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Tuesday, January 8, 2019

Teva’s CEO sees prices in generic drug market stabilizing


Kare Schultz, the head of the world’s largest generics drug maker, Teva Pharmaceutical Industries Ltd., believes global prices of generics have entered a “more stable situation” after five years in which the total value of the US generic market space witnessed a “dramatic reduction.”
“There has been a dramatic change and we no longer have this spiral price declines, but we have a much more stable situation,” Teva’s CEO said Monday at the 37th Annual J.P. Morgan Healthcare Conference in San Francisco, California.
In December 2017, Teva, Israel’s largest publicly traded company and until recently a source of national pride, said it would slash its workforce by 25% over the next two years and close plants in a bid to reduce massive debt of some $35 billion and to cope with declines in its generics business and sooner-than-expected competition to its flagship branded drug, Copaxone, for multiple sclerosis.
In his speech on Monday, Schultz said the company had managed to stem the price drops in generic drugs by talking with “all of its key customers” in the US about products in which prices had gone below reasonable profitability levels.

“I’m happy to say we are through that process,” he said, according to a printed transcript of his talk. “Of course, we had to give up some of the volume,” but “that didn’t hurt us because we were not making money on it.”
“My guess is that for the second quarter, third quarter, and fourth quarter, the total US generics market will in absolute value be very much stable. And I’m also predicting that to be the case for the future. That does not mean that we get back to where we were. It does not mean that the market goes back to doubling from where it came, but it just means that this constant reduction of the marketplace has stopped, and that’s of course very important for us.”
Declining Copaxone sales
Schultz said that he expects sales of its flagship Copaxone product to “continue to decline next year, as we’ve also been predicting from the very beginning.”
Increased competition for Copaxone — both in the US and in Europe — is “the big challenge” the company has faced, with Teva striving to maintain sales volume and doling out discounts.
That policy “is working well so far,” Schultz said, as the company is managing to hold on to “more than 70% of the business in the US.” Even so, he said, revenue is declining, “because of course …as you give more discounts in order to keep the revenue, then your total sales will of course be declining.”
Copaxone, the only non-interferon multiple sclerosis treatment, was developed by Teva Pharmaceuticals in the mid-1990s. (Weizmann Institute of Science/JTA)
Teva has also managed to lower its massive debt levels, he said. “We came from $35 billion, and we’ve been doing our best to bring it down. We’re now down to around $27 billion, and we will continue in the coming years to bring it down.”
To date the firm has already cut $1.8 billion in costs via its two-year restructuring plan, which targets a total of $3 billion of cost cuts.
And Teva’s headcount has been “reduced by approximately 10,000 people, which is completely according to the plan as well. Now the plan is not over yet. We are still executing on the plan this year throughout 2019.”
Teva’s bid to cut manufacturing sites from 80 to around 60 in the short term is also “well underway,” and “there will be probably around 10 closures throughout this year,” Schultz said.

Boston Scientific shares should trade higher after Q4 results, says Piper


Piper Jaffray analyst Matt O’Brien reiterated an Overweight rating and $40 price target on Boston Scientific after the company reported preliminary Q4 revenue at the high end of previously issued guidance of $2.525B-$2565B. In a research note to investors, O’Brien says he is “encouraged” after the preliminary Q4 and sees the stock up “a bit” today, adding that the company’s quarter was “solid” with trends moving int he right direction. He continues to see upside to numbers, which, along with a steady multiple, should push shares higher.
https://thefly.com/landingPageNews.php?id=2845559

Gilead HCV treatment Epclusa approved by Japan MHLW


https://thefly.com/landingPageNews.php?id=2845122

UBS upgrades DaVita to Neutral on better risk/reward profile


UBS analyst Whit Mayo upgraded DaVita to Neutral from Sell while lowering his price target for the shares to $59 from $64. The recent weakness in the shares drives a better risk/reward profile, Mayo tells investors in a research note. The analyst, however, continues to sees structural concerns with payer mix and points out that record industry capacity is for sale.

Novartis therapy crizanlizumab receives FDA Breakthrough Therapy designation


https://thefly.com/landingPageNews.php?id=2845124

Molina Healthcare upgraded to Overweight from Neutral at JPMorgan


JPMorgan analyst Gary Taylor upgraded Molina Healthcare to Overweight.

Exelixis: partner Daiichi Sankyo receives regulatory approval for MINNEBRO


Exelixis announced that its partner Daiichi Sankyo Company, received approval from the Japanese Ministry of Health, Labour and Welfare for esaxerenone tablets, MINNEBRO 1.25 mg, 2.5 mg, and 5 mg, as a treatment for patients with hypertension. This approval allows for the marketing of MINNEBRO for this indication within Japan. MINNEBRO is a compound identified during the prior research collaboration between Exelixis and Daiichi Sankyo, which the companies entered into in March 2006, and has been subsequently developed by Daiichi Sankyo. Per the collaboration agreement between Exelixis and Daiichi Sankyo, Exelixis will receive a $20M milestone payment upon the first commercial sale of MINNEBRO in Japan. Exelixis previously received a $20M milestone payment in the first quarter of 2018 triggered by the filing of Daiichi Sankyo’s associated regulatory application. Exelixis is eligible for substantial commercialization milestones, as well as low double-digit royalties on sales of MINNEBRO. Since the conclusion of Exelixis and Daiichi Sankyo’s joint research period in November 2007, Daiichi Sankyo has been responsible for all subsequent preclinical and clinical development, and also oversees regulatory, manufacturing and commercialization activities for MINNEBRO.