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Wednesday, May 6, 2026

Rigel maintains 2026 guidance after EPS miss, highlights R289 MDS opportunity

 

Rigel grows Q1 net product sales 26%, maintains 2026 guidance after EPS miss, highlights R289 MDS opportunity

  • Q1 net product sales $54.9m, +26% YoY; total revenue $58.8m, +10% YoY, seasonally affected.
  • TAVALISSE led with $37.3m sales, +31% YoY, benefiting from stronger demand and improved gross-to-net dynamics.
  • GAVRETO and olutasidenib each grew 7–31% YoY, though GAVRETO growth is now relatively stable.
  • Q1 2026 non-GAAP EPS $0.44, missing estimates, down 30% YoY; net income $8.7m vs $11.4m on higher spending.
  • 2026 revenue guidance $275–290m and net product sales $255–265m were maintained; profitability reaffirmed.
  • R289 Phase Ib expansion in lower-risk MDS progressing; top-line data expected by year-end 2026.
  • Earlier R289 data showed 33% transfusion independence ≥8 weeks in heavily pretreated MDS patients.
  • Lilly will terminate RIPK1 collaboration effective June 2026; no revenue from this collaboration is assumed in guidance.
  • Debt refinanced: $40m term loan repaid, replaced with $40m revolver, of which $8m has been drawn.
  • Management pursuing late-stage hematology-oncology in-licensing for 2026–2028 launches, leveraging existing commercial infrastructure.
  • Main concern: R289 must deliver compelling MDS data to justify a pivotal trial and sustain growth.
  • Mixed quarter, driven by strong TAVALISSE growth but higher spending and business-development changes.

UroGen revenue beats, reiterates 2026 JELMYTO and operating expense guidance

 UroGen Pharma Q1 2026 revenue rises 152% YoY to $51.0M, ZUSDURI up 109% QoQ to $29.2M above prior expectations, reiterates 2026 JELMYTO and operating expense guidance

https://finviz.com/quote?t=URGN&p=d

Taysha reaffirms FDA alignment and BLA submission pathway for Rett gene therapy TSHA-102

 


  • First-quarter 2026 results include a $42.4 million net loss and higher R&D spending.
  • Ended the quarter with $276.6 million in cash, providing operational runway into 2028.

Tonix Pharma signs commercial payer coverage deal

 Tonix Pharma signs commercial payer coverage deal with leading GPO for TONMYA, reaching approximately 35 million U.S. commercially insured patients

https://finviz.com/quote?t=TNXP&p=d

CVS Boosts Outlook for 2026 After Aetna Profits Increase

 


CVS Health Corp. raised its earnings outlook for the year after profit and revenue in the first quarter exceeded analyst expectations, the latest in a string of positive reports from US health conglomerates.

The company increased its outlook for 2026 adjusted earnings to $7.30 to $7.50 a share, it said in a statement Wednesday. The 30-cent increase puts the new range above Wall Street estimates.


Novo Nordisk Soars After New Obesity Pill Momentum Lifts Guidance

 Novo Nordisk shares jumped as much as 9% in Copenhagen, suggesting the stock may finally be bottoming out after a vicious multi-year bear market. The move followed the Danish drugmaker's decision to raise its 2026 guidance ranges for adjusted sales and adjusted operating profit, citing solid momentum in Wegovy sales.

Novo now expects full-year sales and profit declines of around 12%, down from a previous forecast of around 13%. The upgraded outlook was "driven by increased expectations for GLP-1 product sales," according to the company.

Here's a snapshot of the new full-year forecast, courtesy of Bloomberg:

  • Sees adjusted change in sales at constant exchange rates -4% to -12%, saw -5% to -13%, estimate -7.63% (Bloomberg Consensus)

  • Sees adjusted change in operating profit at constant FX -4% to -12%, saw -5% to -13%, estimate -8.26%

The key bright spot was momentum in the Wegovy pill:

  • Wegovy pill was launched in the US on 5 January 2026, and for the week ending 17 April, total weekly prescriptions exceeded 200,000. Coupled with total prescriptions for Q1 2026 of around 1.3 million and now more than 2 million since launch, it marks the strongest-ever GLP-1 volume launch in the US. Q1 2026 sales for the Wegovy pill reached DKK 2,256 million, impacted by pre-launch pipeline fill with wholesalers and telehealth partners.

  • Pending regulatory decisions, the first Wegovy pill launches outside the US are expected during the second half of 2026.

"We have seen more than 1 million people using the Wegovy pill," CEO Mike Doustdar told analysts on an earnings call earlier. He noted that patients are switching from competing products, with "limited cannibalization" of Novo's other drugs.

Still, Novo's overall business remains under pressure. First-quarter sales fell 10% to 70.1 billion Danish kroner, while adjusted operating profit dropped 15%. Diabetes drug sales fell 18%, with Ozempic hitting its lowest level in two years.

Novo is trying to regain momentum after losing market share to Eli Lilly's Zepbound injection.

Novo shares in Copenhagen jumped as much as 9%. Shares have been locked in a vicious, nearly two-year bear market, down 70% from their peak.

Analyst commentary, courtesy of Bloomberg:

Barclays (equal weight)

  • Oral Wegovy was "off to a strong start," analyst James Gordon writes in a note.

  • Sees questions on supply capacity when the pill launches in other countries, expected in 2H

  • Sees FY consensus expectations being increased by low single- digits

BMO Capital Markets (market perform)

  • The Wegovy pill "makes a splash" in its debut, analyst Evan Seigerman writes in a note.

  • It's encouraging that roughly 15%-16% of pill patients are filling scripts for the highest dosages.

  • This "could be a leading indicator for improved revenue going forward, given their higher price."

  • Wegovy and Ozempic injectables also beat expectations, "showing more resilience in the face of competition within class"

Jefferies (hold)

  • Although the 2026 guidance was nudged higher, it still leaves consensus expectations at the upper end of the range, analyst Michael Leuchten writes in a note.

  • The change in guidance probably won't have a positive impact on consensus estimates.

  • It could actually drag pretax profit and EPS expectations down a couple of percent.

Intron Health (sell)

  • Sales beat expectations by 1%, driven by Wegovy pill stocking of ~$125m, analyst Naresh Chouhan writes in a note

  • Meanwhile, gross margin was 30 bps worse than expected

Morgan Stanley (equal weight)

  • 1Q sales were a "small" beat, driven by the Wegovy pill — helped by stocking — and international operations, analyst Thibault Boutherin writes in a note

  • Lower operating costs helped the adjusted EBIT beat

  • Still sees the bottom end of the guidance as "conservative" and expects the company to finish the year "in the upper half of the guidance."

Did Novo finally bottom?

https://www.zerohedge.com/markets/novo-nordisk-soars-after-new-obesity-pill-momo-lifts-guidance

ADP Employment Report Signals Biggest Job Additions In 15 Months In April

 With non-farm payrolls looming, we get another glimpse at the labor market today from the ADP Employment Report which shows the US economy added 109k jobs in April (a slight disappointment relative to +120k exp). That is the tenth straight month of job additions and strongest monthly addition since January 2025...

Source: Bloomberg

Under the hood, Goods-producing jobs rose 15,000 while Service-providing jobs rose 94,000.

"Small and large employers are hiring, but we're seeing softness in the middle," said Dr. Nela Richardson Chief Economist, ADP.

"Large companies have resources to deploy, and small ones are the most nimble, both important advantages in a complex labor environment."

Health care's continued strength, along with a rebound in trade, transportation, and utilities, fueled last month's acceleration in hiring. 

Pay growth for job-stayers slowed slightly to 4.4 percent, but for job-changers, year-over-year pay gains were steady at 6.6 percent.

Is the economy transforming from 'no hire, no fire' to 'higher hire, still no fire' gains (see JOLTS' record hiring).

https://www.zerohedge.com/personal-finance/adp-employment-report-signals-biggest-job-additions-15-months-april