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Monday, January 6, 2025

Repligen Launches CTech SoloVPE PLUS System for Bioprocessing

 Repligen Corporation (NASDAQ:RGEN), a life sciences company focused on bioprocessing technology leadership, today announced the commercial launch of its CTech™ SoloVPE® PLUS System, the most advanced UV-based Variable Pathlength Technology system now available to biopharmaceutical manufacturers. The SoloVPE PLUS System is engineered to offer unparalleled accuracy, speed, and ease-of-use for at-line ultraviolet-visible (UV-Vis) concentration measurement in complex biological production workflows, from process development scale through cGMP manufacturing.

As the bioprocess industry shifts toward higher drug concentration formulations to improve efficiency and reduce production costs, there has been a growing need for faster, more reliable and more accurate analytical tools. The SoloVPE PLUS System addresses this need, utilizing variable pathlength spectroscopy to deliver precise concentration measurements in under 30 seconds, without the need for dilution or background correction.

https://www.globenewswire.com/news-release/2025/01/06/3004496/24603/en/Repligen-Launches-the-CTech-SoloVPE-PLUS-System.html

'AI-influenced shopping boosts online holiday sales, Salesforce data shows'

 Artificial intelligence-powered chatbots helped consumers purchase and return products during the 2024 holiday season, boosting online sales in the United States by nearly 4% year-over-year, according to a report by Salesforce.

Retailers turned to nifty conversational customer services - or chatbots - among others such as targeted promotions, product recommendations and loyalty programs, to influence customers hunting for trending products and best bargains.


Online sales rose to $282 billion in the United States between Nov. 1 and Dec. 31 from $272 billion a year ago, ahead of Salesforce's forecast of 2% growth, even as discounts were tempered.

Shoppers used AI-based chatbot services 42% more than a year ago, according to Salesforce, which analyzed data from 1.6 trillion page views on its platform.

AI influenced-sales rose to $229 billion of global online sales between Nov. 1 and Dec. 31 from $199 billion in 2023, the report said.

However, a high rate of product returns by customers at 28%, compared with 20% in 2023 was a "significant concern" and could reduce the overall profit margins for retailers, said Caila Schwartz, director of Consumer Insights at Salesforce.

"Retailers who have embraced AI and agents are already seeing the benefits, but these tools will be even more critical in the new year as retailers aim to minimize revenue losses on returns and re-engage with shoppers," Schwartz added.

Orders placed through smartphones peaked on Christmas day, as customers set out to do some last-minute shopping, with about 79% of all orders being placed through mobile devices during the holiday season, the report said.

Apart from AI, retailers used social media sites such as TikTok Shop and Instagram to help generate interest, with social media driving 14% of all traffic to e-commerce sites.


https://finance.yahoo.com/news/ai-influenced-shopping-boosts-online-130413069.html

The January 6 "Insurrection" that Wasn't

 by Thomas Buckley via The Mises Institute,

Typically, coup attempts do not wrap up in time for dinner...

But over the next few days, with the anniversary of the 2021 January 6 Capitol riot having become a progressive political holiday worthy of obsessive memorialization, the nation will be deluged with tales of attempted government overthrow, Trumpian lunacy, and the FBI desperately trying to explain why it has yet to catch a person who—on video—placed two pipe bombs in DC that day but has somehow gloriously managed to track down and prosecute 1,000 trespassers.

Despite what the endless and tedious and inaccurate anniversary media coverage—all delivered with a joyously smirking “kid in a candy store/evil Republicans” tenor—will be claiming, the January 6 riot had all (maybe really only some) of the hallmarks of, well, a riot, and none of the indicators of an actual “insurrection,” let alone an attempted coup d’état.

For an actual and successful coup, one need look no further than the inglorious defenestration of Joe Biden last summer.

A coup is an extremely tricky proposition, as Burt Lancaster’s character in the 1964 film “Seven Days in May,” discovered much to his chagrin. The film (and the book) note the level of detailed planning necessary, the prior co-option of various levers of power that needs to occur, the cruciality for speed of implementation, and—just as importantly—the requirement of a post-coup strategy.

January 6 had none of that—the intentional political censorship and elite scheming of the past few years and, of course, the bye-bye to Biden had all of that (except for his vicious vengeful installation of Kamala Harris, not at all being the choice of Pelosi-Obama plotters, as the heir.)

In a proper insurrection or coup, one of the key elements is control of the media. If January 6 were a legitimate attempt to overthrow the government, the planners, in theory, would have made sure that only evil Fox News was left on the air, that it had changed its logo to incorporate buffalo horns, and that all other media—including social—was broadcasting or re-tweeting or posting reruns of “Welcome Back, Kotter.”

This did not happen on January 6, unlike the instantaneous media rallying around, supporting, and explaining why it was perfectly okay for Biden to be put on an ice floe and that Harris was not at all the squishy, angry, incoherent portrait of pointlessness that it had been portraying her as for the previous four years. In fact, turns out, the media said, she was great and smart and definitely going to be met with universal acclaim by the public.

That did not exactly turn out very well.

The January 6 riot was a very odd combination of chaos and politeness, an attempt at a serious—if utterly misguided—political statement, a tragedy in the killing of Ashli Babbit, featured absurd humans doing absurd and scary things, and was politically almost unimaginably stupid.

But it was not a coup attempt.

People overthrowing a government do not wrap things up in time to get back to the hotel for dinner, they do not call the next day to check if anyone found the coat they left behind, and they do not stay within the stanchions:

In Edward Luttwak’s extremely interesting book—Coup D’état: A Practical Handbook—he outlines a series of practical necessities a successful overthrow entails. A neutralized opposition, media control, military support, dedicated and discrete supporters throughout government offices, speed of implementation, a detailed and logistically-feasible organizational action plan, and the immediate institutionalization of the new government are all among the key elements to prevailing. Since what occurred on January 6 not only lacked any of these elements but, by all accounts, had the exact opposite characteristics means, again, the premise that an actual government overthrow was in process is ludicrous.

To an extent, these simple facts are somewhat akin to the key event in the Sherlock Holmes story, “The Adventure of Silver Blaze.” Holmes focuses on a “curious incident”: the dog on the premises did not bark, leading the detective to the idea that the ne’er-do-well was known to the animal. This concept is also known as a “negative fact,” which involves the absence of one thing proving the truth of another.

A key negative fact is that only a handful of those participants the feds have rounded up and charged have not been charged with anything even remotely related to a treasonous, insurrectionist, coup attempt. Considering that some have received years-long sentences for trespassing, one would think there would be more, that is, unless they know it wouldn’t stand up in even the kangaroo courts in DC.

A second negative fact is that the riot, in fact, ended any consideration of and debate about the status of potentially questionable electors. Again, a proper coup would have let the effort move forward in the hope that it would succeed and only be triggered if there was a failure.

A final negative fact is that, despite the avalanche of anniversary coverage, little has been dedicated to the idea of what would have happened if the insurrection had been successful. If those still pushing the story now actually thought that it could have “worked,” they would be screaming about that horrifying potentiality from the rooftops. Since they haven’t, it means even they do not really take the notion seriously.

None of this is to defend the sheer obnoxiousness of the riot—not only was it wrong and illegal, it was supremely stupid from a political standpoint. With the fact that literally everything else went wrong for the administration and the Democrats in Congress in 2021, the riot provided them with the only even theoretically plausible lifeline to retain political legitimacy.

Congressional reports (St. Liz is getting a medal from Biden) and counter-reports (St. Liz may have committed felony witness tampering) have been issued and the FBI is still trying to explain the difference between informants—who were on scene—and agents, which it says (ludicrously) were not.

Friday, the FBI (presumably to have something to say during the anniversary) released “new” info on the person who put pipe bombs next to the headquarters of both the Republican and Democratic parties. The new info? He’s five foot seven. However, they declined to say why they let random people just stroll by the putative bombs even while they were on-site with robots investigating. All this apparently with a coup going on down the street.

Trump officially lost in 2020. Now whether that was due to a collaborationist media, vapor trails of zeroes worth of dark money, extremely dodgy election systems, the actual Big Lie regarding mental competence that was the Biden campaign, Trump’s personality (but probably not his policies), that there may have been 75,000 white men (the only demographic Trump saw a decline of support in, by the way) who were brainwashed into believing that to vote for him was a racist act, covid, generalized drama exhaustion, a belief that Biden would in fact be a good and decent President, or whatever other reason can be debated, but the fact is that Donald Trump left office.

But now he is back and—knowing Trump’s penchant for in-your-face troll drama—one can be certain that he, maybe half jokingly, asked if he could move the inauguration date up two weeks to January 6. Now that would be a memorable anniversary.

https://www.zerohedge.com/political/january-6-insurrection-wasnt

Renovaro to Acquire Predictive Oncology in All-Stock Transaction

 Acquisition provides access to critical resources encompassing a biobank of more than 150,000 tumor specimens, 200,000 pathology slides and decades of longitudinal drug response data

Data provides a critical pathway to progress AI using the high-speed computing power provided through collaboration with Nebul

Combines Predictive Oncology’s AI-driven multi-omic drug discovery platform with Renovaro’s AI Cube multi-omic artificial intelligence to advance both cancer diagnostics and early drug discovery

Planned test launch to assist physicians in individualizing cancer therapy to improve treatment outcomes\


https://www.globenewswire.com/news-release/2025/01/06/3004710/0/en/Renovaro-to-Acquire-Predictive-Oncology-in-All-Stock-Transaction.html

Teoxane Superior Proposal to Acquire Revance Therapeutics for $3.60 per Share in Cash

 Teoxane SA today announced that on January 6, 2025, it submitted a proposal to the Board of Directors of Revance Therapeutics, Inc. (Nasdaq: RVNC) to acquire Revance for $3.60 per share in cash. Teoxane beneficially owns 6.2% of the outstanding shares of common stock of Revance.

Teoxane's proposal provides a 16% premium over the $3.10 per share price in Revance's amended and restated merger agreement with Crown Laboratories, Inc. ("Crown"), as announced on December 9, 2024. Teoxane believes its proposal is a superior alternative to the amended and restated transaction with Crown.

Teoxane has organized the resources to work as expeditiously as possible toward a transaction with Revance and is prepared to transact promptly. Teoxane has performed due diligence with publicly available information and would have only limited and specific confirmatory due diligence requirements. Teoxane already possesses deep knowledge of Revance's operations and capabilities via its existing commercial relationship: Teoxane's products represent a material portion of Revance's current and prospective revenues under the companies' existing Distribution Agreement.

Closing the transaction would be subject to any applicable regulatory approvals, but Teoxane does not anticipate any significant regulatory risks or delays, and notes that Teoxane's U.S. sales are already conducted effectively entirely through Revance's platform, and that there are no other known geographical or portfolio overlaps today.

Teoxane has substantial cash on hand, is highly profitable, and together with its financial advisor is already in discussions with financing sources that are familiar with Teoxane and the sector in order to secure committed financing for the transaction in a timely manner, in parallel with the completion of due diligence. Teoxane will obtain fully underwritten, binding commitment letters prior to signing a definitive agreement, which will not contain a financing contingency.

Jefferies LLC is acting as financial advisor to Teoxane, and Davis Polk & Wardwell LLP in the USA and Walder Wyss SA in Switzerland are serving as legal counsel.

https://www.prnewswire.com/news-releases/teoxane-sa-announces-superior-proposal-to-acquire-revance-therapeutics-for-3-60-per-share-in-cash-302342992.html

Cardinal Health upped to Buy from Neutral by B of A

 Target to $145 from $132

https://finviz.com/quote.ashx?t=CAH&p=d

Italy In Talks With SpaceX's Starlink For $1.6 Billion Telecom Security Deal

 President-elect Donald Trump hosted Italian Prime Minister Giorgia Meloni at Mar-a-Lago on Saturday.

Following the meeting, Bloomberg reported that a deal between the Italian government and Elon Musk's SpaceX for Starlink satellite internet service could soon be finalized to provide secure telecommunications. 

Starlink and the Italian government have been in discussions since mid-2023. According to the report, talks are ongoing and centered around a five-year contract valued at $1.6 billion. This contract would provide a broad range of top-level encryption for the government's telephone and internet services. Sources indicated that Italy's Intelligence Services and Defense Ministry have already signed a deal with SpaceX. 

Italy confirmed on Monday that discussions continue, stating that no deal has been reached. Officials added, "The talks with SpaceX are part of normal government business."

On Saturday, Trump praised PM Meloni as a "fantastic woman" at the former president's Mar-a-Lago residence in Palm Beach, Florida. 

"This is very exciting," Trump said, adding, "I'm here with a fantastic woman, the prime minister of Italy. She's really taken Europe by storm."

Trump and Meloni were joined by two of his nominees: Senator Marco Rubio (R-Florida) for Secretary of State and Representative Mike Waltz (R-Florida) for National Security Advisor.

Meloni's visit to Mar-a-Lago follows her dinner with Trump and Musk in December during the reopening of the Notre Dame Cathedral in Paris. 

Something about Meloni and Musk...

Last month, Reuters reported that Italy plans to begin tests as early as January to see if Starlink internet will boost the rollout of high-speed internet in the country. 

Musk's SpaceX is the leader in rocket launches and satellite deployment, allowing the US to be many years ahead of China and Russia in the global space race. Starlink has more than 7,000 satellites in low-Earth orbit, along with next-gen satellites being launched regularly for direct-to-cell satellite services. 

https://www.zerohedge.com/technology/italy-talks-spacexs-starlink-16-telecom-security-deal