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Monday, August 10, 2026

Sionna Therapeutics halts SION-719 add-on program after Phase 2a

 

Sionna Therapeutics halts SION-719 add-on program after Phase 2a PreciSION CF trial fails key sweat chloride endpoint

  • Company will not advance SION-719 as an add-on therapy to Trikafta following Phase 2a results
  • Sionna is evaluating next steps for its SION-451 dual-combination program and planning capital-preservation measures

Varex Imaging definitive deal to be acquired by Teledyne for $18.90 per share in cash or $1.1 b

 

Varex Imaging enters definitive deal to be acquired by Teledyne for $18.90 per share in cash, valuing transaction at approximately $1.1 billion

  • Fiscal third-quarter revenue rose nearly 4% to $210.5 million today.
  • Adjusted EPS was $0.31 in fiscal Q3, topping the $0.20 consensus estimate.

Silence Therapeutics' divesiran meets Phase 2 endpoints in polycythemia vera, Phase 3 planned for 1H27

 

Silence Therapeutics' divesiran meets Phase 2 endpoints in polycythemia vera and Phase 3 trial planned for 1H 2027

  • Phase 2 SANRECO trial demonstrated strong efficacy for divesiran in polycythemia vera patients
  • Divesiran showed a favorable safety profile in the Phase 2 SANRECO polycythemia vera study

MarineMax to be acquired by Blackstone Infrastructure's Safe Harbor in ~$1.5 b all-cash deal

 MarineMax to be acquired by Blackstone Infrastructure portfolio company Safe Harbor in ~$1.5 billion all-cash deal

https://finviz.com/stock?t=HZO&p=d

Hormuz traffic weakens further over the weekend

 Shipping through the Strait of Hormuz "weakened further" over the weekend, global data and analytics company Kpler said on Monday.

"From 7 to 9 August, confirmed crossings fell from 15 on Friday to 11 on Saturday and just six on Sunday, bringing the three day total to 32. Routing also remained concentrated, with 17 vessels using the Iranian Unilateral Scheme and 10 classified as Route Undetermined," the firm wrote in a post on X.

Regarding the traffic through the Bab el-Mandeb Strait, where the maritime threat risk was raised to "substantial" due to Houthi attacks, the company said it remained more active, with 116 crossings during the same period. However, Kpler stressed that "12 dark transits and elevated sanctioned activity continued to highlight visibility and risk concerns."

https://breakingthenews.net/Article/Hormuz-traffic-weakens-further-over-the-weekend/66889070

'Pezeshkian: Khamenei talks lasted over 7 hours'

 Iranian President Masoud Pezeshkian said on Sunday that his meeting with Supreme Leader Mojtaba Khamenei lasted seven to eight hours, describing the discussion on state affairs as "highly productive."

Pezeshkian said Khamenei underscored the importance of preserving national unity and cohesion, as well as addressing people's livelihoods. Separately, the president claimed that opponents' calculations had failed despite being based on artificial intelligence data, espionage networks, hired agents and domestic proxies.

"The people rose up, answered the call and came onto the scene, creating a firm barrier against the conspiracies," Pezeshkian concluded.

https://breakingthenews.net/Article/Pezeshkian-Khamenei-talks-lasted-over-7-hours/66888601

Billionaire heiress who backed Mamdani shovels cash to House Dems in hopes of party takeover

 Billionaire heiress Elizabeth Simons is pouring hundreds of thousands of dollars into the Democratic Party’s campaign to retake the House — even as she bankrolls the socialist causes and candidates that have Democrats’ establishment leaders increasingly on edge.

Simons, who previously cut a $250,000 check to a super PAC backing Mayor Zohran Mamdani, has donated $354,000 to the Democratic Congressional Campaign Committee — the party’s chief House campaign arm — and thousands more to individual House candidates this election cycle.

The donations, ironically, put Simons behind the same Democratic leadership forces trying to prevent the party’s increasingly powerful progressive wing from taking over.

Elizabeth Simons speaking at the 2016 Milken Institute Global Conference.
Elizabeth Simons has been pouring campaign contributions to the Democratic Congressional Campaign Committee and individual candidates, after backing “woke” causes over the years.Getty Images

“I can see why a lot of the very woke left is lining up with Hakeem [Speaker Jeffries] because the goal is winning the House,” said one longtime Democratic fundraiser.

The DCCC is headed by Rep. Suzan DelBene (D-Wash.), a member of the party’s centrist New Democrat Coalition, which is the under guidance of House Minority Leader Hakeem Jeffries, who is positioned to take power if Dems snatch back the House. Republicans rule by a narrow 218-212 majority.

Simons is hardly a conventional Democratic establishment donor — she has has poured millions into progressive education initiatives while backing candidates like Mamdani.

Simons is chairwoman of the board of directors of the Heising-Simons Foundation, which she co-founded with her husband, Mark Heising. Her father James Simons founded the hedge fund Renaissance Technologies, and was worth an estimated $31.4 billion at the time of his death in 2024.

Last August, she cut her quarter million dollar dollar check to New Yorkers for Lower Costs, which made it the largest contribution to the group backing democratic socialist Mamdani’s bid against former Gov. Andrew Cuomo.

Her “woke math” support came in the form of $1.7 million in contributions by the foundation to the Racial Justice in Early Mathematics Project at Chicago’s Erikson Institute.

House Minority Leader Hakeem Jeffries speaks at a press conference.
House Minority Leader Hakeem Jeffries (D-NY) is on track to become House Speaker if Dems can seize control of the chamber, which Republicans control by a narrow margin.Anadolu via Getty Images

She and three other California heavy hitters have given to such causes as anti-incarceration prosecutors and cash bail opponents — donating $22 million to ballot measures and candidates in the 2022 election cycle, according to Politico.

“Democrats aren’t just embracing a socialist, anti-police agenda, they’re being bankrolled to do it. Every Democrat backing this radical, pro-crime platform will answer to voters this fall,” blasted Emily Tuttle, a spokeswoman for the National Republican Congressional Committee, the GOP’s campaign arm.

Simons and three other California megadonors — Patty Quillin, Quinn Delaney and Kaitlyn Krieger — have contributed nearly $4 million to House Democrats and Democratic committees this election cycle, according to an analysis of Federal Election Commission data.

Simons and her foundation did not immediately respond to a request for comment on her contributions and strategy.

Quillin is founder of Meadow Fund, a donor-advised fund of the Silicon Valley Community Foundation, and is married to Netflix CEO Reed Hastings. Krieger is married to Instagram co-founder Mike Krieger, and the pair run a nonprofit focused on criminal justice issues.

Delaney is founder and board chair of the Akonadi Foundation, which “supports the development of powerful social change movements to eliminate structural racism and create a racially just society.” She is married to California real estate developer Wayne Jordan.

During the same period, Quillin gave more than $300,000 to the DCCC — but also contributed $650,000 to the Working Families Party, which is one of several groups committed to taking down the party establishment.

The group crowed last week in a release about adding Michigan House primary winner Will Lawrence and US Senate primary winner Abul El-Sayed “to the growing list of WFP-backed candidates winning grueling primaries in purple seats.”