A post hoc analysis of patients with higher transfusion burden at baseline showed a larger percentage of patients achieved transfusion independence ≥ 56 days with roxadustat vs. placebo (36.1% vs 11.5%; p=0.047ǂ).
Dr. Moshe Mittelman’s presentation was selected for the “2024 Highlights of ASH”
“At WCIRDC over the past days, we had the opportunity to lay out the foundational preclinical work and the data sets which supported that beta cell proliferation and their functional improvement is tractable to BMF-219, not only in animals, but also in the human islets, which we studied together with the
At Week 26, 22 weeks after the last dose of a 4-week treatment with BMF-219, approximately 40% of patients from the 200 mg QD cohorts (4/11) displayed durable reduction in HbA1c of 1% or more; effectively near doubling the percentage of patients as compared to 20% observed in the 100 mg QD cohorts (n=20) presented this week at the World Congress Insulin Resistance, Diabetes & Cardiovascular Disease (WCIRDC). At the ATTD taking place in
To date, the dose escalation portion has shown, after only 4-weeks of dosing with BMF-219, that patients across all dosing cohorts (n=52) have consistently experienced generally meaningful HbA1c reductions. Patient cohorts at higher dose levels have seen greater pharmacokinetic exposure of BMF-219. Variability seen in HbA1c reduction is viewed as being related to several factors including patients’ prior lines of therapies, years since diagnosis, beta cell function scores (Homa-B) and others. Based on the preclinical data, including the WCIRDC published presentations, we believe the responses seen to date will improve with longer dose durations and higher dose levels.
The best performing dosing cohort announced so far is cohort 3 (100 mg without food, n=10), where we reported a mean HbA1c reduction of 0.81% after only 4 weeks of dosing. In cohort 3, we enrolled 90% frontline patients on a single diabetic therapy with a mean HbA1c level reported of 8.1% at baseline; here only 10% of the patients were on two or more therapeutic agents. The dose cohorts we enrolled in addition to the 100 mg cohorts (50 mg, 100 mg BID, 200 mg, n=32) had between approximately 30%-100% of patients on two or more background agents, while failing with above normal HbA1c levels (baseline HbA1c ranging from 7.9% to 8.4%). In these cohorts the mean HbA1c reduction was observed between 0.4% to 0.5%, after four weeks of dosing. Considering the consistency of our responses, we believe we have confirmed clinically meaningful activity across all dosing cohorts.
Investors are facing a pivotal week as a key measure of inflation that hits Tuesday and the Federal Reserve’s interest-rate decision on Wednesday are expected to set the tone for the stock market and economy heading into 2024.
Growing speculation that the Fed is done hiking rates and will start cutting by mid-year is fueling a sharp drop in Treasury yields and rekindling investors’ risk appetite. The S&P 500 Index has added roughly $4 trillion in market value since late October, as traders rush into beaten-down areas of the market like small caps, which typically benefit from falling borrowing costs.
The Centers for Disease Control (CDC) issued a travel advisory for Mexico Friday, citing “reports” of Rocky Mountain spotted fever.
“There have been reports of Rocky Mountain spotted fever (RMSF) in people traveling to the United States from Tecate, in the state of Baja California, Mexico,” the CDC said in its advisory.
The CDC said the disease has been found in “urban areas” in some states in northern Mexico like Baja California, Sonora, Chihuahua, Coahuila and Nuevo León, but is “not exclusive” to them. The agency also noted “ticks spread the bacteria” that causes Rocky Mountain spotted fever and that dogs can carry those ticks, but the disease is not spread from person to person.
The agency said people can protect themselves from the disease by using insect repellents, checking for ticks on one’s body and clothing, using tick-preventatives on dogs when traveling with them and getting medical attention if you or a family member “has traveled to Tecate or another city in northern Mexico and develops symptoms during travel or within 2 weeks of returning to the United States.”
The disease has symptoms like fever, headache and rash, according to the CDC. The agency said that rash can appear two to four days “after onset of symptoms, however, some patients never develop a rash.”
“The disease can rapidly progress and be deadly if not treated early with the recommended antibiotic,” the CDC said. “Children younger than 10 years old are five times more likely than adults to die from RMSF.”
Violent crime is quickly spreading to suburbia. A new report shows gangs from South America have targeted mansions in wealthy neighborhoods across the Detroit metro area. This comes as the Biden administration's disastrous open border policies have flooded the country with millions of illegal migrants, as well as progressive cities fail to enforce 'common sense' law and order.
WXYZ Detroit reported at least 30 to 40 homes in upscale neighborhoods across Detroit have been targeted by "highly functional and well-trained" gangs from South America this fall.
Thieves are using high-tech "jammers" to disable WiFi home security systems. They're primarily after cash, jewelry, and expensive handbags.
Last week, Oakland County Sheriff Michael Bouchard said thieves are part of "transnational gangs" operating across the country and are targeting multi-million dollar homes.
In recent months, we have shared an emerging theme of thieves across the country targeting wealthy households:
This disturbing trend comes as illegal migrant encounters by the Customs and Border Protection on the southern border hit a record high. President Biden's disastrous open southern border has flooded the country with 9 million illegals since he took office. Also, Democrat lawmakers, some of whom are Soros-backed, fail to enforce common sense law and order, transforming some metros into lawless, crime-ridden hellholes.
Democrats are turning this nation into a third-world-like state - and now criminals, emboldened by failed progressive policies, have the rich in their crosshairs in suburbia.
The only advice for law-abiding Americans who want to defend their families and homes in suburbia, where the average police could be upwards of ten minutes or more, is to get proper firearms training from a professional.
https://www.zerohedge.com/markets/south-american-gangs-target-dozens-mansions-detroit
The U.S. government has expanded a program offering free COVID-19 and flu tests and treatment.
The Home Test to Treat program is virtual and offers at-home rapid tests, telehealth sessions, and at-home treatments to people nationwide. The program is a collaboration among the National Institutes of Health, the Administration for Strategic Preparedness and Response, and the CDC. It began as a pilot program in some locations this year.
"With its expansion, the Home Test to Treat program will now offer free testing, telehealth and treatment for both COVID-19 and for influenza (flu) A and B," the NIH said in a press release. "It is the first public health program that includes home testing technology at such a scale for both COVID-19 and flu."
The news release says that anyone 18 or over with a current positive test for COVID-19 or flu can get free telehealth care and medicine delivered to their home.
Adults who don't have COVID-19 or the flu can get free tests if they are uninsured or are enrolled in Medicare, Medicaid, the Veterans Affairs health care system, or Indian Health Services. If they test positive later, they can get free telehealth care and, if prescribed, treatment.
"I think that these [telehealth] delivery mechanisms are going to be absolutely crucial to unburden the in-person offices and the lines that we have and wait times," said Michael Mina, MD, chief science officer at eMed, the company that helped implement the new Home Test to Treat program, to ABC News.
ABC notes that COVID tests can also be ordered at covidtests.gov – four tests per household or eight for those who have yet to order any this fall.
Sources:
National institutes of health: "home test to treat program extends nationwide."
ABC News: "Free at-home testing and treatments now available for COVID and flu through federal program."
For relief of acute migraine, triptans, ergots, and antiemetics are two to five times more effective than ibuprofen, and acetaminophen is the least effective medication, new results from large, real-world analysis of self-reported patient data show.
"Our findings that triptans, ergots, and antiemetics are the most effective classes of medications align with the guideline recommendations and offer generalizable insights to complement clinical practice," the authors write.
The study, with first author Chia-Chun Chiang, MD, Department of Neurology, Mayo Clinic, Rochester, Minnesota, was published online November 29 in Neurology.
The findings are based on subjective user-reported ratings of effectiveness and information on side effects, dosages, and formulations were not available. The newer migraine medication classes, gepants and ditans, were not included due to the relatively lower number of treated attacks. The regression model did not include age, gender, pain intensity, and other migraine-associated symptoms, which could potentially affect treatment effectiveness.
Funding for the study was provided by the Kanagawa University of Human Service research fund. A full list of author disclosures can be found with the original article.
https://www.medscape.com/viewarticle/which-migraine-medications-are-most-effective-2023a1000uq9
