Search This Blog

Monday, February 20, 2023

Explosion rocks Ohio factory, scattering molten metal -local media

 

An explosion tore through an Ohio metals plant on Monday, scattering molten metal and debris that rained down on neighboring buildings and sparking a fire that sent smoke billowing into the sky, witnesses told local media.

Video from the scene showed multiple first responders on the site including fire fighters who were spraying flames with water on the damaged factory about 15 miles (24 km) southeast of Cleveland.

The explosion occurred at the I. Schumann & Co. metals plant in Bedford Heights, causing a fire that triggered a call for fire departments across the greater Cleveland and Akron areas to respond, WKYC television news reported, citing witnesses.

WOIO television reported that at least one injured person was transported by helicopter from the scene.

Representatives of the company could not immediately be reached for comment. The business has produced copper alloys since 1917 and also produces brass and bronze alloys, according to its website.

Matthew Wiggins, owner of the neighboring business Rose Colored Gaming, told WOIO he heard a large explosion.

"Within a second or two, it sounded like large amounts of debris were hitting the roof. Things were falling off the walls, falling off shelves. We went out front and there was like smoldering rocks and molten metal in the yard. Tons and tons of smoke. Fire billowing out of the building across the street," Wiggins said.

Another witness, Joe Sarconi, said he was eating lunch in his car across the street when he heard at least two explosions that obliterated a brick wall enclosing the property.

"Flame shot and I just covered. A beam flew across the street. That other beam flew across the street and blew out our window," Sarconi said. "Exciting, but horrible."

Fire departments in the area referred queries to the Bedford Heights Fire Department, where officials could not be reached for comment.

Earlier this month a train loaded with toxic chemicals derailed in East Palestine, Ohio, that caused a fire and sent a cloud of smoke over the town. The derailment forced thousands of residents to evacuate while railroad crews drained and burned off chemicals.

https://www.marketscreener.com/news/latest/Explosion-rocks-Ohio-factory-scattering-molten-metal-local-media--43036251/

18 Inch Pipe Bomb Discovered Near Conrail Tracks In Northeast Philadelphia

 An 18 inch pipe bomb was discovered behind a church in the Holmesburg section of northeast Philadelphia.

The bomb was found on Sunday afternoon behind St. Dominic’s Catholic Church, on the 8500 block of Frankford Avenue, according to reports by Fox 29. 

One Twitter account of the location of the bomb pinned it to train tracks behind the church. The bomb was "near [the] Conrail railroad tracks in Philadelphia’s Holmesburg section".🚨#BREAKING: Police have discovered a 18-inch pipe bomb on Train Tracks

East Palestine Launched A Digital ID Program Days Before Disaster

 Submitted by 'BlueApples',

As Klaus Schwab recently opined, the future of global hegemony will be dependent on the mastery of avant garde technologies which were once relegated to the realm of science fiction. With that power in mind, technologies advancing artificial intelligence, synthetic biology, and other pillars of the World Economic Forum's so-called fourth industrial revolution have begun to permeate into our everyday lives. Perhaps no greater example of the imperative of the technocratic elite to harness these technologies is the digital ID. The premise of an over arching digital identity as a mechanism for vast government surveillance was one of the cornerstones of the authoritarian response to the COVID-19 pandemic. Apparently, that crisis wasn't the only instance of an opportunity to beta test the tools of dystopian oppression.

The town of East Palestine, Ohio shows how deeply embedded this agenda is in the plans of the elite. Before the town entered into the public discourse by becoming the scene of one of the worst environmental disasters in US history, the biggest piece of news to come out of it appears to be another iteration of the ongoing initiative to implement digital surveillance tools into public infrastructure. In late January, East Palestine officially launched its MyID program in order to equip residents of the town and neighboring Unity Township with digital IDs. The premise was purportedly to equip emergency responders with digital health profiles of those who they would be treating. East Palestine's digital ID initiative was first announced in October 2022.

China’s newest weapon to nab Western technology – its courts

 The growing conflict between China and the U.S. extends from computer-chip factories to a suspected spy balloon over American skies. Running through it all is a struggle for technological superiority.

China has striven for years to develop cutting-edge technologies, in part through heavy spending on research. Now, according to Western officials and executives, it also has mobilized its legal system to pry technology from other nations.

Officials in the U.S. and European Union accuse China of using its courts and patent panels to undermine foreign intellectual-property rights and help Chinese businesses. They say China is focusing such efforts on industries it deems important, including technology, pharmaceuticals and rare-earth minerals.

A U.S. manufacturer of X-ray equipment had a decade-old patent invalidated by a Chinese legal panel. A Spanish mobile-antenna designer lost a similar fight in a Shanghai court. Another Chinese court ruled that a Japanese conglomerate broke antitrust law by refusing to license its technology to a Chinese rival.

At China’s Communist Party congress in October, when Xi Jinping secured a third term as party leader, he praised the country for becoming a global innovator and pledged to help it prosper further. "We will increase investment in science and technology through diverse channels and strengthen legal protection of intellectual property rights, in order to establish a foundational system for all-around innovation," he told Chinese lawmakers.

The battle over China’s acquisition of technology has raged for years. Counterfeit products and logo look-alikes are pervasive in China. Recently, Beijing has tried to crack down on domestic companies violating the intellectual-property rights of some foreign firms. In July, luxury shoemaker Manolo Blahnik said it won a long-running trademark dispute against a Chinese businessman accused of improperly selling shoes under a similar name.

Officials in the U.S. and EU and executives at some Western companies, however, say Beijing is going the opposite route in some industries. China’s State Administration for Market Regulation, the government body that oversees all intellectual-property matters, and the Chinese embassy in Washington didn’t respond to requests for comment.

placeholder

The conflict is central to the growing competition between the U.S. and China for technological and economic superiority. The U.S. has slapped restrictions on chip-related exports to China. Beijing has accused the U.S. of politicizing science and technology to try to protect American leadership in those fields.

In December, the EU sued China in the World Trade Organization on behalf of Swedish telecom-equipment maker Ericsson AB and other companies, complaining that China has barred EU companies from suing to protect their patents in courts outside China. The EU called China’s policy "extremely damaging," saying Chinese companies requested the intervention "to pressure patent right holders to grant them cheaper access to European technology."

Canada, Japan and the U.S. had asked to join an initial version of the European complaint, which the EU said could now take about 18 months to adjudicate.

TickerSecurityLastChangeChange %
ERICTELEFONAKTIEBOLAGET LM ERICSSON5.76-0.03-0.52%

China’s Ministry of Commerce said it regretted the EU’s decision, would comply with WTO dispute-settlement procedures and would "resolutely safeguard its legitimate rights and interests."

In a 2021 EU survey about global intellectual-property protection, responding companies and people expressed concerns about "a tendency of court rulings to favor Chinese stakeholders when strategic sectors or companies, in particular state-owned enterprises, are concerned," according to the survey. Respondents called patent invalidation a serious problem in China.

Beijing’s stance on intellectual property has global implications because so many products are made in China.

placeholder

"Intellectual property is a core factor for competitiveness on the international stage, as well a focal point of international dispute," Mr. Xi said in a November 2020 speech to a committee of leading Communist Party members, according to an excerpt in a party publication. "We need to have the courage and the capacity to stand up for ourselves in this regard." After Mr. Xi’s address, leading party members concluded China must "shift from being a major absorber to a major producer of IP and establish itself as a global IP leader," the publication said.

Fractus SA, the Spanish antenna designer, and Vectis IP Ltd., its British technology-licensing partner, were among at least eight companies that had patents overturned in China at the same time in late 2020. A Shanghai court refused to stop what Fractus and Vectis alleged was infringement of their wireless antenna patents by a Chinese company. The two companies, which are litigating several patents with Chinese rivals, are appealing the ruling.

"It is puzzling that so many cases went wrong at the same time," said Vectis Chief Executive Giustino de Sanctis. He said the experience prompted his company to moderate its once-strong expectations for the Chinese market. "We will be more cautious," he said.

Patent holders worldwide are routinely obliged to license technologies that are crucial to an industrial standard, such as 5G telecommunications. In other cases, they are free to select the licensees.

A court in Ningbo, near Shanghai, ruled in 2021 that an affiliate of Japan’s Hitachi Ltd. had violated antitrust law by refusing to license its patented rare-earth magnet technology to a Chinese company. The ruling is "far removed from international practice in relation to the exercise of patent rights and the application of antitrust law," Hitachi Metals said in a written statement. It is appealing to China’s Supreme People’s Court.

Mallentech Electronics Inc., an automotive-sensor maker with 35 employees in Troy, Mich., has accused two Chinese companies of improperly taking trade secrets and Mallentech-designed machinery, and of applying for seven patents using Mallentech’s intellectual property. In 2021, a municipal court in Chengdu said that Mallentech’s evidence was inadmissible because of how it was collected.

placeholder

Mallentech is appealing the decision, arguing that the court erred in dismissing the case.

"The Chinese legal system is biased against foreign companies," said Mallentech President Steve Chen, a Chinese-born naturalized American.

American Science & Engineering is the X-ray equipment maker whose patent was invalidated by China in 2018. The Billerica, Mass.-based company had pioneered X-ray telescopes that helped NASA discover new stars, then shifted its focus after realizing its technology could detect dangerous or illegal items at security checkpoints.

AS&E devised a product to complement the machines it made for airports and seaports. It placed a low-powered X-ray machine on the back of a Ford Motor Co. chassis. The U.S. military used the mobile scanner to detect improvised explosive devices during the wars in Afghanistan and Iraq, the company said. Domestic law enforcement could disguise the vehicle as a delivery van and use it to scan cars in, say, a stadium parking lot.

The X-ray van, called the ZBV, made its debut in 2003. Michael Tropeano, general manager of AS&E’s cargo-scanning division, said he thought the product would be a winner from day one.

Rivals were impressed. "AS&E was far and away the world leader" in its segment, said Stephen Phipson, president from 2004 to 2011 of the detection unit of British rival Smiths Group PLC. Los Angeles-based OSI Systems Inc., which makes Rapiscan airport-security machines, acquired AS&E in 2016 for $269 million.

TickerSecurityLastChangeChange %
OSISOSI SYSTEMS INC.96.01+1.43+1.51%

In 2017, Mr. Tropeano heard from a colleague about a pitch in Argentina by a Chinese rival, Nuctech Co., that appeared to be promoting a ZBV copycat.

placeholder

AS&E didn’t have patent protection in Argentina, but it did in China. An AS&E lawyer sent Nuctech a letter. "Recently we’ve noticed that Nuctech may be offering similar products for sale," it said. AS&E took protection of its intellectual property seriously, the letter said, and suggested that the two companies discuss a licensing agreement.

A few days later, a Nuctech executive responded by saying the company owned all relevant intellectual-property rights. That same day, a Chinese trade group asked China’s Patent Reexamination Board, a legal body, to consider invalidating AS&E’s rights to its scanning van.

In 2018, the board did just that, concluding that AS&E’s patent wasn’t original enough. "Once that happened, I was like, ‘Holy cannoli. Here they come into the market,’" Mr. Tropeano said.

Nuctech played no role in invalidating AS&E’s patent, said Robert Bos, a Nuctech deputy general manager. The company, once led by the son of former Chinese leader Hu Jintao and now controlled by a Chinese state-run nuclear-plant operator, said it developed its own X-ray van and began selling it in 2000.

AS&E’s scanning van was one of the company’s most profitable products, generating sales of more than $1 billion since its introduction. Company executives figured that appealing the Chinese court’s decision likely would be futile, but was worth doing anyway. But first they needed to try to fend off Nuctech in countries where AS&E didn’t have patent protection, including much of Latin America and Eastern Europe.

The company slashed the price of the ZBV, which had sold for about $1 million each. In a reverse auction in Brazil for about a dozen machines, Mr. Tropeano said, he decided to do whatever it took to win because he wanted to prevent Nuctech from breaking into the market.

placeholder

AS&E couldn’t match Nuctech’s pricing offer. "These guys are going to go to a dollar," Mr. Tropeano recalled thinking. AS&E eventually won after local authorities disqualified Nuctech because of errors in the bid procedure, AS&E said.

AS&E boosted research and development to try to stay ahead of Nuctech’s models. Mr. Tropeano said pulling away from Nuctech was hard. "They’re catching up," he said. "It becomes about incremental improvements."

At the time, the Trump administration was trying to ban the use of equipment from Huawei Technologies Co., the Chinese cellular-hardware maker, in the U.S. and allied countries over spying fears.

Jenna Dunay, vice president for international government affairs at AS&E’s parent company, OSI, reached out to U.S. officials in agencies including the International Trade Administration’s Advocacy Center, which helps American companies win foreign-government procurements.

She said she told U.S. officials that Nuctech was an even bigger threat than Huawei, on both commercial and national-security grounds, because it, unlike Huawei, is directly owned by Chinese state entities. She said Nuctech could potentially send data to Chinese authorities, or obscure or alter images or videos. In the worst-case scenario, she said, Nuctech could allow hidden soldiers or weapons through checkpoints.

A Nuctech spokeswoman said AS&E’s argument was "appalling speculation." She said Nuctech was a politically neutral company focused on providing safe, innovative and reliable security systems.

In May 2020, the State Department sent its diplomats a memo outlining a campaign to lobby allies to ban Nuctech from their countries. In December of that year, the Commerce Department’s Bureau of Industry and Security added Nuctech to a list that makes it hard for the Chinese company to buy U.S. components without Washington’s authorization.

In 2021, AS&E exhausted the appeals process in China, which upheld the original ruling. Last August, the company was notified of a new legal proceeding.

A Chinese patent panel opened a new case against AS&E after receiving another petition. The panel will decide whether to invalidate an AS&E patent for the technology behind a stationary vehicle scanner.

https://www.foxbusiness.com/technology/chinas-newest-weapon-nab-western-technology-courts

Unexpectedly high variation in T-cell receptor genes between persons

 T-cells that are part of our immune system are central in the protection against infections and cancer. With the help of TCRs, the cells recognize foreign invaders and tumor cells.

"It was previously unknown how variable human TCR genes are," says Gunilla Karlsson Hedestam, professor at the department of microbiology, tumor and cell biology at Karolinska Institutet and the study's lead author.

Using deep sequencing of blood samples, the researchers examined TCR genes in 45 people originating from sub-Saharan Africa, East Asia, South Asia and Europe. The researchers showed that these genes vary greatly between different persons and population groups. The results were confirmed by analyses of several thousand additional cases from the 1000 Genomes project.

"We found that every individual, other than identical twins, has a unique set of TCR gene variants. These differences reveal possible mechanisms underlying the wide range of responses to infections and vaccines that we observe at the population level," says Martin Corcoran, the first author of the study.

"We discovered 175 new gene variants, which doubles the number of known TCR gene variants. An unexpected and surprising finding is that certain gene variants originate from Neanderthals and one of these is present in up to 20% of modern humans in Europe and Asia."

Gunilla Karlsson Hedestam explains that the variation in these genes cannot be detected with the standard methods used in whole genome sequencing, but with the development of specialized deep sequencing methods and analysis software that allow highly precise definition of B- and T-cell receptor genes, this is now possible.

"As these genes are among the most variable in our genome, the results also provide new information about how our immune system has developed over the course of history, says Martin Corcoran. We are particularly interested in uncovering the function of the TCR variants we have inherited from Neanderthal ancestors. The frequency of these variants in modern humans suggests an advantageous function in our biology and we are keen to understand this," adds Martin Corcoran.

The findings and the new TCR gene database the researchers now publish can be of great importance in the development of new therapeutic approaches in the future.

"Understanding human genetics is fundamental for the development of targeted treatments. The methods described in the study provide new opportunities, not the least in the cancer field where T-cells are central to several promising forms of immunotherapy," says Gunilla Karlsson Hedestam.

The results can also shed light on other areas of research.

"The findings can lead to the development of new diagnostics and therapies in a range of medical disciplines, including precision medicine," says Gunilla Karlsson Hedestam.

What is the next step in your research?

"We are now investigating the functional significance of several of the newly discovered gene variants and how this variation impacts our T-cell responses. We are also planning extended studies involving large groups of individuals to examine the role of TCR gene variation in diseases we know involve T cells, such as infectious diseases, cancer, and autoimmune disorders," says Gunilla Karlsson Hedestam.

Main funding for the study comes from an ERC Advanced Grant and the Swedish Research Council.

Journal Reference:

  1. Martin Corcoran, Mark Chernyshev, Marco Mandolesi, Sanjana Narang, Mateusz Kaduk, Kewei Ye, Christopher Sundling, Anna Färnert, Taras Kreslavsky, Carolina Bernhardsson, Maximilian Larena, Mattias Jakobsson, Gunilla B. Karlsson Hedestam. Archaic humans have contributed to large-scale variation in modern human T cell receptor genesImmunity, 2023 DOI: 10.1016/j.immuni.2023.01.026

Correspondence shows troubling interactions between US officials and the alcohol industry

 There is growing evidence that the alcohol industry uses a variety of strategies to influence public policy in a way that is advantageous to its own corporate interests, rather than the interest of public health. Recent communication between employees of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and alcohol industry groups shows extensive interaction on policy-relevant scientific issues, according to a new study in the Journal of Studies on Alcohol and Drugs.

Researchers at the University of York in the United Kingdom conducted a thematic content analysis on 4,784 pages of email correspondence obtained through Freedom of Information Act requests. The emails were sent between 43 NIAAA staff members and representatives of 15 alcohol industry groups—including producers and trade associations—between 2013 and 2020.

The analysis focused on 12 leaders at the NIAAA and various contacts in the alcohol industry: representatives of two alcohol producers (AB InBev and Diageo), two trade associations (the Beer Institute and the Distilled Spirits Council of the United States [DISCUS]), and the International Alliance for Responsible Drinking (IARD).

The researchers—Gemma Mitchell, Ph.D., and Jim McCambridge, Ph.D.—found that the NIAAA leaders provided the alcohol industry with extensive information about  and its policy implications. The NIAAA leaders communicated often with their industry contacts via email, telephone, and in-person meetings.

"Discussions were facilitated by the willingness of NIAAA leaders to meet with industry and have other informal contacts, as well as NIAAA leadership presence at industry-sponsored and other events," the authors write. "Key industry actors asked NIAAA leaders for help on science and policy issues. At times, NIAAA leaders heavily criticized public health research and researchers in correspondence with industry."

The authors also mention the problem of the "revolving door": Some NIAAA leaders subsequently went to work for industry. This is one way in which  are forged between NIAAA leadership and key industry groups, allowing for the free flow of privileged information and other questionable practices.

Mitchell and McCambridge point to the scope of their data over a long period as a strength of their research, and they also used publicly available data whenever possible to confirm any information contained in the emails. They say their findings add to other recent studies that identify the long-term effects of industry influence on alcohol science.

"Ongoing relationships between NIAAA leaders and the alcohol industry meant that industry representatives could access privileged information on a wide range of topics, from the US Dietary Guidelines to alcohol and cancer," says Mitchell. "Our findings are hugely concerning, and we hope the NIAAA and National Institutes of Health will regard this report not as presenting a  challenge to be managed, but as posing a set of major scientific challenges to which it must rise."

"The depth of the relationships between NIAAA senior leaders and key alcohol industry contacts uncovered here is disturbing," says McCambridge. "The study findings provide examples of alcohol public health science being opposed rather than championed by NIAAA leaders, at least in their direct communications with industry. There is an urgent need to understand better the nature of this problem. The implications are profound when one considers that NIAAA funds the majority of the world's alcohol science."

An accompanying editorial by Thomas Babor, Ph.D., M.P.H., editor of the Journal of Studies on Alcohol and Drugs, underlines the importance of monitoring how the  industry funds research projects and how it is involved in scientific activities.

"What is described in the Mitchell and McCambridge article, and related evaluations . . . provide strong evidence that  influence has penetrated the highest levels of the NIAAA in ways that threaten public health at both a national and global level," Babor writes.

More information: Mitchell, G., & McCambridge, J., Interactions between the U.S. National Institute on Alcohol Abuse and Alcoholism and the alcohol industry: Evidence from email correspondence 2013–2020, Journal of Studies on Alcohol and Drugs (2023). DOI: 10.15288/jsad.22-00184


https://medicalxpress.com/news/2023-02-correspondence-interactions-alcohol-industry.html

60-day bed rest study shows dangers of long-term inactivity for blood sugar levels

 A unique study which involved 20 men lying in bed for two months straight, highlights the negative impact long-term inactivity places on the body's metabolic health, with implications for future space missions as well as life back on Earth.

Put 20 young men in bed for two months with no  and what do you get? A new study from the University of Bath, published today, shows that long-term inactivity significantly increases  levels even if you reduce your  to avoid gaining weight.

The research, led by a team from the University's Centre for Nutrition, Exercise and Metabolism, was part of a European Space Agency (ESA) bed rest study. For 60 days, 20 young, fit and healthy male participants stayed in bed with their feet above their heads while international researchers assessed numerous health measures. Individuals remained in bed even while they ate, showered, and went to the toilet.

Research from the team from Bath focused on participants' metabolic heath: how well your body controls blood sugar. Previous work from the same team in 2018 demonstrated that exercise, even in short bursts, has a major impact on blood sugar in the short term. With this new study, they wanted to understand more about what happens when there is no physical activity or movement over weeks and months. Participants were fed a much-reduced diet to compensate for their much-reduced physical activity and to stop them gaining weight.

The results, published Feb. 16 in the journal Clinical Nutrition, show that even when food intake was reduced to match participants' much lower energy expenditure during bed rest, inactivity negatively and profoundly impacted their blood sugar levels.

Impacts on blood sugar

As a result of taking part in the bed rest study, average blood sugar levels among participants increased by around 6% in the day, and by 10% at night. Their ability to dispose of blood sugar—i.e., to take up blood sugar into muscles—also decreased by nearly a quarter (24%). Participants were struggling to control their blood sugar, which is an important risk factor in developing conditions such as cardiovascular disease or type II diabetes.

The research team explain that the reduction in calorie intake did prevent participants from experiencing even higher blood sugar levels. They speculate that had they eaten the same amount as normal, given the reduction in the ability to dispose of sugar, their blood sugar concentrations would have risen even higher during the bed rest.

The bed rest study was conducted by ESA to help understand the  of crewed future space missions for astronauts. However, the researchers say the implications are also relevant for life back here on Earth, where millions of people face periods of long-term inactivity due to poor lifestyles, chronic conditions, ill health, or injury.

Professor of Human Physiology Dylan Thompson at the University of Bath led the research. He explained, "This was a unique study in which 20 young fit and healthy men were subjected to a series of tests over the course of nearly two months during which time they stayed in bed with no physical activity. Such bed rest studies are used to examine deconditioning as a model for microgravity, and this was one of the longest.

"Our results reveal that the withdrawal of physical activity profoundly impacts physiological health over and above the impact of controlling diet. While the changes were not as large as would be expected had participants maintained the same  as before the study, because of their inactivity, there was a real increase in participants'  and a reduction in their ability to take up and use sugar. This shows that adjusting diet alone sadly cannot overcome all the negative effects from reducing physical activity—even if you manage to avoid gaining weight."

Dr. Angelique Van Ombergen, discipline lead for  at the ESA, added, "Our spaceflight analogs, of which bedrest is the golden standard, don't only allow us to do research that can directly benefit our astronauts, but they also allow us to apply this knowledge for people on Earth such as the elderly and the immobilized. This newly published study from Prof. Thompson and his team is a good example of that. ESA is currently planning two new bedrest studies where we will test a combination of countermeasures."

The team from Bath are working on countermeasures that could help people who are bedbound on Earth as well as people going into space. Recent work from the CNEM team showed that electrical stimulation of leg muscles can help to recreate some of the effects of exercise on the control of blood sugar, which could be developed in extreme cases where individuals have no mobility whatsoever.

Professor Thompson adds, "This study highlights the importance of physical activity for metabolic health. Without movement, long-term inactivity will increase the likelihood that people will develop chronic conditions, such as type II diabetes. Even in extreme cases where individuals have lost movement completely, we believe there are exciting technological options that could impact muscular contraction for blood sugar control which we are keen to explore and develop."

More information: William V. Trim et al, The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males, Clinical Nutrition (2023). DOI: 10.1016/j.clnu.2023.02.006


https://medicalxpress.com/news/2023-02-day-bed-rest-dangers-long-term.html