InduPro will leverage its proprietary platform to develop bi- and tri-specific therapeutics that discover rationally selected Tumor Associated Proximity Antigens (TAPAs) to pair as co-targets with Tumor Associated Antigens, in collaboration with Lilly
InduPro, Inc., a biotechnology company defining membrane protein spatial relationships to create novel therapeutics for the treatment of cancer and autoimmune diseases, today announced a global strategic collaboration and licensing agreement, and equity investment, with Eli Lilly and Company (“Lilly”) to discover novel oncology treatments using InduPro’s proximity-guided platform.
Under the terms of the agreement, the two companies will collaborate on up to three targets, for a total deal value of up to approximately $950M. Lilly will also make an equity investment in InduPro.
By leveraging Tumor Associated Proximity Antigens (TAPAs), surface antigens that are spatially co-localized and often functionally linked to tumor-associated antigens (TAAs) within the tumor microenvironment, the companies will use InduPro's proximity-based platform to discover novel, disease-specific protein-target pairs. This strategy is designed to enable new therapeutic approaches for bispecific antibody drug conjugates (ADCs) and multispecific T-cell engagers, offering improved safety, potency, and tumor selectivity.
“Our partnership with Lilly underscores a shared commitment to advancing a new generation of tumor-selective medicines guided by the spatial biology of cancer,” said Prakash Raman, PhD, CEO of InduPro. “TAPAs represent a fundamentally new way to think about tumor antigens, and we’re thrilled that Lilly shares our vision of leveraging proximity-based biology to enable precision multi-specific therapeutics. We believe this partnership reflects growing confidence in our differentiated, proximity-guided approach to tumor targeting and its promise to improve the design and performance of ADCs and TCEs.”
Through the agreement, Lilly will gain access to InduPro’s proprietary AI/ML-enabled membrane interactomics (MInt) platform. InduPro will lead early discovery efforts, applying its proximity-guided platform to identify co-target pairs and advance bispecific and multispecific antibody programs emerging from the collaboration.
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