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Thursday, August 12, 2021

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

 

  • Amarendra Pegu1,
  • Sarah O’Connell1,
    1. Stephen D. Schmidt1,
    2. Sijy O’Dell1,
    3. Chloe A. Talana1
    4. Lilin Lai2
    5. Jim Albert3
      1. DOI: 10.1126/science.abj4176
          PDF: 
        https://science.sciencemag.org/content/early/2021/08/11/science.abj4176/tab-pdf

          Abstract

          SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the impact of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, and ACE2-competing antibodies elicited by the vaccine mRNA-1273 over seven months. Cross-reactive neutralizing responses were rare after a single dose. At the peak of response to the second vaccine dose, all individuals had responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6-months after the primary series of the mRNA-1273 vaccine. Across all assays, B.1.351 had the lowest antibody recognition. These data complement ongoing studies to inform the potential need for additional boost vaccinations.


    Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection

     Zhongyan Lu, Eric D Laing, Jarina Pena-Damata, Katherine Pohida, Marana S Tso, Emily C Samuels, Nusrat J Epsi, Batsukh Dorjbal, Camille Lake, Stephanie A Richard, Ryan C Maves, David A Lindholm, Julia Rozman, Caroline English, Nikhil Huprikar, Katrin Mende, Rhonda E Colombo, Christopher J Colombo, Christopher C Broder, Anuradha Ganesan, Charlotte A Lanteri, Brian K Agan, David Tribble, Mark P Simons, Clifton L Dalgard, Paul W Blair, Josh Chenoweth, Simon D Pollett, Andrew L Snow, Timothy H Burgess, Allison MW Malloy

    Airbnb warns of Delta impact on bookings, shares fall

     Airbnb Inc (ABNB.O) said on Thursday its current-quarter bookings could be hit by the Delta variant of the coronavirus and a slowing pace of vaccination in the United States, sending its shares down more than 4%.

    https://www.reuters.com/business/airbnb-promises-record-third-quarter-warns-delta-impact-2021-08-12/

    40% Of Bused-In Migrants Covid-Positive -- Biden Admin Uses Texas Airport To Disperse Illegals Over U.S.

     The city of Laredo, Texas has stopped accepting migrants who have been bused in from elsewhere after two local government officials confirmed that 40% of them have tested positive for Covid-19, according to the Washington Examiner.

    Migrants outside the Holding Institute Community Center shelter in Laredo, Texas, on May 15.Jonathan Alpeyrie / Bloomberg via Getty Images file

    Not a peep from the Biden administration about mandatory vaccinations for illegals, of course.

    "That was very high," said Laredo Mayor Pete Saenz in an interview with the Examiner, referring to the infection rate among migrants dropped off by the Border Patrol last week. The figures were confirmed by Laredo's health authority, Dr. Victor Trevino.

    The 40% infection rate is the highest known positivity rate along the U.S.-Mexico border. Last week, McAllen, Texas, reported a 15% positivity rate among migrants released from custody.

    Concerned that migrants arriving in Laredo would further strain hospital resources, Laredo officials contracted private bus companies to transport migrants arriving from the Rio Grande Valley to larger cities across the state. By not admitting migrants on the McAllen buses, the city is not required to test them for the coronavirus and could forward the families elsewhere. Those who test positive cannot travel and must be quarantined for 10 days, a situation Saenz wanted to evade to avoid migrant overflow. -Washington Examiner

    Thousands of migrant families have been transported from the Rio Grande Valley region to Laredo because of overcrowded shelters. The migrants were immediately tested upon arrival - with positivity  rates jumping from 4% in April to 40% in August.

    Meanwhile, Judicial Watch reports that the Department of Homeland Security has quietly been using a small regional airport in central Texas to disperse "large groups of illegal immigrants throughout the U.S. after releasing them from detention facilities in other parts of the state, city and federal sources confirm."

    Local authorities in the city where this is occurring, Abilene, are being kept in the dark and a federal lawmaker is demanding an end to the “reckless and irresponsible practice” as well as answers from DHS after a series of local news reports exposed the covert operation.

    Abilene is located about 180 miles west of Dallas and has a population of around 120,000. The area’s airport is run by the city and its transportation director reveals in a news story that local officials are not aware of what exactly is going on with the illegal immigrant flights. The airport is only given 24 to 48 hours of notice before flights arrive, according to Abilene Director of Transportation Don Green, who verifies the planes are private charters from Immigration and Customs Enforcement (ICE), the DHS agency in charge. The Texas news conglomerate, which also publishes reports in Spanish, writes that it “shot video of strange activity at the airport” and includes the footage on its website. It shows immigrants exiting unmarked planes, getting frisked, then boarding buses. Some footage includes buses arriving at the airport where immigrants are seen getting off and boarding planes to different parts of the U.S. -Judicial Watch

     Read the rest of the report here.

    https://www.zerohedge.com/covid-19/40-bused-migrants-have-covid-19-while-biden-admin-using-texas-airport-disperse-illegals

    Healthcare tech SPAC AfterNext HealthTech Acquisition prices $250M IPO

     AfterNext HealthTech Acquisition, a blank check company formed by TPG targeting healthcare technology, raised $250 million by offering 25 million units at $10. Each unit consists of one share of common stock and one-third of a warrant, exercisable at $11.50.


    AfterNext HealthTech Acquisition is led by CEO and Chairman Halsey Wise, the former CEO of MedAssets and Integraph; President and Director Anthony Colaluca, the former CFO of MedAssets and Integraph; and CFO Martin Davidson, a Partner and CAO of TPG Capital. The company aims to leverage management's experience to target businesses that lie at the intersection of healthcare and technology.

    AfterNext HealthTech Acquisition plans to list on the NYSE under the symbol AFTR.U. Goldman Sachs, Deutsche Bank, and BofA Securities acted as joint bookrunners on the deal.

    SPAC DTRT Health Acquisition files for $200M IPO, led by former Addus HomeCare CEO

     DTRT Health Acquisition, a blank check company targeting home and community based healthcare services, filed on Thursday with the SEC to raise up to $200 million.


    The Oak Brook, IL-based company plans to raise $200 million by offering 20 million units at $10. Each unit consists of one share of common stock and one-half of a warrant, exercisable at $11.50. At the proposed deal size, DTRT Health Acquisition would command a market value of $250 million.

    The company is led by CEO and Chairman Mark Heaney, who previously served as the CEO of Addus HomeCare (Nasdaq: ADUS), leading the company through its 2009 IPO. He is joined by CFO and Director Don Klink, who currently serves as the CFO of United Dental Partners. The company plans to leverage management's experience to target the healthcare industry, specifically home and community based healthcare services, which may include home health, personal and private duty care, and home-based therapy, among other areas.

    DTRT Health Acquisition was founded in 2021 and plans to list on the Nasdaq under the symbol DTRTU. The company filed confidentially on June 9, 2021. Cantor Fitzgerald is the sole bookrunner on the deal.

    DeSantis launches Regeneron rapid response initiative for early COVID treatment

     Florida Gov. Ron DeSantis is launching a rapid response unit for Regeneron COVID-19 treatment to reduce likelihood of hospitalizations. The governor said the data shows the monoclonal antibody treatment would help patients in high-risk categories.

    DeSantis said that the “overwhelming majority” of COVID hospital admissions have been among the unvaccinated, though there are breakthrough cases of COVID-19. He said that what hasn’t been seen is widespread vaccination having a limiting effect on waves of infections, though severe health outcomes are less likely for patients who have been vaccinations.

    “Vaccination is clearly helping reduce serious illness, it’s reducing your likelihood of being hospitalized, but you also have people who are being hospitalized, so what tools do you have that make the most sense,” DeSantis said. “One of things we’ve been talking about recently is doing monoclonal antibody treatment such as Regeneron.”

    Emergency use authorization was granted by the FDA in November. DeSantis says he believes the public, and even some doctors, may not be aware of its availability to the extent they should be.

    Now, the governor is launching a rapid response unit using Regeneron treatment as a way to reduce the likelihood of hospitalizations and provide an early treatment option for the state’s COVID patients, as the delta variant continues to sweep through the population, particularly among the unvaccinated.

    “Different hospital systems have done it, they’re doing it here in northeast Florida, but it was something, that the more we talked about it, the more people had questions, a lot of people had not even heard of it,” DeSantis said. “So, we see an effort to be able to supplement that effort here in northeast Florida, and other parts of the state, we’ll have additional announcements very soon, partially to be able to get more people in, and we’re going to bring a lot more Regeneron into Florida.”

    Calling it the most effective treatment for people infected with COVID-19, DeSantis said the most high-risk patients are the ones who would benefit the most from a higher availability of the treatment, including the elderly, diabetic, and obese patients in Florida.

    He said part of the launch, starting at noon in Jacksonville, would be to deploy the rapid response unit, but also to increase awareness of the treatment and deliver Regeneron to those who need it most.

    Regeneron was the emergency treatment that helped former President Donald Trump overcome his COVID-19 infection in October 2020. After fighting off his own experience with the virus, Trump authorized millions of dollars of purchases of monoclonal antibody treatment from Eli Lilly and Regeneron, with the bulk of the treatments purchased from Regeneron.

    In a release from the company, Regeneron announced that the U.S. government had purchased 1.25 million more doses of Regeneron’s antibody cocktail in early 2021, pushing the U.S. “potential” supply to more than 1.5 million doses.

    “COVID-19 continues to sicken hundreds of thousands of Americans every day and the people of Regeneron are committed to help,” said Leonard S. Schleifer, M.D., Ph.D., President and Chief Executive Officer of Regeneron in January. “Tackling the COVID-19 pandemic will require a combination of public health measures, vaccines and therapeutics. We are pleased to work with the U.S. government to supply our antibody cocktail as an important weapon in this fight.”

    The governor was joined by Mayor Lenny Curry, Division of Emergency Management Director Kevin Guthrie, DOH Interim Duval County Health Officer Tito Rubio and FDEM Chief Medical Officer Dr. Kenneth Scheppke.

    Along with the governor, the state officials and Mayor Curry urged Florida residents to seek out the treatment option, whether or not they have been vaccinated for COVID-19, saying the treatment is “effective, it works” but is not currently well-known in the community.

    “People need to know this exists, they need to know this unit is here if they don’t have access to their healthcare provider,” Curry said.

    Addressing the public and the press, Scheppke thanked the governor for “highlighting the therapeutic advancement” that the Regeneron treatment represents.

    “It’s great for folks who are vaccinated but who are at high risk for progression of the disease, it’s great for folks that are unvaccinated who get this disease, it’s great for folks who are unvaccinated, that are not ill, but have come into contact with a household contact with somebody who has gotten COVID,” Scheppke said. “So as the governor reported, folks who are at high risk for progression to severe disease or death from COVID-19, this therapy can reduce your risk of hospitalization and death by 70%.”

    Scheppke says the treatment can also help prevent risk of developing COVID-19 for those who come into contact with a household contact who has COVID by over 80%. He called it one of the better therapeutics out there, for COVID-19.

    DeSantis said that use of Regeneron for COVID treatment isn’t an “either/or” with vaccines, but that you should seek both. The governor said the state surgeon general has plans to create a standing order for Regeneron treatments. The state also plans to send “strike teams” to bring Regeneron to nursing homes, offering the treatment to patients as “early treatment for the most vulnerable.”

    DeSantis also addressed the reports that the state had received hundreds of new respirators and ventilators, clarifying that there had been questions about respirators, which were not requested, but that the state had requested more ventilators from the Federal Emergency Management Agency to increase the stock of available equipment.

    Returning to Regeneron, DeSantis said the state would be ordering thousands of doses to promote availability.

    “We can place orders for 10,000 treatments at a time,” DeSantis said.

    Still, the governor said the best strategy was early treatment, even with an expected “baseline of exposure” to COVID-19 across the state, and the world. To find locations to receive monoclonal antibody treatments around the entire state, please visit floridahealthcovid19.gov

    “Still do this,” DeSantis urged Florida residents, whether or not you’re a high-risk patient, and whether or not you’re vaccinated. He encouraged Floridians to get their COVID-19 vaccinations as well.

    The governor also said that the state would be considering providing a breakdown of case reports by county as different communities in Florida see different levels of COVID spread amid the delta variant’s surge of cases. He clarified that daily reports to the U.S. Centers for Disease Control and Prevention continue for daily case tracking.

    https://www.wfla.com/news/florida/gov-desantis-to-speak-in-jacksonville-at-1030-a-m-joined-by-emergency-management-doh/