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Saturday, November 2, 2024

Harris comes face-to-face with ‘herself’ in 'surprise' ‘SNL’ appearance

 Democratic nominee for president Kamala Harris made a surprise appearance on Saturday Night Live as part of a final media push before Tuesday’s presidential election.

Harris came face-to-face with her impersonator Maya Rudolph in the show’s cold open on a set made up to look like a backstage area at a rally.

The cold open included an impression of former President Donald Trump dressed in the orange garbage man vest that he wore this past week at a campaign event.

The open cuts to Maya Rudolph, Andy Samberg, and Jim Gaffigan as Harris, Second Gentleman Doug Emhoff and Harris’ running mate, Gov. Tim Walz, respectively.

Dana Carvey also made an appearance as President Joe Biden.

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Rudolph’s Harris clears the room saying she “needs a moment to herself.”

“I wish I could talk to someone in my shoes,” Rudolph said to herself in the empty room.

Then the real Kamala Harris appears in the dressing room mirror.

“You and me both sister!,” Harris said, grinning ear to ear after thirty seconds of applause from the live audience.

Harris went on to say, “I’m here to remind you, you’ve got this, because you can do something your opponent can’t do, you can open doors.”

When Rudolph let out a loud, familar Kamala cackle, the candidate said, “I don’t really laugh like that do I?”

The pair had fun with the veep’s name. Harris said she would end the “dramala” of politics with her election and the two said in unison, “Keep Kamala and Carry Onala.”

“I’m gonna vote for us,” Rudolph says.

“Any chance you’re registered in Pennsylvania?,” Harris quipped.

The veep also joined in on the quintessential “Live from New York, it’s Saturday Night!”

Vice President Harris had a busy schedule Saturday.

Harris was in Atlanta, GA, and Charlotte, NC, earlier in the day —- squeezing in some last minute campaigning in the Peach State in the final 60 hours before the election.

SNL has a history of inviting presidents and presidential candidates.

Former Vice President Al Gore, late Senator John McCain, and Donald Trump each hosted episodes of the historic show. Trump hosted the show in 2004 and in 2015 in the lead up to the presidential election.

Former presidents Gerald Ford and Barack Obama both appeared on the show during their terms in office. Obama in 2018 and Ford appearing in an episode of 50-year-old show’s second season in 1976.

The late President George H.W. Bush appeared on the show in 1994, following his term in office.

Hillary Clinton also appeared on an episode in 2015 in the month leading up to the election.

https://nypost.com/2024/11/02/entertainment/kamala-harris-makes-surprise-appearance-in-snl-final-pre-election-show/

Portents Of Chaos

 by Patrick Lawrence via Consortium News,

At this moment it is hard to locate the limit of what either of the two main political parties in the U.S. will do to avoid losing...

Uh-oh. The New York Times is picking up its familiar theme now that the Nov. 5 elections are but a few days out front: Those mal-intended foreigners are again “sowing discord and chaos in hopes of discrediting American democracy,” it reported in a piece published Tuesday

The Beelzebubs haunting this political season, when everything would otherwise be orderly and altogether copacetic among Americans, are Russia, China and Iran.

Why can’t this year’s version of the old, reliable “Axis of Evil” leave us alone with our “democratic process,” the one the rest of the world envies and resents? Troublemakers, with all their “sowing.” You could probably call them “garbage” and get away with it. 

Uh-oh. We’re already reading of tampered voter-registration forms and forged applications to vote by mail in two districts in Pennsylvania, the populous state where the results in 2020 could not have been blurrier and whose 19 Electoral College votes were decisive in getting Joe Biden into the White House last time around.

But not to worry. In a delightful reprise of one of the truly memorable phrases to come down to us from the 1960s, an election commissioner in one of the districts where officials uncovered the malfeasance tells us, “The system worked.” 

think I understand.  

I tell you, whenever I read of people in other countries sowing anything, whether it is doubt or chaos or disinformation, and at this point even pumpkin seeds, it always turns out the same. This word “sowing” has been a favorite in the mainstream press since 2016, when we read daily — and of this we were to have no doubt — the Rrrrrussians were “interfering in our elections.”  

Since then, everytime I read of someone sowing something it sows more doubt in my mind — more than I already harbored — that one can take our electoral system, as we have it in the 21st century, the slightest bit seriously.  

This is to say nothing of putting one’s name on it behind a little green curtain in a voting booth.

On the one hand you have the Times, which has diminished itself over the past eight years to little more than the Democrats’ house organ, already preparing to suggest that the malign enemies of American democracy corrupted the elections. Believe me, you will hear this if Kamala Harris loses but not if she wins.  

On the other hand, you have early but clear cases of attempted vote-rigging and local election officials waving these cases off as nothing at all to fret about. It is interesting to consider why said officials profess so cavalier a view.  

I have thought for months that the 2024 elections, discord already in plentiful supply, could easily tip over into a degree of civil chaos beyond anything so far recorded in the American story. Just such a day of reckoning now seems to beckon. 

Neither of the main parties appears prepared to lose. At this moment it is hard to locate the limit of what either party will do to avoid losing. 

Remnants of Democracy

All by our lonesome selves, it seems to me, we Americans have made a mess of the remnants of our democracy these past eight years.

This is not to suggest American politics has ever been other than, let’s say, in the way of a barnyard. In this, neither of the major parties, whose function since the mid–19th century has been to circumscribe acceptable politics and policy, is free of responsibility. 

But in the matter of responsibility I assign more to the Democrats than to the G.O.P. It was Hillary Clinton’s loss to Donald Trump eight Novembers ago that confirmed America’s swift drift into post-democracy.

The Democrats have never recovered from the disruption in 2016 of their dream that history was about to end and their idea of the liberal ethos would eternally prevail, all alternatives withering away the way Marx and Engels thought the communist state would.

Anti-Trump protest in Washington, D.C., Nov. 12, 2016. (Ted Eytan/Flickr, CC BY-SA 2.0)

I have long detected that American liberalism has at its core a vein of illiberalism that is essential to its character.

America is simply not, to put this point another way, a tolerant nation. It does not encourage its people to think: It requires them to conform. Alexis de Tocqueville saw this coming two centuries ago in the two volumes of Democracy in America

We are now, post–Clinton, treated to the spectacle of full-dress liberal authoritarianism, and if you do not like the term there are others. De Tocqueville, prescient man, called it “soft despotism.” I’ve always favored “apple-pie authoritarianism.”

Institutional Corruptions

There is a feature of this awful manifestation among NPR–addicted, kale-eating liberals that distinguishes our time as especially discouraging as to the future.

This is their wanton corruption of some of the institutions without which even a semblance of democratic government is impossible. I am thinking particularly of three that figure in the pre-election picture.

One is the judiciary — federal, state, county, local. Beginning with the Mueller investigation, the in-plain-sight corruption of the Federal Bureau of Investigation, the ridiculous court cases brought against Donald Trump, Attorney–General Merrick Garland’s subversion of the Justice Department to protect President Joe Biden as his son’s influence-mongering schemes came to light — all this in behalf of the Democrats:

Well, as I learned during my days as a correspondent abroad, when the judicial system goes down, the path to failed-state status opens.  

Two is the intelligence apparatus and the military. Intel, from the days of James Clapper and John Brennan, has lined up unequivocally behind the Democrats ever since the brash real-estate man from New York foolishly assumed he could “drain the swamp” — his declaration that he would take on the Deep State.

U.S. Secretary of Homeland Security John Kelly at the Munich Security Conference in Germany, Feb. 18, 2017. (U.S. Department of Homeland Security, Wikimedia Commons, Public domain)

As to the military, the generals thought nothing of declaring eight years ago, at the Democrats’ convention in Philadelphia and in open letters published in the Times, that they would refuse the commander-in-chief’s orders were Trump to win and attempt a new détente with Russia and an end to “the forever wars.” 

Yes, you’ve got John Kelly, who served in Trump’s cabinet and then as his chief of staff, suddenly calling Trump a fascist — the Democrats’ favorite epithet these past weeks. Doesn’t anyone want to know why Kelly worked closely with a man he considered a fascist? Doesn’t it occur to anyone — it must, surely — that Kelly, a retired Marine general, says these things to serve the party he trusts to keep the wars going and the tax dollars flowing?  

A paradox here, more apparent than real: John Kelly, H.R. McMaster, James Mattis, Mark Esper, and various others like them did not wear uniforms when they served in the Trump administration, but they never took them off. 

If this election is about anything — apart from the price of groceries, of course — it is about the national-security state’s place in American politics. In our post–2016 era, intel and the military are perfectly welcome to operate openly, unabashedly, in the American political process — this because the Democratic Party gives them a wide berth to do so. 

Deep-State Democracy

Now, do you think the Deep State gives a toot about democratic process? Ask the Italians and the Greeks, the Iranians and the Guatemalans, the Japanese, the South Koreans and the Indonesians, the Chileans and the Venezuelans, and… and damn, ask most of humanity at this point. As others have pointed out since the Russiagate days, what the spooks have long done abroad now visits itself upon the American polity. 

The obvious follow-on: Should we be concerned as to whether the Democrats and these institutional allies would let this election go to Trump just by the vote count? 

I am.

As to the third of the institutions that have corrupted themselves in the Democratic Party cause, may I let mainstream media speak for themselves? Apart from independent publications such as the one you are reading, the intent of American media is no longer to inform the public but to protect the institutions they purport to report upon from the public gaze.   

Trump’s “a threat to American democracy,” Harris its savior: It’s a bust at this point. The New York Times has made itself a re-enactment of The New York TimesThe Washington Post under the ownership of Jeff Bezos and this ghastly new chief executive of his, Will Lewis, cannot manage, and doesn’t seem to attempt, even a re-enactment. 

I do not seem to be the only one ill-at-ease at the prospect of mayhem to come after midnight Nov. 5. The Post published a survey Wednesday, conducted in the first half of October, indicating that among voters in the states where the election could go either way, 57 percent are nervous that Trump supporters won’t accept defeat and may resort to violence, while a third of those surveyed think Harris supporters will take it to the street, as they used to say, if the candidate of joy and vibes loses.

Harris campaigning in Glendale, Ariz., on Aug. 9. (Gage Skidmore, Flickr, CC BY-SA 2.0)

The numbers skewed even more dramatically when The Post asked Democrats about Trump’s people and Trump’s people about Democrats. In a survey The Associated Press published Thursday, you have 70 percent of those polled saying they are “anxious and frustrated.”

Join the party. I cannot, myself, take either candidate seriously. I take seriously the thought that a lot of people will not take the result seriously and a mess will ensue. 

And in this I worry more about Democrats resorting to corrupt conduct than I do the Republicans. Why this, you may ask.

To begin with, I do not at all like the smell of that Times piece quoted at the top of this column. It reeks too strongly of the scene in 2016, when, on either side of the election, the Democrats and all manner of repellent “progressives” conjured of thin air a frenzy of Russophobia from which American has yet to recover. 

Steven Lee Myers, previously of the Times’s Moscow bureau, is now some kind of “disinformation” reporter and led the work on the piece in question. And all is as it was for four years after Clinton’s defeat: no shred of independent reporting or sourcing in anything under his byline. Intel people and other unnamed officials feed this guy like a foie gras farmer feeds his geese. 

This is all you get from our Stevie. And I don’t see anyone trying on this disgraceful stuff in behalf of the Trump campaign. I have suggested my conclusions.

But Jan. 6, Jan. 6, Jan 6! First of all, what happened on Jan. 6 does not rise to “coup” or “insurrection.” It was a protest, with much to suggest the presence of agents provocateurs. And second, there seems to me there was plenty to protest by that point. 

Straight off the top, there was the liberal authoritarians’ perfectly legible collusion to suppress the contents of Hunter Biden’s vastly incriminating laptop computer three weeks before the vote, to the point of blanket censorship of the New York Post, the oldest newspaper in America. If this was not open-and-shut election interference someone will have to tell me what constitutes it.

On less certain ground, I have read of many election officials in many states, Pennsylvania high among them, certifying the 2020 results. But a truly convincing, here-are-the-numbers case for these results in states such as Pennsylvania is hard to come by. You never read of Trump’s claims that the Pennsylvania results were rigged. You read only and always of Trump’s “false claims” or “discredited claims” or “disproven claims” to the point you start thinking of Lady Macbeth and how she doth protest too much, methinks.   

Trump addressing The Believers religious group, in July in West Palm Beach, Fla. (Gage Skidmore, Flickr, CC BY-SA 2.0)

I recall, very imperfectly, seeing research purportedly done by a computer scientist at one of the universities in Philadelphia. Just after the election he or she put out a series of screenshots on social media, time-stamped to the second, that appeared to show the results in a significant number of districts changing all at once and by enough to give Biden a swift come-from-behind victory by a margin of slightly more than 1 percent.  

Genuine or a put-up job, this research? Credible or not credible? I would not dream of judging it, but this is not my point. My point is that there should be no cause to doubt such results as these and, eight years on, as I read it there still is. 

Doubt recreates itself, as you may have noticed, like some organism that regenerates. So we come to the Times’ report Tuesday of attempted voter fraud in Lancaster and York counties, two populous areas of, once again, Pennsylvania.

Campbell Roberston’s piece has just about everything, starting with a headline that has Trump “sowing doubt.” He, Trump, is even “using reports about suspicious voter registrations to cast the election as already flawed.” 

What a cad. What a scoundrel. What a… fascist tyrant. 

It seems that some thousands of forged or otherwise fraudulent voter registration forms and requests to vote by mail arrived recently in the offices of the Lancaster and York election authorities.

So far as one can make out, some official or officials in each county brought these “large batches” of falsified government documents to light. Whereupon other officials in each case smothered this discovery as if suffocating the matter with a pillow. 

Alice Yoder, an election commissioner in Lancaster, put it best, or anyway most preposterously.

“The system worked,” saith Ms. Yoder.

“We caught this.”

I honestly had to read this quotation several times to believe anyone would say this. 

I would like to know a few things about this case that we are not told. 

The batches of forgeries “were submitted by out-of-state canvassing groups,” Robertson reports, groups that remain unidentified.

One, what are canvassing groups and what do they do in whose behalf?

Two, what were such groups doing in Lancaster and York counties if they are not from Pennsylvania?

Three, if they are not from Pennsylvania, what were they doing with Pennsylvania election forms that were purportedly genuine?

Just two more questions.

Four, why are the election officials in these two counties not naming the guilty canvassing organizations? This seems to me very troubling. 

And five, what are the party affiliations or otherwise the voting preferences of officials who will not identify the offending organizations and say things such as “The system worked.”

There are no grounds to draw any conclusions whatsoever on this point, given we know absolutely nothing about these people, but I went to the trouble of looking up Ms. Yoder’s c.v. 

There is a bit of the sociologist in all of us, well– or underdeveloped as the case may be. Journalists often make use of their endowments in this line.

Drawing on mine, I would speculate that Ms. Yoder’s c.v., after a careful peruse, is highly suggestive of a Kamala Harris voter, perhaps even of a liberal authoritarian. 

Could be dead right, could be dead wrong. I cannot go beyond more or less idle speculation.

And not more or less idle doubt as Nov. 5 draws close.

https://www.zerohedge.com/political/portents-chaos

'Can a mammogram identify heart disease risk?'

 When people check in for their annual mammogram these days, some may face a surprising question: In addition to reviewing the mammogram for breast cancer, would the patient like the radiologist to examine the images for heart disease risk?

That's what happened recently when a woman visited Washington Radiology, a practice with more than a dozen locations in Washington, D.C., Maryland, and Virginia.

For $119, she was told, the practice would use artificial intelligence software to analyze her mammogram for calcification in the arteries of her breasts, which could indicate she's at risk for cardiovascular disease.

Washington Radiology is one of a number of practices nationwide offering this type of screening.

Although breast X-rays are typically used to detect and diagnose , the pictures also indicate whether the arteries in the breast have calcifications, which show up as parallel white lines on the film.

Calcifications, which are considered "incidental" findings unrelated to breast cancer, may be associated with someone's . They've been visible on images for decades, and some radiologists have routinely noted them in their reports. But the information hasn't typically been passed on to patients.

Now some practices make the results available to patients—sometimes for a fee.

Washington Radiology didn't respond to interview requests, but in a video on its website describing the practice's "Mammo+Heart" AI screening, Islamiat Ego-Osuala, a breast imaging radiologist there, said, "If the past few decades has taught us anything about the field of radiology, it is that the sky's the limit. The possibilities are endless."

Some imaging experts question that rosy assessment as it relates to screening for breast arterial calcification to gauge heart disease risk.

"What we're seeing on the mammogram is calcification in the breast artery, but that's not the same as the calcification in the ," said Greg Sorensen, chief science officer at RadNet, which has nearly 400 imaging centers in eight states. RadNet doesn't offer breast arterial calcification screening and has no plans to. "It doesn't feel like it's delivering value today," Sorensen said.

(RadNet does offer patients an AI analysis of their mammograms to improve breast cancer detection. KFF Health News reported on that earlier this year.)

Coronary artery calcification is recognized as a strong marker of heart disease risk. But while studies have shown an association between breast arterial calcification and the risk of cardiovascular disease, questions remain.

For one thing, even women who don't have breast arterial calcification might still be at risk of heart disease, heart attack, or stroke. In a study of postmenopausal women, 26% had breast arterial calcification, and over a 6½-year study period it was associated with a 23% increased risk of heart disease of any kind and a 51% increase in risk of heart attack or stroke. However, most  happened to women who did not have breast arterial calcification.

"I wouldn't feel comfortable telling people they have a higher or lower risk of heart disease based on their breast arterial calcification," said Sadiya Khan, a preventive cardiologist at Northwestern Medicine in Chicago who co-authored a  editorial commenting on the study. "I think this is an exciting area, but we need to move cautiously."

It's understandable that women's health clinicians would be eager to embrace the idea of using the annual breast cancer screening that millions of women get every year to screen for heart disease risk as well.

Heart disease is the No. 1 killer in the United States. It was responsible for more than 300,000—or roughly one in five—women's deaths in 2021.

Many women don't recognize their heart disease risk or the many factors that increase it, such as , diabetes, high cholesterol, smoking, drinking too much alcohol, and being overweight.

Online calculators can help people assess their risk of . For those whose 10-year risk is 7.5% or higher, clinicians may recommend  and/or prescribe a statin to lower blood cholesterol.

Laura Heacock, a radiologist who specializes in breast imaging at NYU Langone Health in New York City, pointed out that patients can already get much of the information resulting from breast arterial calcification scoring from their physicians and use of those risk calculators. The key is that breast arterial calcification screening provides another chance to talk about heart disease risk.

One study found that 57% of women who were informed that they had breast arterial calcification after a mammogram reported they had discussed their results with their primary care physician or a cardiologist.

Heacock said she'd like to see more studies showing that reporting breast arterial calcification leads to changes in patient care and fewer heart attacks and strokes.

Every woman who visits the Lynn Women's Health and Wellness Institute in Boca Raton, Florida, for a mammogram is screened for breast . It's been a standard service since 2020, said Heather Johnson, a preventive cardiologist at the center. If calcification is found, the woman is referred to a cardiologist or other health care practitioner at the center to discuss the findings and get more information about heart disease risk.

Johnson acknowledged that more studies are needed to understand the connection between calcification in breast arteries and heart disease. Still, she said, the screening "allows a communication pathway."

Patients at the Boca Raton institute aren't charged for the screening.

https://medicalxpress.com/news/2024-11-mammogram-heart-disease.html

Insulin resistance caused by sympathetic nervous system over-activation: study

 Rutgers Robert Wood Johnson Medical School and collaborating institutions have found that overnutrition leads to insulin resistance and metabolic disorders through increased activity of the sympathetic nervous system (SNS). The study shows that reducing SNS activity can prevent insulin resistance induced by a high-fat diet, suggesting a new understanding of how obesity causes insulin resistance.

Obesity causes type 2 diabetes and metabolic diseases primarily by inducing insulin resistance. Impaired cellular insulin signaling is the most understood mechanism, but it does not always accompany impaired insulin action, indicating other factors must be involved.

The role of the SNS in obesity is complex and somewhat controversial. Previous studies have reported both increased and decreased SNS activity in obese people.

Overnutrition has been known to rapidly increase plasma norepinephrine (NE) levels, indicating overactivation of the SNS. Methods that directly measure SNS activity, such as nerve recordings and NE turnover, often report increased SNS activity in obesity.

In contrast, studies focusing on adrenergic signaling pathways sometimes report reduced catecholamine responses, interpreted as decreased SNS activity.

This discrepancy may be explained by the development of catecholamine resistance due to chronic sympathetic overactivation, leading to diminished physiological responses despite elevated NE levels.

In a study titled "Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity," published in Cell Metabolism, the researchers investigated the conflicting reports on SNS activity in obesity.

The researchers utilized a  with inducible and peripherally restricted deletion of the  gene (THΔper mice). Tyrosine hydroxylase is a required enzyme in synthesizing catecholamines, including NE. By selectively deleting it in peripheral tissues while preserving central nervous system catecholamine levels, the model allowed the study of isolated peripheral SNS activity without affecting central NE functions.

THΔper mice and wild-type littermates were fed either a regular chow diet or a  (HFD) for varying durations to simulate short-term and long-term overnutrition.

Short-term overnutrition

Wild-type mice fed an HFD for 3 to 10 days exhibited increased body fat, impaired glucose tolerance and  compared to regular chow fed mice.

Despite elevated insulin levels, these mice had higher fasting and fed . Cellular insulin signaling remained intact in HFD-fed mice, suggesting that insulin resistance occurred despite normal insulin signaling pathways.

HFD-fed wild-type mice had elevated plasma NE levels, indicating increased SNS activity. There was an impaired ability of insulin to suppress hormone-sensitive lipase activation in white fat tissue, leading to increased lipolysis and higher plasma glycerol levels.

THΔper mice fed an HFD for up to 14 days were protected from the glucose intolerance and insulin resistance observed in wild-type mice. They maintained normal fasting glucose levels and showed improvement in  tests.

Insulin signaling pathways remained comparable between the THΔper and wild-type mice. Improved insulin sensitivity in THΔper mice was independent of any changes in cellular insulin signaling.

THΔper mice showed a more than 90% reduction in NE levels in peripheral tissues, with no significant change in brain NE levels. They exhibited reduced plasma glycerol levels and improved insulin-mediated suppression of hormone-sensitive lipase phosphorylation in white fatty tissues, indicating better regulation of lipolysis.

Subcutaneous infusion of NE for 14 days in regular chow-fed wild-type mice increased plasma NE levels and impaired insulin action without affecting body weight.

Long-term overnutrition

Wild-type mice fed an HFD for 12 weeks exhibited catecholamine resistance. Nerve recordings confirmed that SNS activity was elevated after 16 weeks of HFD feeding in wild-type mice. After 10 to 12 weeks of HFD feeding, these mice displayed glucose intolerance and elevated levels of NE, epinephrine, and glucagon, indicating increased activation of mechanisms that oppose insulin action.

HFD-induced adipose tissue dysfunction in wild-type mice was characterized by reduced expression of lipogenic enzymes in white fatty tissue, larger adipocyte sizes, and increased markers of inflammation, fibrosis, and senescence.

THΔper mice were protected from developing catecholamine resistance. These mice had significantly lower plasma NE levels after HFD feeding, suggesting reduced peripheral SNS activity. These mice continued to be protected from glucose intolerance despite similar weight gain and adiposity compared to wild-type mice. THΔper mice had significantly lower plasma levels of NE, epinephrine, and glucagon after HFD feeding, indicating reduced activation of these counterregulatory hormones.

THΔper mice were protected from HFD-induced adipose tissue dysfunction. They maintained higher expression of lipogenic enzymes in white fatty tissue, had smaller adipocyte sizes, and exhibited reduced markers of inflammation, fibrosis, and senescence.

The researchers suggest their study is a paradigm shift in understanding obesity-induced insulin resistance. SNS overactivation rather than impaired cellular insulin signaling was the primary driver in the mice obtaining or avoiding .

The implications for type 2 diabetes prevention and treatment could be far-reaching. As with any good research that tells us something we did not know before, more research is needed to see how many new things we can learn from it.

More information: Kenichi Sakamoto et al, Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity, Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.09.012


https://medicalxpress.com/news/2024-10-insulin-resistance-sympathetic-nervous-paradigm.html