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Monday, December 11, 2023

Bristol Myers to pay $800 million to Chinese drugmaker to develop cancer drug

 Bristol Myers Squibb said on Monday it will pay $800 million up front and up to $8.4 billion to Sichuan Biokin Pharmaceutical to develop and commercialize one of the Chinese drugmaker's cancer treatments outside China.

Bristol Myers said it will pay Sichuan unit SystImmune up to $500 million in contingent near-term payments to co-develop an antibody-drug conjugate (ADC) that it said has shown promise against a range of solid tumors, including non-small cell lung cancer and breast cancer. The treatment is currently in early stage clinical trials.

SystImmune will be eligible for additional payments of up to $7.1 billion contingent upon the achievement of certain development, regulatory and sales performance milestones.

Under the terms of the agreement, SystImmune will be solely responsible for development and commercialization of the drug in mainland China, while Bristol Myers will have those responsibilities for areas outside the country.

Unlike conventional chemotherapy, which can kill healthy cells, ADCs are like guided missiles designed to target only cancer cells, potentially reducing damage to normal cells.

Interest in ADC-makers has surged over the past year. Pfizer is in the process of buying ADC pioneer Seagen in a $43 billion deal announced in March.

In October, Merck said it would pay Japanese drugmaker Daiichi Sankyo $5.5 billion to jointly develop three ADCs, and AbbVie struck a $10.1 billion deal to buy Immunigen last month.

SystImmune is a U.S.-based unit of Sichuan Biokin. U.S. venture capital firm OrbiMed has also invested in SystImmune.

https://news.yahoo.com/bristol-myers-systimmune-collaborate-cancer-213204840.html

'Why Palestinian displacement in Gaza war alarms the UN and Arabs'

 Israel's orders to Gaza's residents to move ever further south towards the Egyptian border during its offensive and the dire humanitarian situation have sparked Arab and U.N. concerns that Palestinians may eventually be driven over the border.

Israel denies having any plans to push Palestinians into Egypt's Sinai Peninsula as it pursues its goal of destroying Hamas following the group's devastating Oct. 7 attack on Israeli soil. It says it has told Gazans to move for their own safety.

WHAT IS BEHIND THE CONCERNS?

Palestinians have long been haunted by what they call the "Nakba", or catastrophe, when 700,000 of them were dispossessed from their homes when Israel was created in 1948.

Many were driven out or fled to neighbouring Arab states, including to Jordan, Syria and Lebanon, where many of them or their descendants still live in refugee camps. Some went to Gaza. Israel disputes the account that they were forced out.

The latest conflict has seen an unprecedented Israeli bombardment and land offensive in Gaza, devastating urban areas throughout the enclave. Palestinians and U.N. officials say there are no longer any safe areas inside Gaza to seek shelter.

WHAT HAS HAPPENED DURING THIS CONFLICT?

Before Israel launched its ground offensive in Gaza, it initially told Palestinians in north Gaza to move to what it said were safe areas in the south. As the offensive expanded, Israel told them to head further south towards Rafah, located next to Egypt, the only country apart from Israel to share a border with the enclave, which is only 40 km (24.85 miles) long and a few kilometres wide.

According to U.N. estimates, up to 85% of the 2.3 million people in Gaza - one of the most densely populated areas of the world - have already been displaced from their homes and are now crammed in an ever smaller area near the border.

WHAT HAS HAPPENED DURING PREVIOUS GAZA BORDER INCIDENTS?

There has been no precedent for people fleeing en masse from Gaza during conflicts and flare ups with Israel in recent years, although no previous war has been this fierce. However, there have been incidents when Gaza's border with Egypt was breached, although those crossing numbered hundreds or thousands, and those people were not seeking shelter or to stay.

Following Israel's withdrawal from the Gaza Strip in 2005, Palestinians breached the fence, with some clambering over with make-shift ramps and using ropes. At one place, Palestinian militants rammed a concrete barrier to break a hole.

Hamas breached the frontier again in 2008, challenging a blockade imposed by Israel and Egypt after the group seized control of the Gaza Strip in 2007 from the West Bank-based Palestinian Authority. The border remained breached for about 10 days before Egypt resealed it.

COULD A MAJOR DISPLACEMENT HAPPEN IN THIS CONFLICT?

Many Palestinians inside Gaza have said they would not leave even if they could because they fear it might lead to another permanent displacement in a repeat of 1948. Egypt, meanwhile, has kept the border firmly closed except to let a few thousand foreigners, dual nationals and a handful of others leave Gaza.

Egypt and other Arabs strongly oppose any attempt to push Palestinians over the border.

Yet, the scale of this conflict eclipses other Gaza crises or flare up in past decades, and the humanitarian disaster deepens for Palestinians by the day, leaving them without enough food or water, while few hospitals still function.

WHAT ARE ARAB STATES AND THE U.N. SAYING?

From the earliest days of the conflict, Arab governments, particularly Israel's neighbours Egypt and Jordan, have said Palestinians must not be driven from land where they want to make a future state, which would include the West Bank and Gaza.

Like Palestinians, they fear any mass movement across the border would further undermine prospects for a "two-state solution" - the idea of creating a state of Palestine next to Israel - and leave Arab nations dealing with the consequences.

As the humanitarian crisis has worsened, top U.N. officials have added their voices to concerns about a mass displacement.

"I expect public order to completely break down soon and an even worse situation could unfold including epidemic diseases and increased pressure for mass displacement into Egypt," U.N. Secretary General Antonio Guterres said on Dec. 10.

Philippe Lazzarini, head of the U.N. Palestinian refugee agency UNRWA, wrote in the Los Angeles Times on Dec. 9 that "developments we are witnessing point to attempts to move Palestinians into Egypt, regardless of whether they stay there or are resettled elsewhere."

WHAT HAVE ISRAEL'S GOVERNMENT AND ITS POLITICIANS SAID?

The Israeli government says it is only telling Palestinians to leave their homes temporarily for their safety but comments by some Israeli politicians - including some close to the government - have stoked Palestinian and Arab fears of a new Nakba.

Asked about the Israel Defense Forces (IDF) offensive and the displacement of Gazans, Israeli Agriculture Minister Avi Dichter told Israel's Channel 12 on Nov. 11: "This is Gaza's Nakba, operationally there's no way to conduct a war the way the IDF wants to conduct it inside Gaza territories while the masses are between the tanks and soldiers."

Dichter is a member of Prime Minister Benjamin Netanyahu's Likud party and is also a minister in the security cabinet.

After Jordanian Foreign Minister Ayman Safadi said on Dec. 10 that Israel's offensive was "a systematic effort to empty Gaza of its people," Israeli government spokesperson Eylon Levy called those comments "outrageous and false accusations."

https://news.yahoo.com/un-agency-chief-says-israel-104851650.html

Charity, Due Diligence, and Hamas

 At this time of year, we look for charities to support. Before we pick them, we look into how those charities spend the money they receive. Which is the worthiest cause; which charities carefully spend their income on the purposes we want them to? As individuals, we can research those charities before we write a single check.

Does our government do the same?

Our government spends an enormous amount of our money on “causes” big and small all over the world.

Before they decide to spend billions of dollars in aid and provide favorable public relations to a foreign country or organization, does our establishment take anywhere near the same level of care in these choices that we do in our personal charitable giving?

For example, the above representatives have long given billions of their dollars -- and that means our dollars -- to Hamas, as the administrators of the Gaza Strip.

Since the world was shocked on October 7 by Hamas’ surprise attacks on Israel -- murdering over 1200 innocents, kidnapping over 200, injuring thousands more -- the world has begun to learn things about Hamas that it never suspected.

For many Westerners -- not just Americans -- Hamas has been thought of as two different things: a political activist group happy to use terror, and simultaneously the legitimate, elected government of the Gaza Strip, a section of Israel given home rule powers in 2006.

The world has known that Hamas never really stopped being terrorist in inclination and method. But the world still felt an obligation to “the people of the Gaza Strip” (they call themselves “Palestinians”), so the public accepted the fiction that Hamas wears these two hats, and they would just speak to Hamas, and view Hamas on matters of public policy, as if it were only wearing the hat of the legitimate government of the Gaza Strip.

“We have to send money and aid to Gaza, for the people. We have to send in food and medical equipment. We have to give them irrigation pipes and fertilizer for their nascent farming efforts. We have to give them plumbing and electrical systems so they can develop the infrastructure for a manufacturing community. Hamas is the legitimate government, so we’ll give it to them to distribute.”

The world has imagined that Hamas respected these two distinct hats, and would wear the terrorist hat when receiving guns and bombs from Iran and Lebanon, but would wear the government hat when receiving humanitarian aid from us, and of course Hamas would honor a clear line of demarcation between the two.

All has been revealed since October 7.

As “the innocent residents of Gaza” have pled for food since the war began, the world has been forced to ask, “what about all that agricultural equipment we’ve been sending all these years?” and we learn that they’ve grown precious little food with it.

As “the innocent residents of Gaza” have pled for water since the war began, the world has had to confront the question, “your whole territory is basically shoreline, wouldn’t water treatment plants have been among the first things built with the billions of dollars in aid we’ve sent you?” And the answer comes back that no, they just expected water and food to be supplied for free by others, forever, no matter how they behaved.

As “the innocent residents of Gaza” have pled for a restoration of all the incoming humanitarian aid they’ve grown accustomed to over the years, the world has been forced to realize the truth at last: that there has never been anything humanitarian about it. They’ve been using that aid for something else, all along.

In a revealing December 3 posting, Reuters has had to admit that Israel has discovered far more Hamas tunnels than the West had dared imagine. Over 800 shafts leading to hundreds of kilometers of tunnels. Reuters tellingly compared the network to the New York subway system, crammed into an area less than half the size of NYC.

The intention of such a comparison is to educate the reader on how difficult a job it is for Israel to destroy these illegal terror tunnels.

But there is an added benefit to this comparison: we can now gain some more tangible idea than ever before of exactly how Hamas has been spending the world’s billions and billions of dollars in aid, all these years.

We know what it costs to build a subway system. The digging, the wall construction, the arched ceilings for safety, the depth for security. The electrical wire and plumbing.

Now add the additional cost of doing all this construction in secret, to keep the tunnels hidden. The added cost of doing it under existing buildings rather than open fields. And we -- the West -- have been giving them the materials for this project, all along, without realizing it.

Hamas is a terror network, and it has spent our billions in building a war machine, not in caring for the non-Hamas residents, who have always been nothing more than future conscripts and human shields anyway, in the eyes of Hamas.

It makes you wonder, doesn’t it? Is Hamas the only foreign “legitimate government” misusing our foreign aid, and redirecting humanitarian relief for its own malevolent purposes?

Our government -- and the UN, and other such groups we fund -- all give an incredible amount of our money to foreign governments, and foreign organizations. Academia chooses for us which foreign groups to speak favorably about to our children, and which ones to oppose. Our business community donates incredible resources to the ones we’re supposed to like, and denies the requests of the ones we’re not.

Do any of them even make an effort to be as rigorous with the dollars they manage as we are with our own?

And is Hamas the only one they’ve gotten wrong?

Makes you wonder if perhaps we should take a long hard look at all the money and aid we send to foreign countries. There’s really no hard evidence, yet, to prove that Hamas is an outlier, is there?

John F. Di Leo is a Chicagoland-based international transportation professional and trade compliance consultant. A one-time Milwaukee County Republican Party chairman, he has been writing a regular column for Illinois Review since 2009. Read his book on vote fraud (The Tales of Little Pavel) and his political satires on the current administration (Evening Soup with Basement Joe, Volumes I and II, and the brand new Volume Three).


https://www.americanthinker.com/articles/2023/12/charity_due_diligence_and_hamas.html

Ford's "Test For EV Adoption" Fails: Carmaker Slashes Production Plans For Electric F-150 In Half

 Less than a week after Elon Musk unveiled his apocalypse-surviving, Porsche-out-accelerating, bulletproof CyberTruck, Ford's EV effort is crashing on the Biden-administration ignited fire of unaffordability and high costs.

Having signaled in October during its Q3 earnings call plans to “adjust” production of its all-electric vehicles and delay about $12 billion in investments due to softening demand for higher-priced premium electric vehicles; a memo to suppliers - which was viewed and reported first tonight by Automotive News - indicated plans beginning in January to produce an average of about 1,600 Lightning trucks a week at its Rouge Electric Vehicle Center in Dearborn, Michigan.

Ford had planned for an annual production capacity of 150,000 Lightnings a year, or about 3,200 a week.

That means its production target for 2024 has been halved.

“We’ll continue to match production with customer demand,” a Ford spokeswoman said Monday.

In May 2021, during a flashy introduction, Ford CEO Jim Farley told reporters that the electric F-150 could serve as a proxy for how mainstream buyers will accept battery power.

“I am looking at this vehicle as a test for adoption for electric vehicles,” Farley said.

“We should all watch very carefully how this does in the market.”

It would appear Ford failed that test.

Obviously, while this could be an idiosyncratic F-150 issue, it does not bode well for overall EV adoption... and along with it, the Biden administration's plans to save the world.

It appears Stephen Moore's grim prediction in early November is coming true.

The senior economist at FreedomWorks and former senior economic adviser to President Trump told Fox News in an interview.

"I'm here to tell you, if these trends continue, we're going to see the EV market become the next big flop because car buyers don't want them."

"The obvious lesson for the industry: you can’t bribe Americans to buy cars they don’t want. Given the all-in approach mentality for EVs at Ford and GM, it’s clear that Detroit never got this message," he wrote.

President Biden has set a goal of 50% of all new vehicles by 2030 being either EVs or plug-in hybrids.

https://www.zerohedge.com/technology/fords-test-ev-adoption-fails-carmaker-slashes-production-plans-electric-f-150-half

How patients live with — and fight -- chronic fatigue syndrome

 Chronic fatigue syndrome, also known as myalgic encephalomyelitis, was once considered a rare disease — if it was even considered a real disease at all.

People who complained to their doctor about feeling sick and exhausted were often accused of hypochondria, and their symptoms were written off as the “yuppie flu.”

But the Centers for Disease Control and Prevention released a report last week citing research that revealed 3.3 million American adults have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), making the disease more common than was previously thought.

It’s “a complicated disorder,” according to the Mayo Clinic, and it causes extreme fatigue that lasts for at least six months.

There’s no known cause of ME/CFS, though it might be triggered by a range of different factors, including a bacterial or viral infection, an injury or surgical procedure or severe emotional trauma.

The disease can also run in families, suggesting that it might have a genetic cause.

Symptoms of ME/CFS

The symptoms of ME/CFS can vary from one person to the next, and from day to day. In addition to fatigue, symptoms may include:

  • Extreme exhaustion after physical or mental exercise
  • Problems with memory or thinking
  • Dizziness that worsens with moving from lying down or sitting to standing
  • Muscle or joint pain
  • Unrefreshing sleep
  • Tender or swollen lymph nodes
  • Headaches
ME/CFS, better known as chronic fatigue syndrome, is a difficult-to-diagnose set of symptoms.
ME/CFS, better known as chronic fatigue syndrome, has a difficult-to-diagnose set of symptoms.Getty Images

There are many overlapping symptoms between ME/CFS and fibromyalgia — a disorder characterized by muscle and joint pain — leading some experts to suggest that the two disorders might be different aspects of the same disease.

Lack of support can be a barrier

An added burden to those with ME/CFS is the lack of recognition from friends, family and healthcare professionals. No test or tool can provide a definitive diagnosis, so it can be challenging to get any help.

“I traveled out of state to see an ME/CFS specialist. When I found this doctor, I felt like I was finally supported,” said “Marlene,” a former high school athlete, on the CDC’s “Voice of the Patient” website.

“I also found an adult infectious disease doctor locally who was willing to work with the ME/CFS specialist to come up with the best treatment plan for me,” she added.

Other patients describe similar difficulties with finding support from medical professionals.

“My symptoms started quickly with a sinus infection and did not stop. Each month, there was something new. I would start to get tired for no reason and had a cold that turned into walking pneumonia,” said “Max,” a former hard-charging pharmaceutical executive.

“I was not unlike the many who met with physicians for more than a decade, only to be told it was my imagination,” he said. “Most of my friends don’t believe I am sick (faking that I am OK has become a habit) because I don’t look sick to them.”

Living with ME/CFS — what experts advise

Many people with ME/CFS struggle to get an accurate, timely diagnosis.
Many people with ME/CFS struggle to get an accurate, timely diagnosis.Getty Images

People with ME/CFS sometimes have worsening symptoms after physical or mental exertion, an experience known as post-exertional malaise. It may start within 24 hours after the activity and can last for weeks.

Because there’s no known cure for ME/CFS, medical professionals advise that people living with the disease try “pacing” their activity level to avoid post-exertional malaise. Pacing involves moderating their exertion levels to find a balance between activity and rest.

How medicine can alleviate some pain and suffering

Some medications also can help relieve symptoms of ME/CFS, including antidepressants to reduce the suffering that can occur with any chronic illness.

Some over-the-counter pain relievers might also help with symptoms. And prescription drugs including pregabalin (Lyrica), duloxetine (Cymbalta), amitriptyline or gabapentin (Neurontin) — which are also prescribed for fibromyalgia — might also alleviate pain and fatigue.

Medications are also available to help with orthostatic intolerance, a condition common with ME/CFS that causes people — especially adolescents — to feel faint or nauseous when they stand or sit upright.

Accept a level of ‘new normal’

Despite these therapies, many people with ME/CFS still struggle with day-to-day living.

“I find it takes strength knowing a chronic disease that is not curable is actually controlling you, and that there are physical, as well as mental costs to pay for trying to be ‘normal,'” said Max.

“For this reason, I focus each day on managing the symptoms ME/CFS presents. I still promise myself to be driven and passionate but, mostly, to accept my ‘new normal.'”

https://nypost.com/2023/12/11/lifestyle/what-is-chronic-fatigue-syndrome-how-patients-live-with-the-disease/

Biden warns ‘public opinion can shift’ on Israel as WH accused of snubbing hostage families on Hanukkah

 President Biden warned Monday that global public opinion “can shift overnight” toward Israel’s war in Gaza — as the White House was accused of snubbing family members of hostages held by Hamas from an 800-person Hanukkah celebration.

“Several family members of the American citizen hostages missing in Gaza had asked the White House to attend its Hanukkah reception tonight, but did not receive invitations, one of them tells me,” reported CNN journalist MJ Lee, who recently covered relative pleas for Biden to “get creative.”

White House event invitations and perceived snubs routinely draw attention and it’s unclear who on the West Wing staff would have been responsible for the decision.

Up to seven US citizens and one permanent resident, in addition to dozens of Israelis, are believed to remain captive in the Gaza Strip after being abducted from southern Israel in the Oct. 7 attacks that killed about 1,200 people including 33 Americans.

The Post was not immediately able to confirm the exclusions and the White House did not respond to a request for comment.

US President Joe Biden arrives to speak during a Hanukkah reception in the East Room of the White House in Washington, DC, on December 11, 2023.
US President Joe Biden arrives to speak during a Hanukkah reception in the East Room of the White House in Washington, DC, on December 11, 2023.POOL/AFP via Getty Images

The alleged snubs come as Biden, 81, continues to staunchly support Israel’s invasion of Gaza — potentially putting his own re-election at risk by upsetting younger, Arab and Muslim voters.

At the Hanukkah event Monday night, Biden said “we’re committed to providing military assistance to Israel until they get rid of Hamas” and proclaimed “I’m a Zionist” to cheers.

“But, but, we have to be careful — they have to be careful. The whole world’s public opinion can shift overnight. We can’t let that happen,” Biden said, without elaboration.

“We’re working relentlessly for the safe return of the hostages. I personally spent countless hours — I mean probably up to 20 hours — with the Qataris, the Egyptians, the Israelis to secure the freedom of hostages, to get the trucks in and get humanitarian aid flowing, to convince them to open the gate.”

Ranking member Rep. Gregory Meeks (D-NY) (2nd R) of U.S. House Foreign Affairs Committee speaks during a news conference on the Israel-Hamas war at Rayburn House Office Building on Capitol Hill
Ranking member Rep. Gregory Meeks (D-NY) (2nd R) of U.S. House Foreign Affairs Committee speaks during a news conference on the Israel-Hamas war at Rayburn House Office Building on Capitol Hill.Getty Images

Biden also praised a recent Senate speech on antisemitism from Majority Leader Chuck Schumer (D-NY) in which he said Jews feel “abandoned” and slammed “dogwhistles” from “friends and allies.”

“Everyone in America should read it,” Biden said of Schumer’s address.

“I also recognize your hurt from the silence and the fear for your safety because the surge of antisemitism in the United States of America and around the world is sickening,” Biden said, two days after University of Pennsylvania President Liz Magill resigned after declining to say at a congressional hearing that it was against school rules to call for the genocide of Jews.

“You know we see it across our communities in schools and colleges and social media,” Biden said. “They surface painful scars from millennia to hate of hate to genocide for the Jewish people.”

https://nypost.com/2023/12/11/news/biden-warns-public-opinion-can-shift-on-israel-as-wh-accused-of-snubbing-hostage-families-from-hanukkah-event/