that charge reasonable prices and offer high-quality care.

The American Hospital Association opposes reference-based pricing, saying it can increase the amount patients must pay for care. One way that could happen is through balance billing, when a provider charges a patient for the difference between the cost set by the plan and the amount the provider charges.

Those advocating for pricing reform have said that hospitals’ initial prices before negotiations can be arbitrary and that Medicare’s rates are a fair starting point. Medicare reimbursements can be adjusted if a provider faces steep expenses such as operating in a rural place or hiring staffers to offer specialty care.

In the contract awarded in September, the state set a ceiling of no more than 200% of Medicare rates for the amounts the Blue Cross plan would pay providers overall in its first year. The contract says Blue Cross will target reimbursing providers an overall rate of 180% of Medicare’s rates by year three of the agreement.

The state left it to Blue Cross to find a way to reach those goals.

After KHN shared Blue Cross’ reimbursement details in the state contract with Chris Whaley, a health economist and policy researcher for Rand, he said it’s hard to know how the new approach will work out. Blue Cross’ plan doesn’t say how often the company will negotiate deals with providers outside of reference-based pricing. Whaley said that could lead Montana to lose focus on its reimbursement strategy.

“It seems like the model is already working really well,” Whaley said. “Is the reference-based pricing model something that’s going to be developed and improved upon? Or is it something that is maybe going to be stripped down and not have the same impact as before?”

Allegiance is alleging that the contract was awarded through an illegal bidding process and that it could end up raising health care costs for state employees and taxpayers.

Belinda Adams, a Department of Administration spokesperson, said state officials are reviewing the issues raised by Allegiance but believe the hiring process was fair and legal.

The state has 30 days from when Allegiance submitted its protest to issue a decision on the company’s claims if the two sides don’t reach an agreement that settles the dispute. In the meantime, Adams said, Blue Cross is preparing to take over administration of the public employee health plan in January.

https://www.statnews.com/2022/10/27/montana-may-be-moving-away-from-its-innovative-plan-for-setting-hospital-prices-for-public-workers/

Healthcare System Didn't Plan Poorly for Disaster — It didn't plan at all

 I was, for a while, a lecturer/consultant for the "Domestic Preparedness Program." This was an initiative by the Department of Justice to ensure that first responders around the U.S. were prepared to deal with the medical consequences of nuclear, biological, chemical, and blast injuries. This was before the terrible events of 9/11.

Our job as instructors was to go to cities around the country and educate police, fire, EMS, and medical personnel. We also engaged in table-top exercises, "war-gaming" what mass casualty events might look like.

It was fun and fascinating. But it also caused us to have a uniquely dark way of looking at things. We engaged in a lot of "what if" discussions, mostly about terrorism. We recounted terrorist events that had occurred and discussed lessons from military history. We studied events like the Tokyo subway sarin gas attack by the group, AUM Shinrikyo, and the use of mustard gas in the Iran/Iraq war.

One thing we often discussed was the vulnerability of populations if responders or medical facilities were targeted. This had been a well-known tactic of terrorists: the use of an explosive device, followed by a second once responders arrived.

Without question, we see this today. From Ukraine to Afghanistan to Florida, or anywhere that war or natural disasters occur, healthcare is badly compromised.

Looking back on those discussions, and my time with the incredible experts with whom I worked, I am forced to consider our situation right now. American healthcare, in the semi post-COVID era, is hanging by a thread. I am not trying to spin conspiracies. I am not trying to say that American healthcare has been intentionally attacked. But I do think American healthcare has been criminally neglected.

What I want to do is point out our vulnerability. Because it wouldn't take much to tip our already fragile balance. Hospital beds are still in short supply and the things I have been writing about are not improving. They will likely get worse as winter approaches. So, what could happen?

America could suffer a dramatic natural disaster. More hurricanes like the one that devastated Florida. Earthquakes are always a possibility, as are meteor strikes or solar flares. (In the case of a solar flare, which has the potential to disrupt communications systems and power grids on Earth, it's hard to imagine a modern hospital without computers, or the Internet, or perhaps even much of our life-saving equipment.)

Theoretically, there could be the use of an improvised nuclear weapon by terrorist groups or use of a strategic nuclear weapon by a nation. (While the purchase of drugs to treat radiation poisoning may or may not have to do with Putin's threats, the timing is certainly concerning.)

Another new pathogen could emerge; perhaps one completely unlike SARS-CoV-2, requiring us to learn about it all over again. This could be accidental or intentional. It doesn't take conspiratorial thinking to recognize that nations have worked with biological weapons for millennia -- the U.S. being no exception. This isn't crazy talk, it's just history.

So, to put this into focus, right now we're struggling to find one or two intensive care unit beds for someone with relatively mundane problems (well, not for the patient but in the big picture). A patient who needs a ventilator for pneumonia. A patient who needs surgery for a complicated abdominal infection. A child with ongoing seizures.

Looking for one inpatient bed or looking for two intensive care unit beds can be the labor of hours to days. Much less, as I have pointed out, the difficulty of getting them transported once the beds are available.

Now, imagine looking for 50 ICU beds for patients with severe burns. Imagine trying to find 2,000 hospital beds for patients with an unknown but life-threatening infection that, for example, causes dehydration from vomiting and diarrhea. Consider finding 10,000 beds for victims of an earthquake in an urban area where there were crush injuries and fire.

Those beds wouldn't be available. Even national guard units would take days to ramp up capacity, and their use of deployed personnel would strip staff from their civilian jobs.

Any of these nightmare events, especially coupled with supply chain issues and diminished energy resources, would be incalculable tragedies with ripples and repercussions for a decade.

And they would result in so many deaths -- unnecessary, if only we had planned ahead. If only we had built healthcare to be flexible and part and parcel of national defense. And if our planning, at least in part, had been driven by a concern for the health of the nation rather than the profits of vast corporations (for whom patient care is well down the list from profit, growth, and virtue signaling).

These are perilous times. And we need to start acting like it if we care for the future of our nation.

Our "leaders" need to start acting like real leaders.

Edwin Leap, MD, is an emergency physician who blogs at edwinleap.com, and is the author of The Practice Test and Life in Emergistan. You can read more of his writing on his Substack column, Life and Limb, where a version of this post originally appeared.

https://www.medpagetoday.com/opinion/rural/101472

Workers leave iPhone factory in Zhengzhou amid COVID curbs

Workers in a manufacturing facility in the central Chinese city of Zhengzhou appear to have left to avoid COVID-19 curbs, with many traveling on foot for days after an unknown number of employees were quarantined in the facility after a virus outbreak.

Videos circulating on Chinese social media platforms showed people who are allegedly Foxconn workers climbing over fences and carrying their belongings down the road.

The Foxconn plant in Zhengzhou, Henan province, is one of the largest factories in China that assembles products for Apple Inc., including its latest iPhone 14 devices.

Not all the videos that showed workers purportedly leaving the facility could be verified. It is unclear if the workers leaving the facility had escaped or if they were allowed to leave.

https://www.marketscreener.com/quote/stock/FOXCONN-TECHNOLOGY-CO-L-6496501/news/Workers-leave-iPhone-factory-in-Zhengzhou-amid-COVID-curbs-42131875/.

 The sports and modeling worlds have been rocked by news of a high-profile divorce. Could one of corporate America’s most famous unions also be headed for the splits?

An activist challenge to the consumer-goods giant Colgate-Palmolive has started a discussion over whether and how it could be broken up. No big moves are imminent, but the chatter could ultimately lead to many far-reaching outcomes

Third Point, led by the activist investor Dan Loeb, blasted the company’s stock as a perennial underperformer In a quarterly investor letter Oct. 18. That isn’t unfair. Over the past five years, the company has posted a total return including dividends of just 19.5%, according to FactSet. That compares with 61.2% for the S&P 500 and 56.9% for its consumer-staples subindex.
Colgate-Palmolive has four broad categories: oral care, including its namesake toothpaste; home care, including its namesake dish detergent as well as Ajax; personal care, including Speed Stick deodorant and Irish Spring soap; and pet care, with Hill’s Pet Nutrition, a high-end pet-food brand sold mainly through veterinarian and other specialist channels.
Third Point’s most headline-grabbing assertion was that Hill’s might be better off on its own. This got a cold reception from the company and some analysts. Bernstein analyst Callum Elliott
dismissed the idea, saying in a note that over the past 10 years, “Hill’s has contributed more than 100% of the revenue and profit growth” of the overall company.
That pretty well explains why Colgate-Palmolive might not want to part with Hill’s. But the question for investors should be whether Hill’s would create more value somewhere else, not whether it makes the rest of the company look less bad.
The case for Hill’s as a stand-alone company might not be as strong as the case for it pairing up with someone else. Many other pet-food brands fall under the umbrellas of major food companies, where synergies for such things as ingredient costs are far more obvious. Mars has brands including Pedigree, Nestlé has Purina, J.M. Smucker
has an assortment including Meow Mix, and General Mills
has the high-end brand Blue Buffalo.
Perhaps more important, Third Point also argued that the spinoffs of two major consumer-health businesses could create conditions for more deals in the space.Johnson & Johnson
is planning a separation of its consumer division</a>, which includes Tylenol and Listerine, while the former consumer unit of
GSK andPfizer now called Haleon, has already started  trading in London. Its stable of brands includes Advil and some specialty toothpastes including Sensodyne.
 Those toothpaste brands could make a formidable addition to Colgate-Palmolive’s portfolio, or else to rival Crest’s 
Those are just two of many possible permutations on this new chessboard. For instance, Colgate-Palmolive’s underperformance arguably puts its weakest category, home care, under the spotlight.
Colgate-Palmolive reported decent quarterly results Friday with sales and earnings that were more or less in line with analyst estimates. It posted organic sales growth—a key metric that strips out the impact of currency moves and mergers—of 7% from a year earlier. It reported that Hill’s had 7.5% organic sales growth. Frustratingly, though, it didn’t disclose a breakdown of performance at the other units. For the September quarter, it merely said that there was high single-digit organic growth in oral and personal care and some unspecified amount of growth in home care.
Becoming more transparent would itself be a shareholder-friendly move. But Colgate-Palmolive managers, on a conference call with analysts, also faced questions about their portfolio and whether it could somehow be reshaped.
Intriguingly, Mr. Elliott, the same analyst whose note waved off talk of a Hill’s spinoff, hinted at the possibility of a much bigger deal: “Can you talk please about the operational integration of the oral care business with the personal care and home care businesses, and specifically with a view to how difficult would it be to separate parts of or all of personal care, home care?” he asked. 
Chief Executive Noel Wallace’s answer wasn’t very satisfying. He cited the company’s “science-driven approach” that relies on “clinical substantiation for our products” and allows for “professional endorsement” such as dentist or veterinarian recommendations. He also said that the company’s overall “digital transformation” was led by Hill’s. “We have now taken their capabilities, their talent and use those across the entire enterprise to further our digital capabilities,” he said.
Colgate-Palmolive will have to do a lot better than that to make its case. Otherwise, talk will keep circling that this storied union might not be forever.

Radical Gender Ideology Invades Small-Town Schools

by Jackson Elliott via The Epoch Times,

When the school called his 14-year-old son to the principal’s office for refusing to say a female student was a boy, Matthew Duncan decided he’d had enough. 

At first, Duncan’s son thought his longtime classmate was joking when she told him to say she was a man. He refused.

“You can’t do that! You can’t call somebody by something that they’re not,” Duncan said school administrators in Grants Pass chastised the boy.

“Just so you know, if you do it again, you’re gonna get in trouble,” they warned his son, Duncan said.

After the school year ended, Duncan transferred his two children to a private school.

Grants Pass is a small, conservative town, but locals have found they can’t control what their children get taught in public school. Families have found directives from Oregon’s governor trample their own beliefs. Teachers who want a politically neutral curriculum say local schools have actively promoted LGBT ideology.

Matthew Duncan, photographed in Grants Pass, Ore., on Oct. 18, 2022, moved his two children to a private school after administrators at the local high school threatened to punish his son for refusing to say a girl classmate was a boy. (Jackson Elliott/The Epoch Times)

“There was never a push towards dominance and control like it is now,” said Duncan. “You can’t voice your opinion.”

In response, many families in Grants Pass have withdrawn their children from public school, enrolling them in private school or starting to homeschool, Grants Pass teachers, school administrators and parents told The Epoch Times.

But those solutions can be expensive and inconvenient, and private schools sometimes don’t have enough space to absorb the exodus of students.

Boys Aren’t Girls

In just a few years, LGBT ideology has swept into Oregon schools, said Betty, a former school employee who used her first name only to avoid backlash within the community. She retired early because she was tired of trying to help kids, while simultaneously fighting left-wing ideology, she told The Epoch Times.

Just a few years ago, there wasn’t any LGBT indoctrination in her school, Betty said. Then, education workers slowly and quietly filled schools with pro-LGBT material.

“I mean, we’re out in the country. It’s conservative. And it’s like [the truth is], ‘Beware! It’s not!'” she said.

One day, Betty discovered a poster in the library that stated left-wing talking points.

This sign promoting left-wing ideology was displayed at a public high school in Grants Pass, Ore. (Courtesy of Betty)

“We believe black lives matter, no human is illegal, love is love, women’s rights are human rights, science is real, water is life, injustice anywhere is a threat to justice everywhere,” it read.

It didn’t seem like education to provide just one perspective on controversial issues, she said. So she put up her own poster next to it.

“We believe all lives matter, legal immigration, marriage is one man & one woman, unborn female and male babies have rights, God’s creation supports science, water is life, return to law abiding Constitutional America,” Betty’s poster read.

Then she got called to the principal’s office.

“They said, ‘You know what? This is unacceptable. You need to clear everything with us,'” Betty recalled.

The school forced her to take her poster down, but allowed the left-wing poster to remain, she said.

In another incident, when Betty stopped a young elementary school boy from walking into the girls’ bathroom by mistake, administrators expressed their disapproval.

“Oh, did I get it for that!” she exclaimed.  “They said, ‘Betty, don’t you understand? They can walk wherever they want.'”

Radical gender ideology broke into schools after younger teachers embraced it in their training in college.

“They bought the propaganda,” Betty lamented. “They were immersed in the propaganda at the college level, so they’re just spewing that out. My sense is that they don’t have the same morality that us oldsters do.”

Another conservative teacher, Deborah, left her job after facing pressure to resign, she said. Deborah chose not to use her real name because she was concerned about drawing criticism.

Before she left, a school-mandated lecture told all teachers to raise their hands if they had “white privilege,” she said. She was the only one not to signal affirmation.

“No one else, as far as I know—no one else spoke up,” she said.

A school bus outside Grants Pass High School in Grants Pass, Ore., on Oct. 18, 2022. (Jackson Elliott/The Epoch Times)

In another incident, a student expressed panic after Donald Trump was elected president.  The girl said she feared Trump would put her in a concentration camp because she was a lesbian, Deborah recalled.

Deborah assured her it wouldn’t happen, she said. The student filed a complaint, and the school’s administration talked with Deborah about the incident.

“It was so ridiculous,” she said. “It never went anywhere, and is not even documented in my employment file. But I was visited by the administration because of it.”

Then, after Deborah accidentally handed a graded test to the wrong student, the student filed a complaint against her. Documents she provided to The Epoch Times show that the school assigned her “focus goals” that included passing out papers to the correct students.

Deborah has 22 years of teaching experience. She said she believes the school used the complaint to make her job so frustrating that she would quit. She suspects the school wanted her out because of her political beliefs.

“I think that people knew that I probably wouldn’t call a girl a boy,” Deborah said.

After the complaint, the school subjected all her work to intense scrutiny, she said.

“I would have to email my every single detail [in a] plan, at 5 in the morning to the principal and the personnel director,” Deborah recalled. “And then they would have people coming in my class every day. Different administrators were picking apart everything. And I found that many of the things that they said were just flat-out lies.”

Tired of the pressure, Deborah retired in 2019.

Local Kids, State Standards

Some in the community believe schools have also swung left in towns like Grants Pass, because Oregon’s state government sets educational standards that promote radical gender ideology.

“The whole system is set up to reprogram the kids. I mean, that’s what they’re doing. They’re literally destroying these innocent little brains,” said Betty.

The Oregon State Board of Education (OSBE) sets educational policies and standards for the state. The governor selects the board’s members.

Democrats have controlled the governor’s office since 1986. Oregon’s current governor, Kate Brown, is the nation’s first openly bisexual politician.

Some have accused the Oregon Department of Education (ODE) of pushing left-wing ideology at the expense of educational excellence. Its website urges administrators to educate while focusing on race and ethnicity.

Oregon’s health education standards also say children should learn there are “many ways to express gender” in kindergarten. They should learn about sexual orientation in third grade, the standards state, and they should be taught how to prevent the spread of AIDS in third grade as well.

By third grade,  the guidelines continue, students should “recognize differences and similarities of how individuals identify regarding gender or sexual orientation.”

From kindergarten, students should learn to “recognize the importance of treating others with respect including gender expression,” the standards read. Students of the same age should also “identify different kinds of family structures.”

Sometimes, Oregon state curriculum is pornographic, in the opinion of Heidi Napier, a Grants Pass local who works with the area’s Republican Party education committee.

Napier paid for a copy of the state’s curriculum and discovered it included photographs of diseased genitals and line drawings of people having sex.

When Napier showed the pictures to a police officer, he told her that it would be a crime if she distributed them to children.

It’s legal, however, to use the same materials in the classroom.

“These are from the CDC,” the officer told her. “And as long as they’re used by a schoolteacher, they’re not pornography. But if anybody else used them, they would be considered pornography.”

Napier wondered if she could even show them at a school board meeting without facing repercussions.

The outside of Grants Pass High School suggests the school promotes left-wing gender ideology. The school has a rainbow LGBT pride heart above its main entrance and LGBT pride stickers on the windows of its classrooms.

The Epoch Times requested an interview with the Grants Pass school district, but one had not been scheduled by press time.

Pushing Private School

In response to ideological teaching, many Grants Pass parents have removed their children from public schools.

Admissions for Grants Pass New Hope Christian School have skyrocketed in the last three years, according to school administrator Annie Burnham.

Since 2020, the school has gone from 190 students to 340, with about 30 students on a waiting list, she said. To meet the need, New Hope more than doubled its staff. This switch is part of a nationwide post-COVID-19 trend.

https://www.zerohedge.com/political/radical-gender-ideology-invades-small-town-schools

Saturday, October 29, 2022

Large stroke trial finds intensive blood pressure lowering after clot removal worsens recovery

 A large stroke trial has shown that intensive blood pressure lowering after clot removal worsens recovery. The results of the trial, stopped early due to the significance of the findings, were presented in a late-breaking session at the World Stroke Congress and simultaneously published in The Lancet.

Professor Craig Anderson, Director of Global Brain Health at The George Institute for Global Health, said the rapid emergence of this effect suggested the more aggressive approach was compromising the return of blood flow to the affected area.

"Our study provides a strong indication that this increasingly common treatment strategy should now be avoided in ," he said.

Around 85 percent of strokes are ischemic strokes, caused by the loss of blood flow to an area of the brain due to a blockage in a blood vessel, leading to a loss of neurological function.

Endovascular thrombectomy is an increasingly used non-surgical treatment for ischemic stroke, in which microcatheters or thin tubes visible under X-rays are inserted into the blood clot to dissolve it.

"A potential downside of this now widely used and effective treatment is that the rapid return of blood supply to an area that has been deprived of oxygen for a while can cause  known as ," said Professor Anderson.

"This has resulted in a shift in medical practice towards more intensive lowering of blood pressure after clot removal to try and minimize this damage, but without evidence to support the benefits versus potential harms."

To try and address the evidence gap, researchers recruited 816 adults with acute ischemic stroke who had elevated blood pressure after clot removal from 44 centers in China between July 2020 and March 2022. They had an average age of 67 and just over a third were female.

407 were assigned to more-intensive (target <120 mm Hg) and 409 to the less-intensive (target 140-180 mm Hg) systolic blood pressure control, with the target to be achieved within one hour of entering the study and sustained for 72 hours.

Researchers looked at how well the patients in both groups recovered according to a standard measure of disability, ranging from 0-1 for a good outcome without or with symptoms but no disability, scores of 2-5 indicating increasing levels of disability (and dependency), and a score of 6 being death.

Patients in the more-intensively treated group had significantly worse scores on the scale compared to those allocated to those treated less intensively.

Compared to the less-intensive group, they had more early brain tissue deterioration and major disability at 90 days but there were no significant differences in brain bleeds, mortality, or serious adverse events.

Patients who had their blood pressure more intensively controlled also rated their quality of life as significantly worse due to limitations on their physical abilities resulting from their stroke.

Prof. Anderson said that after scouring the medical literature the research team had been unable to find strong enough evidence to recommend the ideal target for blood pressure control after blood  removal in patients with acute .

"While our study has now shown intensive  control to a systolic target of less than 120 mm Hg to be harmful, the optimal level of control is yet to be defined," he said.


Explore further

Children with severe stroke may fare better if treatment includes mechanical clot removal

More information: Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial, The Lancet (2022). DOI: 10.1016/S0140-6736(22)01882-7
https://medicalxpress.com/news/2022-10-large-trial-intensive-blood-pressure.html

New pan-coronavirus vaccine passes key experiments, demonstrates protection

 In laboratory and primate tests, a new pan-coronavirus vaccine developed by the Duke Human Vaccine Institute (DHVI) has demonstrated wide protection against SARS-CoV-2 viruses and variants, including omicron BA.5.

Publishing in the journal Nature Communications, the DHVI and collaborating researchers reported that three doses of the pan- vaccine induced neutralizing antibodies against beta, delta and omicron variants, including the subvariant BA.5.

The vaccine was also tested by exposing vaccinated animals to various SARS-CoV-2 strains. It demonstrated protection against infection from the original SARS-CoV-2 strain, as well as beta and delta variants.

"This provides proof-of-concept for a first generation pan-SARS-like virus vaccine," said Barton F. Haynes, M.D., director of the DHVI.

The vaccine candidate is a combination of a nanoparticle antigen developed at Duke, along with an adjuvant—an ingredient that boosts a vaccine's effects—formulated by the Access to Advanced Health Institute. The adjuvant formulation, 3M-052-AF, significantly enhanced the immune responses in the animals when combined with the antigen.

"While SARS-CoV-2 continues to mutate during the ongoing pandemic, there are conserved regions on the virus that our vaccine will continue to successfully bind to, regardless of mutations," Haynes said. "That will be critical for present and future protection."

The  will now move to production and an initial Phase I clinical trial in humans. Ongoing research will focus on developing the  as a booster for the currently vaccinated population, aiming to optimize the induction of antibodies that would neutralize new variants.


Explore further

Follow the latest news on the coronavirus (COVID-19) outbreak

More information: Dapeng Li et al, Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine, Nature Communications (2022). DOI: 10.1038/s41467-022-33985-4
https://medicalxpress.com/news/2022-10-pan-coronavirus-vaccine-key.html