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Wednesday, July 2, 2025

Novartis Phase III Cosentyx Trial Misses Primary Endpoint



Novartis (NYSE:NVS) announced that its Phase III GCAptAIN study of Cosentyx® (secukinumab) in giant cell arteritis (GCA) did not meet its primary endpoint of sustained remission at Week 52. The study evaluated Cosentyx in combination with a 26-week steroid taper versus placebo with a 52-week steroid taper in adults with newly diagnosed or relapsing GCA.

While secondary outcomes showed numerically better results for cumulative steroid dose and steroid-related toxicity compared to placebo, they did not achieve statistical superiority. The safety profile remained consistent with Cosentyx's known safety data across approved indications. Novartis plans to conduct a full evaluation of the study data and share detailed results in the future.

Comey’s daughter Maurene suffers high-profile loss as prosecutor in Diddy trial

 Assistant U.S. Attorney Maurene Comey played a leading role on the eight-member team that prosecuted rapper Sean “Diddy” Combs in a sex trafficking and racketeering trial that came to a close Wednesday with mixed results.

The daughter of former FBI Director James Comey, Maurene Comey faced a setback when the jury found the performer not guilty of some of the most serious charges, including racketeering conspiracy and sex trafficking. However, the jury did side with prosecutors on two counts, finding Combs guilty of violating the Mann Act of 1910 by transporting women across state lines for prostitution.

Maurene Comey was a prosecutor in the Jeffrey Epstein trial prior to his death in prison and also had a lead role in Ghislaine Maxwell’s trial.

She leads the violent and organized crime unit in the U.S. Attorney’s Office for the Southern District of New York (SDNY).

SDNY is the same stepping stone her father, James Comey, used to catapult himself to national prominence.

Maurene Comey arrives at the Federal courthouse during the Sean “Diddy” Combs’ sex trafficking and racketeering conspiracy trial at U.S. court in Manhattan, in New York City, U.S., May 21, 2025.REUTERS

The ex-FBI director and prominent Trump foe worked similarly as a federal prosecutor there in the 1980s, when noted Trump ally Rudolph Giuliani was the Reagan-appointed U.S. attorney.

He returned to Manhattan in the 2000s after former President George W. Bush appointed him to the role once held by “America’s Mayor.”

Lately, the elder Comey received blowback for posting a photo of stones on a beach in the shape of “86 47,” which many observers considered to be a wish for President Donald Trump’s death – with “86” being a cipher for “kill” and “47” denoting Trump as the 47th president.

Sean “Diddy” Combs listens as prosecutor Maurene Comey makes her closing arguments during Combs’ sex trafficking trial in New York City, New York, U.S., June 27, 2025, in this courtroom sketch.REUTERS

In court, Maurene Comey offered the prosecution’s rebuttal prior to the jury being sent off to deliberate the charges against Combs.

Maurene Comey argued from the dais that Combs “never thought the women he abused would have the courage to speak out loud what he had done to them,” and suggested the rapper believed he was “untouchable.”

She also offered arguments that Combs had been involved in firebombing a Porsche owned by rapper Scott “Kid Cudi” Mescudi, according to TMZ. his rhetorical battles with Trump.

https://nypost.com/2025/07/02/us-news/former-fbi-director-james-comeys-daughter-suffers-loss-as-prosecutor-in-diddy-trial/

US Lifts Chip Design Software Curbs on China in Trade Deal

 


President Donald Trump’s administration has lifted recent export license requirements for chip design software sales in China, as Washington and Beijing implement a trade deal for both countries to ease some restrictions on critical technologies.

The US Commerce Department informed the world’s three leading semiconductor design software providers — Synopsys Inc.Cadence Design Systems Inc. and Germany’s Siemens AG — that requirements to seek government licenses for business in China are no longer in place, according to company statements.

https://www.bloomberg.com/news/articles/2025-07-03/siemens-says-us-has-rescinded-chip-software-curbs-on-china

Trump says Powell should ‘resign immediately’

 

Lew: Mamdani policies not ‘good for New York’

 Former Treasury Secretary Jack Lew slammed New York City Democratic mayoral candidate Zohran Mamdani for his policy proposals based on socialist initiatives. 

Mamdani has promised to push for free buses, free child care and rent freezes if elected to office.

“The policies that he’s outlined are not policies that are good for New York. He’s running for mayor of New York, and I worry deeply having spent most of my life in New York about a city that I call home,” Lew, who served in the Obama administration, said during a Wednesday appearance on CNBC.

“You know, I see a similarity between the kind of policy solutions to the left and the right, and — you know, that satisfy populist sentiment don’t always go through the filter of do they work. I don’t think they work, and I think that’s a problem,” he added. 

Republicans, including the president, have openly railed against Mamdani.

“As President of the United States, I’m not going to let this Communist Lunatic destroy New York,” President Trump wrote in a Wednesday post on Truth Social, referencing Mamdani. 

“Rest assured, I hold all the levers, and have all the cards. I’ll save New York City, and make it ‘Hot’ and ‘Great’ again, just like I did with the Good Ol’ USA!”

Others have alleged that Mamdani, a Muslim, is antisemitic and criticized him for urging the U.S. to recognize Palestine as a state.

However, the most frequent point of contention remains his economic policies.

“You might have a democratic socialist sprinkled here and there, but that ain’t what America is. America’s about capitalism! America’s about dollars and cents,” Stephen A. Smith said during his Tuesday show, urging Democrats not to promote others like Mamdani. 

Despite critiques, Mamdani edged out former Gov. Andrew Cuomo (D) in the Democratic primary and captured a majority of the votes from the Washington Heights, Flatbush, Williamsburg, Astoria, Park Slope, Bedford-Stuyvesant and Crown Heights neighborhoods.

“I’ve already had to start to get used to the fact that the president will talk about how I look, how I sound, where I’m from, who I am,” Mamdani said about Trump’s remarks during a Sunday appearance on MSNBC’s “Meet the Press.”

“He wants to distract from what I’m fighting for. I’m fighting for the very working people he ran a campaign to empower that he has since then betrayed.”

The two have already publicly clashed over Mamdani’s promise to help New York City remain a sanctuary city if elected as mayor.

https://thehill.com/homenews/state-watch/5382716-former-obama-treasury-secretary-mamdani-polices-not-good-for-new-york/

Left nonprofits — and taxpayer money — lifted Mamdani’s campaign

 New Yorkers are under the false impression that the taxpayer-funded city Campaign Finance Board is leveling the playing field to make Gotham’s elections fair.

Just the opposite is true: The CFB is actually doling out obscene amounts of our money to tilt the scales for left-wing candidates, including Democratic mayoral nominee Zohran Mamdani. 

If November’s election is anything like 2021’s, taxpayers will shell out more than $100 per vote cast — while the board kneecaps Mamdani’s moderate rivals. 

The CFB, an independent city agency, was formed in 1988 to give political newbies a fair shot against established pols.

The idea was to match small private contributions dollar-for-dollar with taxpayer funds.  

Since then, the match has increased sharply: Now it’s a staggering 8-to-1 in the primary, and another 8-to-1 in the general election. 

The CFB paid out nearly $63 million in taxpayer money to candidates in last week’s primary, and its general-election expenditures will likely double that figure.

It’s a gold mine for political operatives, campaign professionals and candidates in the CFB’s good graces. As Zohran Mamdani apparently appears to be.

But not everyone is. 

Last December, the CFB declared incumbent Mayor Eric Adams ineligible for public financing, alluding to federal allegations that have since been withdrawn.

It was straight-up election meddling — the old “guilty until proven innocent” trick.

It’s not the first time. 

In 2013 the CFB denied matching funds to then-Comptroller John Liu in his race for the mayoralty, citing unproven allegations. 

That let communist-loving dimwit Bill de Blasio win the primary — a disaster for the city.

This time around, the CFB is turning a blind eye to abuses that violate at least the spirit, and possibly the letter, of the public campaign-finance system. 

When Mamdani in May urged his followers to help the floundering campaign of City Council Speaker Adrienne Adams, some 370 of them did so, making her eligible for nearly $15,000 in public funding. 

That sent taxpayer money to a candidate who didn’t have the grassroots support to qualify. 

Not a word from the CFB, even after Adams then instructed her supporters to add Mamdani to their ranked-choice ballots. 

Wink-wink, a publicly financed quid pro quo.

CFB also chose to ignore Mamdani’s biggest in-kind contributor: the Democratic Socialists of America.

On Monday, a DSA Zoom call boasted of its work on Mamdani’s behalf: 1.6 million door knocks, 2.3 million phone dials and 30,000 volunteers, who canvassed in at least 60 neighborhoods. 

Businesses face severe restrictions on such donations, and candidates have to report every penny of the in-kind resources they receive.

But the DSA poured millions of dollars’ worth of expertise and sweat equity into Mamdani’s hostile takeover of the Democratic Party — and the CFB was mum. 

Mamdani was also backed by a broad network of leftist nonprofits that receive taxpayer funding courtesy of Democratic legislators and supply the expertise, manpower and connections to win political races.

These nonprofits are outstripping the unions in impact and influence. 

A close look at Mamdani’s fund-raising illustrates how taxpayers are getting fleeced by this nonprofit advocacy-industrial complex.

Mamdani raised $1,708,494 in individual contributions, which the CFB matched 8-to-1, giving him $7,050,417 in taxpayer funds.

That’s a whopping $8.75 million, just for the primary race.

But according to CFB filings, 94% of Mamdani’s small-dollar haul was “bundled” by one person, Jerrod MacFarlane.  

Bundling is a technical term for gathering donations from multiple givers, and MacFarlane is a professional fund-raiser with Action Lab, a left-of-center group.

The bundling suggests that Mamdani’s campaign was less a groundswell of spontaneous support — and more an organized effort by powerful leftist groups with long fund-raising lists at their disposal.

It may not violate the law, but it is contrary to the principle behind the taxpayer-funded matching program.

The CFB did not respond to my questions regarding MacFarlane’s bundling — and his name then disappeared from its list of fundraising “intermediaries.”

Action Lab is headquartered in Brooklyn, thanks to a “community projects” grant sponsored by Rep. Nydia Velazquez that paid for the building.  

There’s a pattern here: In a city and state dominated by the left, lawmakers are using taxpayer money to boost the nonprofit radical advocacy-industrial complex, which in turn helps orchestrate their re-election. 

The CFB pretends not to see, and lavishly doles out tax dollars to fund the rigged system.

CFB also puts a thumb on the scale through its own aggressive voter “education and engagement” operation — frequently collaborating with leftist groups like the Legal Defense Fund. 

The goal isn’t maximum turnout, but to turn out specific groups, including former felons, new immigrants and the youth vote. 

That is, likely Democratic voters.

CFB even provides provide food, paid transportation and paid childcare — all courtesy of the taxpayers — to engage those targeted audiences.

Sounds almost illegal.

It’s past time to eliminate the CFB, let taxpayers off the hook — and ask whether Mamdani actually won the Democratic primary in a fair fight. 

Betsy McCaughey is a former lieutenant governor of New York and co-founder of the Committee to Save Our City.

https://nypost.com/2025/07/02/opinion/how-lefty-nonprofits-and-taxpayer-money-lifted-mamdanis-campaign/

Dip Buyers Set to Pounce as Tariff Deadline Nears, Markets Pulse Survey Shows

 


Even if the run-up to this month’s deadline for US trade deals weighs on stocks, bargain hunters will step in to stem losses, the latest Markets Pulse survey showed.

Nearly two-thirds of 168 respondents said buying the dip will prove profitable beyond the July 9 deadline for higher tariffs to resume. That’s because President Donald Trump is seen as likely to postpone the levies again, according to just over half of survey participants.

https://www.bloomberg.com/news/articles/2025-07-02/dip-buyers-set-to-pounce-as-tariff-deadline-nears-markets-pulse