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Thursday, September 24, 2026

siRNA biotech ADARx Pharmaceuticals sets terms for $350 million IPO

 ADARx Pharmaceuticals, a phase 3 biotech developing siRNA therapies for various diseases, announced terms for its IPO on Monday.


The San Diego, CA-based company plans to raise $350 million by offering 21.9 million shares at a price range of $15 to $17. AbbVie has agreed to purchase a number of shares in a concurrent private placement that would result in a 4.9% stake, implying an $80 million investment at the midpoint; it will not invest more than $100 million. At the midpoint of the proposed range, ADARx Pharmaceuticals would command a fully diluted market value of $1.8 billion. 

ADARx Pharmaceuticals is focused on developing next-generation small interfering RNA (siRNA) therapeutics designed to treat a broad spectrum of diseases. The company's pipeline includes three clinical-stage programs and two advanced preclinical programs. Its three clinical-stage candidates each target hepatic tissues and are being evaluated for the treatment of complement-mediated diseases, hereditary angioedema, and thrombotic diseases. Its other two programs are in or advancing to the IND-enabling stage to target obesity and neurodegenerative diseases, including Alzheimer's. 

ADARx Pharmaceuticals was founded in 2019 and booked $6 million in revenue for the 12 months ended June 30, 2026. It plans to list on the Nasdaq under the symbol ADRX. J.P. Morgan, Morgan Stanley, TD Cowen, UBS Investment Bank, and LifeSci Capital are the joint bookrunners on the deal. It is expected to price during the week of Monday September 21, 2026.

'Progressive pols, celebrities block road at Netayahu address at UNGA



New York City Mayor Zohran Mamdani may not be protesting Israeli Prime Minister Benjamin Netanyahu’s speech at the United Nations on Thursday. But other New York politicians did, with some getting arrested for blocking the road and refusing to move during the demonstration, including Democratic nominee for the 13th congressional district, Darializa Avila Chevalier, and City Council Members Chi Ossé and Alexa Avilés.


More than a dozen elected officials and candidates, including congressional nominee Brad Lander, state Sen. Jabari Brisport, City Council Members Sandy Nurse and Tiffany Cabán and Assembly Member Emily Gallagher were among the roughly 250 protesters who sat in the street at the corner of 1st Avenue and 39th Street in Manhattan. The action organized by pro-Palestinian group Jewish Voice for Peace, just blocks away from the U.N. headquarters, was meant to protest both Netanyahu’s speech at the U.N. and the United States’ aid to Israel’s military, including throughout the war in Gaza. The group was surrounded by around 100 New York City police officers, including members of the Strategic Response Group.

About an hour into the protest, officers moved in and arrested dozens of protesters who were left, including Avila Chevalier, Ossé and Avilés, without issue. According to an organizer with Jewish Voice for Peace, the total number of people arrested topped 100, and included Council Member Jennifer Gutiérrez, Gallagher, and state legislative candidates Aber Kawas, Christian Celeste Tate, David Orkin and Illapa Sairitupac.

“As the Democratic Nominee for New York’s 13th Congressional District, I refuse to allow a war criminal to roam the streets of our city unchallenged,” Avila Chevalier said in a statement on her arrest shared exclusively with City & State. “I refuse to play host to a man who has overseen the slaughter or injury of more than 64,000 children in Gaza with American taxpayer dollars.” Avila Chevalier, who is virtually guaranteed to win election in her deep blue district in November, has been a vocal pro-Palestinian activist and critic of Israel. She ousted Rep. Adriano Espaillat in June’s Democratic primary.

The electeds and protestors who joined them rained chants of “It is right to rebel, Netanyahu go to hell” in the direction of the United Nations, where Netanyahu later spoke. In his speech, Netanyahu addressed Mamdani, his vehement critic, directly.

“Mr. Mamdani, since you were elected mayor of this city, many Jews no longer feel safe in New York,” Netanyahu said. “You falsely, repeatedly accuse Israel of genocide. Mr. Mamdani, you tried to stop me from coming here. You tried to silence me. Well, you can't silence me. You can't silence the truth.”

The mayor responded to Netanyahu’s vitriolic speech with familiar scathing criticism. “As he has done time and again, Prime Minister Netanyahu used his speech to repeat baseless lies meant to sanitize his genocide of Palestinians,” Mamdani said in a statement. “Yet no lie can change the fact that he remains the subject of an International Criminal Court arrest warrant alleging war crimes and crimes against humanity.”

Just before Netanyahu was scheduled to speak, Mamdani posted a video on social media of him planting an olive tree at Gracie Mansion with Palestinian families from Gaza with part of the caption saying, “May peace be our future.”

Since Hamas’ attack on Israel on October 7, 2023 in which 1,200 people were killed and hundreds taken hostage, more than 70,000 Palestinians have been killed by the Israeli Defense Forces according to the United Nations.

Later on Thursday, the New York City chapter of the Palestinian Youth Movement, in coordination with Jewish Voice for Peace and several other organizations, hosted another march that began in Bryant Park before converging with a much larger group on Fifth Avenue.

The large crowd traveled down East 42nd Street, chanting, “Netanyahu you can’t hide, we charge you with genocide.” Some signs advocated for Gaza, while other signs protested war in Iran and U.S. financial support of Israel. The group made a couple turns before stopping close to the United Nations and the Trump World Tower residential building.

RNA interference biotech City Therapeutics files for a $100 million IPO

 City Therapeutics, a Phase 1 biotech developing RNA interference therapies for thromboembolic diseases, filed on Thursday with the SEC to raise up to $100 million in an initial public offering.


City Therapeutics is a clinical-stage biotech developing RNA interference (“RNAi”) therapeutics designed to silence the expression of disease-relevant proteins. It states that its current pipeline focused on indications with significant unmet medical need, including thromboembolic diseases, Stargardt disease type 1, and anemia of chronic disease, which it believes disease biology supports RNAi-mediated knockdown as a differentiated approach compared to other modalities. Its lead candidate, CITY-FXI, is a City-engineered GalNAc-conjugated small interfering RNA (“siRNA”) therapeutic candidate targeting Factor XI (“FXI”). City Therapeutics initiated a Phase 1 clinical trial for CITY-FXI in 2026, and states that initial data from the first three cohorts of the single-ascending dose (“SAD”) portion of the study in healthy volunteers showed that CITY-FXI was generally well-tolerated by participants with greater than 60% FXI knockdown observed following a single 15 mg subcutaneous dose, close to 80% FXI knockdown after a single 50 mg subcutaneous dose, and 85% knockdown three weeks after a single 150 mg subcutaneous dose. It expects to report additional data from the SAD portion of the Phase 1 study in late 2026.

The Cambridge, MA-based company was founded in 2023 and booked $14 million in revenue for the 12 months ended June 30, 2026. It plans to list on the Nasdaq under the symbol CTY. City Therapeutics filed confidentially on July 15, 2026. Goldman Sachs, Jefferies, Stifel, and Oppenheimer & Co. are the joint bookrunners on the deal. No pricing terms were disclosed.

Coast Guard Intercepts Alleged Smuggling Vessel With 13 Chinese Nationals

  by Jack Phillips via The Epoch Times,

Federal officials on Monday said the Coast Guard and Customs and Border Protection (CBP) intercepted an alleged smuggling vessel with nearly two-dozen people on board, including 13 Chinese nationals, near Florida's coast.

Last week, the Coast Guard and CBP detected "a surface target of interest" near Angelfish Creek, Florida, according to a Border Patrol news release. When they intercepted the vessel, they discovered it was a 27-foot-long cabin vessel before it was interdicted.

They found that one suspected human smuggler, a Cuban national, and 22 illegal immigrants of various nationalities were on board. That included 13 Chinese nationals, eight Ecuadorian nationals, and one from the Dominican Republican, officials said.

The people who were apprehended were transferred to Coast Guard cutter ship Pablo Valent for more processing, while the 27-foot long vessel was seized by federal authorities, the release said.

Lt. Corryn Ulrich, commanding officer of the Pablo Valent, said that the apprehensions show that the Coast Guard is "ready to save lives and enforce federal law at sea."

"Attempting to enter the United States illegally by sea is extremely dangerous and will not go undetected," a CBP regional director, Andres Blanco, said in a statement. "This interdiction demonstrates the strength of our maritime partnerships and our commitment to stopping human smuggling organizations before they can put more lives at risk. Those who attempt these dangerous voyages face arrest, prosecution, removal, and the very real possibility of losing their lives at sea."

The interdiction was carried out under the Coast Guard's Operation Vigilant Sentry, which is designed to stop illegal immigration into the United States from sea.

Photos of the arrest were published by an official Coast Guard X account earlier this week, showing a Coast Guard ship approaching the alleged smuggling vessel as well as the individuals who were on board.

Coast Guard officials this week said they discovered and interdicted a 30-foot-long vessel around a mile east of Ocean Reef, Florida, on Sept. 15.

On the vessel, Coast Guard boat crew members found 23 people before they transferred 20 of them to the Bahamas for processing. The other three were taken into Homeland Security Investigations custody, the Coast Guard said.

The Trump administration has made border security alongside mass deportations of illegal immigrants a priority. Since January 2025, President Donald Trump has issued a number of executive orders to stop border crossings.

The Department of Homeland Security, which oversees both the Coast Guard and CBP, reported 16 straight months of releasing no illegal immigrants into the United States at the U.S. - Mexico border, according to a statement published last week.

https://www.zerohedge.com/political/coast-guard-intercepts-alleged-smuggling-vessel-13-chinese-nationals

'Mamdani Campaign Alum In China Talks US Revolution: "Surprised If There's No Violence Going Forward"'

 Explicit calls to overthrow capitalism only suggest revolutionary goals within the reformist socialist movement. There have been reports that some of these reformist socialists have coordinated with foreign subversion networks in Cuba and China or used NGOs to conduct hybrid information warfare.

President Trump has clearly been briefed. 

The latest comments about revolution and the hope for violence in America come from far-left influencer Hasan Piker's China-based producer, Eric Hovagim, who also worked on socialist Zohran Mamdani's campaign and said on a recent podcast that he would be "very surprised if there is no violence going forward in the United States." 

Hovagim said, "I mean, it is simply the situation that they have put the working masses in. And I mean, we're seeing what's happening in the Global South, where you have October 7th happening. You know, this is something that happens when you put people in a pressure cooker, a concentration camp, when you do not allow them the basic human rights that we love to champion in the West."

"The workers of the United States are in the exact same predicament as the workers of the Global South. And it is frankly in their long-term interest to partner with them, to ensure that they can see eye to eye, to build an internationalist movement that goes beyond the four walls of the capitalist states of the United States of America. Because frankly, otherwise they are doomed," he continued.

He noted, "There is no militant group that has had any success whatsoever, maybe since the Black Panthers. But again, we saw what happened when the Black Panthers did have any success. So I don't know what's going to happen." 

In a separate podcast, Hovagim discussed his close friendship with China-based Marxist billionaire Roy Singham, whose network of revolutionary NGOs has been accused of promoting pro-Beijing and communist propaganda through what some describe as a possible foreign subversion network.

Via Free Press:

Taken together, these comments from Hovagim point to the broader far-left agenda, suggesting that the Democratic Socialists of America are not truly focused on affordability, Palestine, climate change, opposition to data centers, or whatever the hottest issue of the day may be.

Instead, they appear more focused on dismantling the foundations of America's capitalist system.

In fact, DSA leaders state their intentions very bluntly:

On another stream earlier this year, Hovagim told his followers: "I'm friends with Roy Singham. He's dope."

Roy Singham and a network of far-left NGOs are under intense scrutiny by the federal government ...

According to investigative reports (e.g., New York Times, 2023), Singham has worked closely with pro-CCP propaganda networks targeting the US.

Where self-described socialist reformers advocate dismantling capitalism and existing US institutions, their stated objectives point toward a violent revolution.

Any shift toward socialist unrest would raise a separate national security concern: who stands to benefit from social unrest?

Well, it's a shared interest of foreign adversaries as two wars rage in Eurasia, resource nationalism explodes, and the world is on a dangerous path. The good news is that Scott Bessent's NGO team may have disrupted any mobilization of riots this summer, since there were none. But that only suggests more chaos is just around the corner as these revolutionaries regroup. 

https://www.zerohedge.com/political/mamdani-campaign-alum-living-china-talks-us-revolution-very-surprised-if-theres-no

'Macron denies CIA warning of possible Russian attack'

 French President Emmanuel Macron on Thursday rejected reports that the CIA had warned France of a possible Russian drone attack targeting southern Europe, saying French intelligence had received no such alert.

"We can deny this information. The CIA did not inform the French intelligence services" of such a possibility, Macron said during an interview with TF1 and France 2. He nevertheless warned that the situation was concerning and such attacks "could happen."

His remarks echoed Italian Defense Minister Guido Crosetto, who, hours earlier, said reports of potential Russian attacks on Italy, Spain and France "find no confirmation" and urged against adding "fuel to the fire." The claims were reported by Spain’s El Mundo, which cited US intelligence and Lithuanian sources on possible sea-launched Russian Gerbera drones targeting Mediterranean countries.

https://breakingthenews.net/Article/Macron-denies-CIA-warning-of-possible-Russian-attack/67172918

As vertical integration scrutiny grows, UnitedHealth takes center stage

 “UnitedHealth Group should not be allowed to exist in the form that it currently does.”


That was late-night TV host John Oliver’s verdict in his Sept. 20 episode on the inner workings of UnitedHealth Group, digging into a dramatic multi-year saga for the company that’s included a massive cyberattack, a sharp earnings decline and the killing of UnitedHealthcare CEO Brian Thompson. The episode aired ahead of Luigi Mangione’s Dec. 18 federal sentencing.

And while everything from algorithmic care decisions and prior authorization to pharmacy benefit manager conduct and the opioid crisis was discussed (and made the butt of many jokes), the core of the segment centered on a topic that continues to hang over the wider health insurance industry: vertical integration.

It’s certainly not a new term or concept in healthcare; the idea of combining the insurer and the physician under one roof most notably traces back to the 1940s and Kaiser Permanente. But over the last two decades, the health insurance mega-conglomerate has emerged, combining insurance, providers, pharmacy and data services under one parent organization. National health spending roughly tripled over the same period to an estimated $5.7 trillion in 2025, according to CMS projections, and scrutiny of the business model has grown in tandem.

UnitedHealth is now the fourth-largest company in the world by revenue, having posted more than $447 billion last year, up 11.8% year over year. It reported just 10 “significant subsidiaries” to the federal government for 2025, down from thousands the year before, after a July 2025 report that pegged its overall corporate structure at nearly 2,700 companies spanning insurance, care delivery, pharmacy, technology and administrative assets across the two core divisions of UnitedHealthcare and Optum. Similarly, Cigna has Evernorth, CVS Health’s portfolio includes Aetna, Elevance owns Carelon, and Humana with CenterWell.

Take the January congressional hearings as an example of the growing scrutiny, where the CEOs of the nation’s largest insurers drew the ire of lawmakers on both sides of the aisle. At one, Rep. Greg Murphy, R-N.C., told the executives they “need to be broken up” and that he’d like to “turn all of you guys into dust.” Rep. Alexandria Ocasio-Cortez, D-N.Y., said, “I think corporate monopolies are a problem. And this vertical integration is destroying people’s ability to access care.”

For their parts, the leaders of UnitedHealth, CVS, Elevance, Cigna and Ascendiun defended their respective organizations and the role each plays within the wider healthcare system, pointing to things like improved care coordination, data usage and integration of expensive drugs and therapies.

UnitedHealth CEO Stephen Hemsley described the company’s structure as “a very substantial value dynamic in terms of bringing a better care experience and more value to the healthcare environment in total.”

Then in February, the two parties joined forces again when Sens. Elizabeth Warren, D-Mass., and Josh Hawley, R-Mo., introduced the Break Up Big Medicine Act, which would prevent companies from simultaneously owning a health insurer or pharmacy benefit manager and a provider or management services organization. The proposal won the endorsement of Cost Plus Drugs’ Mark Cuban, who publicly called for divestment from publicly-traded insurers in August.

Democrats have even reportedly discussed a healthcare policy agenda that could include breaking up large healthcare organizations should the party win back control of the House during November’s midterms. In Texas, Democratic Senate candidate James Talarico released a plan to break up what he called “Big Medicine monopolies.” 

To level-set on the actual outcome of the hearings and the wider political rhetoric: no new consequential laws have passed, and the integrated business model is full steam ahead. In public, President Donald Trump has blasted “big, fat, rich insurance companies,” even as his administration’s annual Medicare Advantage rate-setting process produced a 2.48% increase in payments to insurers for 2027, worth more than $13 billion.

Still, federal regulators have continued scrutinizing individual transactions and business practices, with the Justice Department requiring UnitedHealth to divest more than 160 home health and hospice locations before approving its $3.3 billion Amedisys acquisition last year, along with the company previously disclosing that it was complying with criminal and civil DOJ requests tied to its MA business.

UnitedHealth has also taken additional steps to try and temper the negative environment, releasing the results of independent audits of its MA, utilization management and pharmacy practices in December and opening its headquarters to reporters for on-the-record access to senior leadership in June. 

Complicating matters further is that a “vertically integrated healthcare company” is not an easy thing to define or explain in scope within a wider industry that has rapidly consolidated in recent years. While health insurers, and certainly UnitedHealth as the largest, consistently face the most heat, many large health systems have their own insurance company, and that typically flies more under the radar of lawmakers, media and the wider public.

Most workers with employer-sponsored health insurance (63% in 2024), are also in self-funded plans, meaning their company pays claims directly and decides what is and isn’t covered, while insurers like UnitedHealthcare are hired to administer those benefits. But as commercial premium costs have surged across nearly every market, the insurer names on the most benefits cards are understandably seeing the biggest pushback.

Recent research points in different directions, too. The OIG found in May that enrollees without financial assistance in vertically integrated Medicare Part D plans paid lower premiums but nearly 40% more in out-of-pocket costs for the drugs studied than those in other plans. A Health Affairs analysis published last September argued that insurers that own providers can use internal payments to meet medical loss ratio requirements under the ACA and shrink their rebate obligations. And a study published this month in Health Affairs found no decline in procedure volume or quality at the nearly 300 ASCs UnitedHealthcare acquired over the last decade. Researchers there also found slightly lower complication rates for colonoscopies and lower facility prices negotiated by UnitedHealthcare relative to other insurers following the acquisitions.

These complexities rarely make it into the wider public conversation, where frustration with insurers is notably running high. In his segment, Mr. Oliver cited a NORC poll taken shortly after Mr. Thompson’s killing, where 69% of respondents said coverage denials by health insurers bore a great deal or moderate amount of responsibility for it, compared with 78% who said the same of the person who committed the killing. Costs are also voters’ top healthcare concern heading into the midterms, with 51% calling the issue “extremely important” for candidates to discuss, according to a July KFF poll. The Last Week Tonight episode has tapped directly into that frustration and to date has drawn 3.5 million views on YouTube alone. Mr. Oliver closed the segment with his own much broader indictment of the industry’s structure.

“I know United may well continue to try to tune out the critical noise or argue that nobody designed this system. It simply evolved,” Mr. Oliver said. “But what is clear is that everybody but them wants it to work very differently, because right now, the way that companies like United exist — they are at best, pointless, time-wasting middlemen, and at worst, algorithmically-driven, ruthless arbiters of who lives and who dies.”

Becker’s has reached out to UnitedHealth for comment.

https://www.beckershospitalreview.com/finance/as-vertical-integration-scrutiny-grows-unitedhealth-takes-center-stage/