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Thursday, January 30, 2020

Siemens Healthineers: Partial IPO, resilient activity

Siemens Helthineers (hereafter “Helthineers”) comprises the Siemens’ healthcare group of businesses. Like SAP — discussed last week in this section — the company ranks as a prime investment candidate among MarketScreener’s quantitative ratings.

Here, a peculiarity is that only 15% of equity capital was put on sale two years ago, while the Siemens mothership kept — as of now — the remaining 85% under control. Popular in Germany, these partial IPOs enable large conglomerates to monetize their assets in a timely fashion, and their subsidiaries to raise capital on their own.
Helthineers employs 52,000 people over 70 countries, and generates €14.5bn in revenue. Business is split into three segments: Medical Imaging (€8.9bn in revenue) sells scanner and radiography equipment, among others; Advanced Therapies (€1.6bn) develops high-precision surgical equipment, as well as linear particle accelerators used for radiotherapy treatments; finally, Diagnostics (€4.1bn) supplies laboratories with a comprehensive and integrated set of capabilities.
Remarkably, within the first two segments the company operates as an oligopoly with GE and Philips. Growth rates outmatch GDPs, driven to a large extent by thriving demand from China and the Middle East. Margins are high and returns on capital employed highly rewarding, for business is mature and protected by unassailable barriers to entry.
The Diagnostics business remains more fragmented and competitive. Margins are less juicy but a total addressable market of €30bn exceeds Medical Imaging’s (€19bn) and Advanced Therapies’ (€3bn). Management intends to consolidate Helthineers’s geographies and portfolio of services portfolio into a dominant offering — scale will make the difference — alongside the costly but promising launch of the Atellica suite.
Sluggish growth in Europe has been offset by continuing dynamism in North America, Middle East, Asia and the Oceania regions. Of course, the company’s fortunes remain directly tied to government spending in healthcare, in particular where equipment rate lags behind — precisely the opposite of what happens in Europe, where hospitals are well provided and social security systems on the brink of insolvency.
On the financial level, the restructuring plan deployed simultaneously with the IPO led to a staggering margin expansion (16% last year) in a short period of time. Going public certainly helped management to implement though but needed decisions — such as trimming redundant workforce — and deal with Siemens’ redoutable unions.
Improved profitability should also cast light upon the company’s excellent foundations. In addition to the high barriers to entry, all segments deliver recurring revenues and earnings — in Imaging and in Advanced Therapies with software licences, spare parts and maintenance services, and in Diagnostics where customers buy steady volumes of reagents and consumables.
Balance sheet is solid, with most of the loans (€4.1bn out of €4.5bn in total) granted by majority shareholder Siemens on preferred terms, and operating earnings covering interest charge by a factor of ten. So far, half of current indebtedness finances working capital requirements, while the other half was used for acquisitions.
One should expect Siemens to progressively withdraw and let Helthineers tap the bond markets. Additional capital will be required, for management has high acquisitive ambitions, and a plan to replicate within the Diagnostics business the excellent competitive positions that have been established in Medical Imagery and Advanced Therapies. That strategy has a cost.
Shares trade at x23 2019 earnings, and x21 expected earnings by 2022. Albeit typical of a mature business growing slightly above GDP, these valuation levels give little credit to analysts’ guidance — surveyed in real time by MarketScreener — which has been uplifted following the takeovers of ECG Management Consultants and Corindus in the United States.
With GE in trouble and Philips announcing its desire to solely focus on its healthcare business, it is obvious that management intend to get an upper hand with cross-support from financial markets and its former parent company, which next moves will be interesting to track. In effect, in a comparable case of partial IPO, Bayer took advantage of a momentous valuation frenzy to unload its 70% stake in Covestro.
Siemens acting likewise would warrant a second look at Helthineers’ investment case, whereas the former parent staying on board would signal that things go according to the plan.
https://www.marketscreener.com/SIEMENS-HEALTHINEERS-42379342/news/Siemens-Healthineers-Partial-IPO-resilient-activity-29914477/

Astellas files application in Japan for expanded use of roxadustat

Astellas Pharma (OTCPK:ALPMF) has submitted a supplemental marketing application in Japan seeking approval to use Evrenzo (roxadustat) to treat chronic kidney disease-associated anemia in non-dialysis-dependent patients.
It is currently approved there for dialysis-dependent patients.
https://seekingalpha.com/news/3536362-astellas-files-application-in-japan-for-expanded-use-of-roxadustat

Pulmatrix nabs accelerated review status in U.S. for itraconazole

The FDA has granted Fast Track status to Pulmatrix’s (PULM +2.7%) inhaled itraconazole for the treatment of allergic bronchopulmonary aspergillosis in asthma patients.
A Phase 2 study is in process with topline results expected by year-end.
Fast Track status provides for more frequent interaction with the FDA review team and a rolling review of the marketing application.
https://seekingalpha.com/news/3536365-pulmatrix-nabs-accelerated-review-status-in-u-s-for-itraconazole

Aprea Therapeutics nabs accelerated review status in U.S. for APR-246

Thinly traded Aprea Therapeutics (APRE -0.2%) announces Breakthrough Therapy status in the U.S. for lead candidate APR-246, combined with chemo agent azacitidine, for the treatment of myelodysplastic syndromes (MDS) with a susceptible TP53 mutation.
A Phase 2 study evaluating the combo as maintenance therapy after allogeneic hematopoietic stem cell transplant in patients with TP53-mutant MDS or AML is in process with an estimated primary completion date in July 2021.
The company says small molecule APR-246 reactivates the mutant form of the tumor suppressor protein p53.
https://seekingalpha.com/news/3536374-aprea-therapeutics-nabs-accelerated-review-status-in-u-s-for-aprminus-246

Catalyst Bio up 6% on positive DalcA data

Nano cap Catalyst Biosciences (CBIO +6.3%) is up, albeit on only 94K shares, in apparent response to preliminary results from a Phase 2b clinical trial evaluating dalcinonacog alfa (DalcA) in patients with severe hemophilia B [factor IX (FIX) levels typically 1 – 5%]. The data will be presented next week at the European Association for Hemophilia and Allied Disorders (EAHAD) Annual Congress in The Hague, The Netherlands.
Per the abstract (OR07), treated patients showed FIX levels between 16% and 27% at day 29. No anti-drug antibodies were detected and no thrombotic (blood clotting) or bleeding events occurred during the study.
Dalcinonacog alfa is a recombinant FIX variant with 22x greater potency and longer half-life compared to wild- type FIX.
https://seekingalpha.com/news/3536396-catalyst-bio-up-6-on-positive-dalca-data

Allergan expands partnership with Histogen

Privately held regenerative medicine firm Histogen announces that it has granted exclusive rights to collaboration partner Allergan (AGN -0.8%) to incorporate and commercialize its cell conditioned media (CCM) technology in microabrasion therapies and new Histogen intellectual property in the aesthetic field.
The companies inked their original agreement in 2017 when Allergan acquired exclusive rights to develop and commercialize CCM to healthcare providers in the aesthetic field. It subsequently in-licensed the rights to CCM in new distribution channels like digital platforms, health spas and salons.
Related ticker: AbbVie (ABBV -2.2%)
https://seekingalpha.com/news/3536406-allergan-expands-partnership-histogen

Bayer may end private sales of glyphosate

Bayer (OTCPK:BAYRY) is considering stopping sales of the weedkiller glyphosate to private users who apply it in their gardens, Germany’s Handelsblatt reports.
The move is part of ongoing settlement talks with tens of thousands of plaintiffs in the U.S. who attribute their cancer to the glyphosate-based weedkillers.
https://seekingalpha.com/news/3536153-bayer-may-end-private-sales-of-glyphosate