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Tuesday, January 21, 2025

'Early signs of dementia could be spotted through your eyes with new AI tool'

 Your optometrist could soon be your first line of defense against dementia. 

Data scientists and clinical researchers are working with opticians to develop a digital tool capable of detecting the early signs of neurodegenerative disease — just by scanning your eyes. 

“The eye can tell us far more than we thought possible,” said Baljean Dhillon, professor of clinical ophthalmology at the University of Edinburgh and co-lead of the project. 

Baljean Dhillon, a professor of clinical ophthalmology at the University of Edinburgh, is one of the leaders of the project.Edinburgh Innovations / University of Edinburgh

Scotland’s eye-opening research

The NeurEye research team, led by the University of Edinburgh and Glasgow Caledonian University, has already collected nearly a million eye scans from opticians across Scotland, making it the largest dataset of its kind. 

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Using artificial intelligence and machine learning, they plan to analyze the images for patterns that could indicate a person’s risk of developing dementia, while also offering a broad picture of their overall brain health.

“The blood vessels and neural pathways of the retina and brain are intimately related. But, unlike the brain, we can see the retina with the simple, inexpensive equipment found in every high street in the UK and beyond,” said Dhillon. 

A growing problem

In 2024, an estimated 6.9 million Americans aged 65 and older were living with Alzheimer’s disease, the most common form of dementia. As the population continues to age, that number is only expected to grow. 

The NeurEye team is optimistic that AI-powered eye scans will one day enable optometrists to identify early signs of dementia during routine exams.

The software could lead to earlier diagnoses, providing patients and their families with a critical head start in managing the memory-robbing disease. It could also potentially be used as a way to monitor cognitive decline, experts say. 

Researchers believe blood vessels in the eye could offer early warning signs for neurodegenerative diseases.Edinburgh Innovations / University of Edinburgh
Researchers are hopeful that identifying people at risk of dementia could also accelerate the development of new treatments by helping scientists pinpoint patients who are most likely to benefit from clinical trials and better monitor their responses. 

At a personal level, being aware of one’s dementia risk could inspire some people to make lifestyle changes that may help delay or reduce their likelihood of developing the disease, according to the Lancet Commission, which added vision loss to its list of dementia risk factors last year.

The American Optometric Association currently recommends that healthy adults between the ages of 18 and 64 undergo a comprehensive eye exam every two years, while those over 65 should have an exam annually.

Research suggests that a balanced diet and regular exercise may help reduce the risk of Alzheimer’s.Coetzee/peopleimages.com – stock.adobe.com

One family’s heartbreaking journey

David Steele, a retired mechanical engineer from Scotland, knows firsthand the toll of a late diagnosis. 

His mother had been visiting the optometrist regularly as her vision worsened. Initially diagnosed with macular degeneration, it wasn’t until later that doctors realized the real cause was cerebral blindness linked to Alzheimer’s.

In an interview with BBC Scotland News, Steele shared how an earlier diagnosis could have given his family much-needed time to prepare for his mother’s cognitive decline before it became too severe. 

“You might not want to know the message, but you do really need to know,” he said. “Anything that can be put in place early is really, really important because you’ve got to prepare for the moment it no longer becomes easy to manage life.”

https://nypost.com/2025/01/21/health/early-signs-of-dementia-could-be-found-in-eyes-with-new-ai-tool/

Adams accuses Dems of abandoning him, working class in preview of Carlson interview

 Mayor Eric Adams said the Democratic Party has abandoned him – and everyday New Yorkers.

“People often say, ‘Well, you know, you don’t sound like a Democrat and you seem to have left the party,’” Adams told host Tucker Carlson during an interview due to air Tuesday night. “No. The party left me and left working-class people.”

Adams revealed Biden’s flippant response in the sit down interview.X@TuckerCarlson

Adams added that he believes the Biden administration punished him for being vocal about the migrant crisis plaguing the Big Apple – claiming the White House response to his gripes about being a sanctuary city was: “be a good Democrat, Eric.”

According to a preview of the interview, the mayor also said New York did not welcome the flood of migrants into the five boroughs, noting that, “We have Venezuelan gang leaders that were coming to the city creating crimes.”

Adams, who has cooled on his backing of New York’s sanctuary city status in recent months, told Carlson he’s also at a loss on how to deal with the crisis.

Adams thinks that the Biden administration punished him for being vocal about New York City’s migrant crisis.AP

The mayor has stepped up calls for the sanctuary restrictions to be loosened so migrants suspected of serious crimes can be turned over to federal immigration agents — standard practice before the migrant-friendly policies were implemented under ex-mayors Ed Koch and Michael Bloomberg.

Under sanctuary city laws, local authorities are prohibited from holding misbehaving migrants until Immigration and Customs Enforcement agents show up to begin deportation proceedings.

On Saturday, Adams said he would be unable to help President Donald Trump carry out his promised mass deportation of illegal immigrants because of the city’s status.

Adams called for sanctuary restrictions to be loosed in New York City.Christopher Sadowski

“The law is the law,” he said over the weekend. “I answered that over and over again. I’m not going to keep doing the same question over and over again about the cooperation of city agencies.”

Trump has said he would consider pardoning Adams in the federal corruption case against the mayor — and extended an inauguration invitation to Hizzoner, which Adams happily accepted

Adams has been openly courting Trump to issue a pardon in the federal corruption case against the mayor — and was invited to attend the president’s inauguration on Monday. 

Adams has been openly courting Trump to issue a pardon in the federal corruption case against the mayor.POOL/AFP via Getty Images

However, he faces a battle to win re-election and is still handcuffed on dealing with the migrant crisis, blaming the Big Apple lawmakers who control the status for not bending.

“Damn it,” he complained to Carlson in the upcoming interview. “I’m at the end of the line here.”

The interview is slated to air on Carlson’s network at 6 p.m. Tuesday. 

A spokesperson for the city defended the dem gov’s decision to sit down with the conservative commentator.

“Mayor Adams does not believe we should be living in silos and speaking into echo chambers,” Kayla Mamelak said in a statement. “At a time where our country is so divided, the mayor believes we must break out of our comfort zones and speak with everyone – even those we may not always agree with.”

https://nypost.com/2025/01/21/us-news/eric-adams-hammers-biden-over-flippant-response-to-nyc-migrant-crisis-in-biting-interview-with-tucker-carlson/

Ketamine-Induced Uropathy: What Urologists Need to Know

 The increasing misuse of ketamine for pleasure and medical purposes causes severe urinary complications. At the 118th French Congress of Urology, experts presented the importance of a multidisciplinary approach in managing ketamine-induced uropathy, a condition marked by intense pain and frequent urination, reportedly as high as “30-50 times a day.”

“The treatment approach must be multidisciplinary, involving addiction specialists, pain management experts, and psychiatrists,” François Meyer, MD, from Saint-Louis Hospital in Paris, France, stated. According to the literature, these urinary disorders can be reversed in 50%-85% of cases with “complete and sustained” ketamine withdrawal. 

To guide the management of ketamine-induced uropathy, the French Association of Urology (AFU) recently recommended treatments, such as oral pentosan polysulfate (Elmiron) and intravesical injections of botulinum toxin A (Botox or Dysport).

Ketamine’s Growing Misuse

Originally used as an anesthetic, ketamine is widely misused because of its euphoric and hallucinogenic effects. It is also used off-label for the treatment of resistant depression and chronic pain.

Ketamine in the liquid form evaporates into fine crystals or a white powder, which is then sold for approximately 30-40 euros per gram and is consumed in parties for pleasure at half the price of cocaine. It is mainly snorted but can also be injected intravenously or intramuscularly.

According to data from the French Observatory of Drugs and Addictive Trends, 1.0% of high school students in France reported having experimented with ketamine in 2022. A 2023 survey revealed that 2.6% of adults have already tried ketamine, which brings the consumption of this product “ahead of that of heroin,” noted Meyer. 

Several countries have warned of the increase in recreational use of the drug as well as its misuse as medicine. In England and Wales, 3.8% of young adults (age, 16-24 years) experimented with ketamine in 2022-2023. Its off-label use for depression is gaining attention amid the growing mental health crisis. 

Currently, ketamine is being evaluated as a treatment for resistant depression. However, its misuse with the risk for addiction can have serious consequences. In the United States, the death of Friends actor Matthew Perry, caused by “the acute effects” of taking ketamine to treat his depression and anxiety, has raised awareness of this issue. 

Risks of Prolonged Use

The French National Agency for the Safety of Medicines and Health Products (ANSM) has warned about the risks associated with the misuse of ketamine and the precautions to be taken, particularly when ketamine is used off-label to treat intractable pain in palliative care or even chronic pain.

Serious complications associated with the administration of ketamine in a medical setting are regularly reported, indicated the ANSM. These include liver and biliary tract disorders (hepatitis, cholestasis, or cholangitis) or urinary tract disorders (noninfectious interstitial cystitis), with possible repercussions to the kidneys (acute renal failure, hydronephrosis, etc.).

The ANSM noted that these complications most commonly result from prolonged or repeated use of ketamine, which can lead to ketamine dependence. Among its recommendations, the agency advises against long-term prescribing or administration of ketamine and urges healthcare providers to instruct patients to monitor for symptoms, particularly the appearance of blood in the urine.

Clinical Presentation and Evaluation

Patients with lower urinary tract symptoms due to ketamine misuse are generally young, with an average age of 25 years, and have been using ketamine chronically for at least a year before the onset of voiding problems.

The symptoms include severe suprapubic pain, intense pollakiuria, and urgency, “with the need to urinate 30-50 times a day,” Meyer specified. Upper urinary tract disorders such as ureteral stenosis and kidney dilation (hydronephrosis) are common and are observed in 30% of patients.

The pathophysiology of the effects of ketamine on the urinary system “quite complex.” The active metabolite of ketamine is excreted via the urine, damaging the entire urinary tract. This results in disorders that go beyond those commonly known as ketamine-induced cystitis.

The clinical assessment includes a cytological cytobacteriological examination of the urine, a creatinine measurement to assess renal function, and an ultrasound to measure the post-micturition residue and look for possible dilation of the upper urinary tract.

Cystoscopy is also essential for assessing the condition of the mucous membranes and performing biopsies to rule out carcinoma. However, the examination must be performed under general anesthesia because of the intense pain it can cause. The same applies to urodynamic assessment.

Management Strategies

Sustainable withdrawal is essential to reduce these disorders. In cases of relapse, symptoms can return rapidly. Regular urine tests are advised to ensure the patient is successfully weaned off ketamine. Ongoing follow-up should include routine renal function tests.

The AFU guidelines recommend analgesics, such as paracetamol and ibuprofen for pelvic pain, as they have shown good efficacy, said Meyer. Phenazopyridine can also be used to treat urinary pain. However, opioids and pregabalin are less often recommended because of the risk for dependence.

Other Treatments

For persistent symptoms, oral pentosan polysulfate (Elmiron), a standard treatment for interstitial cystitis, is recommended as a first-line drug for ketamine-induced cystitis. However, anticholinergics are not recommended for this indication.

As with the treatment of painful bladder syndrome, hydrodistension, which fills the bladder with saline, is a first-line intervention. For symptoms of overactive bladder, intravesical injections of botulinum toxin are also recommended.

Reconstructive surgery involving the intestinal mucosa should be considered as a last resort, according to the AFU. Given that ketamine can also damage the intestinal mucosa, the effectiveness of this technique is limited, not to mention the risk for complications. 

As treatments for this indication are currently limited, other approaches are being considered. The use of mesenchymal stem cells or platelet-rich plasma facilitates the restoration of the urothelium.

https://www.medscape.com/viewarticle/ketamine-induced-uropathy-what-urologists-need-know-2025a10001dp

Brookhaven, LI, Officials to Host Battery Energy Storage Forum Today

 'The event will include qualified panelists and is described as educational with a focus on residential impact.'


Brookhaven Town will host a community forum on battery energy storage systems at Suffolk County Community College in Selden, Supervisor Dan Panico said.

It will be held from 7 to 9 p.m. at the Shea Theater at the college's Ammerman Campus on College Road.

The event will include qualified panelists and is described as educational with a focus on residential impact.

There will be no live questions at the forum, according to a news release from the town.

There are at least two battery storage facilities plans being floated in the township.

One includes a 1.9-megawatt facility in Patchogue, Newsday reported.

https://patch.com/new-york/sachem/brookhaven-officials-host-battery-energy-storage-forum-tuesday