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Saturday, March 7, 2020

Diamond Princess passenger dies, bringing ship’s death toll to seven

A man who had been aboard the Diamond Princess cruise ship and was infected with coronavirus has died, bringing the death toll from the ship to seven, Japanese public broadcaster NHK said on Saturday.

The man was not Japanese, NHK said, without giving details of his nationality or age. That would make him the second foreigner from the ship to die, after a British man died last month.

Japan’s handling of the outbreak on the luxury cruise ship, which was quarantined at the port of Yokohama, sparked international criticism and has tarnished what was supposed to be a triumphant Olympic year for Prime Minister Shinzo Abe.
The ship was evacuated last month.
The number of domestic infections has risen to 1,149 cases, NHK said, including 10 new infections in Osaka.
https://www.reuters.com/article/us-health-coroanvirus-japan/diamond-princess-passenger-dies-bringing-ships-death-toll-to-seven-nhk-idUSKBN20U0KQ?il=0

U.S. financial regulators start contingency plans as virus hits DC

U.S. financial regulators are preparing contingency arrangements, including travel restrictions and home-working, to ensure they can effectively oversee the financial markets as the coronavirus closes in on the U.S. capital.
On Friday, U.S. officials said the first three cases of the flu-like disease had been diagnosed in Montgomery County, Maryland, home to thousands of federal workers who travel in to offices in nearby Washington daily.
Agencies including the Commodity Futures Trading Commission (CFTC), the Securities and Exchange Commission (SEC), and the banking regulators also have offices in New York, San Francisco and New Jersey where other cases have been reported.
As New York banks start triggering their contingency plans, their watchdogs have also begun to take precautions, allowing more home-working, cancelling and limiting travel, calling off conferences, and restricting some external meetings.
“The safety and health of CFTC employees is our top priority,” Michael Short, director of public affairs at the agency said on Friday. “The CFTC continues to make all necessary preparations to accommodate scenarios that might arise.”
The derivatives watchdog has canceled some foreign travel and is allowing essential overseas trips on a case-by-case basis, he said. Domestic travel is still permitted, but staff are free to reschedule trips unless it is mission-critical.
Likewise, the Federal Deposit Insurance Corporation said it had taken steps to limit non-essential international travel. The Office of the Comptroller of the Currency (OCC) said it had reviewed its contingency plans, without elaborating.
On Thursday, the OCC along with the Federal Reserve and the FDIC canceled a joint conference on fair lending scheduled for next week “out of an abundance of caution,” they said.
Reuters also reported on Friday that the U.S. Federal Reserve had taken the unusual step of quarantining U.S. dollars it receives from Asia for up to 10 days.
A spokeswoman for the SEC said the agency was following government advice that staff stay home when they are sick or when they have returned from coronavirus hotspots.
“The agency also is focused on ensuring telework readiness and adjusting travel arrangements where appropriate,” she added.

JUGGLING

The coronavirus has spread to 85 countries, infecting more than 100,000 people, according to a Reuters tally based on statements from health ministries and government officials.
U.S. Treasury debt yields plunged to historic lows on Friday, while U.S. stocks tanked and the Dow Jones shed more than 800 points before paring losses.
The U.S. Office of Personnel Management, which oversees federal workers, trains federal agency staff annually on contingency plans for disruptions like a lapse in funding or epidemic-type scenarios.
“The first level of planning is behind the scenes and to make sure that you’ve got a contingency plan for anything and everything that can happen,” said Thomas Vartanian, a George Mason law professor and former senior OCC official.
Still, the market turmoil is adding to the regulatory workload, requiring officials to ramp-up market monitoring, and communicate daily with one another and the industry.
Short said the CFTC’s market intelligence team was providing multiple daily briefings, while the OCC said it had stepped up scrutiny of banks to ensure their plans are “relevant” and reflect a “comprehensive understanding” of their specific risks.
The agencies are also grappling with other issues, including how companies should disclose financial risks created by the virus, and which trading and lending rules may need to be relaxed to accommodate the disruption.
On Friday, the Fed said it was considering how it could encourage financial firms to ease loan repayment terms for people adversely affected by the virus. The central bank, alongside the OCC and FDIC and other agencies, also on Friday issued updated contingency planning guidelines to the industry.

Vartanian said regulators had to strike a balance between bolstering confidence in system safeguards, without taking measures that could actually increase market panic.
“Your job as a regulator is to make sure everybody has complete confidence in the system, because if the confidence disappears, it doesn’t matter what the crisis is.”
https://www.reuters.com/article/us-health-coronavirus-usa-regulators/u-s-financial-regulators-start-contingency-planning-as-virus-reaches-washington-idUSKBN20T2WH?il=0

Leader of Italy’s Democratic Party contracts coronavirus

The leader of Italy’s co-ruling Democratic Party (PD), Nicola Zingaretti, said on Saturday he had tested positive for coronavirus becoming the first senior Italian politician to be infected.
“I have coronavirus too”, Zingaretti said in a video posted on Facebook, adding he was well and in self-isolation at home.
Italy has been the country hit hardest by the epidemic in Europe with a total of 4,636 cases and 197 deaths as of Friday, and is reporting more deaths per day form the virus than any other nation in the world.
The government this week ordered the closure of schools, universities, cinemas and theaters to stem infections.
The case of Zingaretti, who is also governor of the central region of Lazio, which includes the capital Rome, could cause concern among government ranks given the frequent contacts he has with ministers, regional administrators and PD members.
In his message, Zingaretti said his family was following the required protocols and all the people he had been in contact with in recent days were being contacted for checks.
“I said it before, no panic. Let’s fight. I will set a good example and follow to the letter the rules set by doctors and scientists,” he said.
Italy’s Industry Minister Stefano Patuanelli has put himself in isolation after one of his aides tested positive. Attilio Fontana, regional governor of the northern region of Lombardy, the most affected area of the country, did the same thing.

Politicians of all stripes sent Zingaretti messages of support.
“In this emergency our common enemy is the coronavirus, we’ll only be able to defeat it if we stay united and work together,” said Vito Crimi, the caretaker leader of the anti-establishment 5-Star Movement which governs with the PD.
https://www.reuters.com/article/us-health-coronavirus-italy-pd/leader-of-italys-democratic-party-contracts-coronavirus-idUSKBN20U0IA?il=0

Zentalis Pharmaceuticals readies IPO

Zentalis Pharmaceuticals (ZNTL) has filed a preliminary prospectus for a $100M IPO.
The New York City-based biopharmaceutical firm develops small molecule cancer therapies based on its Integrated Discovery Engine. Lead candidate is ZN-c5, an oral selective estrogen receptor degrader (SERD) in Phase 1/2 development for ER+/HER2- advanced/metastatic breast cancer. Topline data from the first phase should be available in H2. Other pipeline candidates include Phase 1/2-stage ZN-c3 for solid tumors and Phase 1/2-stage ZN-e4 for non-small cell lung cancer (NSCLC).
2019 Financials: Operating Expenses: $46.8M (+97%); Net Loss: ($45.7M) (-117%); Cash Burn: ($39.1M) (-61%).
https://seekingalpha.com/news/3549545-zentalis-pharmaceuticals-readies-ipo

Lyra Therapeutics on deck for IPO

Lyra Therapeutics (LYRA) has filed a prospectus for a $57.5M IPO.
The Watertown, MA-based firm develops integrated drug and delivery solutions for the localized treatment of ear, nose and throat disorders leveraging its technology platform called XTreo, designed to deliver medicines directly to affected tissue for sustained periods via a single administration.
Lead candidate is Phase 2-stage LYR-210, a bioresorbable polymeric matrix administered non-invasively in a doctor’s office, that delivers medication (mometasone furoate) for as long as six months to the sinonasal passages for the treatment of chronic rhinosinusitis (sinus inflammation). Mometasone furoate, a corticosteroid, is the active ingredient in certain nasal sprays for sneezing and runny noses and topical treatments for dermatitis and psoriasis.
2019 financials: Operating Expenses: $16.5M (+94%); Net Loss: ($16.3M) (-172%); Cash Burn: ($13.8M) (-109%).
https://seekingalpha.com/news/3549546-lyra-therapeutics-on-deck-for-ipo

Amazon wants to cure common cold

Amazon’s (NASDAQ:AMZN) secretive “Project Gesundheit” is working on a cure for the common cold, according to CNBC sources.
The small group of scientists and technologists in the project are working under the umbrella of the Grand Challenge, Amazon’s R&D group within AWS.
The team wants to develop a vaccine but is exploring other approaches.
Project Gesundheit would be Amazon’s latest push into healthcare, which has also included the PillPack acquisition and launch of the employee-focused Amazon Care clinics.
https://seekingalpha.com/news/3549488-amazon-wants-to-cure-common-cold-cnbc

FDA OKs Novartis’ osilodrostat for adrenal gland disorder

The FDA approves Novartis’ (NYSE:NVS) Isturisa (osilodrostat) oral tablets for the treatment of adults with Cushing’s disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease.
Cushing’s disease, or hypercortisolism, is a rare metabolic disorder in which the adrenal glands produce too much of the hormone cortisol leading to high blood pressure, bone loss and physical changes such as a rounded face and fally lump between the shoulders. A common cause is a pituitary tumor secreting excess adrenocorticotropic hormone (ACTH) which stimulates the production of cortisol.
Osilodrostat controls the level of cortisol by inhibiting an enzyme called 11β-hydroxylase that plays a key role in the final step of cortisol biosynthesis in the adrenal glands.
https://seekingalpha.com/news/3549544-fda-oks-novartis-osilodrostat-for-adrenal-gland-disorder