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Tuesday, September 8, 2026

Pharvaris Phase 3 trial once-daily deucrictibant XR cut HAE attack rates 83% vs placebo, supporting 1H27 NDA

 

Pharvaris Phase 3 CHAPTER-3 trial shows once-daily deucrictibant XR cut HAE attack rates 83% vs placebo, supporting 1H 2027 NDA and global filing plans

  • CHAPTER-3 met its primary endpoint and all secondary endpoints in hereditary angioedema attack prophylaxis.
  • Trial evaluated once-daily oral deucrictibant XR as prophylactic treatment for hereditary angioedema patients.
  • CHAPTER-3 reported a favorable safety profile for once-daily deucrictibant XR in hereditary angioedema prophylaxis.
  • Detailed CHAPTER-3 data will support planned NDA and global marketing submissions in the first half of 2027.

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