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Tuesday, August 5, 2025

Madrigal: Goldman reiterates buy on strong sales

 Madrigal Pharmaceuticals (NASDAQ:MDGL) reported second-quarter earnings with Rezdiffra sales significantly exceeding expectations, according to Goldman Sachs. According to InvestingPro data, the company maintains strong financial health with a current ratio of 5.91x, indicating robust liquidity to support its growth trajectory.

The company posted Rezdiffra sales of $212.8 million, representing a 55% quarter-over-quarter increase and substantially surpassing Goldman Sachs estimates of $150.9 million and FactSet consensus of $159.4 million. Management attributed the strong performance to robust patient demand and increased prescriber penetration. With a market capitalization of $7.5 billion and impressive gross profit margins of 96.6%,

Goldman Sachs maintained its Buy rating and $567.00 price target on Madrigal, noting that while 80% of the 6,000 target physicians have prescribed Rezdiffra, none have reached peak prescribing levels. The current 23,000+ active patients represent only 7% of the 315,000 initially identified patient population. Analyst consensus remains strongly bullish, with price targets ranging from $256 to $541, reflecting the market’s confidence in Rezdiffra’s potential. 

The investment bank projects Rezdiffra will exit 2025 at an annualized run rate exceeding $1 billion despite expected competition from semaglutide in NASH treatment. European approval is expected imminently, with a German launch to follow.

Goldman Sachs anticipates a potential share re-rating as investors recognize both near-term and long-term opportunities for Rezdiffra as a cornerstone NASH therapy, supported by possible expansion to F4 cirrhotic NASH patients and new intellectual property extending exclusivity to February 2045.

https://www.investing.com/news/analyst-ratings/madrigal-pharmaceuticals-stock-surges-as-goldman-reiterates-buy-on-strong-sales-93CH-4171526

Supernus ups guidance after Q2

 

  • Net sales of Qelbree® increased 31% in the second quarter of 2025, compared to the same period in 2024.
    • Net sales of Qelbree of $77.6 million and $142.3 million in the second quarter and first six months of 2025, respectively.
  • Net sales of GOCOVRI® increased 16% in the second quarter of 2025, compared to the same period in 2024.
    • Net sales of GOCOVRI of $36.7 million and $67.4 million in the second quarter and first six months of 2025, respectively.
  • ONAPGO™ (apomorphine hydrochloride) launched in April 2025.
  • Total revenues were $165.5 million and $315.3 million for the three and six months ended June 30, 2025, respectively, compared to $168.3 million and $312.0 million, respectively, for the same periods in 2024.
    • Total revenues excluding Trokendi XR® and Oxtellar XR® net sales (non-GAAP)(1) increased 17% and 21% for the three and six months ended June 30, 2025, respectively, compared to the same periods in 2024.
  • Operating income of $12.1 million and $1.9 million for the three and six months ended June 30, 2025, respectively.
  • Adjusted operating earnings (non-GAAP)(1) were $40.9 million and $66.9 million for the three and six months ended June 30, 2025, respectively.
  • Completed acquisition of Sage Therapeutics, Inc. (Sage) on July 31, 2025.
  • Increasing full year 2025 revenue guidance and updating full year 2025 operating earnings (loss) guidance to reflect strong first-half 2025 performance and the Sage acquisition.

Oracle Health data breach exposes Baptist Health South Florida

 Coral Gables-based Baptist Health South Florida said its patient data was compromised in a hack of EHR vendor Oracle Health.

Baptist Health said it learned in March that an unauthorized party had accessed and stolen some of its patient records stored on Oracle Health (formerly Cerner) systems as early as Jan. 22, according to a July 29 notice. Federal law enforcement had asked that affected organizations delay patient notification amid the investigation.

The patient data may have included Social Security numbers and medical records such as diagnoses, medications and treatments.

“We sincerely apologize for this incident and assure you that protecting your information remains a top priority for Baptist Health,” the health system said in a statement on its website.

Baptist Health is the latest health system to disclose it was ensnared in the Oracle Health breach, joining Terre Haute, Ind.-based Union HealthTallahassee (Fla.) Memorial Healthcare and St. Joseph, Mo.-based Mosaic Life Care. Healthcare organizations in California, South Carolina and Texas were also impacted.

https://www.beckershospitalreview.com/healthcare-information-technology/ehrs/oracle-health-data-breach-exposes-baptist-health-south-florida/

Senators call on UnitedHealth to protect health data after Episource breach

 U.S. Sens. Bill Cassidy (R-La.) and Maggie Hassan (D-N.H.) are demanding answers from UnitedHealth Group following another cyberattack on one of the company’s subsidiaries.

Here are six things to know:

  1. The senators sent a letter August 4 to UnitedHealth Group CEO Stephen Hemsley expressing “serious concerns” after a recent hack of Episource, a risk adjustment analytics firm acquired by UnitedHealth in 2023. The breach impacted 5.4 million individuals and ensnared health systems.

  2. The Episource data breach follows 2024’s cyberattack on Change Healthcare, also a UnitedHealth subsidiary, which disrupted care nationwide and exposed sensitive information for as many as 190 million Americans.

  3. In the letter, the lawmakers criticized UnitedHealth for what they described as a pattern of neglecting basic security protocols across newly acquired companies. The senators cited UnitedHealth’s failure to implement multi-factor authentication and to modernize legacy systems at Change Healthcare, which ultimately contributed to the February 2024 ransomware attack.
  1. The senators also took issue with the company’s financial response, noting that UnitedHealth has sought repayment from providers who received loans to mitigate revenue losses following the Change Healthcare disruption.

  2. Mr. Cassidy and Ms. Hassan are requesting detailed responses from UnitedHealth by Aug. 18, including timelines for when the company discovered the breach at Episource, which federal agencies were notified, and what efforts are underway to identify and communicate with impacted individuals. They also asked whether UnitedHealth has made changes to its acquisition due diligence processes to better account for cybersecurity risks.

  3. Episource wrote on its site that it began notifying affected individuals of the breach on April 23, and that it has “taken several steps to mitigate and help prevent events like this from happening in the future.”

Rep. Delia Ramirez declares her loyalty to Guatemala first at a Mexican leftist gathering

 


With U.S. citizenship reduced to a cheap consumer durable that every third-world denizen as a 'right' to have, it doesn't take long to start hearing declarations like these from actual elected officials living off the U.S. taxpayer dime:

According to Fox News:

During her remarks at the opening of the [radical leftwing Panamerican Congress] event [in Mexico City], Ramirez spoke about the Trump administration's illegal immigration crackdown and her own ancestry.

"I’m a proud Guatemalan before I’m an American," she declared in Spanish. The congresswoman also accused the U.S. of prioritizing "imperialism, militarization, conquest, control, competition in its attempt at domination."

On her website, Ramirez, the child of [illegal -ed] immigrant parents, said her husband is in the country illegally and that she is the only congressional lawmaker "in a mixed-status marriage, and fights for the rights of DREAMers like her husband, Boris, and for comprehensive immigration reform."

Obviously, she didn't mean it, like, seriously, when she took an oath of office swearing fealty to the U.S. alone when she assumed her congressional seat in 2023.

And with that loyalty to Guatemala openly worn openly on her sleeve, it's worth reminding that as a congresswoman, she writes laws the rest of us have to live by. That she could be so loyal to Guatemala, and a 'proud Guatemalan first,' (a country now led by a leftist government and going downhill), over the United States, is astonishing.

Not recognizing the incredible privilege that U.S. citizenship is tells us a lot about what's rolling in from abroad, and worse still, the wokester atmosphere at home and at school that the children of such illegal aliens are being raised in as anchor babies, which she apparently is. 

What we have here is an incredible disloyalty to the United States, a hatred of the American people who voted in the current government.  Apparently, she only likes America when she can exert power over it as a proud Guatemalan, or sees her allies like the Obama crew working to dismantle it in the name of 'transforming' it.

To declare loyalty to another country while under oath to be loyal to the U.S. as an elected leader is treasonous. Spies reveal their disloyalty in secret, but this person actually shows it in public. 

She ought to be impeached and booted from Congress for this, a person utterly unfit to serve, and made an example of. This reveals a major cultural problem of unassimilated immigrants allowed in by the millions in Joe Biden's open border. The woman, in fact, is pathetic, surrounded entirely by illegal aliens throughout her life -- her parents illegals, her husband Boris illegal, too, as a DACA recipient. An investigation into how he got that status is in order, and how her illegal parents (who were almost certainly supporters of Guatemala's communist guerrillas) got in without consequences and managed to have her ought to be investigated, too. She needs to learn a lesson about the value of U.S. citizenship and her amazing unworthiness to have it.

If Congress could kick Rep. George Santos out of office for an inflated resume, then it certainly can expel someone who proclaims her loyalty to Guatemala first.

She has taken to defending herself by declaring anyone criticizing her loyalty problems as a "white supremacist authoritarians."

According to Fox News:

"Let’s call it what it is: today’s attacks are a weak attempt to silence my dissent and invalidate my patriotic criticism of the nativist, white supremacist, authoritarians in government. It is the definition of hypocrisy that members of Congress —who betray their oath each day they enable Trump— are attacking me for celebrating my Guatemalan-American roots," she asserted.

"No one questions when my white colleagues identify as Irish-American, Italian-American, or Ukrainian-American to honor their ancestry. I’ve consistently expressed pride in my heritage and history - a pride also often reflected in the origin stories of my colleagues. Only those who believe America should not include the children of immigrants or be diverse would attack me - and Americans like me - for honoring my roots," Ramirez continued.

Not a hint of apology for what she said. No clarification. No declaration of any loyalty to the U.S.

No acknowledgment of the men and women in our armed forces who fought and died for this country, nor any recognition of why U.S. citizenship is not like other citizenships, nor anything suggesting she views is as anything more than free stuff for herself.

Just hurled insults at Republicans, and slippery semantic shifts and question-begging accusing Irish-Americans and others of putting their ancestral homelands first as she did, ignoring that those people don't do that, and a claim that Republicans hate the children of immigrants, as if many are not just that. Then a weird claim that she was only 'honoring her roots' instead of ranking her loyalties, with America coming up short.

She's disgusting, a vile, disloyal, ungrateful, person, and as an anchor baby, she's exactly what's wrong with the immigration system in our country. Her entire community in Chicago which spawned this outrage needs a good ICE raid. 

And as for her, she really needs to be thrown out of Congress for this. Loyalty to America should be a minimum.

https://www.americanthinker.com/blog/2025/08/rep_delia_ramirez_calls_herself_a_proud_guatemalan_first_at_mexican_leftist_gathering.html

Seasonal adjustments are easy to manipulate in job numbers

 


In the September 2024 jobs report from the Department of Labor, the seasonal adjustment was the largest on record. They had a seasonal adjustment of 460,000 which gave them a chance to claim that 254,000 jobs were created:

US Job Growth Surges on the Strongest Seasonal Adjustment Effect on Record

September 2024 had the biggest seasonal adjustment factor on record compared to like months of September in history (chart 1). I had expected a strong seasonal adjustment factor to be a turning point in favour of a strong gain in jobs, but not this strong! Chart 2 shows why this mattered. The 460k gain in seasonally unadjusted nonfarm payrolls last month (red bar) translated into a seasonally adjusted gain of 254k.

The report happened to be the last one before the 2024 election. That does not look like a coincidence. It looks like the rigging of the numbers or cooking the books.

Besides monthly negative adjustments on job numbers that are rarely amplified, the BLS made a huge 818,000 negative adjustment in August 2024 for the period April 2023 to March 2024.

How much inaccuracy would it take for the media to think someone should ever be fired from the government if that person were appointed by a Democrat?

How much inaccuracy would it take for the Federal Reserve to question the accuracy of a report under the Democrats? I never heard them question Biden’s reports, but yet they’re worried about reports under Trump because of some budget cuts.

The American Spectator ran a good article by David Catron explaining why the head of the Bureau of Labor Statistics should have been canned a long time ago. Her tenure, which ran from January 2024 until her recent firing a few days back, involved “implausibly robust job growth estimates during former President Biden’s final year in office and recurring technical issues.”

Fake news outlet The Washington Post was forced to acknowledge her incompetency, running this story: “The Bureau of Labor Statistics said Wednesday that a technical issue caused delays last week in the scheduled release of jobs data … The episode is at least the third in a series of missteps this year.”

Also from Catron, speaking to the whopping negative adjustment of 818,000:

This gigantic downward revision was not merely the second largest on record, it doesn’t include normal monthly revisions. When those adjustments are added, McEntarfer’s BLS leadership appears either incompetent or corrupt. As the Daily Caller reported at the time, ‘Including monthly revisions, the Biden administration overstated the number of jobs in the U.S. economy by 1.18 million in the year through March, accounting for approximately 36 percent of the 3.24 million jobs initially claimed.’ The legacy media have made much of President Trump’s claim that the job numbers are rigged, but McEntarfer’s record hardly rules it out.

The CBO routinely underestimates costs by huge amounts on government spending programs like Obamacare and the Inflation Reduction Act, and the CBO routinely underestimates revenue under tax rate cuts. Supposedly, these people are “experts” and “experienced,” so how can they be materially wrong so consistently? It sure looks like it could be intentional manipulation to support big government.

The Democrats are complaining about all staff cuts as they are blocking Trump from staffing up. Isn’t that hypocritical?

How many numbers reported from the government have to be wrong before the complicit media doesn’t treat them as gospel?

https://www.americanthinker.com/blog/2025/08/seasonal_adjustments_are_easy_to_manipulate_in_job_numbers.html

Lawfare, Biden Style

 by John Hinderaker

It is commonly believed that the Russia collusion hoax was the worst scandal in American history, and certainly it has a strong claim. But if smearing Donald Trump with Hillary-concocted lies was a major scandal, how about trying to put him in prison?

Alex Marlow, editor in chief of Breitbart News, has written a book titled Breaking the Law: Exposing the Weaponization of America’s Legal System Against Donald Trump. It hits bookstores tomorrow. Marlow’s theme is that the multiple criminal and civil cases that were brought against Trump before the 2024 election were coordinated from the Joe Biden White House. The whole thing was a Democratic Party put-up job. Marlow writes:

The Joe Biden White House orchestrated the lawfare against President Donald Trump in the run-up to the 2024 election, hoping to jail or bankrupt the Republican standard bearer in order to prevent him from becoming president of the United States. The fact-pattern that I establish in my new book…reveals a vast conspiracy to use lawfare to rig the race by engaging in an unprecedented level of coordination across branches of government, Democrat power structures, and the White House itself.

For example, the lead prosecutor in Alvin Bragg’s Stormy Daniels case was a high-ranking official in Biden’s Department of Justice:

[T]he clearest evidence that the Biden administration was actively involved in the case was that Bragg’s lead prosecutor, Matthew Colangelo, had left his principal deputy associate attorney general job in Biden’s DOJ (he was the third-ranking official at the Department of Justice out of more than 100,000 people!). Colangelo, who has a pristine resumé and was in a job at the DOJ that has been a steppingstone for Supreme Court Justices and Cabinet Secretaries, but instead took a massive demotion, taking a job that lawyers might take fresh out of school.

“It’s the rough equivalent of like a four-star general in the army, quitting his job and enlisting in the National Guard as a private,” said Will Scharf, the White House staff secretary and one of Trump’s attorneys.

On November 9, Joe Biden held a press conference and said, “We just have to demonstrate that he [Trump] will not take power, if he does run, making sure he, under legitimate efforts of our Constitution, does not become the next president again.”

Days later, Colangelo was moved from the top of the DOJ to Bragg’s court room.

Then there was the Georgia prosecution undertaken by Fani Willis and her paramour, Nathan Wade. Wade was an Atlanta family lawyer whom no one had heard of, and who had zero qualifications to pursue a criminal case against anyone. But he was welcome in Joe Biden’s White House:

On November 18…Nathan Wade, prosecutor for and boyfriend of Fulton County District Attorney Fani Willis, was at the White House meeting with counsel for eight hours.

Why was Nathan Wade at the White House?

Wade was a family law attorney—that means his area of law is divorces and prenuptial agreements—with no prosecution experience. …

Nathan Wade met with the White House counsel at least twice. He billed the Fulton DA’s office for eight hours from the White House on at least two separate occasions: May 23, 2022, and on November 18, 2022, both before Trump was indicted.

Wade has refused to say what was discussed in these White House meetings, but what could the subject possibly have been other than the indictment of Trump?

What, indeed? Family law in Georgia?

I look forward to reading Marlow’s book. In the meantime, I will say this: I did nothing but litigation for 41 years, and I never saw anyone try to bring a case as obviously stupid as the New York prosecution of Trump, or the Georgia prosecution of Trump. The New York case was a tortured attempt to revive a misdemeanor prosecution on which the statute of limitations had run, and I expect the convictions that Bragg corruptly obtained in that case to be reversed on appeal. The Georgia prosecution was a purported RICO case in which the complaint alleged exactly one–count ’em, one–illegal act, with which Trump had nothing to do. That case has died a merciful death.

These prosecutions were an outrageous abuse of our legal system. We can only hope that someday, the Democratic Party will pay a heavy price.

https://www.powerlineblog.com/archives/2025/08/lawfare-biden-style.php