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Tuesday, January 7, 2025

Wainwright cuts Acelyrin stock target, keeps neutral on trial data

 H.C. Wainwright analyst adjusted the price target on shares of Acelyrin Inc (NASDAQ: SLRN) to $6.00 from the previous $8.00 but maintained a Neutral rating on the company's shares. Currently trading at $3.49, InvestingPro analysis suggests the stock is fairly valued, though analyst targets range from $5 to $20.

Despite recent challenges, the stock has shown resilience with an 11.15% gain over the past week. Bodnar provided commentary on the recent developments from Acelyrin, noting that the company had announced updated data from its Phase 1/2 study of lonigutamab (loni) for the treatment of thyroid eye disease (TED) after the market closed on Monday.

The company also shared details about the forthcoming Phase 3 program, which is set to begin in the first quarter of 2025.

Acelyrin revealed that the dosing regimen for the next phase would be a 100 mg loading dose followed by 50 mg every two weeks (Q2W). This decision was based on the updated data, which showed that lower doses administered every four weeks (Q4W) were subtherapeutic.

The ideal minimum concentration (Cmin) required for consistent and maximized efficacy was determined to be 3 ug/ml, a level achieved with a 50 mg loading dose followed by 25 mg weekly (QW). This regimen resulted in a Cmin of 3.6 ug/ml, while the 50 mg Q4W regimen only reached a Cmin of 0.1 ug/ml, leading to a loss of proptosis response after Week 6.

The company's analysis indicated that the pharmacokinetic (PK) data with the 100 mg loading dose plus 50 mg Q2W regimen was comparable to the 50 mg loading plus 25 mg QW regimen, suggesting that it could achieve receptor saturation and therapeutic concentration within days.

https://www.investing.com/news/analyst-ratings/hc-wainwright-cuts-acelyrin-stock-target-keeps-neutral-on-trial-data-93CH-3800024

Hoth Phase 2a: 100% Success in Combating Cancer Treatment Skin Toxicities

 

  • 100% of Patients in Cohort 1 Achieve Primary Efficacy Endpoint
  • No Treatment-Related Adverse Effects Observed
  • Preserves Cancer Treatment Efficacy with Zero Dose Reductions

Getty Images and Shutterstock to Merge, Creating a Premier Visual Content Company

 

  • Merged company will be well-positioned to meet the evolving needs of creative, media, and advertising industries through combined investment in content creation, event coverage, and product and technology innovation
  • Expected annual cost synergies between $150 million and $200 million by year three
  • Expected to be accretive to earnings and cash flow beginning in year two
  • Companies will hold conference call to discuss the transaction with investment community today at 8.30a.m. EST

Getty Images and Shutterstock will hold a conference call to discuss the transaction today, January 7, 2025, at 8:30 a.m. Eastern Time. The live webcast will be accessible through the Investor Relations section of the each company’s website at https://investors.gettyimages.com/ and https://investor.shutterstock.com.

To access the call through a conference line, dial 1-800-445-7795 (in the U.S.) or 1-785-424-1699 (international callers). The conference ID for the call is GETTY. A replay of the conference call will be posted shortly after the call and will be available for fourteen days following the call. To access the replay, dial 1-844-512-2921 (in the U.S.) or 1-412-317-6671 (international callers). The access code for the replay is 11156500.

https://www.globenewswire.com/news-release/2025/01/07/3005175/0/en/Getty-Images-and-Shutterstock-to-Merge-Creating-a-Premier-Visual-Content-Company.html

Monday, January 6, 2025

Hookipa: Holder Gilead to vote for merger

 Further to the announcement on 2 January 2025 (the “2.4 Announcement”), the Boards of Poolbeg and HOOKIPA are pleased to confirm that significant HOOKIPA shareholder, Gilead Sciences Inc. (“Gilead”), has indicated its intention to vote consistent with the HOOKIPA Board's recommendation if a formal offer were to be made and to participate in the proposed concurrent Fundraise, consistent with its current contractual obligations. Gilead owns 1,875,947 HOOKIPA common shares, representing 19.4% of HOOKIPA’s existing issued share capital. 

Additionally, HOOKIPA has amended the details of the Fundraise that were disclosed in the 2.4 Announcement. HOOKIPA is now expected to undertake a 100% primary private placement fundraise of approximately $30 million+. The 2.4 Announcement stated that HOOKIPA is expected to undertake a 100% private placement fundraise of up to approximately $30 million. An updated version of the Fundraise Presentation will be available on both companies’ websites in due course.

Oppenheimer & Co. Inc. has been engaged by HOOKIPA as placement agent in connection with the private placement fundraise.

https://www.globenewswire.com/news-release/2025/01/07/3005095/0/en/Poolbeg-Pharma-plc-Poolbeg-and-HOOKIPA-Pharma-Inc-HOOKIPA-Update-on-Potential-Combination-of-Poolbeg-and-HOOKIPA.html

Top 3 takeaways from Nvidia's CES 2025 keynote

 Nvidia (NVDA) CEO Jensen Huang kicked off CES 2025 with a keynote outlining the company's AI ambitions for consumer and enterprise users for the year ahead. Huang debuted a number of new software technologies designed to help train humanoid robots and power a variety of AI applications.

The company also announced new gaming hardware, including its high-flying $1,999 GeForce RTX 5090 graphics card for desktop PCs.

Huang covered a lot of ground during his speech, but these are the biggest takeaways from the event.

A new AI chip

Nvidia has a new AI superchip. No, it's not the successor to the company's latest Blackwell chip, which it debuted during its GTC 2024 conference last March. This is a pint-sized version of its high-powered GB200 platform.

Called the GB10, the chip is based on the GB200, which customers including Amazon, Google, Meta, Microsoft, and Tesla are snatching up in droves. But while the GB200 pairs two Blackwell graphics processing units (GPUs) with one of Nvidia's Grace central processing units (CPUs), the GB10 marries one Blackwell GPU to a Grace CPU.

"This little thing here is in full production," Huang said during the keynote. "We’re expecting this computer to be available in the May time frame.”

Nvidia also isn't touting the GB10 as a data center platform. Instead, the company says it will be available in a desktop it's calling Project DIGITS. Project DIGITS combines the GB10 with 128GB of unified memory and 4TB of storage to create an AI computing system that can sit on your desk.

Nvidia CEO Jensen Huang delivers a keynote address at the Consumer Electronics Show (CES) in Las Vegas, Nevada on January 6, 2025. Gadgets, robots and vehicles imbued with artificial intelligence will once again vie for attention at the Consumer Electronics Show, as vendors behind the scenes will seek ways to deal with tariffs threatened by US President-elect Donald Trump. The annual Consumer Electronics Show (CES) opens formally in Las Vegas on January 7, 2025, but preceding days are packed with product announcements. (Photo by Patrick T. Fallon / AFP) (Photo by PATRICK T. FALLON/AFP via Getty Images)
Nvidia CEO Jensen Huang delivers a keynote address at the Consumer Electronics Show (CES) in Las Vegas, Nevada on January 6, 2025. Gadgets, robots and vehicles imbued with artificial intelligence will once again vie for attention at the Consumer Electronics Show, as vendors behind the scenes will seek ways to deal with tariffs threatened by US President-elect Donald Trump. The annual Consumer Electronics Show (CES) opens formally in Las Vegas on January 7, 2025, but preceding days are packed with product announcements. (Photo by Patrick T. Fallon / AFP) (Photo by PATRICK T. FALLON/AFP via Getty Images) · PATRICK T. FALLON via Getty Images

Robots and self-driving cars

In addition to its new chip and desktop, Nvidia showed off its new Cosmos platform for developing physical AI systems like robots and self-driving vehicles. The platform uses world foundation models, or WFMs, which are AI models that simulate conditions in the real world.

The idea is for companies to use Cosmos to help develop the software needed to power robots and self-driving cars by simulating various usage scenarios in a virtual setting without having to use pricey robots or putting cars on the road in the real world.

Nvidia also provided information about its Isaac GROOT Blueprint software, which developers will be able to use via Apple's Vision Pro headset to teach humanoid robots how to move in certain scenarios and situations.

As for vehicles, Nvidia said Toyota, Continental, and Aurora are using its automotive suite of technologies to power their advanced driving and autonomous driving systems.

"The [autonomous vehicle] revolution has arrived," Huang said during the keynote. "I predict that this will likely be the first multi-trillion-dollar robotics industry.”

Gaming graphics cards

Nvidia owes its incredible performance over the past year to its early investments in AI technologies. But that doesn't mean it's leaving its gaming roots behind. The company on Monday showed off its new GeForce RTX 50 series of graphics cards for desktop and laptop computers.

The top-of-the-line RTX 5090 promises twice the performance of last generation's top dog, the RTX 4090, while Nvidia says its new entry-level RTX 5070 can match the RTX 4090's gaming capabilities thanks to advances to its proprietary DLSS software, which can do things like render and generate frames for games using AI.


https://finance.yahoo.com/news/top-3-takeaways-from-nvidias-ces-2025-keynote-044257032.html

Germany's Gun-Grab? Saxony-Anhalt Begins Disarming AfD Members

 Via Remix News,

Authorities in Germany have begun withdrawing gun ownership licenses from Alternative for Germany (AfD) members, who are deemed a “danger to public safety.”

So far, five AfD members have received a notice that their gun license would be revoked, while another member voluntarily returned his license after a revocation procedure was initiated. Another 51 cases are currently being examined by authorities, according to data released by the Saxony-Anhalt Interior Ministry in response to a request for information from the Left Party.

Hunters and sport shooters will also have their gun licenses canceled by authorities. In total, there are 74 members of the AfD in Saxony-Anhalt that hold a firearms license, with 49 registered as sport shooters and 25 as hunters.

The revocation of gun licenses comes after the Office of the Protection of the Constitution (BfV), Germany’s powerful domestic intelligence agency, classified the AfD as “certainly right-wing extremist.” With this designation, AfD members suddenly faced a litany of problems. For one, authorities could spy on their communications without any warrant; however, authorities could also seize their firearms, and members could also face issues with government employment.

The efforts to disarm AfD members won praise from the Left Party’s parliamentary group leader Eva von Angern.

“The first revocation notices show that, after individual examination, these people pose a threat to public safety,” she said to German news outlet Mitteldeutsche Zeitung.

As Remix News has reported in the past, the BfV has also been active designating the AfD as an extremist threat in other states such as North Rhine-Westphalia, where gun owners are also under threat of having their firearms taken away from them.

The BfV is a highly politicized intelligence agency targeting domestic “threats” to the constitutional order, while critics contend it is designed to snuff out political opposition. The agency is currently monitoring AfD members in a number of states, including tapping their phones and surveilling their internet communications, all without a warrant. Currently, their membership in the party offers enough legal grounds to target what is the second-largest party in the country.

In 2023, the Gera Administrative Court ruled that the Thuringian Ministry of the Interior cannot revoke firearms licenses of AfD members in a blanket measure; however, it left the door open for individual cases.

AMD’s new GPUs were a complete no-show at CES 2025

 Many awaited AMD’s CES 2025 keynote with bated breath. After all, the company was expected to divulge more information about the RX 9000 series, which could soon compete against some of the best graphics cards.

But, by the end of the keynote, the YouTube chat and my own mind were both flooded with just one question: “What about new graphics cards?”

AMD’s 45-minute keynote was packed with announcements. We got a lot of updates on various CPUs, including the new Ryzen 9950X3D, and a slew of laptop processors and APUs. However, the graphics segment didn’t receive any love from AMD, even though that was clearly what many viewers were hoping for.

Jack Huynh, the senior vice president and general manager of AMD’s Computing and Graphics Group, teased the RDNA 4 architecture and machine-learning-based upscaling with FSR 4. This is when I thought we’d hear some exciting RX 9070 XT news, but instead, we got a video from Matt Booty, the president of Game Content and Studios at Microsoft.

Although he teased that technologies like FSR 4 make games like Starfield run better, there was nothing concrete to back up these statements. FSR 4 is still a mystery, as is RDNA 4.

“We absolutely love the gaming community, and we look forward to telling you more about RDNA 4 and FSR 4 later this quarter,” Huynh said. “Now, let’s shift gears to AI PCs.” And that they did, as the rest of the presentation focused largely on non-gaming experiences, including workstations and enterprise-AI-focused CPUs and APUs.

A promise of learning more later this quarter was the last thing I expected. Possible specs for RX 9000 series GPUs have been floating around the internet for weeks now, and yet, there was next to no mention of these cards during CES 2025.

Mind you, the weirdest part is that AMD did share some information about its upcoming GPUs with the media, but it was admittedly pretty scarce. This is another reason why I’m surprised. I went into the keynote thinking we’d get to learn more during the presentation, but we actually got much less than I ever expected, as those RDNA 4-related slides never made it in.

What do we know? We know that the new GPUs will be dubbed the RX 9070 and the RX 9060 (as well as their XT counterparts), which we’ve already expected based on previous leaks. AMD shared a slide explaining this change in its naming scheme, saying that it wanted to “simplify it.”

AMD teased the RDNA 4 architecture, pointing to various hardware- and software-level improvements, including better ray tracing capabilities thanks to third-gen RT accelerators. The slides also revealed that we may not get Made By AMD RX 9000 cards, and that all the GPUs will instead be made by AMD’s partners, including Acer, Asus, XFX, Gigabyte, and more.

FSR 4 got its own slide, and arguably, it got more screen time during the presentation than RDNA 4 itself did. It feels like AMD is taking a page out of Nvidia’s playbook here, as Nvidia’s DLSS 3 is an RTX 40-series exclusive, whereas FSR 3 used to be widely available. That will no longer be the case with FSR 4, which will only be available in RDNA 4 GPUs.

In addition, AMD gave us some insight as to the kind of performance we can expect from the new RDNA 4 GPUs. The RX 9070 cards are listed as competitors to the RTX 4070 Ti and the RTX 4070 Super. On AMD’s side, the top GPU is set to keep up with the RX 7900 XT; last-gen’s flagship RX 7900 XTX will remain undefeated. Meanwhile, the RX 9060 will match up against the RTX 4060 Ti and the RX 7700 XT at the most.

This performance bracket is useful, but it doesn’t tell us anything in the way of actual GPU specifications. Leakers have long said that the new AMD flagship will be based on the Navi 48 GPU, and recent rumors claim that it’ll come with 4,096 cores, 16GB of GDDR7 VRAM across a 256-bit bus, and memory speeds of 18Gbps. Clock speeds are said to be high in this generation, with some tipsters saying we can expect up to 3.1GHz.

That’s all well and good, but the problem with all of those spec-related statements is that they’re rumors. They may be true, they may be false — we just don’t know. That’s a strange place to be in, given that AMD just held a 45-minute presentation during the year’s biggest computing event.

Personally, I was really excited about the prospect of AMD’s RX 9070 XT. I still am, but it’s hard not to feel surprised at the way AMD glossed over all the details of one of its most-anticipated gaming products set to come out this year.

Sure, we now know that the RX 9070 XT will be an upper-midrange card targeting the mainstream market — but we already knew as much, and today brought us very little in the way of new information. The biggest revelation was the fact that FSR 4 will be an RDNA 4 exclusive; everything else was already speculated about for weeks.

We still have a lot of unknowns, including some of the most basic information, such as specs, prices, and release dates for these new cards. All we know is that we’ll learn more during this quarter, but that could mean in two weeks or in two months.

In 2024, AMD CEO Lisa Su teased RDNA 4 while divulging that the company’s gaming revenue declined by 69% year-over-year. Despite a tumultuous year for AMD’s gaming business, Su also promised that RDNA 4 will launch in early 2025, which is reassuring. But it does make me wonder what AMD is waiting for.

Meanwhile, Nvidia is just hours away from announcing its next-gen RTX 50-series. It’s hard to say how much Team Green will be ready to reveal, but at this point, Nvidia won’t need to do much to beat AMD at CES 2025. All Nvidia has to do is say which graphics cards are coming and give a rough overview of each. That’ll still be more than we got from AMD — and it’s hard not to feel a little disappointed.

https://www.yahoo.com/tech/amd-gpus-were-complete-no-234212018.html