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Sunday, August 30, 2026

Bayer Phase III Study with PET Radiotracer is Late-Breaker at ESC

 

Phase III results in patients with suspected cardiac amyloidosis were presented at the European Society of Cardiology (ESC) Congress 2026 and simultaneously published in The Journal of the American Medical Association

 Bayer today announced the presentation of first detailed results from the Phase III REVEAL study, an investigator-initiated study by Brigham and Women’s Hospital, that evaluated the investigational positron emission tomography (PET) radiotracer iodine 124 evuzamitide (I 124 evuzamitide) for the diagnosis of cardiac amyloidosis.1 The pivotal study met its primary endpoints in the assessment of sensitivity and specificity for the diagnosis of cardiac amyloidosis based on visual scan interpretation.1 Safety data and data from secondary endpoints assessing the sensitivity and specificity in light-chain amyloidosis (AL) and, separately, in transthyretin amyloidosis (ATTR) were also presented.1 I 124 evuzamitide is an investigational compound and has not been approved by any health authority for use in any country for any indication.

 

These results were shared in a late-breaking oral presentation at the European Society of Cardiology Congress 2026 (ESC) in Munich, Germany, on August 30, 2026, and simultaneously published in The Journal of the American Medical Association.

https://www.bayer.com/en/us/news-stories/phase-iii-reveal-study

Ousted Ukraine defense minister Fedorov accepts job advising Italian minister

 


Ukraine's ousted defense minister Mykhailo Fedorov – whose firing last month prompted rare wartime protests – said Friday, August 28, that he had accepted a job working as an advisor to Italy's defense minister.

Fedorov, a tech-savvy 35-year-old, was dismissed as defense minister in July after reports of disagreements between him and the country's military leadership. His dismissal by Ukrainian President Volodymyr Zelensky prompted thousands to protest across Ukraine, many of whom called for him to be reinstated to the role.

Fedorov said Friday he had agreed to become "advisor on defense innovation" to Italian Defense Minister Guido Crosetto, six weeks after his dismissal. "In this role, I will help Italy develop technologies for modern warfare, improve its defense sector, and adapt to the world's new security challenges," Fedorov said. Crosetto offered Fedorov the job in July, according to Italy's La Repubblica newspaper.

Fedorov will continue living and working in Kyiv for the role, his press office said. There was no immediate comment from the Ukrainian presidential administration.

Fedorov had been a longtime Zelensky ally, having worked with the president since he took office in 2019. Relations between the two soured after his dismissal, with Fedorov earlier this month calling for Ukraine to hold elections that had been postponed since Russia invaded in 2022. Zelensky rejected the proposal as risky and divisive.

https://www.lemonde.fr/en/international/article/2026/08/28/ousted-ukraine-defense-minister-fedorov-accepts-job-advising-italian-minister_6756946_4.html

Jordan says it intercepted 8 missiles

 Jordanian air defense systems intercepted eight missiles that entered the country's airspace in early hours on Monday, the Jordan Armed Forces-Arab Army said, according to the Jordan News Agency.

The military did not immediately specify where the missiles were launched from.

The announcement comes after Iran's Islamic Revolutionary Guard Corps (IRGC) said it launched missile and drone attacks on two US bases in Jordan in retaliation for the US strike on Larak Island.

https://breakingthenews.net/Article/Jordan-says-it-intercepted-8-missiles/67010353

Iran says it is laying new mines near Hormuz

 The Khatam al-Anbiya Central Headquarters, Iran's top joint military command, said new and advanced naval mines are being laid along routes south of the Strait of Hormuz.

In a post online, the headquarters' spokesperson Ebrahim Zolfaghari said the deployment was taking place while United Stats forces were occupied defending their bases.

He ended the message with "Thank you for your attention to this matter," a phrase often used by US President Donald Trump to close his statements.

https://breakingthenews.net/Article/Iran-says-it-is-laying-new-mines-near-Hormuz/67010404

Has the Horror of the Act Itself Become the Defense?

 

Cora Clancy.  Dawson Clancy.  Callan Clancy.

A person killed them.

There is no elegant way around that sentence, which is precisely why we ought to begin there.  We can discuss postpartum psychosis, psychiatric medications, doctors, prescriptions, institutional failures, sleep deprivation, delusions, and every other circumstance that might help explain how Lindsay Clancy arrived at the moment when she killed her children.  We should discuss them, but there is a peculiar danger in allowing explanation to become so elaborate that the person who committed the act begins to disappear from the story.

That is the question beneath this case.  What happens when an act is so horrifying that assigning responsibility to the person who committed it becomes psychologically unbearable?  Do we begin searching, almost instinctively, for something else to blame, not because the evidence necessarily leads there, but because the alternative is too terrible to contemplate?

The Horror Problem

The defense does not have to persuade a jury that the killings did not happen.  Everyone knows they happened, and nobody disputes who physically carried them out.  The more difficult proposition is that the woman who killed her children was, at the relevant moment, so profoundly affected by postpartum psychosis that she lacked the criminal responsibility ordinarily attached to her actions.

That argument presents the jury with a peculiar psychological dilemma.  The defendant is not some remote stranger whose conduct can be contemplated with clinical detachment; she is a mother accused of brutally killing her own children.  The horror of the act itself may therefore become an argument about the condition of the actor: Surely a mother could not knowingly do something like this.  And if the mind finds that proposition impossible to absorb, it searches for an explanation that makes the unbearable slightly more bearable.

This is where the defense theory becomes rhetorically powerful without requiring anyone to behave improperly.  The more incomprehensible the conduct appears, the more compelling the proposition becomes that something must have happened to the person who committed it.  Psychosis offers one explanation, medication another, medical treatment another, and institutional failure another.  The jury can then begin moving backward through the chain, searching for the point at which responsibility can be transferred from the mother to something that seems less morally horrifying.

Follow the Chain

The medication questions are therefore important, but perhaps not for the reason most often suggested.  The relevant question is not merely what doctors prescribed, but what Clancy actually took, what she was instructed to stop, what she was instructed to begin, whether medications overlapped, whether doses changed, and whether she followed those instructions consistently.  A prescription record describes an intended regimen; it does not necessarily establish the regimen that actually existed inside the patient’s body.

Clancy herself has acknowledged that she did not always take medication precisely as prescribed.  That does not establish intentional manipulation, and it certainly does not establish that she understood what a particular combination might do.  But it does make the distinction between prescription and ingestion important, particularly when the defense asks the jury to attribute her behavior to the pharmacological and psychiatric consequences of her treatment.

There is another question we should be willing to ask without pretending to know the answer.  If someone has repeatedly experienced the effects of different psychiatric medications, could she learn that particular drugs, doses, or combinations produced particular sensations or states, and could that knowledge influence what she chose to take?  Perhaps.  But an intriguing possibility is not evidence of intent, and a responsible article should not convert an unanswered question into an accusation merely because the accusation would make the theory more dramatic.

The larger issue is what happens once the investigation begins moving upstream.  Perhaps psychosis contributed to the killings; perhaps medication contributed to the psychosis; perhaps physicians contributed to the medication regimen; perhaps the medical system contributed to the physicians’ failures.  Each link may deserve investigation.  Yet if we keep traveling backward, we eventually encounter a peculiar paradox: The more completely we explain the circumstances surrounding the act, the easier it becomes to forget the person who actually performed it.

When Responsibility Flows Uphill

This phenomenon is not confined to criminal defendants.  Consider the recent legal reckoning surrounding Meta, where allegations against Facebook and Instagram have centered on whether the company deliberately created features that encouraged compulsive use and contributed to harm among young people.  The principle involved is perfectly intelligible: If an institution creates conditions that foreseeably produce harmful consequences, responsibility may properly travel upstream to the institution that created those conditions.

There is nothing inherently wrong with that principle.  The difficulty begins when tracing responsibility upstream becomes so reflexive that we forget to ask whether the person at the end of the chain still possesses agency.  Call it flow-through responsibility: We begin with the act, then move backward through mental state, circumstance, treatment, institution, environment, and history until we arrive at an explanation sufficiently distant from the defendant to make the original act psychologically easier to comprehend.

Sometimes that journey produces legitimate legal responsibility elsewhere.  Sometimes it produces nothing more than an elaborate explanation.  The jury’s task is not to determine which explanation makes the tragedy easiest for human beings to bear; it is to determine what the evidence establishes about criminal responsibility.

That is why the horror itself deserves examination.  The jury must not confuse its inability to imagine a mother doing something with the defendant’s inability to understand what she was doing.  We can acknowledge psychosis without assuming that every terrible act committed by a mentally ill person was beyond that person’s control.  We can investigate medication without turning medication into an actor, examine medical care without turning doctors into murderers, and identify institutional failure without allowing the institution to replace the individual who acted.

We should follow responsibility upstream wherever the evidence takes us.  But we must not follow it so far upstream that the person who committed the act disappears beneath the accumulation of explanations.

Cora Clancy.  Dawson Clancy.  Callan Clancy.

A person killed them.

That person is Lindsay Clancy.

Luis Gonzalez is the owner and publisher of The Last Wire, an independent blog covering news, politics, opinion, and the rabbit holes beneath the headlines.  His work has also appeared in the American Thinker.  He has been writing online since 2000 and is the founder of Boiling Frogs, a personal blog launched in 2008.  A retired food service professional, Gonzalez spent more than 40 years on both the operator and supply sides of the industry.  He hangs his hat at The Briefing Room, where he excels at the role of resident curmudgeon.

https://www.americanthinker.com/articles/2026/08/has-the-horror-of-the-act-itself-become-the-defense/

Russia Hoaxers Quiet about Canadian Election Interference

 by J.B. Shurk

As President Trump has repeatedly pointed out, the Canadian government embraces a peculiar notion of national sovereignty: It depends upon the U.S. military for security and expects to sell its domestic products to Americans as if Canada were just another U.S. state.  At the same time, it insists on censoring American sources of news, restricting the flow of American goods into Canada, and rebuking American foreign policy decisions.  

When former Prime Minister Justin Trudeau flew to Mar-a-Lago to meet with President Trump following his 2024 re-election, the Canadian leader’s foremost concern was to prevent the new Trump administration from seeking fair and reciprocal trade (actual free trade) between the two countries — a goal that the president and his economic team had pursued during Trump’s first term and which ultimately resulted in the replacement of the North American Free Trade Agreement (NAFTA) with the U.S.-Mexico-Canada Agreement (USMCA).  From Trump’s point of view, USMCA did not resolve decades-long trade imbalances between Canada and the United States, but it did kill NAFTA and put the U.S. in a legal position to recalibrate its economic relationship with Canada by 2026.  Trudeau and the Canadians needed for the old system to endure, and he told Trump that Canada could not economically survive if Canada were forced to remove its own trade barriers against the U.S.  This is when Trump suggested to Trudeau that if Canada cannot exist without American welfare, then it is operating as a de facto American state.  

Trump’s unvarnished truth-telling created an international brouhaha.  Never one for pretending or backing down, the president spent the next several months advising Canada to make its dependence upon the American Union official by becoming the fifty-first state.  Canadians from British Columbia to Newfoundland took great offense, and the Canadian Establishment used the issue as a catalyst for installing central banker Mark Carney as prime minister, under the rationale that the former governor of both the Bank of Canada and the Bank of England was the ideal candidate for taking on President Trump.  

Since his premiership began, Carney has been on a mission to ruffle Trump’s feathers and cause friction between Canada and the U.S.  He has worked to strengthen Canada’s economic bonds with communist China.  He has repeatedly described Canada as an extension of Old Europe, rather than part of the New World.  He has promised to “defend” Greenland from any American attempts to assert dominion over the island.  He has pledged additional Canadian support for Ukraine in a war against Russia that President Trump wishes to end.  He has used every public speech to insult the United States as an unreliable and dangerous nation that cannot be trusted.  He has declared Canada to be in an economic “war” with the U.S. and has encouraged Canadian citizens to be obnoxiously hostile toward Americans.

These provocative stances and statements might make sense if Canada were not so economically and militarily dependent upon the United States.  If Carney wishes to strengthen communist China at America’s expense, he cannot expect the U.S. to give Canada the most favorable trade terms of any nation in the world.  Nor can he expect America to protect Canada as an ally if Canada allies itself with America’s principal geopolitical foe.  If Carney wishes to fight Americans so that the Kingdom of Denmark can continue to lay claim to a North American territory whose 56,000 residents are nearly all Inuit, then he should not expect the U.S. military to defend Canada from invasion.  Furthermore, Carney should not expect the U.S. to protect Canada under a Golden Dome missile defense system for North America that depends upon having operational control of Greenland.  He certainly shouldn’t expect American taxpayers to foot the bill for Canada’s national security when Canada is working to provoke a direct U.S.-Russia conflict over Ukraine.  He also shouldn’t expect preferential treatment from the United States when he undermines American strategic objectives around the world.

Canada’s flamboyant pomposity is obscene.  

Canada’s Hillary Clinton, Chrystia Freeland, was the trade negotiator who tried to keep Canada’s one-way tariffs intact during President Trump’s first term.  She’s currently serving as an unpaid “infrastructure reconstruction” advisor (or what some might call, “the CEO of wartime money-laundering in Europe”) to Ukraine’s holdover-president, Volodymyr Zelenskyy.  She popped her head up from Ukraine’s funny money operations last week to denounce the United States for treating Canada as a “vassal state.”  

Since Canada is not economically or militarily viable without enormous welfare assistance from the U.S., Canada is a vassal state; pretending otherwise is absurd.  

But here’s the thing: Central banker Mark Carney and the Canadian Establishment have chosen to fight back against President Trump’s efforts for reciprocal trade by binding Canada to communist China, the United Kingdom, and the European Union.  Carney can’t beg for help from General Secretary Xi Jinping, King Charles III, and Queen Ursula von der Leyen without making Canada a vassal state of communist China and Old Europe

Canada is not a “middle power” because it has no power.  It has squandered its natural resources and economic wealth by pursuing foolish “climate change” policies that have no effect on the weather.  Sovereign nations capable of militarily defending themselves do not indulge costly, “woke” delusions.  Only vassal states commit economic suicide while puffing out their chests and acting tough.  Why?  Because real nation states stand behind and take care of them.

It is also fascinating how Chrystia Freeland publicly argues that the best way to fight back against the Trump administration is to assist Democrats in the upcoming midterm elections.  Calling it the “Donut Strategy,” Freeland says that the Canadian government must go around the White House and manipulate the American people.  Canada’s minister of industry, Mélanie Joly, is doing exactly that by strategizing with prominent Democrats around the country on the best ways to undermine President Trump’s trade policies.  Ontario Premier Doug Ford not only pledged to interfere in the U.S. midterm elections but also told Trump to “kiss his ass.”  Central banker Mark Carney and his globalist friends are coordinating an information war against American voters.  In other words, all the Canadians who whine about President Trump not respecting Canadian sovereignty have absolutely no respect for American sovereignty.

Prominent members of the Canadian government nonchalantly admit to interfering in American elections, and corporate news talking heads just nod and smile.  Do you remember when news media spent years lecturing Americans about “foreign election interference” after Trump clobbered Hillary in the 2016 election?  All we heard during the president’s first term was, “Russia, Russia, Russia!”  Now Canadian officials admit to manipulating American voters in past elections and promise to do so again this year, and not a single pundit is even whispering, “Canada, Canada, Canada.”  After Hillary Clinton’s campaign and Barack Obama’s intelligence agencies used the Russian Collusion Hoax to perpetrate a fraud against the American people, Democrats collude openly with the Canadian government to manipulate elections.  Do you think that “foreign election interference” might have been just another propaganda press talking point to advance another anti-Trump narrative?

Along with Canada, the United Kingdom seems to play a central role in sabotaging Trump’s government.  It was MI6 spy Christopher Steele who put together Hillary’s fake dossier on Donald Trump that triggered Robert Mueller’s two-year special counsel investigation into the president.  Later, British “Russia expert” Fiona Hill testified against the president when Democrats (and Mitt Romney) turned a Biden Family corruption scandal involving Ukraine into a Trump impeachment.  During her testimony, Hill insisted that Russia “meddled” in the 2016 election.  Now King Charles III’s North American prime minister, Mark Carney, is openly meddling in the 2026 midterms.  Will Chris Steele and Fiona Hill return to testify about Canada’s election interference?  Let’s not hold our breath.

https://www.americanthinker.com/articles/2026/08/russia-hoaxers-quiet-about-canadian-election-interference/

Trump goes after companies ranchers blame for beef price squeeze

 President Donald Trump is moving to give ranchers a new way around the powerful meatpacking companies that stand between their cattle and the grocery-store shelf, following backlash in farm country over his decision to allow more foreign beef imports.

Trump said Friday that he was authorizing legal documents to be drafted to give farmers and ranchers "the right to process their own food," casting the move as an effort to break what he called a "nasty monopoly" in the meat industry.

The announcement came after cattle producers and some Republicans pushed back on Trump’s plan to temporarily allow tariff-free imports of up to 300,000 metric tons of foreign beef, a move intended to ease pressure on consumers facing high prices at the meat counter.

For ranchers, however, the fight is not only about imports. It is also about who controls the path from pasture to plate.

Four companies — Cargill, Tyson Foods, JBS USA and National Beef Packing Co. — control roughly 85% of the country’s meat-processing capacity. Ranchers have long argued that the concentration leaves them with too few buyers for their cattle and forces smaller producers to rely on distant, federally inspected slaughter facilities to bring beef to market.

Under current law, ranchers can slaughter and process animals for their own use, but meat intended for sale generally must be processed in facilities that meet federal food-safety and inspection requirements.

Trump has not released the legal details of his proposal, and it remains unclear how far an executive action could go in changing those rules. Agriculture Secretary Brooke Rollins said the administration would begin unveiling beef-processing actions Monday, including steps to reduce red tape, support smaller processors and expand ranchers’ ability to sell meat across state lines.

A cattle rancher in Florida moves cows on a pasture.

For ranchers, rebuilding their herds is a slow and costly process, meaning the supply crunch now pushing up prices is unlikely to disappear anytime soon. (Ty Wright/Bloomberg/Getty Images / Getty Images)

The political pressure comes as beef prices remain elevated and the U.S. cattle herd sits at its smallest level in roughly 75 years. Drought, high costs and years of herd liquidation have reduced domestic supply, while rebuilding the herd can take years.

That reality has put Trump in a difficult position, finding a way to ease grocery bills without further undercutting the ranchers producing the country’s beef.

Texas cattle rancher loads feed on a truck

Ranchers are pushing for more control over how their cattle reach consumers as Trump targets the nation’s largest meatpackers. (Scott Olson/Getty Images / Getty Images)

Still, the proposal gives him a new way to address the affordability challenge by shifting the focus from imported beef to the meatpacking giants ranchers say are driving a wedge between what producers earn and what consumers pay.

https://www.foxbusiness.com/politics/trump-goes-after-companies-ranchers-blame-beef-price-squeeze