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Monday, June 3, 2024

Fentanyl Mixed With Potent Animal Sedative Can't Be Reversed with Naloxone

 by Matt McGregor via The Epoch Times (emphasis ours),

Public health authorities are warning of a new fentanyl drug concoction laced with a veterinary sedative more potent than previous cocktails.

According to a libertarian drug policy analyst, the emergence of this new drug continues an acrimonious relationship between illicit substances and law enforcement’s attempt to control them that began in the first chapter of the War on Drugs: Prohibition.

Both cities of Chicago and Philadelphia have issued health alerts warning of the drug medetomidine being mixed with fentanyl after an increase in overdoses.

According to the Chicago Department of Public Health (CDPH), medetomidine is more potent than xylazine, also a veterinary sedative that has made it into street narcotics labeled the “zombie drug.”

Multiple associated drug samples from the West Side of Chicago tested positive for elevated levels of medetomidine,” the CDPH said. “Medetomidine has not previously been detected in Chicago, although it has recently been detected in Philadelphia. In Chicago, medetomidine has been detected in combination with fentanyl, heroin, xylazine, alprazolam and nitazenes.”

Medetomidine is similar to Precedex in humans and can cause respiratory depression, the CDPH said, adding that its effects can’t be reversed by Naloxone, a medication that restores breathing after an overdose.

According to a May press release from The Center for Forensic Science Research & Education, among the effects of medetomidine are muscle relaxation, sedation, and hallucinations, which can lead to severe adverse reactions.

The Department of Public Health for the City of Philadelphia reported in its alert that the drug has appeared in Maryland, Ohio, Florida, and Canada.

It has been identified in drug samples in Philadelphia from April to May, the alert said.

‘Iron Law on Prohibition’

Dr. Josh Bloom, director of chemical and pharmaceutical science at the American Council on Science and Health (ACSH), wrote in a May 2024 article on medetomidine that “attempts to rein in illicit fentanyl or control the chemicals used to synthesize it resulted in even more dangerous drugs” that have prompted the appearance of drugs like xylazine and medetomidine. 

Another day another more dangerous street drug in an unwinnable war,” Dr. Bloom said.

Dr. Jeffrey Singer, a health policy analyst with the libertarian Cato Institute, told The Epoch Times that the emergence of this new drug is unfortunate, but not unexpected.

“This is what we call in the drug policy field the ‘Iron Law of Prohibition,’” Dr. Singer said, further explaining that this is a theory proposing that when law enforcement cracks down on illicit substances, their potency and danger only increases.

As an example, Dr. Singer points to the prohibition era from 1920 to 1933 when people turned to harder concentrations of alcoholic beverages when they could no longer legally obtain beer and wine.

Another more modern example, he said, is people bringing liquor into stadiums where beer and wine aren’t allowed because the smaller volumes are easier to smuggle.

“Prohibition incentivizes whatever is being prohibited,” Dr. Singer said.

When drug enforcement agencies cracked down on prescription opioids during the Obama administration, heroin then became cheaper and easier to obtain, he said.

Later, fentanyl was used because it increased the potency of heroin and made it easier to smuggle in smaller sizes, he said.

“What really set things off was the pandemic because the border closures and supply chain issues made it difficult to get opium,” he said.

It was also hard to get the supplies used to make opium into heroin, so the cartels began to deal only in fentanyl, which can be synthesized and reproduced in a lab, he said.

“There wasn’t a problem getting the supplies for this because you can make it in a lab and you don’t have to grow anything,” he said. “When the pandemic was over, the cartels just stuck with fentanyl because it’s easier.”

Never Enough

But it’s never enough, he said, so the cartels started adding xylazine to increase the potency of fentanyl, and now the more potent medetomidine.

“After that, there will be something else,” he said. “There’s always something else.”

There’s already a new class of synthetic opioids, he said, called nitazenes, which is considered 40 times more potent than fentanyl.

“It’s a game of cat and mouse, and it’s going to go on and on until lawmakers realize they can’t win the War on Drugs,” he said.

Federally Legalized; State Regulated

According to Dr. Singer, prohibited drugs should be federally legalized like alcohol, with it left up to the states to decide if they want to criminalize them.

If drugs are legalized, age, public use, and driving while under the influence restrictions could be imposed.

Essentially, we should follow the model we used when we ended alcohol prohibition,” he said. “When I buy an alcohol product in the liquor store, I never worry that it might be tainted with some other drug, like fentanyl, or that it might be of greater percentage alcohol than it states on the label.”

He added that government obstacles should be removed from groups seeking to provide harm-reduction strategies to drug users.

“Harm reduction strategies will be needed whether or not prohibition is ended,” he said.

‘Transnational Organizations’

Dr. Singer added that he prefers to no longer call those trafficking drugs “cartels.”

Instead, he refers to them as “transnational organizations.”

“Our drug war has made them so powerful and so wealthy that though some of their leaders may be headquartered in some places like Mexico, these cartels have begun partnering with cartels in other countries,” he said.

Plan Colombia, the 1999 U.S. foreign aid initiative to combat Colombian drug cartels in Colombia, only moved the cocaine trade to Central America and Mexico, he said.

“In fact, cocaine has never been more abundant and cheap than it is now, so all they’ve done is move it from one place to the other, and it’s not stopping,” he said.

https://www.zerohedge.com/medical/fentanyl-mixed-potent-animal-sedative-all-rage

Novartis sues Maryland on role of contract pharmacies in drug discount program

Novartis has filed a lawsuit seeking to block a Maryland law that requires the company to ship its medicines to any pharmacy working with hospitals participating in a controversial U.S. government drug discount program.

The drugmaker maintained that the state law, which goes into effect on July 1, improperly forces pharmaceutical companies to supply so-called contract pharmacies as part of the discount program known as 340B, according to the lawsuit filed in federal court. Novartis argued the law is illegal because it is preempted by federal law and also violates the U.S. Constitution.

https://www.statnews.com/pharmalot/2024/05/30/maryland-novartis-340b-medicines-pharmacies-astrazeneca-arkansas-pharma/

Affimed promising lung cancer data

 Affimed N.V. (NASDAQ:AFMD) shares are trading higher on Monday. On Saturday, the company announced longer follow-up data from the EGFRwt cohort and initial clinical efficacy data from the EGFRmut cohort from the ongoing AFM24-102 study in non-small cell lung cancer (NSCLC).

As of the updated data cutoff on May 13, for the 17 EGFRwt patients previously reported, 15 patients were response-evaluable.

Four confirmed objective responses were seen: 1 complete response (CR) and three partial responses (PR).

In addition, eight patients achieved stable disease (SD), resulting in a disease control rate of 71%.

Median progression-free survival was 5.9 months, with a median follow-up of 7.4 months.

3 of 4 responses were ongoing for more than seven months.

All responders were resistant to checkpoint inhibitor treatment before the study, which supports the hypothesis that combining AFM24 with atezolizumab may provide an alternative strategy to overcome resistance to existing therapies.

As of May 21, 2024, 21 heavily pretreated EGFRmut patients had received the combination therapy, of which 13 were response-evaluable.

The combination of AFM24 with atezolizumab showed encouraging signals of clinical activity, including 1 CR, 3 PRs, and six patients with stable disease (SD).

As of the data cutoff, all responses were ongoing. The data suggests that the combination of AFM24 and atezolizumab could be acting synergistically to improve efficacy outcomes.

AFM24 and atezolizumab combination therapy demonstrated a manageable safety profile. The most frequent side effects observed were mild to moderate infusion-related reactions and transient mild to moderate increase in liver enzymes.

The study’s EGFRwt NSCLC cohort will enroll up to 40 patients, and the EGFRmut NSCLC cohort will enroll up to 25 patients.

Recruitment in both cohorts is ongoing, and further updates are expected in H2 2024.

https://finance.yahoo.com/news/why-german-biotech-affimed-stock-201308687.html

E-Trade May Ban 'Roaring Kitty' From Platform For Market Manipulation

 ETrade has had enough of the stock shenanigans of meme stock guru Keith Gill, also known as Roaring Kitty, who just happens to be a client of the online brokerage now owned by Morgan Stanley. Gill's non-stop promotion of GameStop on social media, coupled with giant trades, raised concerns about potential stock manipulation. This could force E*Trade to dump the retail trader, according to Wall Street Journal sources.

The scale of Gill's online influence, with millions of followers across various social media platforms, and his active promotion of the struggling video game retailer, has sparked concern among executives at the Morgan Stanley-owned trading platform. The firm is uncomfortable with Gill's presence on the trading platform, as it could attract unwanted attention, given his significant reach. 

That power created concerns he can pump up a stock for his own benefit. Their debate includes whether his actions amounted to manipulation and whether or not the firm is willing to risk drawing the attention of his meme army by removing him, according to people familiar with their internal discussions. -WSJ 

With the SEC unable to decide how to approach the bizarre pump (and dump), and whether to classify Gill's unique social media style as market manipulation, brokerages are now taking action into their own hands.

The sources confirmed what became public knowledge late on Sunday, namely that Gill bought a "large volume of GameStop options on E*Trade" before the first pump in May. 

Morgan Stanley employees, knowing that Gill is a customer, looked at his E*Trade account, according to people familiar with the matter. That sort of monitoring of clients is routine.

The employees saw he had purchased call options before the tweet, the people said. A call option gives a trader the right to buy the stock by a certain date at a stated price. At least some of those options expired that week, one of the people said. That meant Gill's trades likely generated profits thanks to the stock move his tweet generated.

Gill's trading continued, likely loading up with equity and short-term options ahead of Sunday's posting of his E*Trade account. He showed GME stock valued at $115.7 million, $65.7 million in GME short-term options, and $29 million in cash.

The post alone on Reddit triggered a stock frenzy in GME on Monday but quickly faded late into the session.

The people said the debate about Gill as a client at Morgan Stanley began three weeks ago, around the time of the first GME pump. They said no decision has been made yet. 

One of the biggest red flags around the first pump was GME's ability to slam the market with an offering of 45 million shares, allowing the company to raise $933 million, and sparking speculation that Gill was working alongside the company.

Meanwhile, sentiment around Gill is shifting: far from the "authentic" retail daytrading beacon that he became in early 2021 when his foray into the historic Gamestop short squeeze sparked the meme stock frenzy, his latest AUM which is clearly in the hundreds of millions "appearing more like manipulation without a solid thesis", has prompted speculation that far from working for himself, Gill may be in cahoots with one or more hedge funds...

... while established voices such as Clifford Asness slammed the "internet scammer" whose "coming back to pump and dump again is insane. It’s a cult. It’s an angry clueless cult (are there other kinds) angry about nonexistent scams and following ridiculous cult leaders."

But what may be the most damning twist in this latest episode of meme stonk mania is that the other OG of the daytrading movement, Dave Portnoy himself, asked if he is a big mark for Roaring Kitty.

Report finds China lab leak most likely source of COVID, blames US for pumping millions into research

A damning new report found that the COVID-19 virus most likely leaked from a Chinese lab — and that the US bears responsibility for pumping tens of millions of dollars into high-risk research on extremely infectious viruses at a facility with weak safety protocols.

The analysis by Alina Chan, a Harvard and MIT molecular biologist, was published as a guest essay in the New York Times, a publication which was for a long time skeptical and dismissive of the lab leak theory.

It comes as Dr. Anthony Fauci faces a grilling before a House panel on Monday over his backing for the research at the Wuhan Institute of Virology.

Chan — who has long advocated more study of the “lab leak theory” — said that until recently, “reflexive partisan politics have derailed the search for truth” in getting to the bottom of the pandemic’s origin.

Dr. Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases, answers questions Monday at a House hearing about the US’ response to the pandemic.Getty Images
If the theory is correct, the global pandemic — which claimed 1 million lives in the US and at lest 25 million around the world — is “the most costly accident in the history of science,” Chan, the co-author of “Viral: The Search for the Origin of Covid-19,” wrote.

Her findings paint an alarming picture of how the virus was sourced in China, supercharged for maximum infectiousness with US government support, and ultimately allowed to escape under inadequate containment conditions.

Where did COVID originate?

Scientists at the Wuhan Institute of Virology spent more than a decade looking for SARS-like viruses, led by Dr. Shi Zhengli, to learn more about how they infect humans.

Their research determined that SARS-CoV-2, the virus that caused the pandemic, was known to exist in bats located around 1,000 miles away from Wuhan.

Shi’s team made multiple trips to southwestern China and Laos to collect samples of the virus, during which samples traveled through “hundreds” of large cities on their way back to the Wuhan lab.

Dr. Alina Chan concluded in her in-depth analysis of COVID-19’s origin that the deadly virus “most likely” escaped from a research lab in Wuhan, China.Future Publishing via Getty Images

Despite the virus being highly contagious, even between species, no trace of infection was discovered anywhere along the 1,000-mile route, Chan wrote.

Her research also shot down a popular theory early in the pandemic that the virus was unleashed on the world via the Huanan Seafood Market in Wuhan — where exotic game was being sold for human consumption.

This theory, Chan says, “is not supported by strong evidence,” noting it’s likely the outbreak at the market likely occurred after the virus was already passing between humans.

The report debunks the theory involving the Huanan Seafood Wholesale Market, pictured here,AP

What does evidence say about if COVID occurred naturally?

Wuhan researchers collected samples from both infected humans and animals in an effort to learn more about the highly infectious nature of viruses like SARS-CoV-2.

Much of this work was done in partnership with EcoHealth Alliance, a US-based scientific organization researching infectious diseases, which the federal government has funded with more than $80 million since 2002, Chan wrote.

The Wuhan Institute of Virology, where the “risky” research was conducted with US funding.AFP via Getty Images

The Wuhan lab’s “risky” research involved “genetically reconstructed and recombined” virus samples collected across several different types of animals, resulting in never-before-seen infections that were repeatedly forced to mutate in order to survive in each new host species.

The researchers published an extensive database in 2019 containing more than 22,000 collected samples.

However, Chan notes, access to the data was “shut off” in the fall of that year, and was not shared with American research partners even after the pandemic began.

In 2021, a leaked grant proposal for a collaboration between EcoHealth, the Wuhan Institute, and US-based coronavirus researcher Ralph Baric to create new viruses “strikingly similar” to SARS-CoV-2 was published by The Intercept.

What does new evidence say about the theory COVID was released from a lab?

The idea that the virus which led to the pandemic originated from a lab in China is far from new.

But it’s only recently begun to be discussed in a serious way after years of mainstream media outlets like The New York Times, CNN, MSNBC and others downplaying it as nothing more than a “racist” conspiracy theory.

The Post was one publication sounding the alarm about the lab leak theory early on, as shown in our front page from February, 2023.

According to Chan, the Wuhan lab where the dangerous research was being conducted was woefully inadequate to contain an airborne virus as infectious as SARS-CoV-2.

US virologists dealing with highly infectious diseases like those in the SARS family would generally use Biosafety Level 3 containment, which requires protocols like respirators and proper exhaust systems to protect against airborne pathogens , to ensure the virus can’t infect lab researchers.

However, the Wuhan lab did its work under the lower Biosafety Level 2 conditions, which focus on merely protecting researchers against skin contact with viruses and bacteria, according to Chan, “could not prevent a highly infectious virus like SARS-CoV-2 from escaping.”

According to Chan, the lab was woefully inadequate to contain an airborne virus.AP

Scientists at the Wuhan lab reportedly became sick with COVID-like symptoms as early as the fall of 2019, according to information leaked to the Wall Street Journal and later confirmed by US government sources.

However, Chan wrote, the scientists denied that they were ever sick.

The first international report of a “mysterious viral pneumonia” in Wuhan did not emerge until Dec. 31, 2019.

US funded ‘unprecedented collection’ of virsuses

In Chan’s sharply worded conclusion, she urged investigators to subpoena exchanges between Wuhan scientists and international partners, especially during the key pre-pandemic period of 2018-2019.

She also singled out Fauci, saying he “should cooperate with the investigation to help identify and close the loopholes that allowed such dangerous work to occur.”

The US government itself wasn’t spared from her criticism for its role in the pandemic.

“Whether the pandemic started on a lab bench or in a market stall, it is undeniable that US federal funding helped to build an unprecedented collection of SARS-like viruses at the Wuhan institute, as well as contributing to research that enhanced them,” Chan wrote.

“The world must not continue to bear the intolerable risks of research with the potential to cause pandemics.”

https://nypost.com/2024/06/03/us-news/us-funded-covid-lab-leak-in-china-damning-report-finds/