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Thursday, August 27, 2020

LHC Group and University Health Care System announce joint venture

LHC Group (NASDAQ:LHCG) and University Health Care System signs a definitive agreement to form a new joint venture to enhance home health and hospice services across eight cities in Georgia and South Carolina.

The joint venture will include 10 total locations, including three University Health home health providers, three University Health home health branches, two LHC Group home health providers, and two LHC Group hospice providers.

The JV will be finalized by October 1.

It will focus on delivering patient-centered care in the comfort of the patient’s home or place of residence. 


EU pays 336 million euros to secure AstraZeneca’s potential COVID-19 vaccine

The European Commission has made a 336 million euro ($396 million) downpayment to British drug maker AstraZeneca (AZN.L) to secure at least 300 million doses of its potential COVID-19 vaccine, a spokesman said on Thursday.

The deal covers development, liability and other costs faced by the vaccine maker. The EU has also secured an option to buy 100 million additional doses of the vaccine under development.

The 27 EU states could buy it at a later stage, should the vaccine prove successful.

The overall price they will pay to acquire the doses has not been revealed, but under an earlier deal struck in June with AstraZeneca by Germany, France, Italy and the Netherlands, all members of the EU, AstraZeneca agreed to sell 300 million doses for 750 million euros ($843 million).

The EU deal completed the preliminary accord reached with the drug maker by the four countries, the Commission said in a statement.

“We cannot indicate at this stage the specific pricing per dose. However, a significant part of the overall costs are funded by a contribution from the overall ESI funding for vaccines,” the commission spokesman said, referring to the 336 million euros paid through the bloc’s so-called emergency support instrument.

It is the first contract signed by the EU with a maker of potential COVID-19 vaccines.

AstraZeneca has already agreed the supply of 300 million shots of the same vaccine to the United States for $1.2 billion, and of up to 30 million doses to Britain for 65.5 million pounds ($86.5 million).

Brussels has previously said it is also in advanced talks with Johnson & Johnson (JNJ.N), Sanofi (SASY.PA), Moderna (MRNA.O) and CureVac CVAC.O for their potential vaccines.

EU officials told Reuters in July the bloc was also talking with Pfizer (PFE.N) and BionTech (BNTX.O) for the shot they are developing together.

The contract with AstraZeneca follows an advance purchase agreement signed by Brussels with the company earlier in August.

Part of the money the EU pays for supply deals covers legal risks faced by vaccine makers if their shots have unexpected side effects. These risks are increased by the hastened process to develop a vaccine in the race against the COVID-19 pandemic.

“In order to compensate for such high risks taken by manufacturers, the Advanced Purchase Agreements provide for member states to indemnify the manufacturer for liabilities incurred under certain conditions,” the commission said.

“Liability still remains with the companies,” it added.

This issue has been one of the stumbling blocs in talks with other vaccine makers, official told Reuters, as companies prefer to have a broader shield.


US to purchase 150 million Abbott COVID-19 tests for $750 million

The Trump administration will purchase 150 million rapid coronavirus tests from Abbott Laboratories (ABT.N) for about $750 million, a White House spokeswoman said on Thursday.

The portable antigen tests, which can deliver results within 15 minutes and will sell for $5, received emergency use authorization from the U.S. Food and Drug Administration on Wednesday.

The portable test from Abbott is about the size of a credit card, requires no additional equipment to operate, and can be conducted using a less invasive nasal swab than traditional lab tests.

Antigen tests are cheaper and faster than molecular diagnostic tests, but somewhat more likely to fail to identify positive cases of the virus than lab-based diagnostic tests.

Becton Dickinson and Co (BDX.N) and Quidel Corp (QDEL.O) already market antigen tests.

Abbott shares rose 8% to $111.54 in afternoon trading, and the company declined to comment on the latest development.


VBI Selects Clinical Candidates with Potential as 1-Dose Covid Vaccines

 – VBI-2901 and VBI-2902 selected as trivalent and monovalent coronavirus vaccine candidates, respectively, for an adaptive Phase 1/2 clinical study expected to begin around year-end 2020, subject to regulatory approvals

– After one dose, compared to high-titer convalescent sera, preclinical data demonstrated 10x higher antibody binding geometric mean titer (GMT) and 4x higher neutralizing antibody GMT, with neutralizing antibody GMT increasing to 64x after a second dose

– GMP clinical manufacturing expected to begin in September 2020 at Therapure Biomanufacturing – potential to leverage capacity to support large-scale manufacturing

– VBI hosted conference call and webcast today, Wednesday, August 26 at 8:30 a.m. ET


Akers Biosciences down on early data on COVID-19 vaccine candidate

Nano cap Akers Biosciences (AKER -28.1%) slumps on more than a 5x surge in volume in reaction to proof-of-concept data from animal studies assessing the safety and immunogenicity of its SARS-CoV-2 vaccine candidate, dubbed PRAK3202, that it is co-developing with Premas Biotech.

The company says the vaccine was well-tolerated and induced a robust immune response to the three coronavirus antigens, S, E and M, adding that the vaccine elicited neutralizing antibody titers across all doses levels (5, 10, 20 mcg). After three doses all 10 cohorts of mice showed binding antibody levels similar to convalescent plasma.

Investors appear to be reacting to the absence of more compelling data since the companies significantly lag the leaders whose candidates are in or are about to enter Phase 3 studies. For example, three doses to achieve antibody levels on par with convalescent plasma implies that one or two doses, the regimens that will be the standard for commercialized vaccines, failed to achieve the desired effect.

By comparison, VBI Vaccines just reported that its candidates produced 10x higher binding antibody titers and 4x higher neutralizing antibody titers after one dose (jumped to 64x after the second dose).


AIM ImmunoTech Ampligen shows encouraging prophylactic effect v. Covid

Results from a 3D-mucociliary tissue culture showed AIM ImmunoTech’s (AIM +12.3%) Ampligen, a dsRNA TLR3 agonist, decreased SARS-CoV-2 infectious viral yields by 90% at clinically achievable intranasal Ampligen dosage levels.

“We are pleased with these results, as they establish Ampligen’s bio-activity against SARS-CoV-2 as well as support our decision to test Ampligen in humans as an intranasal prophylaxis and early-onset therapy against COVID-19,” said its CEO Thomas Equels


How easily can COVID-19 spread in an elevator? Otis is finding out

Otis Worldwide (NYSE:OTIS) is commissioning a study into elevator airflow, how it affects the risk of transmission of the COVID-19 virus among passengers, and how to mitigate those risks through science-based safety protocols.

The study will be led by Dr. Qingyan (Yan) Chen, the James G. Dwyer Professor of Mechanical Engineering at Purdue, who is widely recognized for his research into the spread of infectious disease through indoor air systems – and how to prevent it.

“My team and I are looking forward to conducting this study to help the industry and riding public better understand the likelihood of COVID-19 transmission in an elevator environment as compared to other everyday activities, like shopping at a grocery store or eating at a restaurant,” said Dr. Chen. “Using state-of-the-art research techniques, we will also be able to scientifically validate preferred methods of mitigating passenger risks associated with the virus.”

Other industries are also exploring similar solutions. American Airlines just received approval from the EPA to use a surface coating that kills coronavirus for up to seven days.