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Thursday, August 20, 2020

Centogene and Evotec expand collaboration into Gaucher disease

Centogene (NASDAQ:CNTG) and Evotec (OTCPK:EVOTF) have expanded their existing drug discovery partnership related to Gaucher disease – a genetic lysosomal storage disorder caused by mutations in the glucocerebrosidase gene. The parties intend to develop a treatment for Gaucher patients.

The partnership brings together Evotec’s induced pluripotent stem cell (“iPSC”) platform and drug discovery capabilities with Centogene’s global proprietary rare disease platform.

The collaboration builds on the partnership Evotec and Centogene entered in 2018 with the goal to discover and develop novel small molecules in rare hereditary metabolic diseases.


Cigna affirms 2020 outlook ahead of investor meetings

Ahead of planned meetings with analysts and investors, Cigna (NYSE:CI) affirms its 2020 revenue guidance of $154B-156B and non-GAAP EPS of $18.00-18.60.

2021 non-GAAP EPS outlook is $20.00-21.00.

It reported 2020 guidance with Q2 results on July 30 that included a 14% rise in revenue and a 35% jump in non-GAAP EPS.


Co-Diagnostics nabs U.S. patent covering COVID-19 test

August 20, 2020

The USPTO has issued a new patent to Co-Diagnostics (NASDAQ:CODX) covering its CoPrimer technology used in its COVID-19 test and other molecular assays. The patent, which builds on an earlier patent awarded in October 2018 covering certain applications of the CoPrimer molecule, applies to the physical structure of the molecule.

CytoDyn on go with UK late-stage study of leronlimab for COVID-19

August 20, 2020

The UK’s Medicines and Healthcare products Regulatory Agency has signed off on a Phase 3 clinical trial evaluating CytoDyn’s (OTCQB:CYDY) leronlimab in severely ill and critically ill COVID-19 patients.
Yesterday, it requested Fast Track approval of the drug based on the results from a mid-stage study.

CureVac to supply 225M COVID-19 vaccine doses to EU

The European Commission concludes exploratory talks with CureVac (NASDAQ:CVAC) for a contractual framework to purchase as many as 225M COVID-19 vaccine doses, once proved to be safe and effective.

The Company made a successful U.S. debut on August 14, jumping out of the gate in its IPO at $44.


Wednesday, August 19, 2020

NYC’s plan to ax first responders

“People will die” if City Hall follows through with a plan to lay off nearly 400 EMTs and paramedics, the head of the union representing those workers told The Post.

Oren Barzilay, head of EMS Local 2507, said FDNY brass told him that 10 percent of the city’s 3,700 EMTs and paramedics will be cut under Mayor Bill de Blasio’s plan to slash 22,000 municipal workers.

“The response times will go through the roof. That would put people at risk. People will die,” Barzilay warned.

De Blasio has said the reductions will come in October if the city doesn’t get state or federal aid to fill a major budget deficit caused by the coronavirus. Earlier this month he ordered agencies to come up with lists of cuts, according to Politico.

The number of EMTs and paramedics has already dropped from 4,100 before the pandemic. Four of his members died from the virus and three others committed suicide, Barzilay said. They were on the frontline of the crisis, rushing patients to hospitals around the five boroughs.

“People will die” if City Hall follows through with a plan to lay off nearly 400 EMTs and paramedics, the head of the union representing those workers told The Post.

Oren Barzilay, head of EMS Local 2507, said FDNY brass told him that 10 percent of the city’s 3,700 EMTs and paramedics will be cut under Mayor Bill de Blasio’s plan to slash 22,000 municipal workers.

“The response times will go through the roof. That would put people at risk. People will die,” Barzilay warned.

De Blasio has said the reductions will come in October if the city doesn’t get state or federal aid to fill a major budget deficit caused by the coronavirus. Earlier this month he ordered agencies to come up with lists of cuts, according to Politico.

The number of EMTs and paramedics has already dropped from 4,100 before the pandemic. Four of his members died from the virus and three others committed suicide, Barzilay said. They were on the frontline of the crisis, rushing patients to hospitals around the five boroughs.

During the pandemic, his members responded to 7,000 emergency 911 calls, nearly double the normal amount.

“We were the only ones going into homes to save lives. That’s what we did. This is the thanks the men and women from EMS are now getting,” Barzilay fumed.

“COVID is not over. What happens if there is a surge?” he asked.

Reps for FDNY and City Hall did not immediately respond to requests for comment. Another union source said the cuts are nearly inconceivable.

“I don’t know where they would trim EMS, we are understaffed,” said Anthony Almojera, vice president of EMS Local 3621.

“The city has asked for a list of where they can cut by the end of August. This is expected to be acted upon by the end of September. There’s been some tough conversations about EMS workers and uniformed firefighters … demotions,” an FDNY source said.

A high-ranking FDNY insider confirmed “hundreds of EMTs” will be laid off as part of cuts.

City Hall Bill Neidhardt said no pink slips have been sent and the cuts are not final.

“To be clear: City Hall does not want these layoffs to happen, but this is the hole we are in without a stimulus or borrowing authority.

“Our EMTs and firefighters save lives every day and we are working with their unions to find personnel savings to avoid layoffs, but unfortunately all agencies will face layoffs. Without a stimulus or borrowing authority, EMTs and firefighters will have to find personnel savings,” the spokesman said.


Fauci: Here’s How Schools Can Safely Reopen

While the nation’s goal should be getting children back to school, there’s a “big ‘however’ there,” NIAID Director Anthony Fauci, MD, told Rhode Island Gov. Gina Raimondo (D) during a Facebook Live event Thursday.

“The ‘however’ is that the primary consideration should always be the safety, health, and welfare of the children and teachers, and the families of both of those groups,” Fauci said.

Fauci pointed to the country’s heterogeneity as the reason for confusion about school reopenings and noted that public health officials have designated zones as either red, yellow, or green to aid determinations about allowing students back into classrooms.

Green zones, like many in Rhode Island, have a test positivity rate lower than 5% and fewer than 10 cases per 100,000 residents, and “should be able to open up safe and clear,” as long as they have good surveillance and contact tracing and isolation in place, Fauci said.

Yellow zones have a 5% to 10% test positivity rate and 10 to 100 cases per 100,000, while red zones are above a 10% test positivity rate with more than 100 cases per 100,000.

“The best way for a state, city, or county that’s red to get their children back to school is to do what’s needed to become yellow, and do what’s needed to become green,” Fauci said.

“If you are a red state and you want to get your schools open, you can ask yourself the question — you have a choice. You can either close the bars or close the schools,” Fauci said. “If you want to have people congregating in bars, it’s likely you’re going to stay red. If you do something about that, it’s very likely you’ll transition to yellow or green.”


While the nation’s goal should be getting children back to school, there’s a “big ‘however’ there,” NIAID Director Anthony Fauci, MD, told Rhode Island Gov. Gina Raimondo (D) during a Facebook Live event Thursday.

“The ‘however’ is that the primary consideration should always be the safety, health, and welfare of the children and teachers, and the families of both of those groups,” Fauci said.

Fauci pointed to the country’s heterogeneity as the reason for confusion about school reopenings and noted that public health officials have designated zones as either red, yellow, or green to aid determinations about allowing students back into classrooms.

Green zones, like many in Rhode Island, have a test positivity rate lower than 5% and fewer than 10 cases per 100,000 residents, and “should be able to open up safe and clear,” as long as they have good surveillance and contact tracing and isolation in place, Fauci said.

Yellow zones have a 5% to 10% test positivity rate and 10 to 100 cases per 100,000, while red zones are above a 10% test positivity rate with more than 100 cases per 100,000.

“The best way for a state, city, or county that’s red to get their children back to school is to do what’s needed to become yellow, and do what’s needed to become green,” Fauci said.

“If you are a red state and you want to get your schools open, you can ask yourself the question — you have a choice. You can either close the bars or close the schools,” Fauci said. “If you want to have people congregating in bars, it’s likely you’re going to stay red. If you do something about that, it’s very likely you’ll transition to yellow or green.”

Of course, Fauci warned, even in green areas, “there will always be cases. But how you prevent those blips of cases from becoming something that obviates the whole program, that’s what you’re preparing for.”

“I think people need to appreciate that nothing is 100%; it’s how you respond to the outlier that counts,” Fauci said.

Raimondo noted that even in the green state of Rhode Island, teachers and families are nervous about getting back into the classroom. To ease that anxiety, Fauci said that communities need to be “doing everything we can to keep the community green.”

“Your responsibility doesn’t end at the schoolroom door, it’s throughout your entire existence,” Fauci said. “To say, ‘I want my child to be safe in school,’ or, ‘I want to be the teacher who feels safe in school,’ then when you go home you go inside and have a party with 30 of your best friends with no mask, that doesn’t make sense.” https://tpc.googlesyndication.com/safeframe/1-0-37/html/container.html

Raimondo said Rhode Island is on track to reopen schools on Sept. 14, but some areas are not “green” and if they remain so they will be advised to begin with hybrid learning until they transition to green. In those cases, younger children will be able to start with in-person instruction but older children will have virtual classes. “We learned that high schools did better with distance learning while younger kids really struggled,” she said.

She also plans to use the next month to shore up testing and said schools won’t open until test turnaround time can be in the range of 48 to 72 hours.

When schools reopen, Fauci recommended a number of steps to keep infections down, such as being outdoors as much as possible, using masks, enforcing social distancing as much as possible, avoiding crowds, and keeping windows open if weather permits.

Fauci ended the discussion by doubling down on his optimism about the availability of a vaccine.

“We’ve done this for 6 months now thinking, my God, is this is never going to end? It will end for sure, and it will end with a combination of maintaining the public health principles that the governor and I have been speaking about, together with my cautious optimism about a vaccine by the end of the year, beginning of next year,” he said. “We’ll get out of this, we’ll get out of it together. The more effort you put into keeping yourselves as green as you possibly can, the better it is.”

“We’re gonna be a year from now, probably, celebrating how we got through this together,” he said.