Autolus Therapeutics reported fourth-quarter and full-year 2025 results that reflect its first commercial year for AUCATZYL. Net product revenue reached $23.3 million in Q4 2025 and $74.3 million for the full year, driving total 2025 revenue to $75.4 million including license revenue.
Autolus projects 2026 AUCATZYL net product revenue of $120 million to $135 million and expects to achieve a shift to positive gross margin in 2026 as volumes rise and manufacturing efficiency improves. Cost of sales were $96.4 million in 2025, research and development expenses $117.7 million, and selling, general and administrative expenses $131.9 million, resulting in a full-year net loss of $287.5 million.
Cash, cash equivalents and marketable securities totaled $300.7 million as of December 31, 2025, down from $588.0 million a year earlier, and the company expects this funding, together with anticipated AUCATZYL revenue, to support operations into Q4 2027. Autolus also highlighted advancing trials of obe-cel in pediatric B-ALL, lupus nephritis, progressive multiple sclerosis and systemic lupus erythematosus with multiple data readouts expected between year-end 2026 and 2028.
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